Successful Achievement of Demanding Outcomes in Upadacitinib-Treated Atopic Dermatitis Patients: A Real-World, 96-Week Single-Centre Study by Stamatios Gregoriou, Ioannis-Alexios Koumprentziotis, Ileana Afroditi Kleidona, Michail Bakakis, Eleni Hatzidimitriou, Theodora Douvali, Aikaterini Tsiogka, Styliani Mastraftsi, Aristeidis Vaiopoulos, Alexander Stratigos

“…Abstract Introduction Results from randomized controlled trials of upadacitinib, a Janus kinase (JAK) inhibitor, have led to its approval for the treatment of moderate-to-severe atopic dermatitis (AD) in patients aged ≥ 12 years. …”
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Game-thinking; utilizing serious games and gamification in nursing education – a systematic review and meta-analysis by Mats Nylén-Eriksen, Marko Stojiljkovic, Daniela Lillekroken, Katrin Lindeflaten, Elisabeth Hessevaagbakke, Tone Nygaard Flølo, Olav Johannes Hovland, Ada Marie Svarstad Solberg, Sylvia Hansen, Ann Kristin Bjørnnes, Christine Tørris

“…In the end, 70 studies, consisting of 27 Randomized Controlled Trials (RCTs) and 43 Quasi-experimental studies were included in the review. …”
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Treatment Options for Psychotic Depression in Adolescents: A Comprehensive Review by Perez-Rodriguez V, Aymerich C, Catalan A, Jauhar S, Salazar de Pablo G

“…For mild cases with predominance of depressive symptoms, antidepressant monotherapy with a serotonin selective reuptake inhibitor (eg fluoxetine, sertraline or citalopram) could be trialed first. In severe presentations, antidepressant-antipsychotic combination would be the treatment of choice. …”
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Digital Health Solutions for Cardiovascular Disease Prevention: Systematic Review by Yihan Qi, Emma Mohamad, Arina Anis Azlan, Chenglin Zhang, Yilian Ma, Anqi Wu

“…After excluding ineligible studies, 30 studies remained, including 24 randomized controlled trials. The reviewed digital solutions for CVD prevention focused on baseline assessment (29/30, 97%), physical activity counseling (18/30, 60%), tobacco cessation (14/30, 47%), blood pressure management (13/30, 43%), and medication adherence (10/30, 33%). …”
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Effect of Aerobic Exercise on Blood Glucose Among Those with Prediabetes: A Systematic Review and Meta-Analysis by Tianyi Jiang, Zichen Ye, Qu Lu, Peixia Cheng, Qi Gao

“…Five databases, including PubMed, Embase, the Cochrane Library, Web of Science, and CINAHL, were searched up to September 2024 to identify randomized controlled trials measuring the effect of aerobic exercise on blood glucose levels among individuals with prediabetes. …”
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Does drug dispensing influence patients’ medication knowledge and medication adherence? A systematic review and meta-analysis by Elizabete Priscila Costa Santana, Haidelucia Rodrigues Vieira Javarini, Dyego Carlos Souza Anacleto de Araújo, Sabrina Cerqueira-Santos, Tiago Marques Reis, Genival Araujo dos Santos-Junior, Kérilin Stancine Santos Rocha

“…The data was analyzed through qualitative synthesis and a meta-analysis was conducted for randomized controlled trials which used the outcome of medication adherence using the RStudio version 4.3.3 program. …”
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Association of extreme heat events with sleep and cardiovascular health: a scoping review by Nathan Ashe, Sarah Wozniak, Malcolm Conner, Rayan Ahmed, Olivia Keenan, Michelle R. Demetres, Nour Makarem, Parisa Tehranifar, Rajalakshmi Nandakumar, Arnab K. Ghosh

