The Impact of Step Recommendations on Body Composition and Physical Activity Patterns in College Freshman Women: A Randomized Trial by Bruce W. Bailey, Ciera L. Bartholomew, Caleb Summerhays, Landon Deru, Sharla Compton, Larry A Tucker, James D. LeCheminant, Joseph Hicks

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I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations by Carolyn S Calfee, Michael A Matthay, Paul Henderson, Martin Eklund, Laura J Esserman, Chirag Patel, Angela Haczku, Michelle Jung, Tony Oliver, Alessio Crippa, Andrea Discacciati, Kathleen D Liu, Ellen L Burnham, Nuala J Meyer, Fady A Youssef, Derek W Russell, Julie Lang, Kevin W Gibbs, Daniel C Files, Sheetal Gandotra, Purnema Madahar, Nathan K Cobb, Timothy E Albertson, Rajiv Sonti, John P Reilly, Alejandra Jauregui, Iván García, Luis E Huerta, Daniel Clark Files, Neil R Aggarwal, Adam L Asare, Jeremy R Beitler, Paul A Berger, George Cimino, Melissa H Coleman, Paul T Henderson, Caroline A G Ittner, Kashif T Khan, Jonathan L Koff, Mary LaRose, Joe Levitt, Ruixiao Lu, Jeffrey D McKeehan, Karl W Thomas, Aaron M Mittel, Albert F Yen, Alexis E Suarez, Alexis L Serra, Alpesh N Amin, Amanda Rosen, Amy L Dzierba, Anna D Barker, Ariel R Weisman, Brian M Daniel, Brian M Morrissey, Caroline AG Ittner, Chayse Jones, Christina Creel-Bulos, Christina M Angelucci, Diana Ng, Fredy Chaparro-Rojas, Gavin H Harris, Harsh V Barot, Heny Su, Jacqueline B Sutter, Jamal Dodin, Jerry S Lee, John Kazianis, Joshua F Detelich, Julie E Lang, Justin Muir, Katarzyna Gosek, Katherine L Nugent, Kimberly Yee, Laura G Rodrigues, Laura R Macias, Lindsey A Orr, Lindsie L Boerger, Lissette Rosario-Remigio, Lucia Kufa, Maged Tanios, Maria B Reyes, Max W Adelman, Maya M Juarez, Michelle Meyers, Mitchell P Sternlieb, Neil Aggarwal, Nilam S Mangalmurti, Patrice Jones, Paul L Saban, Peter S Marshall, Philiip A Robinson, Philip Yang, Rahul Nair, Richard Anthony Lee, Richard G Wunderink, Romina Wahab, Roxana A Lupu, Santhi I Kumar, Sara C Auld, Scott Fields, Se Fum Wong, Skyler J Pearson, Spencer Whealon, Timothy F Obermiller, Anita Darmanian, John Schicchi, Esmeralda Martinez, Farjad Sarafian, Julie Nguyen, Bethany Weiler-Lisowski, Jaime Wyatt, Daniel Blevins, Marylee Melendrez, Brenda Lopez, Hiwet Tzehaie, Omowunmi Amosu, Austin Simonson, Erin Hardy, Brett Lindgren, Gregory Peterfreund, Leigha Landreth, Lisa Parks

“…This manuscript outlines the design, rationale, implementation and challenges of the ISPY COVID-19 trial during the first phase of trial activity from April 2020 until December 2021.Methods and analysis The ISPY COVID-19 Trial is a multicentre open-label phase 2 platform trial in the USA designed to evaluate therapeutics that may have a large effect on improving outcomes from severe COVID-19. …”
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A phase 2, double-blind, placebo-controlled trial of a valproate/lithium combination in ALS patients by M.-C. Boll, M. Alcaraz-Zubeldia, C. Rios, D. González-Esquivel, S. Montes

“…Methods: Outpatients with a typical ALS presentation were enrolled in a randomized, placebo-controlled trial to assess the efficacy of orally administered VPA-Li. …”
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Benefits and harms of pregabalin in the management of neuropathic pain: a rapid review and meta-analysis of randomised clinical trials by Igho J Onakpoya, Elizabeth T Thomas, Joseph J Lee, Ben Goldacre, Carl J Heneghan

