THE TRANSFORMATION PERIODS IN THE RUSSIAN-TURKISH RELATIONS (1991-2016) by D. G. Bdoyan

“…Russian-Turkish relations, spanning more than five centuries, have gone through a number of trials. However, at the end of the 20th and at the beginning of the 21st century these relations became especially dynamic. …”
Get full text

Ketamine Boluses Are Associated with a Reduction in Intracranial Pressure and an Increase in Cerebral Perfusion Pressure: A Retrospective Observational Study of Patients with Sever... by Bradley A. Dengler, Oliver Karam, Colleen A. Barthol, Aaron Chance, Laura E. Snider, Clare M. Mundy, Michael T. Bounajem, William C. Johnson, Moustafa M. Maita, Paola M. Mendez-Gomez, Ali Seifi, Shaheryar Hafeez

“…This was a retrospective review of 43 patients and is therefore limited in nature, but further randomized controlled trials should be performed to confirm the findings.…”
Get full text

Risk prediction models for stress urinary incontinence after pelvic organ prolapse (POP) surgery: a systematic review and meta-analysis by Bi Jun Yu, Hao Chong He, Li Wang, Han Mei Shao, Ying Min Liu, Xiao Ying Yan, Jian Liu

“…All studies had a high risk of bias, primarily due to retrospective design, small sample sizes, single-center trials, lack of blinding, and missing data reporting. …”
Get full text

Pembrolizumab plus Pemetrexed and Platinum in Metastatic Non-Squamous Non-Small Cell Lung Cancer: A Real-Life Study at a Portuguese Centre by Maria João Santos, Filipa Ferro, Andrea Machado, Ana Sofia Vilariça, Direndra Hasmucrai, Paula Alves

“…With median progression-free survival and overall survival of 6.7 and 12.2 months, respectively, and no new safety signals, these results complement data from clinical trials, providing information from a real-world setting. …”
Get full text

The use of methylene blue in adult patients with septic shock: a systematic review and meta-analysis by Ka Ting Ng, Pei En Kwok, Wei En Lim, Wan Yi Teoh, Mohd Shahnaz Hasan, Mohd Fitry Zainal Abidin

“…Methods: Databases of MEDLINE, EMBASE, and CENTRAL were searched from their inception date until October 2023. Randomized Clinical Trials (RCT) comparing methylene blue and placebo in adults with septic shock were included. …”
Get full text

Efficacy of PD-1/PD-L1 Inhibitors versus Chemotherapy in Lung Cancer with Brain Metastases: A Systematic Review and Meta-Analysis by Xiaojun Yang, Yihong Zeng, Qinquan Tan, Zhihua Huang, Jun Jia, Guanming Jiang

“…We included 694 patients with BM from lung cancer from 11 randomized controlled trials. Statistical analysis showed that compared with chemotherapy, PD-1/PD-L1 inhibitors could significantly prolong OS (hazard ratio HR=0.75, 95%confidence interval 95%CI=0.51–0.99) and PFS (HR=0.65, 95%CI=0.51–0.80). …”
Get full text

Adaptive potential of spring durum wheat (<i>Triticum durum</i> Desf.) under the conditions of Primorsky Territory by P. M. Bogdan, A. G. Klykov, I. V. Konovalova, N. V. Kuzmenko

“…The adaptive potential of 16 genotypes was determined through multi-environment trials at the Federal Scientific Center of Agricultural Biotechnology of the Far East named after A.K. …”
Get full text

A comprehensive comparison of PARP inhibitors as maintenance therapy in platinum-sensitive recurrent ovarian cancer: a systematic review and network meta-analysis by Shiya Ji, Lu Chen, Yebo Yu, Xupeng Chen, Liwen Wei, Lili Gou, Cheng Shi, Susu Zhuang

“…Results Six randomized controlled trials were examined and the four PARPis (olaparib, niraparib, rucaparib and fuluzolparib) have been found to significantly increase the PFS in entire population as well as in subgroups of HRD and BRCAm (BRCA mutation). …”
Get full text

Brodalumab: Six-Year US Pharmacovigilance Report by Mark G. Lebwohl, John Y. Koo, April W. Armstrong, Bruce E. Strober, Soo Han Yoon, Nicole N. Rawnsley, Earl L. Goehring, Gina D. Mangin, Abby A. Jacobson

“…Conclusion Pharmacovigilance data throughout 6 years are consistent with the safety profile of brodalumab established in clinical trials and previous US pharmacovigilance reports, with no completed suicides and a low fungal infection rate. …”
Get full text

Designing an intervention to improve cognitive evaluations in primary care by Kyra S. O’Brien, Kristin Harkins, MaryAnne Peifer, Melanie Kleid, Cameron Coykendall, Judy Shea, Jason Karlawish, Robert E. Burke

“…This holds substantial promise for improving cognitive assessments in primary care in future implementation trials.…”
Get full text

A Systems-Based Analysis of the CardioMEMS HF Sensor for Chronic Heart Failure Management by Jeffrey S. Tran, Aaron M. Wolfson, Daniel O’Brien, Omid Yousefian, David M. Shavelle

“…Hemodynamic-guided therapy using the CardioMEMS™ system has been shown to reduce heart failure hospitalization (HFH) in both clinical trials and real-world settings. However, the CardioMEMS system requires input from multiple independent elements to achieve its effect, and no studies have been done to investigate those elements. …”
Get full text

