Comparison of Healthcare Encounters and Drug Persistence in Patients With Pulmonary Arterial Hypertension Receiving Oral Selexipag, Inhaled Iloprost, or Parenteral Treprostinil: A... by Ci Song, Peter Kunovszki, Amélie Beaudet

“…No head-to-head clinical trials have compared outcomes between the 3 different PGI~2~-pathway drugs most commonly available in countries with advanced healthcare: oral selexipag, inhaled iloprost, and parenteral (subcutaneous or intravenous) treprostinil. …”
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Efficacy and safety of Xiaoyao San in the treatment of chronic fatigue syndrome: a systematic review and meta-analysis by Qianqian Wang, Jian Zhou, Guanwen Gong

“…Eligible studies included randomized controlled trials comparing XYS or XYS + SBT to SBT alone. Primary outcomes were effective rate (ER) and fatigue scale-14 (FS-14). …”
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Intensity-Dependent Effects of Acute Exercise on Executive Function by Aylin Mehren, Cecilia Diaz Luque, Mirko Brandes, Alexandra P. Lam, Christiane M. Thiel, Alexandra Philipsen, Jale Özyurt

“…Moderate exercise compared to high-intensity exercise was associated with a tendency towards improved behavioral performance (sensitivity index d′) in the Go/No-go task and increased brain activation during hit trials in areas related to executive function, attention, and motor processes (insula, superior frontal gyrus, precentral gyrus, and supplementary motor area). …”
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Real-World Clinical Outcomes and Treatment Patterns Among Black and Non-Black Patients With Prostate Cancer Initiated on Apalutamide in a Urology Setting by Benjamin H. Lowentritt, Carmine Rossi, Erik Muser, Frederic Kinkead, Bronwyn Moore, Patrick Lefebvre, Dominic Pilon, Shawn Du

“…**Discussion:** While clinical trials have demonstrated the efficacy and safety of apalutamide, there is limited real-world data describing treatment persistence and clinical outcomes among patients with mCSPC and nmCRPC who initiated apalutamide. …”
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“Inclisiran: Early LDL-C target achievement in a real-life population” by Francesco Briani, Mauro Bagli, Gabriele Venturi, Francesco Bacchion, Antonio Mugnolo

“…Inclisiran, a small interfering RNA, has been observed to effectively and sustainably reduce LDL-C in large randomized controlled trials (RCTs); however, real-world data on its short-term efficacy and use are limited. …”
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Aberrant heterochromatin silences immune response genes in chronic lymphocytic leukemia by Olivia M. Depies, Qianqian Guo, Yuan Gao, Sutapa Sinha, Zhenqing Ye, Weiguo Han, Kari G. Rabe, Mingma S. Hoel, Heather C. Darby, Chuanhe Yu, Esteban Braggio, Sameer A. Parikh, Susan L. Slager, Neil E. Kay, Zhiquan Wang

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Description and biomechanical evaluation of the modified laparoscopic-assisted percutaneous gastropexy technique in dogs by Dong Woo Kim, Ho Hyun Kwak, Ho Hyun Kwak, Junhyung Kim, Heung Myong Woo

“…However, further clinical trials are warranted to further validate this technique and confirm its effectiveness.…”
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QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration by Jayshree Advani, Puja A. Mehta, Andrew R. Hamel, Sudeep Mehrotra, Christina Kiel, Tobias Strunz, Ximena Corso-Díaz, Madeline Kwicklis, Freekje van Asten, Rinki Ratnapriya, Emily Y. Chew, Dena G. Hernandez, Sandra R. Montezuma, Deborah A. Ferrington, Bernhard H. F. Weber, Ayellet V. Segrè, Anand Swaroop

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Complete metabolic response as early predictor of long-term efficacy after adoptive T cell therapy using tumor-infiltrating lymphocytes by Rikke Andersen, Troels Holz Borch, Eva Ellebaek, Inge Marie Svane, Helle Westergren Hendel, Kasper Madsen

“…In this study the predictive value of early metabolic response after TIL therapy is explored.Materials and methods: 60 patients treated with TIL therapy in 4 different clinical trials and with available [18F]2-fluoro-2-deoxy-d-glucose positron emission tomography-CT (FDG-PET/CT) scans at baseline and at least one follow-up scan 6–8 weeks and/or 12–16 weeks post-TIL infusion were included.Results: Obtaining complete metabolic response (CMR) was associated with significantly superior median overall survival (mOS) compared with not obtaining CMR (p<0.0001). …”
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Konsep Decision Tree Reptree untuk Melakukan Optimasi Rule dalam Fuzzy Inference System Tsukamoto by Tundo Tundo, Shofwatul 'Uyun

“…A minimum and practical rule may not be the best, to prove that there is a need for trials and proofs. Proof carried out in this research is one of them by using a comparison of decision trees J48 and Random Tree with the aim to find out the optimization of rules formed using the Tsukamoto system's fuzzy inference method, after calculating that the REPTree decision tree has a more average Forecasting Error Rate (AFER) error tree small of 23.17% with a truth value of 76.83%, while J48 has an error rate of 24.96%, with a truth value of 75.04%, while Random Tree has an error rate of 36.51%, with a truth value of 63, 49% in the case of prediction of palm oil production at PT Tapiana Nadenggan. …”
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Prognostic value and clinicopathological significance of pre-and post-treatment systemic immune-inflammation index in colorectal cancer patients: a meta-analysis by Yueting Tan, Bei’er Hu, Qian Li, Wen Cao

