Beta-Blockers After PCI for Stable Coronary Artery Disease and Preserved Left Ventricular Ejection Fraction by Safi U. Khan, MD, MS, Usman Ali Akbar, MD, Muhammad Shahzeb Khan, MD, Kershaw V. Patel, MD, Amna Nadeem, MBBS, Samarth Thakkar, MD, Hassaan B. Arshad, MD, Salim S. Virani, MD, PhD, Khurram Nasir, MD, MPH, Sachin S. Goel, MD, Alpesh R. Shah, MD, William Zoghbi, MD, Neal S. Kleiman, MD

Subjects: Get full text

Comparative effectiveness of laparoscopic versus open colectomy in colon cancer patients: a study protocol for emulating a target trial using cancer registry data by Semaw Ferede Abera, Gabriele Robers, Anika Kästner, Ulrike Stentzel, Kerstin Weitmann, Wolfgang Hoffmann

Subjects: “…Target trial emulation…”
Get full text

A randomized, double-blind, Phase 1, single- and multiple-dose placebo-controlled study of the safety and pharmacokinetics of IN-006, an inhaled antibody treatment for COVID-19 in... by Thomas R. Moench, Lakshmi Botta, Brian Farrer, Jason D. Lickliter, Hyunah Kang, Yoona Park, Cheolmin Kim, Marshall Hoke, Miles Brennan, Morgan D. McSweeney, Zachary Richardson, John B. Whelan, Jong Moon Cho, Soo Young Lee, Frances Faurot, Jeff Hutchins, Samuel K. Lai

Subjects: Get full text

Study on the comparison between Bosentan and Macitentan in the treatment of persistent pulmonary hypertension of the newborns, simultaneously on sildenafil: A randomized double-blinded non-inferiority parallel clinical trial by Mandana Kashaki, Arash Mohazzab, Mohammad Radgoudarzi, Arash Bordbar, Sama Dabbagh

Subjects: Get full text

Hexenprozesse als Sinnbild frühneuzeitlicher Vorstellungswelten by Laura Glöckler

Subjects: Get full text

Effect of daily alcohol consumption and age over 40 years on COVID-19 vaccination antibody titers in the Delta era among hospital workers in northern Okinawa, Japan: A retrospectiv... by Takuji Kishimoto, Daisuke Tasato, Yoshitaka Nagasawa, Akihiro Yamashiro, Hayashi Shokita

Subjects: Get full text

Phase 1 study of safety, tolerability, and efficacy of intradermal DNA vaccine ASP2390 in adults allergic to house dust mites by Thomas Kayser, MD, BS, Ronald Smulders, MD, PhD, Tomohiro Kusawake, PhD, Erik Wambre, PhD, Gurunadh R. Chichili, PhD, Mary B. Blauwet, DrPH, Anna Spence, MS, Melanie Patton, BS, Rima Tabash, PhD, Hannah A. DeBerg, PhD, Sugandhika Khosa, MS, Philipp Badorrek, MD, Jens M. Hohlfeld, MD, Brian C. Ferslew, PharmD, PhD

Subjects: Get full text

Sample size calculations based on day-to-day variability of stress biomarkers in persons with dementia and their family caregivers by Azita Emami, Jeehye Jun, Gabriella Engström, Lars Berglund, Töres Theorell

Subjects: Get full text

A randomized comparative effectiveness trial to evaluate two programs for promotion of physical activity after spinal cord injury in manual wheelchair users by Jenna M. Martinez, Jenna M. Martinez, Lisa L. Haubert, Valerie J. Eberly, Walter B. Weiss, Jeffery W. Rankin

Subjects: Get full text

Pilot clinical trial of neoadjuvant toll-like receptor 7 agonist (Imiquimod) immunotherapy in early-stage oral squamous cell carcinoma by Angela J. Yoon, Richard D. Carvajal, Evan M. Graboyes, John M. Kaczmar, William G. Albergotti, Alexandra E. Kejner, Scott H. Troob, Elizabeth Philipone, Jean-Sebastien Anoma, Kent E. Armeson, Elizabeth G. Hill, Mary S. Richardson, Tina R. Woods, Bhishamjit S. Chera, Farzad Nourollah-Zadeh, Byung J. Lee, Subramanya Pandruvada, Antonis Kourtidis, Christina Kingsley, Elizabeth C. O’Quinn, Stephanie Mills, Victoria C. Jordan, Mike Spencer, Danielle Fails, Trevor D. McKee, Mark Zaidi, Alan Brisendine, Shane Horn, Shikhar Mehrotra, Besim Ogretmen, Jason G. Newman

Subjects: Get full text

Therapy of genomic unstable solid tumours (WHO grade 3/4）in clinical stage III/IV using individualised neoantigen tumour peptides-INP trial (individualised neoantigen tumour peptides immunotherapy): study protocol for an open-label, non-randomised, prospective, single-arm trial by Ling Wang, Xia Chen, Juan Zhao, Jiaxi Tang, Wanyan Tang, Bin Liao, Weiqi Nian

