The effect of caregiver opinion leaders to increase demand for evidence-based practices for youth anxiety: A cluster randomized controlled trial by Margaret E. Crane, Marc S. Atkins, Sara J. Becker, Jonathan Purtle, Gillian C. Dysart, Sydney Keller, Olivia Brauer, Sirina E. Tiwari, Thomas M. Olino, Lara Baez, John Lestino, Philip C. Kendall

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The sarcoma ring trial: a case-based analysis of inter-center agreement across 21 German-speaking sarcoma centers by Siyer Roohani, Jolina Handtke, Kamal Hummedah, Markus Albertsmeier, Dimosthenis Andreou, Leonidas Apostolidis, Marinela Augustin, Sebastian Bauer, Moritz Billner, Florian Bösch, Christoph K. W. Deinzer, Niklas Deventer, Anna Duprée, Franziska Eckert, Lars Engel, Katja Fechner, Hagen Fritzsche, Verena Gaidzik, Saeed Ghani, Robert Grützmann, Wiebke K. Guder, Rainer Hamacher, Judith S. Hecker, Anne Hendricks, Axel Hillmann, Philipp Houben, Georg Hübner, Philipp Ivanyi, Christina Jentsch, Maren Jordan, Peter Kappl, Moritz Kaths, Torsten Kessler, Johanna Kirchberg, Carolin Knebel, Robert Krempien, Burkhard Lehner, Ulrich Lenze, Lars H. Lindner, Alisa Martina Lörsch, Nadia Maguire, Sophie Müller, Pompiliu Piso, Vlatko Potkrajcic, Peter Reichardt, Stephan Richter, Simone Schewe, Lars M. Schiffmann, Felicitas Scholten, Jana Käthe Striefler, Matthias Schwarzbach, Katharina Seidensaal, Sabine Semrau, Joanna Szkandera, Christoph J. Szuszies, Beate Timmermann, Armin Tuscherer, Armin Wiegering, Moritz T. Winkelmann, David Kaul, Jens Jakob

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Yishenyangsui granule for degenerative cervical myelopathy: a randomized, double-blind, placebo-controlled trial with long-term follow-up by He Yin, Xin Chen, Zhiwei Liu, Zhiwei Liu, Bo Xu, Zhefeng Jin, Yan Liu, Baoyu Qi, Bin Tang, Ping Wang, Fanping Xu, Xu Wei, Jie Yu, Liguo Zhu, Liguo Zhu

“…ObjectiveThis randomized controlled trial aims to evaluate the efficacy and safety of Yishenyangsui granule for treating Degenerative Cervical Myelopathy.Materials and methodsA randomized, double-blind, placebo-controlled clinical trial was conducted with 152 participants recruited from three centers and randomly assigned to receive either Yishenyangsui granule or placebo. …”
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Effects of a cardiopulmonary rehabilitation programme on submaximal exercise in Tunisian patients with long-COVID19: A randomized clinical trial by Rania Kaddoussi, Hadhemi Rejeb, Amine Kalai, Eya Zaara, Naceur Rouetbi, Zohra Ben Salah Frih, Piotr Zmijewski, Helmi Ben Saad

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Nurse Participation in Colonoscopy Observation versus the Colonoscopist Alone for Polyp and Adenoma Detection: A Meta-Analysis of Randomized, Controlled Trials by Lei Xu, Yu Zhang, Haojun Song, Weihong Wang, Sijie Zhang, Xiaoyun Ding

“…The PUBMED, EMBASE, and Cochrane Library databases were searched for randomized controlled trials (RCTs) published in English. The outcome measurements included (1) the polyp and adenoma detection rate (PDR and ADR); (2) the advanced lesions detection rate; and (3) the mean polyp and adenoma detection rate per colonoscopy. …”
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Therapeutic Effects of BCG Vaccination on Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Yu-Chen Chang, Chien-Ju Lin, Yu-Hsuan Hsiao, Yu-Han Chang, Shu-Jung Liu, Hsin-Yin Hsu

“…The randomized controlled trials (RCTs) that evaluated glycemic control in response to the BCG vaccine for T1DM were enrolled. …”
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Evaluating novel approaches for estimating awake and sleep blood pressure: design of the Better BP Study – a randomised, crossover trial by Paul Muntner, Ligong Chen, Daichi Shimbo, Joseph E Schwartz, Maria Cepeda, Demetria Hubbard, Suzanne Oparil, Byron C Jaeger, Shakia T Hardy, Julia Medina

“…The study results will be disseminated at scientific conferences and published in peer-reviewed journals.Trial registration number NCT04307004.…”
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Comment on: Effect of combined training on body image, body composition and functional capacity in patients with breast cancer: controlled clinical trial by Piyush Bharadwaj, Divya Khati, Simran Sunil Khutarkar, Sweta Verma

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DAILY – A personalized circadian Zeitgeber therapy as an adjunctive treatment for alcohol use disorder patients: results of a pilot trial by Naomi Springer, Naomi Springer, Lisa Echtler, Lisa Echtler, Paul Volkmann, Anisja Hühne-Landgraf, Anisja Hühne-Landgraf, Jasmin Hochenbleicher, Eva Hoch, Eva Hoch, Gabi Koller, Dominic Landgraf