“…Methods Databases including PubMed, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science were scrutinized up to March 27, 2024. …”
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Clinical Characteristics and Outcomes in Heart Failure Patients with Implantable Pulmonary Artery Pressure Monitors: A Single Centre Irish Experience by Niall Leahy, Cillian O’Brien, Sara Essa Alsubai, Eileen Coen, Darragh Murphy, Faisal Sharif

“…., Chicago, IL, USA) in University Hospital Galway, Ireland, as part of three separate clinical trials—SIRONA 1, SIRONA 2, PROACTIVE HF, was performed. …”
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Effect of home-based interventions on basic activities of daily living for patients who had a stroke: a systematic review with meta-analysis by Ping Qin, Canxin Cai, Xuan Chen, Xijun Wei

“…Objectives To investigate the effectiveness of home-based interventions in improving the ability to do basic activities of daily living in patients who had a stroke.Methods Randomised controlled trials were searched through MEDLINE, Embase and CINAHL from their inception to 31 December 2021. …”
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Is Topical Tranexamic Acid Effective in Reducing Hematoma and Seroma in Breast Surgery? A Systematic Review and Meta-analysis by Ammar S.A. Hashemi, MD, Sara M. Hussein, MD, Zainab H. Alshehab, Abdullah A. Al Qurashi, MD, Lucas Kreutz-Rodrigues, MD, Basel A. Sharaf, MD, DDS, FACS

“…English-language databases were searched through April 2024 to identify randomized controlled trials and cohort studies assessing the effects of topical TXA on postoperative outcomes in breast surgery, including hematoma, seroma, infection rates, and drain output/duration. …”
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Apolipoproteins A and B and PCSK9: Nontraditional Cardiovascular Risk Factors in Chronic Kidney Disease and in End-Stage Renal Disease by Cristiana-Elena Vlad, Liliana Foia, Roxana Popescu, Iuliu Ivanov, Mihaela Catalina Luca, Carmen Delianu, Vasilica Toma, Cristian Statescu, Ciprian Rezus, Laura Florea

“…Randomized controlled trials, observational studies (including case-control, prospective or retrospective cohort), and reviews/meta-analysis were included if reference was made to those keys and cardiovascular outcomes in CKD/ESRD. …”
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Approximate and Sample Entropy of the Center of Pressure During Unperturbed Tandem Standing: Effect of Altering the Tolerance Window by Jayla Wesley, Samhita Rhodes, David W. Zeitler, Gordon Alderink

“…Six participants completed five, 30 s trials, feet-together and tandem standing with eyes open and eyes closed. …”
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COVID-19 in the years 2020 to 2022 in Germany: effects of comorbidities and co-medications based on a large-scale database analysis by Roland Linder, Jonas Peltner, Anatoli Astvatsatourov, Willy Gomm, Britta Haenisch

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Efficacy and safety of faricimab for neovascular age-related macular degeneration: a systematic review and network meta-analysis by Francisco Rodríguez, Daniel Samacá-Samacá, Claudia Hernández-Castillo, Laura Prieto-Pinto, Carolina Sardi, Hugo Ocampo, Joshua Kock, Fabián Hernández

“…The Cochrane Collaboration guidelines and the Confidence in Network Meta-Analysis framework were used for the SR and the certainty of evidence, respectively.Results From 4128 identified records through electronic databases and complementary searches, 63 randomised controlled trials (RCTs) met the eligibility criteria, with 42 included in the NMA. …”
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Altered Knee Loading Following Primary ACL Repair versus ACL Reconstruction by Steven Singleton, Harrison Scofield, Brittany Davis, Alexandra Waller, Craig Garrison, Shiho Goto, Joseph Hannon

“…Bilateral peak knee extension moment and total knee joint power as a measure of eccentric loading (contraction) during the descent phase of the squat were calculated on the surgical and non-surgical limb and averaged across the middle three of five trials. Participants also completed quadriceps strength testing on both limbs three months after surgery on an isokinetic dynamometer at 60°/sec. …”
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Effects of Diet on Larval Survival, Growth, and Development of the Sea Cucumber Holothuria leucospilota by Zonghe Yu, Hong Wu, Youkai Tu, Zesen Hong, Jiewen Luo

“…Identifying an appropriate diet is important for successful hatchery culture of the H. leucospilota. In this study, we trialed different ratios of microalgae Chaetoceros muelleri (2.00–2.50×106 cells/mL) and yeast (Saccharomyces cerevisiae, ~2.00×106 cells/mL) in diets for H. leucospilota larvae (6 d after fertilization, referred to as “day 0”) at proportions 4 : 0, 3 : 1, 2 : 2, 1 : 3, and 0 : 4 by volume, in 5 treatments (A, B, C, D, and E, respectively). …”
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