Multiple Sessions of Antimicrobial Photodynamic Therapy Improve Periodontal Outcomes in Patients with Down Syndrome: A 12-Month Randomized Clinical Trial by Rafael Ferreira, Sebastião Luiz Aguiar Greghi, Adriana Campos Passanezi Sant’Ana, Mariana Schutzer Ragghianti Zangrando, Carla Andreotti Damante

“…A randomized, double-blind, parallel trial was conducted with 37 individuals with DS. …”
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Electroacupuncture combined with cognitive rehabilitation outperforms cognitive rehabilitation alone in treating post-stroke cognitive impairment: a randomized controlled trial by Yisha Guo, Tingting Sun, Fengxi Qiu, Xueyi Li, Weiwei Cui, Zhenhua Liao, Jiajia Yao

“…These findings indicate that EA, combined with CR, is a safe and effective treatment for cognitive impairment following stroke, potentially via structural brain network improvements.Clinical trial registrationhttps://clinicaltrials.gov/, ChiCTR2200066160.…”
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Peritoneal instillation of magnesium sulfate and bupivacaine improves postoperative pain in laparoscopic cholecystectomy: A prospective, double-blind, randomized clinical trial by Santosh Kumar Sahu, Prerna Biswal, Madhusmita Patro, Sushree Das

“…Materials and Methods: We carried out this prospective, double-blind, randomized trial in 90 patients aged between 20 and 60 years who were randomly divided into three groups. …”
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Randomized Control Trial for Reduction of Body Weight, Body Fat Patterning, and Cardiometabolic Risk Factors in Overweight Worksite Employees in Delhi, India by Usha Shrivastava, Mahrukh Fatma, Smriti Mohan, Padam Singh, Anoop Misra

“…Trial Registration. This trial is registered with NCT03249610.…”
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Impact of the Smarter Safer Homes Solution on Quality of Life and Health Outcomes in Older People Living in Their Own Homes: Randomized Controlled Trial by Wei Lu, David Silvera-Tawil, Hwan-Jin Yoon, Liesel Higgins, Qing Zhang, Mohanraj Karunanithi, Julia Bomke, Joshua Byrnes, Jennifer Hewitt, Vanessa Smallbon, Jill Freyne, Deepa Prabhu, Marlien Varnfield

“…Trial RegistrationAustralian New Zealand Clinical Trials Registry ACTRN12618000829213; https://tinyurl.com/2n6a75em International Registered Report Identifier (IRRID)RR2-10.2196/31970…”
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Sleep Promotion among Critically Ill Patients: Earplugs/Eye Mask versus Ocean Sound—A Randomized Controlled Trial Study by Abhilasha Chaudhary, Vinay Kumari, Neetu Neetu

“…However, further research in this area needs to be conducted. This trial is registered with NCT03215212.…”
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A Pilot Trial of Pioglitazone HCl and Tretinoin in ALS: Cerebrospinal Fluid Biomarkers to Monitor Drug Efficacy and Predict Rate of Disease Progression by Todd D. Levine, Robert Bowser, Nicole C. Hank, Stephen Gately, Dietrich Stephan, David S. Saperstein, Kendall Van Keuren-Jensen

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HELLO: a protocol for a cluster randomized controlled trial to enhance interpersonal relationships and team cohesion among ICU healthcare professionals by Elie Azoulay, Nancy Kentish Barnes, Sheila Nainan Myatra, Maria-Cruz Martin Delgado, Yaseen Arabi, Carole Boulanger, Giovanni Mistraletti, Maria Theodorakopoulou, Vernon Van Heerden, José-Artur Paiva, Oktay Demirkýran, Gabriel Heras La Calle, Abdulrahman Al Fares, Gaston Burghi, Guy Francois, Anita Barth, Jan De Waele, Samir Jaber, Michael Darmon, Maurizio Cecconi

“…It holds the potential to provide valuable insights into effective strategies for addressing burnout in ICU settings, ultimately benefiting both HCPs and patients. Trial registration: This trial was registered on ClinicalTrials.Gov on June 18, 2024. …”
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Comparative Evaluation of Implant-Protected Occlusion in Partially Edentulous Fixed Restoration Using Qualitative and Quantitative Assessment – A Prospective Clinical Trial by Ramesh Chowdhary, S Bukkapatnam

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Four Weeks of Inspiratory Muscle Training Improves Self-Paced Walking Performance in Overweight and Obese Adults: A Randomised Controlled Trial by A. M. Edwards, G. P. Maguire, D. Graham, V. Boland, G. Richardson

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Effect of Staggered vs. Simultaneous Co-Administration of Bempedoic Acid on Pharmacokinetics of Pravastatin: Randomized, Cross-Over Clinical Trial in Healthy Volunteers by Felicitas Stoll, Salvatore Amato, Max Sauter, Jürgen Burhenne, Johanna Weiss, Walter E. Haefeli, Antje Blank