“…Two studies were controlled trials, and one was a cohort study. During EHEs, individuals slept for shorter periods of time and less efficiently, with greater degrees of HR variability in two of the three studies lasting at most 1–2 days; BP (both systolic and diastolic) significantly decreased during EHEs in two of the studies. …”
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Preliminary Effectiveness of a Telehealth-Delivered Exercise Program in Older Adults Living With and Beyond Cancer: Retrospective Study by Emily R Dunston, Sonal Oza, Yang Bai, Maria Newton, Leslie Podlog, Kish Larson, Darren Walker, Rebecca W Zingg, Pamela A Hansen, Adriana M Coletta

“…There were no significant differences for the 2-minute standing march, plank, single leg stance, sit and reach, shoulder mobility, or clock test (P ConclusionsOur findings suggest a one-on-one, supervised telehealth exercise program may positively influence measures of physical function, muscular endurance, balance, and flexibility among older adults with cancer, but more adequately powered trials are needed to confirm these findings.…”
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Glasswort as a Strategic Crop in Coastal Wetlands: Intercropping Results with Swiss Chard by Anna Rita Bernadette Cammerino, Michela Ingaramo, Vincenzo Rizzi, Maurizio Gioiosa, Massimo Monteleone

“…<i>cicla</i> (Swiss chard) in a 1:1 cropping pattern. The field trials were conducted in the coastal wetland “King’s Lagoon”, a private nature reserve in the Apulia/Puglia region (southern Italy), during two consecutive spring–summer seasons in 2023 and 2024 and under different management conditions of irrigation and fertilization. …”
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Short-term and long-term effect of non-pharmacotherapy for adults with ADHD: a systematic review and network meta-analysis by Xinyue Yang, Lin Zhang, Jing Yu, Meng Wang

“…Nevertheless, the comparative efficacy of these interventions, particularly with respect to diverse ADHD-related outcomes and their long-term impacts, remains insufficiently investigated.ObjectiveThis study aims to evaluate and compare the short-term and long-term effects of various non-pharmacological therapies on core ADHD symptoms (inattention, hyperactivity, and impulsivity) and emotional disorders (depression and anxiety) in adults with ADHD and to rank these therapies accordingly.MethodsA systematic search was conducted for relevant randomized controlled trials (RCTs) in the Web of Science, PubMed, Cochrane Library, and EMBASE databases from inception to Sep 2024. …”
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Human Factors Studies to Assess the Usability of the Faricimab Prefilled Syringe by Barakat MR, Kwong Jr HM, Marcon G, O'Leary OE, Paris LP, Schneider P, Tang Y, Graff JM

“…Injections were performed into single eyes of 35 patients with nAMD or DME in three US clinics and patients were followed for 7 days for safety reporting (ClinicalTrials.gov identifier: NCT05569148).Results: In the simulated-use study, most retina specialists and ophthalmic assistants completed all tasks deemed essential for PFS preparation and administration correctly and without error. …”
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Buffalo whey proteins as innovative raw material for nanoparticles building by Pablo A. Solis Cizek, Gustavo A. Crudeli, Darío Spelzini, Franco E. Vasile

“…The interactions were monitored through turbidimetric analysis (absorbance by spectrometry at 600 nm), zeta-potential and particle size distribution (by dynamic light scattering), and relative viscosity (in a Cannon-Fenske capillary viscometer). Analytical trials were performed at least in triplicate. Analysis of variance (ANOVA) was performed to find statistical differences among samples. …”
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Budget Impact of Rivaroxaban for the Prevention of Thromboembolic Events after Hip or Knee Replacement in Spain by Xavier Granero Xiberta, Antonio Murcia, José Ricardo Troncoso Durán, Claudio Gómez Zubeldia, Aleix Llorac Moix, Ruth Graefenhain De Codes, Maria Giovana Ferrario, Luis Lizán

“…Rivaroxaban is an oral antithrombotic drug that has shown superior efficacy and similar safety profile compared to enoxaparin regimens in randomized clinical trials. The aim of the study was to estimate the budget impact of increasing the use of rivaroxaban with respect to enoxaparin in the prophylaxis of VTE in patients undergoing elective THR or TKR. …”
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Relationships between Serum Levels of Atazanavir and Renal Toxicity or Lithiasis by C. I. Marinescu, M. Leyes, M. A. Ribas, M. Peñaranda, J. Murillas, A. A. Campins, L. Martin-Pena, B. Barcelo, C. Barceló-Campomar, F. Grases, G. Frontera, Melchor Riera Jaume