“…Currently, a few studies have reported using a mixture of neoantigen peptides derived from multiple genetic mutation sites in the treatment of genomic unstable advanced solid malignancies. The trial aims to evaluate the safety and efficacy of individualised tumour neoantigen peptide mixtures in the treatment of genomic unstable advanced solid malignant tumours.Methods and analysis This is a prospective, non-randomised, open, single-centre, single-arm, phase I trial. …”
Get full text

Comparison of aprepitant versus ondansetron for prevention of postoperative nausea and vomiting: A systematic review and meta-analysis with trial sequential analysis by Madhusudan P. Singh, Meenalotchini P. Gurunthalingam, Ayushee Gupta, Juhi Singh

Get full text

The Effect of Vitamin D3 on Serum Creatine Phosphokinase Level in Patients with Multiple Trauma: A Pilot Randomized Clinical Trial by Mehran Kouchek, Niloufar Taherpour, Mahya Farasat, Mirmohammad Miri, Sara Salarian, Seyedpouzhia Shojaei, Rezvan Hassanpour, Hossein Amini, Mohammad Sistanizad

“…Conclusion: The current study revealed that vitamin D3, could prevent the increasing trend of CPK during the first days and accelerate the normalization of CPK in patients with elevated CPK due to multiple trauma.Trial registration number: IRCT20120703010178N23.…”
Get full text

Effects of Palatal Expansion with Torque Activation using a Transpalatal Arch: A Preliminary Single-Blind Randomized Clinical Trial by Fataneh Ghorbanyjavadpour, Vahid Rakhshan

“…The present single-blind, randomized clinical trial examined 60 observations on 30 individuals with nonfunctional single-tooth unilateral crossbites in the first permanent molar area. …”
Get full text

Effect of core stability exercises on upper limb reaching in children with spastic hemiparetic cerebral palsy: a randomized controlled trial by Nadia Hassan Abd-Elhameed, Heballah Mohammed Kamal, Mai Elsayed Abbass

“…Conclusion Core stability exercises may be used to improve reaching in children with hemiparetic cerebral palsy. Trial registration This study was authorized by the Faculty of Physical Therapy’s ethics committee under the number “REC/012/003125” and registered in ClinicalTrial.gov with the number “NCT05316090” on 9 April 2022 retrospectively.…”
Get full text

Safety and Effectiveness of a Perturbation-based Neuromuscular Training Program on Dynamic Balance in Adolescent Females: A Randomized Controlled Trial by Alison Bulow, Judith E Anderson, Jeff R S Leiter, Peter B MacDonald, Jason D Peeler

“… # Study Design Prospective randomized trial. # Methods Twenty-four healthy and an exploratory group of 10 ACL-injured females (ages 12-18) were equally randomized into a perturbation-based NM training or control group and evaluated before and after a five-week intervention period. …”
Get full text

Comment on “A Better Way to Decrease Knee Swelling in Patients with Knee Osteoarthritis: A Single-Blind Randomised Controlled Trial” by Max Broere, Yoshka van der Tuijn, Ingrid A. Szilagyi, Erin M. Macri

Get full text

Effects of the Use of Non-Calcium Phosphate Binders in the Control and Outcome of Vascular Calcifications: A Review of Clinical Trials on CKD Patients by Piergiorgio Bolasco

Get full text

The Effect of Vitamin D Supplementation on Blood Lipids in Patients with Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Controlled Trials by Hong Gao, YanTao Li, WenNan Yan, Fei Gao

“…PubMed, Embase, Cochrane Library, CNKI, and Wanfang databases were searched up to May 2020, to identify randomized controlled trials of the effect of vitamin D supplementation on blood lipids in patients with polycystic ovary syndrome. …”
Get full text

Efficacy of a Blended Low-Intensity Internet-Delivered Psychological Program in Patients With Multimorbidity in Primary Care: Randomized Controlled Trial by Alicia Monreal-Bartolomé, Adoración Castro, M Ángeles Pérez-Ara, Margalida Gili, Fermín Mayoral, María Magdalena Hurtado, Esperanza Varela Moreno, Cristina Botella, Azucena García-Palacios, Rosa M Baños, Yolanda López-Del-Hoyo, Javier García-Campayo, Jesus Montero-Marin

“…It justifies the exploration of the conceptualization of depression in type 2 diabetes as well as the analysis of the implementation of such interventions in routine clinical practice. Trial RegistrationClinicalTrials.gov NCT03426709; https://clinicaltrials.gov/study/NCT03426709 International Registered Report Identifier (IRRID)RR2-10.1186/S12888-019-2037-3…”
Get full text