Effect of Local Warm Compression on Restless Leg Syndrome and Fatigue among Critical Care Nurses: A Parallel Randomized Clinical Trial by Maryam Ameri, Hossein Ebrahimi, Ahmad Khosravi, Seyedmohammad Mirhosseini, Mohammad Reza Khatibi

“…This parallel randomized clinical trial was conducted on 120 CCNs in Shahroud by the census sampling method. …”
Get full text

Clinical Comparison of MEBO and Hyaluronic Acid Gel in the Management of Pain after Free Gingival Graft Harvesting: A Randomized Clinical Trial by Ahmed Hassan, Enji Ahmed, Dalia Ghalwash, Azza Ezz Elarab

Get full text

Effects of functional strength training on pain, function, and lower extremity biomechanics in patients with patellofemoral pain syndrome: a randomized clinical trial by Zheyu Xiong, Wei Zheng, Haiwen Wang, Yuan Gao, Chengshuo Wang

“…Conclusion Interventions focused on functional adaptations result in differential kinematic and muscle activation changes that may result in greater improvements in pain and knee function than lower limb muscle strengthening alone. Trial registration chictr.org.cn. NO: ChiCTR2400087664. …”
Get full text

Coronectomy versus total odontectomy of impacted lower third molars with close relation tothe inferior alveolar canal: An open clinical trial. by Hundren Muhammad, Rozh Mumtaz, Dilman Najmaddin, Omed Ikram

Get full text

Effectiveness of nefopam-dexamethasone versus pethidine-dexamethasone for postoperative pain management in cesarean sections: a double-blind, prospective clinical trial by Julian Ojebo, Joseph Achi, Ifeanyichukwu Michael Chukwu, Osadebamen Mercy Oboh, Benedict Ezeife, Aisha Sanusi Muazu, Christian Osemudiamen Igibah, Salami Ezekiel Kelvin

Get full text

Persistent effect of salt reduction in schoolchildren and their families: 1-year follow-up after an application-based cluster randomized controlled trial by Yuan Li, Puhong Zhang, Feng J. He, Rong Luo, Jing Song, Changqiong Wang, Fengge Chen, Wei Zhao, Yuhong Zhao, Hang Chen, Tianyong Wu, Xiaoyan Wang, Hui Zhou, Zhi Han, Jie Zhang

“…Abstract Background A 12-month cluster randomized controlled trial (RCT) demonstrated the effectiveness of an application-based education program in reducing the salt intake and systolic blood pressure (SBP) of schoolchildren’s adult family members. …”
Get full text

Macrophages Phenotype Regulated by IL-6 Are Associated with the Prognosis of Platinum-Resistant Serous Ovarian Cancer: Integrated Analysis of Clinical Trial and Omics by Xiaoqing Wu, Wenping Lu, Chaojie Xu, Cuihong Jiang, Zhili Zhuo, Ruipeng Wang, Dongni Zhang, Yongjia Cui, Lei Chang, Xi Zuo, Ya’nan Wang, Heting Mei, Weixuan Zhang, Mengfan Zhang, Chen Li

Get full text

Examining anti-inflammatory therapies in the prevention of cardiovascular events: protocol for a systematic review and network meta-analysis of randomised controlled trials by George A Wells, Kevin Emery Boczar, Sheojung Shin, Kathryn A Bezzina, Aishwarya Geejo, Alexander Liam Pearson, Saba Shahab, Christophe A Fehlmann, Sarah Visintini, Rob Beanlands

“…Studies will be retrieved from Medline, Embase, the Cochrane Central Register of Controlled Trials, as well as clinical trial registry websites, Europe PMC and conference abstract handsearching. …”
Get full text

Evaluation of parent and youth experiences in advisory groups as part of a mental healthcare clinical trial: protocol for a mixed-method study by Maria-Jose Santana, Gina Dimitropoulos, Suneeta Monga, Isabelle J Gagnon, Bruce Wright, Jananee Rasiah, Katrina Hurley, Antonia Stang, Amanda Newton, Stephen Freedman, Jennifer Thull-Freedman, Kassi Prisnie, Yazid N Al Hamarneh, Ellen Louise Lipman, Yaron Finkelstein, Robert Porter, Mohamed Eltorki, Lee Macdonald, Gareth Hopkin, Matthew Prebeg, Margaret Steele, Ahmed Mater, Laurence Katz, Brian Greenfield, Laurie Plotnick

“…Introduction Patient engagement in healthcare research is a necessity to ensure that research objectives align with priorities, outcomes and needs of the population under study, and to facilitate ease of implementation and adoption of findings. In clinical trials, there is an increasing focus on patient engagement during the planning and conduct of clinical trials due to the potential for ethical and methodological benefits. …”
Get full text

First-in-human exploratory trial assessing safety, feasibility, and efficacy of artificial protein (silk-elastin) in promoting healing in patients with meniscus injuries by Masakazu Ishikawa, Shunya Tsuji, Goki Kamei, Kyohei Nakata, Akinori Nekomoto, Naofumi Hashiguchi, Tomoyuki Nakasa, Atsuo Nakamae, Naosuke Kamei, Keiichiro Inoue, Shingo Kawabata, Keiko Ueda, Nobuo Adachi