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Evolocumab safety and efficacy in hypercholesteremia patients with or without diabetes: a retrospective real-world analysis by Sultan Ibrahim Alraddadi, Hind Almodaimegh, Abdullah Kharbosh, Hadeel Alharbi, Ahmed Ibrahim Fathelrahman, Mona Yaser Alsheikh, Lama Alfehaid

“…Conclusion The study demonstrated that the addition of evolocumab to maximally tolerated statin and ezetimibe therapy reduced LDL-C levels but with a smaller average reduction and a lower proportion of patients achieving recommended LDL-C targets than in landmark clinical trials. Additionally, there was a potential negative effect on glycemic control, warranting further investigation.…”
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The Closer, The Harder? Investigating the use of peripheral vision in 3vs3 counter-attack VR situations in football by Božo Vukojević, Svitlana Pinchuk, Christian Vater

“…In case there was an overrun on one side, a defensive movement to the right or left direction should be initiated as before the pass was played, ensuring that they would monitor the peripheral players and not wait for the pass. In half of the trials, both wing strikers out-ran their defenders, so the correct decision was to move after the direct opponent played the pass. …”
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Adaptability of spring oat yield in the environments of the Near-Irtysh area in Omsk Province by P. N. Nikolaev, N. I. Aniskov, O. A. Yusova, I. V. Safonova

“…The object of the research were 9 spring oat cultivars recommended for cultivation in the region and undergoing the State Variety Trials: ‘Orion’ (reference), ‘Irtysh 13’, ‘Irtysh 21’, ‘Irtysh 23’, ‘Tarsky 2’, ‘Pamyati Bogachkova’, ‘Skakun’, ‘Fakel’ and ‘Sibirsky Gerkules’. …”
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Réprimer par le droit : L’intervention de la Brigade nationale de police judicaire dans les procès du Hirak El-Rif by Mariam Benalioua

“…The argument I defend consists in showing how the BNPJ has changed its methods and strategy of repression, from a brigade whose mission was to dismantle clandestine left-wing political organizations through torture and secret detention, with the sole aim of gathering information leading to the location and tracking down of political activists in order to make them disappear, to a Brigade whose strategy of repression involved judicial action, conducting interrogations and drawing up reports aimed at collecting legal evidence that could be used during trials. My presentation is divided into four parts. …”
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Cohort profile: Noncommunicable diseases and ideal cardiovascular health among people living with and without HIV in Zambia and Zimbabwe (NCDzz cohort) by Gilles Wandeler, Samuel Bosomprah, Cleophas Chimbetete, Belinda Varaidzo Chihota, Guy Muula, Carolyn Bolton-Moore, Tinei Shamu, Ardele Mandiriri, Esau Banda

“…Additionally, we seek to pilot NCD interventions using novel methodologies like the trials within cohorts. Beyond the initial funding support, we aim to collect at minimum yearly data for an additional 5-year period.…”
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Effectiveness of eHealth literacy interventions: a systematic review and meta-analysis of experimental studies by Chiara Barbati, Elvira Maranesi, Cinzia Giammarchi, Matteo Lenge, Manila Bonciani, Elisa Barbi, Giacomo Pietro Vigezzi, Mauro Dragoni, Tania Bailoni, Anna Odone, Roberta Bevilacqua

“…Methods Following the PRISMA guidelines, we conducted a systematic review in PubMed/Medline, Scopus, Web of Science, Embase, Cochrane Library and ClinicalTrials.gov, including original experimental studies quantifying the effectiveness of interventions aimed at increasing eHL, as assessed by the eHealth Literacy Scale (eHEALS) or other validated scales. …”
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