First-in-human phase 1 dose-escalation results with livmoniplimab, an antibody targeting the GARP:TGF-ß1 complex, as monotherapy and in combination with the anti–PD-1 antibody budi... by Toshio Shimizu, Toshio Shimizu, John Powderly, Albiruni Abdul Razak, Patricia LoRusso, Kathy D. Miller, Steven Kao, Sarah Kongpachith, Catherine Tribouley, Michelle Graham, Brian Stoll, Maulik Patel, Mohammad Sahtout, Martha Blaney, Rachel Leibman, Talia Golan, Talia Golan, Anthony Tolcher

“…The first-in-human, phase 1, dose-escalation results are presented herein (ClinicalTrials.gov: NCT03821935).MethodsThe dose-escalation phase enrolled adult patients with advanced solid tumors. …”
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Genetic profiling of extended-spectrum β-Lactamase and carbapenemase-producing Escherichia coli O157:H7 from clinical samples among diarrheal patients in Shashemene, Ethiopia by Shimelis Teshome Ayalneh, Biruk Yeshitela Beshah, Yeonji Jeon, Ashenafi Alemu Wami, Seifegebriel Teshome, Solomon Gebreselassie, Se Eun Park, Mekonnen Teferi, Woldaregay Erku Abegaz

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Efficacy and Safety of Dual Antiplatelet Therapy in Patients Undergoing Coronary Stent Implantation: A Systematic Review and Network Meta-Analysis by Yi Xu, Yimin Shen, Delong Chen, Pengfei Zhao, Jun Jiang

“…Randomized controlled trials (RCTs) comparing longer-term (>12 months) DAPT (L-DAPT), 12-month DAPT (DAPT 12Mo), 6-month DAPT (DAPT 6Mo), 3-month DAPT followed by aspirin monotherapy (DAPT 3Mo + ASA), 3-month DAPT followed by a P2Y12 receptor inhibitor monotherapy (DAPT 3Mo + P2Y12), or 1-month DAPT with a P2Y12 receptor inhibitor monotherapy (DAPT 1Mo + P2Y12) were searched. …”
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Incidence of shoulder dislocations in the UK, 1995–2015: a population-based cohort study by Gary S Collins, Sarah E Lamb, Sally Hopewell, Daniel Prieto-Alhambra, Andrew Judge, Amar Rangan, Andrew J Carr, Jonathan L Rees, Nigel K Arden, Katherine Edwards, Tim A Holt, Anjali Shah, Antonella Delmestri, Rafael A Pinedo-Villanueva

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Tobacco control research in South Africa from 1978 to 2022: A scoping review by C O Egbe, C Dare, S Gwambe, C van Walbeek

“…A total of 79% of the studies used cross-sectional survey design, followed by randomised controlled trials (3.6%; n=8), time series studies (3.1%; n=7) and longitudinal and qualitative studies (2.2%; n=5 each), while costs and benefits analysis (0.4%; n=1) was used much less. …”
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Association of preoperative blood biomarkers with postoperative major adverse cardiac events and mortality in major orthopaedic surgery: a systematic review and meta-analysis by Lin Lu, Yi Ren, Zhen Hua, Yanxia Sun, Zhenghao Wen, Suzhen Zhou

“…This study aimed to assess the association between preoperative blood biomarkers and postoperative MACEs as well as all-cause mortality in patients undergoing major orthopaedic surgery.Design A systematic review and meta-analysis.Data sources PubMed, EMBASE, the Cochrane Controlled Trials Register and Cochrane Database of Systematic Reviews from inception to 20 October 2024 were searched.Eligibility criteria Observational or experimental studies reporting the correlation between preoperative blood biomarkers and postoperative MACEs—categorised as short-term (within 3 months) or long-term (beyond 3 months)—and all-cause mortality in patients undergoing major orthopaedic surgery.Data extraction and synthesis Data from studies reporting OR or HR and its 95% CI were pooled for analysis using random-effects model.Results 21 preoperative blood-based biomarkers from 80 studies with 226 468 patients were analysed. …”
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The Effect of Combining mHealth and Health Professional–Led Intervention for Improving Health-Related Outcomes in Chronic Diseases: Systematic Review and Meta-Analysis by Masashi Kanai, Takahiro Miki, Toshiya Sakoda, Yuta Hagiwara

“…ObjectiveThis study aims to investigate the effectiveness of combining mHealth and health professional–led intervention for improving health-related outcomes in chronic diseases MethodsThis systematic review and meta-analysis focused on randomized controlled trials. We searched Web of Science, CENTRAL, MEDLINE, and CINAHL through July 17, 2023. …”
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Effects of cold-water immersion on health and wellbeing: A systematic review and meta-analysis. by Tara Cain, Jacinta Brinsley, Hunter Bennett, Max Nelson, Carol Maher, Ben Singh

“…<h4>Methods</h4>Electronic databases were searched for randomized trials involving healthy adults aged ≥ 18 years undergoing acute or long-term CWI exposure via cold shower, ice bath, or plunge with water temperature ≤15°C for at least 30 seconds. …”
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Peer- and community-led responses to HIV: A scoping review. by George Ayala, Laurel Sprague, L Leigh-Ann van der Merwe, Ruth Morgan Thomas, Judy Chang, Sonya Arreola, Sara L M Davis, Aditia Taslim, Keith Mienies, Alessandra Nilo, Lillian Mworeko, Felicita Hikuam, Carlos Garcia de Leon Moreno, José Antonio Izazola-Licea

“…We limited our search to articles reporting findings from randomized controlled trials as well as from quasi-experimental, prospective, pre/post-test evaluation, and cross-sectional study designs. …”
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Association between the composite dietary antioxidant index and non-alcoholic fatty liver disease: evidence from National Health and Nutrition Examination Survey 2005–2016 by Yidian Fu, Yidian Fu, Chao Jiang, Zonglin Li, Xiangyun Shi, Peiyuan Lv, Peiyuan Lv, Jingbo Zhang