“…<b>Methods</b>: This was a single-centre, open-label, randomized, two-arm, cross-over, phase I drug interaction trial in healthy volunteers (EudraCT-No: 2022-001096-13). …”
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Estimating the Effect of Adhering to the Recommendations of the 2019 Canada’s Food Guide on Health Outcomes in Older Adults: Protocol for a Target Trial Emulation by Didier Brassard, Nancy Presse, Stéphanie Chevalier

“…Although ideal, conducting a large randomized controlled trial is unrealistic in the short term. An alternative is the target trial emulation framework for causal inference, a novel approach to improve the analysis of observational data. …”
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The Role of Butirprost^® as an Adjuvant in Enhancing the Effect of Antibiotics in Patients Affected by Chronic Bacterial Prostatitis: A Randomized Prospective Trial by Felice Crocetto, Armando Calogero, Michele Santangelo, Agostino Fernicola, Filippo Varlese, Benito Fabio Mirto, Fabio Machiella, Alfonso Falcone, Giovanni Pagano, Fabrizio Dinacci, Gaetano Giampaglia, Domenico Varriale, Francesco Trama, Salvatore Iaconis, Francesco Del Giudice, Gian Maria Busetto, Matteo Ferro, Francesco Lasorsa, Giuseppe Lucarelli, Ciro Imbimbo, Biagio Barone

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Terbinafine versus itraconazole: a long-term, randomized, double-blind, clinical trial in chronic pulmonary aspergillosis. A pilote study by Gianfranco Schiraldi, Salvatore Lo Cicero, Claudio Rossetti, Delia Colombo, Michele Chiericozzi, Elvana Kola, Luigi Allegra

“…Methods: A randomised, double-blind, multicentre trial compared terbinafine (500 mg b.i.d) with itraconazole (200 mg b.i.d.) with respect to successful outcomes for up to 6 months in 24 patients with chronic pulmonary aspergillosis. …”
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Once-Daily, Controlled-Release Tramadol and Sustained-Release Diclofenac Relieve Chronic Pain due to Osteoarthritis: A Randomized Controlled Trial by André D Beaulieu, Paul M Peloso, Boulos Haraoui, William Bensen, Glen Thomson, John Wade, Patricia Quigley, John Eisenhoffer, Zoltan Harsanyi, Andrew C Darke

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Intubation Success through I-Gel® and Intubating Laryngeal Mask Airway® Using Flexible Silicone Tubes: A Randomised Noninferiority Trial by Latha Naik, Neerja Bhardwaj, Indu Mohini Sen, Rakesh V. Sondekoppam

“…The study aims to test whether flexible silicone tubes (FST) improve performance and provide similar intubation success through I-Gel as compared to ILMA. Our trial is registered in CTRI and the registration number is “CTRI/2016/06/006997.” …”
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Role of Tailored Timing and Frequency Prompts on the Efficacy of an Internet-Delivered Stress Recovery Intervention for Health Care Workers: Randomized Controlled Trial by Auguste Nomeikaite, Odeta Gelezelyte, Maria Böttche, Gerhard Andersson, Evaldas Kazlauskas

“…Future research is needed to test the effects of the stress recovery intervention supplemented by goal setting and tailored prompts. Trial RegistrationClinicalTrials.gov NCT05553210; https://clinicaltrials.gov/study/NCT05553210…”
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IMPACT-CABG Trial: Implantation of CD133+ Stem Cells in Patients Undergoing Coronary Bypass Surgery—Presentation of the First Treated Patient by Jessica Forcillo, Louis-Mathieu Stevens, Samer Mansour, Ignacio Prieto, Denis-Claude Roy, Nicolas Noiseux

“…Herein, we report the first Canadian patient treated with IM injection of CD133+ cells during CABG surgery as part of the IMPACT-CABG trial.…”
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Acceptability and efficacy of the culturally adapted problem management plus intervention for people with disability in Pakistan: a pilot cluster randomized controlled trial by Basharat Hussain, Basharat Hussain, Muhammad Tahir Khalily, Muhammad Tahir Khalily, Ahmed Waqas, Atif Rahman, Ioannis Angelakis, Anum Nisar, Sabir Zaman, Tanveer Akhtar

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A systematic review and meta-analysis of randomized controlled trials for physical activity among colorectal cancer survivors: directions for future research by Jiayu Mao, Xiaoke Qiu, Yi Zhang, Can Wang, Xueli Yang, Qiuping Li

“…However, further high-quality clinical trials are needed to determine the optimal timing, duration, and delivery methods of PA interventions to maximize their effectiveness in this population.…”
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