“…Objective To assess the benefits and harms of pregabalin in the management of neuropathic pain.Design Rapid review and meta-analysis of phase III, randomised, placebo-controlled trials.Participants Adults aged 18 years and above with neuropathic pain defined according to the International Association for the Study of Pain criteria.Interventions Pregabalin or placebo.Primary and secondary outcome measures Our primary outcomes were pain (as measured using validated scales) and adverse events. …”
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Peculiarities of initiating a pre-trial investigation on domestic violence (Article 126-1 of the Criminal Code of Ukraine) by S. Ye. Ablamskyi, Yu. V. Lukianenko

“…It has been identified and analyzed the peculiarities of initiating a pre-trial investigation on domestic violence, in particular: firstly, domestic violence (Article 126-1 of the Criminal Code of Ukraine) is classified as a criminal proceeding carried out in the form of private prosecution, and therefore it is initiated at the request of the victim; secondly, when an investigator, interrogator or prosecutor enters information about a criminal offense into the Unified Register of Pre-trial Investigations under Article 126-1 of the Criminal Code of Ukraine, there must be information about repeated (three or more times) bringing the offender to administrative responsibility under Article 173-2 of the Code of Ukraine on Administrative Offenses or about committing systematic actions related to domestic violence. …”
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Dataset on travellers’ acceptance of border control technologies: Insights from METICOS pilot trialsPilot) supported by Zenodo by Sarang Shaikh, Sule Yildirim Yayilgan, Erjon Zoto, Mohamed Abomhara

“…This paper presents a dataset from the METICOS11 https://meticos-project.eu/. project pilot trials related to the acceptance of border control technologies. …”
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One Bite or Two? A Prospective Trial Comparing Colonoscopy Biopsy Technique in Patients with Chronic Ulcerative Colitis by Lawrence C Hookey, David J Hurlbut, Andrew G Day, Paul N Manley, William T Depew

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The Effect of Aloe vera and Chlorhexidine as Disinfectants on the Success of Selective Caries Removal Technique: A Randomized Controlled Trial by Ahmad Al-Abdullah, Samer Edris, Amjad Abu Hasna, Lara Steffany de Carvalho, Talal Al-Nahlawi

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Effects of Anti-Obesity Strategies on Bone Mineral Density: A Comprehensive Meta-Analysis of Randomized Controlled Trials by Myung Jin Kim, Seonok Kim, Han Na Jung, Chang Hee Jung, Woo Je Lee, Yun Kyung Cho

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The Efficacy and Brain Network Mechanism of Acupuncture for Knee Osteoarthritis: A Study Protocol for Randomized Controlled Neuroimaging Trial by Sun YY, Wang ML, Zhao RH, Hao MY, Song S, Zhou Y, Zhang N

“…Therefore, this study uses KOA as the research vehicle, focuses on the abnormal connectivity patterns of brain functional networks, and integrates clinical pain assessments to thoroughly investigate the central mechanisms of acupuncture therapeutic effects on KOA.Patients and Methods: In this parallel, randomized, sham-controlled neuroimaging trial, 60 KOA patients will be randomly divided into the acupuncture group and sham acupuncture group in a 1:1 ratio, treated three times weekly for a total of 12 sessions. …”
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The Impact of Atorvastatin on Intraprostatic Biomarkers – Prognostic Value of 3LS-score – Follow-up of ESTO1-Trial by Eemil Lehtonen, Maiju Vertanen, Heimo Syvälä, Teemu Tolonen, Seppo Auriola, Teuvo Tammela, Aino Siltari, Teemu Murtola

“…Objective: This study investigates the effects of atorvastatin intervention on PCa tissue markers, long-term clinical outcomes, and the prognostic value of the 3LS derived from prostate tissue lipidome. Methods: The ESTO1 trial randomized 158 statin-naïve PCa patients to receive high-dose atorvastatin (80 mg daily) or placebo before prostatectomy. …”
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Pirfenidone Accelerates Wound Healing in Chronic Diabetic Foot Ulcers: A Randomized, Double-Blind Controlled Trial by Luz E. Gasca-Lozano, Silvia Lucano-Landeros, Héctor Ruiz-Mercado, Adriana Salazar-Montes, Ana Sandoval-Rodríguez, Jesus Garcia-Bañuelos, Arturo Santos-Garcia, Judith R. Davila-Rodriguez, José Navarro-Partida, Hiram Bojórquez-Sepúlveda, Juan Castañeda-Gomez, José Domínguez-Rosales, Myriam A. Ruiz-Arcos, María Guadalupe Sánchez-Parada, Juan Armendariz-Borunda