“…In our view, these data justify a continuation of the DAILY study with the addition of further measurements such as the determination of endogenous circadian rhythms.Clinical trial registrationhttps://drks.de, identifier DRKS00019093.…”
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A randomised trial comparing preoperative administration of single-dose kefazolin to kefazolin plus metronidazole as prophylactic antibiotics at caesarean section by R Lamfel, L Snyman, L Seopela, G Jahn, P Becker

“…Pregnancy-related sepsis was listed as a top-six cause of maternal mortality in the South African Saving Mothers report between 2017 and 2019. Multiple trials have been conducted in an attempt to optimise administration of prophylactic antibiotics in an effort to reduce postpartum infection and maternal sepsis, and current practice guidelines suggest that there is sufficient evidence that extended-spectrum antibiotics, in combination with kefazolin, result in reduction of postpartum infections. …”
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Effect of conservative treatment on greater trochanteric pain syndrome: a systematic review and network meta-analysis of randomized controlled trials by Si-Qi Wang, Ning-Yi Guo, Wei Liu, Hong-jie Huang, Bing-bing Xu, Jian-quan Wang

“…Methods In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, the PubMed, Embase, Cochrane Library and ClinicalTrials.gov along with other databases were searched to identify relevant studies. …”
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A Randomized Placebo-Controlled Dose-Response Trial of Muvz™ for Knee and Low-Back Support in Physically Active Adults by Kalman D, Srivastava S, Desale A, Chatte Snr MD, Nalavade RJ, Shah Snr KM, Karvir S, Bhasale S

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Adapting the World Health Organization’s Surgical Safety Checklist to High-Income Settings: A Hybrid Effectiveness-Implementation Trial Protocol by Nathan Turley, MA, MBA, Karolina Kogut, BA, Barbara Burian, PhD, Rachel Moyal-Smith, DrPH, PA-C, James Etheridge, MD, MPH, Yves Sonnay, MScPH, William Berry, MD, MPH, Alan Merry, MD, MBChB, Alexander Hannenberg, MD, Alex B. Haynes, MD, MPH, Roger D. Dias, MD, PhD, MBA, Kathryn Hagen, MD, George Molina, MD, MPH, Lisa Spruce, DNP, RN, Carla Williams, RN, MHSM, Mary E. Brindle, MD, MPH, FRCSC

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A Randomized Trial to Evaluate the Sustained Efficacy of a Mucus Clearance Device in Ambulatory Patients with Chronic Obstructive Pulmonary Disease by Norman Wolkove, Marc A Baltzan, Hany Kamel, Michael Rotaple

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Comment on “Long-Term Outcome of Immediate Versus Postponed Intervention in Patients With Infected Necrotizing Pancreatitis (POINTER)”: Multicenter Randomized Trial by Shuirong Lin, MD, Ziming Song, MD, PhD, Xi Yu, MD, Wenxuan Xie, MD,PhD, Shunli Shen, MD, PhD, Ming Kuang, MD, PhD

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A Vaginal Inlay for Reduction of Stress Urinary Incontinence: Outcome of a Randomized Clinical Trial and Four User Acceptance Studies by Aino Fianu Jonasson, Karin Bryder, Elisabeth Sthengel

“…A multicenter, randomized, controlled clinical trial and four postmarket user acceptance investigations were carried out to document the safety, performance, and user acceptance of Efemia Bladder Support, a novel vaginal inlay for the temporary reduction of stress urinary incontinence (SUI). …”
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A randomized controlled trial to study the efficacy of 1% vs. 2% lignocaine in topical airway anesthesia in routine bronchoscopy procedures by Danny Prasad, Prince James, Richa Gupta

“…This double-blinded, randomized controlled trial compared the efficacy of 1% and 2% lignocaine solutions for topical anesthesia during routine flexible bronchoscopy procedures. …”
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Role of Platelet-rich Plasma in Unexplained Recurrent Implantation Failure – A Systematic Review and Meta-analysis of Randomised Control Trials by Harpreet Kaur, Meenakshi Meenu, Shivam Pandey, Anil Chauhan, Mishu Mangla

“…Materials and Methods: An electronic database search for randomised clinical trials comparing PRP against routine care in women with unexplained RIF was performed on PubMed, EMBASE, SCOPUS and Cochrane Central. …”
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Efficacy and Safety of a Novel Herbal Medicine in the Treatment of Irritable Bowel Syndrome: A Randomized Double-Blinded Clinical Trial by Ghasem Bordbar, Mohammad Bagher Miri, Mahmoud Omidi, Saeed Shoja, Malihe Akhavan

“…(AG) are being used as an antiseptic, carminative, and antispasmodic in traditional medicine. This trial investigated the efficacy and safety of a combination of ZM, AG, and TA essential oils in the treatment of IBS. …”
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Viable Extreme Preterm Birth and Some Neonatal Outcomes in Double Cerclage versus Traditional Cerclage: A Randomized Clinical Trial by Farzaneh Broumand, Fatemeh Bahadori, Tahereh Behrouzilak, Zahra Yekta, Farkhondeh Ashrafi

“…The pregnant women at higher risk of preterm labor, referred to the perinatal clinic of Kosar University Hospital in Urmia district of Iran, were enrolled into a parallel randomized clinical trial. In the investigational arm of the clinical trial, a double cervical cerclage procedure was performed addition to McDonald cerclage. …”
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