Get full text

Transcranial direct current stimulation combined with physical exercise in rotator cuff tendinopathy: a protocol for a blinded randomised controlled trial by César Augusto Medeiros Silva, Clécio Gabriel de Souza, Vinicius Batista Lima, Hannely Beatriz Menezes Cosme, Romário Nóbrega Santos Fonseca, Fuad Ahmad Hazime, Rodrigo Scattone da Silva, Rodrigo Pegado de Abreu Freitas

“…The results will be published later in peer-reviewed journals and scientific events.Trial registration number The Brazilian Registry of Clinical Trials (RBR-59xmv6s); Results.…”
Get full text

Nutrition Education Improves Knowledge of Iron and Iron-Rich Food Intake Practices among Young Adolescents: A Nonrandomized Controlled Trial by Michael Akenteng Wiafe, Charles Apprey, Reginald Adjetey Annan

Get full text

Mobile Phone App to Promote Lifestyle Change in People at Risk of Type 2 Diabetes: Feasibility 3-Arm Randomized Controlled Trial by Gyri Skoglund, Gunvor Hilde, Pernille Lunde, Venessa Vera Cruz Naceno, Cecilie Fromholt Olsen, Birgitta Blakstad Nilsson

“…The secondary aim was to assess recruitment rate, resource requirements, and change in potential outcomes for a full scale randomized controlled trial (RCT) study . MethodsA 3-arm feasibility RCT lasting 12 weeks was designed. …”
Get full text

Effects of biophilic virtual reality on cognitive function of patients undergoing laparoscopic surgery: study protocol for a sham randomised controlled trial by Bin Gao, Yanling Zhou, Jianhua Wang, Binbin Zhu, Qiuyan Weng, Wenjun Luo, Xiuchao He, Lufei Jin, Qinwen Wang, Ahmad Khaled Ahmad Harb

“…All information acquired will be disseminated via national or international conferences and published in peer-reviewed journals.Trial registration number ChiCTR2000040919.…”
Get full text

Rapid Adaptation to Prevent Drug Use (RAPD): protocol of a pilot randomized trial to enhance the impact of an evidence-based intervention for youth by Andria B. Eisman, Christine Koffkey, Robert T. Partridge, Suzanne Brown, Bo Kim

“…The rationale for the proposed research is that designing and testing RAPD will advance implementation science in responding to urgent public health events and ensure equitable responses across youth populations. Trial registration ClinicalTrials.gov NCT05806840 .…”
Get full text

Induction Versus Noninduction Antiviral Therapy for Chronic Hepatitis C Virus in Patients with Congenital Coagulation Disorders: A Canadian Multicentre Trial by A Chatterjee, MG Swain, SS Lee, VG Bain, K Peltekian, K Croitoru, PC Adams, K Kaita, J Teitel, EJ Heathcote

Get full text

Comparison of Different Machine Learning Methodologies for Predicting the Non‐Specific Treatment Response in Placebo Controlled Major Depressive Disorder Clinical Trials by Roberto Gomeni, Françoise Bressolle‐Gomeni

Subjects: Get full text

Comparative evaluation of intravenous versus intranasal dexmedetomidine on emergence delirium and hemodynamics in pediatric patients undergoing adenotonsillectomy: a randomized controlled trial by Chenxu Dai, Chenxu Dai, Xuemei Zhao, Xuemei Zhao, Aoxue Li, Xuedong Zhang, Penglei Wang, Ye Zhang, Yun Wu

“…Intranasal administration of dexmedetomidine provided more stable hemodynamics and more prolonged analgesia and sedation than intravenous infusion of dexmedetomidine.Clinical Trial Registrationhttps://www.chictr.org.cn/showproj.html?…”
Get full text

Effects of Pioglitazone on Asymmetric Dimethylarginine and Components of the Metabolic Syndrome in Nondiabetic Patients (EPICAMP Study): A Double-Blind, Randomized Clinical Trial by Pedram Shokouh, Adel Joharimoghadam, Hamidreza Roohafza, Masoumeh Sadeghi, Allahyar Golabchi, Maryam Boshtam, Nizal Sarrafzadegan

“…The present trial aimed to investigate the effects of pioglitazone on the serum level of asymmetric dimethylarginine (ADMA), a marker of endothelial function, and some indices of inflammation and glucose and lipid metabolism in nondiabetic metabolic syndrome patients. 104 eligible participants (57% female; age between 20 and 70) were enrolled in a double-blind placebo-controlled trial and were randomized to receive either pioglitazone (uptitrated to 30 mg/day) or matching placebo for 24 weeks. …”
Get full text

Microneedling in Combination with Topical Pimecrolimus 1% versus Topical Pimecrolimus 1% for the Treatment of Refractory Stable Vitiligo: A Randomized Clinical Trial by Fariba Iraji, Ali Asilian, Zahra Talebzadeh, Mina Saber, Fatemeh Mokhtari, Amirhossein Siadat, Seyed Mohsen Hosseini

“…Methods. This clinical trial was conducted on 30 skin lesions on 15 Al-Zahra hospital patients. …”
Get full text