“…To evaluate efficacy of topical PFD + M-DDO in a randomized, double-blind trial versus ketanserin in the treatment of noninfected chronic DFU. …”
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Efficacy and safety of Mahuang Fuzi and Shenzhuo Decoction for treatment of primary membranous nephropathy: a multicenter prospective trial by Naiqian Zhang, Hanxue Jiang, Haoran Dai, Shuxian Huang, Qihan Zhao, Na Zhang, Wenbin Liu, Zhaocheng Dong, Yu Gao, Xuan Dong, Yuehong Hu, Fanyu Hou, Hongliang Rui, Qingquan Liu, Baoli Liu

“…Background This study aims to undertake a comprehensive assessment of the effectiveness and safety profile of Mahuang Fuzi and Shenzhuo Decoction (MFSD) in the management of primary membranous nephropathy (PMN), within the context of a prospective clinical investigation.Methods A multicenter, open-label clinical trial was executed on patients diagnosed with PMN. …”
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Virtual reality technology improves the gait and balance function of the elderly: a meta-analysis of randomized controlled trials by Junyu Chen, Shuxia Yan, Haiyan Yin, Dan Lin, Ziqi Mei, Zichun Ding, Meng Wang, Yamei Bai, Guihua Xu

“…Material and methods Two authors independently searched EMBASE, PubMed, Web of Science, ClinicalTrials, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang and Weipu databases up to October 20, 2023 for randomized controlled trials (RCTs) on the application of VR in improving the gait and balance function in the elderly. …”
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Trial by YouTube: effects of expert psychiatric witness testimony on viewers' opinions of Amber Heard and Johnny Depp by Oliver Mason, Beth Horton, Caitlin Starrett

“…Clinical implications It is plausible that mass media trial coverage further stigmatises mental illness. …”
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Comparison of the Effectiveness of Paracetamol and Ibuprofen in the Management of Patent Ductus Arteriosus in Preterm Neonates: A Randomized Controlled Trial by S. Mohsin Ali Shah, Shaista Azeem Khan, Faran Sadiq, Ruba Gul, Faizan Sadiq, Misbah Ullah Khan, Muhammad Khalid Khan, Faryal Uzma, Arooj Khan, Sabir Khan

“…Conclusion Our study has concluded that paracetamol is more effective than ibuprofen in closing patent ductus arteriosus. The trials were retrospectively registered at NIH Trial Registry (NCT06601114) https://clinicaltrials.gov/study/NCT06601114 dated 15/09/2024.…”
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Effect of nutrition education on hemoglobin level of pregnant women in Southeast Ethiopia: a cluster randomized controlled trial by Girma Beressa, Susan J. Whiting, Tefera Belachew

“…Methods A community-based two-arm parallel cluster randomized controlled trial was carried out among 447 randomly selected pregnant women attending antenatal care (224 intervention and 223 control groups) at health facilities from February to December 2021. …”
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Impact of topical cetylated fatty acid cream on hand osteoarthritis: a randomized, double-blind clinical trial by Sitthiphong Suwannaphisit, Nitiphoom Sinnathakorn, Pormes Suwanno, Warangkana Fongsri, Boonsin Tangtrakulwanich

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The effect of low vision rehabilitation on the quality of life and caregiver burden of low vision patients – a randomized trial by Chunling Cai, Yuwei Shuai, Gonghui Li

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Transcutaneous electrical acupoint stimulation for hypertension complicated by anxiety or sleep disorders: A pilot randomized controlled trial by Xue-Ying Bao, Cun-Zhi Liu, Zi-Tong Qian, Lu Wang, Jian-Feng Tu, Bin-Yan Li, Xiao Wang, Fang Wan, Zhi-Han Li, Zhao-Yi Liu, Liang-Xiao Ma, Li-Qiong Wang

“…Therefore, a largescale trial is warranted.…”
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