Minimally Manipulated Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Systematic Review of Clinical Evidence by B. Di Matteo, F. Vandenbulcke, N. D. Vitale, F. Iacono, K. Ashmore, M. Marcacci, E. Kon

“…Of these, only 4 were randomized controlled trials (RCTs). Bias risk evaluation, performed using a modified Coleman score, revealed an overall poor quality of the studies. …”
Get full text

Pendeteksi Citra Masker Wajah Menggunakan CNN dan Transfer Learning by Mohammad Farid Naufal, Selvia Ferdiana Kusuma

“…Based on the results of trials using 5-cross validation, Xception has the best accuracy of 0.988 with a total computation time of training and testing of 18274 seconds. …”
Get full text

Impacts of medical and non-medical cannabis on the health of older adults: Findings from a scoping review of the literature. by Dianna Wolfe, Kim Corace, Claire Butler, Danielle Rice, Becky Skidmore, Yashila Patel, Premika Thayaparan, Alan Michaud, Candyce Hamel, Andra Smith, Gary Garber, Amy Porath, David Conn, Melanie Willows, Hanan Abramovici, Kednapa Thavorn, Salmaan Kanji, Brian Hutton

“…<h4>Methods</h4>Electronic databases (MEDLINE, Embase, PsycINFO, Cochrane Library) were searched for systematic reviews (SRs), randomized controlled trials (RCTs) and non-randomized/observational studies (NRSs) assessing the health effects and associations of cannabis use (medical or non-medical) in adults ≥ 50 years of age. …”
Get full text

Skin Microbiota: Mediator of Interactions Between Metabolic Disorders and Cutaneous Health and Disease by Magdalini Kreouzi, Nikolaos Theodorakis, Maria Nikolaou, Georgios Feretzakis, Athanasios Anastasiou, Konstantinos Kalodanis, Aikaterini Sakagianni

“…Emerging therapies, such as probiotics and postbiotics, aim to restore microbial diversity, while phage therapy selectively targets pathogenic bacteria like <i>Staphylococcus aureus</i> without disrupting beneficial flora. Clinical trials have demonstrated significant reductions in inflammatory lesions and improved quality-of-life metrics in patients receiving these microbiota-targeted treatments. …”
Get full text

Population pharmacokinetics of iruplinalkib in healthy volunteers and patients with solid tumors by Guihong Yang, Yimei Wang, Huimin Zhao, Ziyi Jiang, Shansong Zheng, Mingjing Ge, Meimei Si, Xiaoyan Kang

“…Plasma concentration–time data were collected from 392 participants (16 healthy volunteers and 372 patients with solid tumors) who received single or multiple doses of iruplinalkib in four trials. Data were analyzed using non‐linear mixed‐effects modeling. …”
Get full text

Efficacy of Health Literacy Interventions for Caregivers of Individuals with Neurodevelopmental and Chronic Conditions: A Rapid Review by Thom Nevill, Jessica Keeley, Susan Hunt, Rachel Skoss, Olivia Lindly, Jenny Downs, Amanda Marie Blackmore

“…Half (<i>n</i> = 7) of the trials with moderate to high evidence levels reported significant between-group differences in caregiver HL outcomes and/or individuals’ health-related outcomes. …”
Get full text

Sistem Kontrol Perangkat Inframerah Menggunakan Speech Recognition dengan Spectrogram dan Convolutional Neural Network Berbasis Mikrokontroler by Irfan Muzakky Nurrizqy, Barlian Henryranu Prasetio, Rekyan Regasari Mardi Putri

“…Testing results show that the accuracy of the CNN model is 93% and the accuracy of trials on users is 74.25%. The system can also run the speech recognition process with an average time of 0.105 seconds. …”
Get full text

Coffee, including caffeinated and decaffeinated coffee, and the risk of hepatocellular carcinoma: a systematic review and dose–response meta-analysis by Paul Roderick, Peter Clive Hayes, Julie Parkes, Ryan Buchanan, Oliver John Kennedy, Jonathan Andrew Fallowfield

“…However, due to a lack of randomised controlled trials, potential publication bias and there being no accepted definition of coffee, the quality of evidence under the GRADE criteria was ‘very low’.Conclusions Increased consumption of caffeinated coffee and, to a lesser extent, decaffeinated coffee are associated with reduced risk of HCC, including in pre-existing liver disease. …”
Get full text

Need to clamp indwelling urinary catheters before removal after different durations: a systematic review and meta-analysis by Xiaoyan Fan, Sumin Ma, Jiayi Gu

“…Objective This meta-analysis aimed to evaluate the effect of bladder training by clamping on bladder urethral function in patients with indwelling urinary catheters used for different durations.Design Systematic review and meta-analysis.Data sources The UpToDate, Cochrane Library, OVID, PubMed, China National Knowledge Infrastructure, CINAHL and Embase were screened from 1 January 2000 to 28 February 2022.Eligibility criteria for selecting studies Randomised controlled trials (RCTs) or quasi-experimental designs comparing the efficacy of bladder training in patients with an indwelling urinary catheter by clamping or free drainage before urinary catheter removal were published in English or Chinese.Data extraction and synthesis Two reviewers independently extracted the data and assessed the quality of studies. …”
Get full text