“…This association highlights the potential for dietary interventions to reduce NAFLD incidence and underscores the need for future research, including clinical trials and mechanistic studies, to further explore the role of dietary antioxidants in NAFLD prevention and management.…”
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Association of albumin to non-high-density lipoprotein cholesterol ratio with mortality in peritoneal dialysis patients by Yongjie Xie, Xiaoran Feng, Youqun Gao, Xiaojiang Zhan, Fenfen Peng, Qian Zhou, Xianfeng Wu, Xiaoyang Wang, Na Tian, Qingdong Xu, Ning Su, Xingming Tang, Jianbo Liang, Jiao Li, Yueqiang Wen

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Using Health Utility Index (HUI) for Measuring the Impact on Health-Related Quality of Life (HRQL) Among Individuals with Chronic Diseases by Frank Mo, Bernard C.K. Choi, Felix C.K. Li, Joav Merrick

“…Using the HUI (constructed based on eight attributes: vision, hearing, speech, mobility, dexterity, cognition, emotion, and pain/discomfort) to measure the HRQL for chronic disease patients and to detect possible associations between HUI system and various chronic conditions, this study provides information to improve the management of chronic diseases.This study is of interest to data analysts, policy makers, and public health practitioners involved in descriptive clinical studies, clinical trials, program evaluation, population health planning, and assessments. …”
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Comparisons of open surgical repair, thoracic endovascular aortic repair, and optimal medical therapy for acute and subacute type B aortic dissection: a systematic review and meta-... by Jianping Liu, Xiaohong Chen, Juan Xia, Long Tang, Yongheng Zhang, Lin Cao, Yong Zheng

“…The results require further large-scale randomized controlled trials.…”
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School-based screening for childhood anxiety problems and intervention delivery: a codesign approach by Tamsin Ford, Alastair Gray, Cathy Creswell, Victoria Williamson, Obioha Ukoumunne, Falko Sniehotta, Mara Violato, Ian McDonald, Paul Brown, Paul Stallard, Michael Larkin, Tessa Reardon, Samantha Pearcey, Claire Hill, Susan H Spence, Maria Breen, Jason Stainer, Michelle Sancho, Roberta Button, Iheoma Green, Fran Morgan, Bec Jasper

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Efficacy and safety of various drug combinations in treating plaque Psoriasis: A meta-analysis [version 2; peer review: 2 approved] by Nayak Snehasis, Karshe Haji Ali, Pendyala Siri, Ngabo Herve, Sayed Zafar

“…These findings suggest that personalized treatment plans could improve outcomes; however, confirmation through larger trials is crucial before wider use. This opens doors to research on optimal combinations for individual patients.…”
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Daily home monitoring of potassium, creatinine, and estimated plasma volume in heart failure post‐discharge by Patrick Rossignol, Renaud Fay, Nicolas Girerd, Faiez Zannad

“…Capillary blood samples were drawn by study nurses at home (7–12 am), and haematocrit, blood haemoglobin, creatinine, and potassium were measured using an approved home‐based device (ABOTT i‐STAT) (ClinicalTrials.gov: NCT01655134). Among the 15 home‐monitored patients, two patients died (one suddenly), and one was readmitted for ischaemic acute pulmonary oedema, with a subsequent acute coronary syndrome, and did not have a complete 2‐month follow‐up. …”
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Construction and characterization of chimeric FcγR T cells for universal T cell therapy by Juanjuan Zhao, Manling Chen, Xudong Li, Zhaoqi Chen, Wei Li, Rongqun Guo, Min Wang, Zhongxing Jiang, Yongping Song, Jianxiang Wang, Delong Liu

“…The CFR T cells therefore have the features of universal T cells with specificity directed by MoAbs. 16s3 CFR T cells are chosen for clinical trials.…”
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Mixed methods evaluation of the Getting it Right First Time programme in elective orthopaedic surgery in England: an analysis from the National Joint Registry and Hospital Episode... by Stephen Morris, James Mason, Rosalind Raine, Peter Martin, Naomi J Fulop, Elena Pizzo, Andrew Hutchings, Helen Barratt, Jean Ledger, Raj Mehta, Sarah Jasim, Fiona Aspinal, Rafael Gafoor

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Telenursing on primary family caregivers and children with disabilities: a scoping review by Kaori Nishigaki, Noyuri Yamaji, Noyuri Yamaji, Naho Adachi, Tomoko Kamei, Kyoko Kobayashi, Shota Kakazu, Yuki Yonekura

“…A comprehensive search was conducted on March 14, 2021 using six databases: MEDLINE via PubMed, Cumulative Index to Nursing &amp; Allied Health Literature, Cochrane Central Register of Controlled Trials, Embase, PsycINFO, and Ichushi Web. Two or more reviewers individually screened eligible studies according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram. …”
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Analysis of the correlation between the dose exposure intensity and apatinib in advanced gastric cancer: a retrospective cohort study by Xiao Ma, Xiao Ma, Lan Gao, Siying Che, Chaofeng Tao

“…BackgroundApatinib is a small molecule anti-angiogenesis targeted drug that has demonstrated significant efficacy as a late-line treatment in advanced gastric cancer in phase 3 clinical trials. This study amid to evaluate the correlation between dose exposure intensity and efficacy and safety of apatinib in the treatment of advanced gastric cancer.MethodsWe conducted an observational, retrospective cohort study of patients with advanced gastric cancer who received apatinib targeted therapy in Beijing Friendship Hospital affiliated to Capital Medical University between June 1, 2018, and June 30, 2021. …”
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