Isosorbide mononitrate for preinduction cervical ripening at or post-term pregnancy: randomised placebo-controlled clinical trial by Ramy Mohamed El-Naggar, Ahmed Nagy Shaker, Mohamed Attia Raslan, Heba Rady El-Bassyouny

“…This study evaluates the efficacy and safety of ISMN for cervical ripening before labour induction at term or post-term.Methods In this double-blinded randomised controlled trial, 160 primigravidas with an unripe cervix (Bishop score<6) undergoing labour induction at term or post-term were enrolled. …”
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Artificial intelligence-assisted clinical decision support for childhood asthma management: A randomized clinical trial. by Hee Yun Seol, Pragya Shrestha, Joy Fladager Muth, Chung-Il Wi, Sunghwan Sohn, Euijung Ryu, Miguel Park, Kathy Ihrke, Sungrim Moon, Katherine King, Philip Wheeler, Bijan Borah, James Moriarty, Jordan Rosedahl, Hongfang Liu, Deborah B McWilliams, Young J Juhn

“…<h4>Rationale</h4>Clinical decision support (CDS) tools leveraging electronic health records (EHRs) have been an approach for addressing challenges in asthma care but remain under-studied through clinical trials.<h4>Objectives</h4>To assess the effectiveness and efficiency of Asthma-Guidance and Prediction System (A-GPS), an Artificial Intelligence (AI)-assisted CDS tool, in optimizing asthma management through a randomized clinical trial (RCT).…”
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Eccentric strengthening vs. conventional therapy in sub-acute stroke survivors: a randomized controlled trial by Kalthoum Belghith, Kalthoum Belghith, Mustapha Zidi, Lhéo Vincent, Lhéo Vincent, Jean-Michel Fedele, Rayan Bou-Serhal, Wael Maktouf

“…A randomized controlled trial will be conducted, adhering to CONSORT guidelines, with participants assigned to either a Conventional Therapy Group or an Eccentric Training Group. …”
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Gut microbiota differences between sports and non-sports major students: a population-controlled trial by Benlong Ma, Yifang Zhang, Wenbo Yuan, Nan Hu, Shanshan Li

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A Systematic Review of Postoperative Pain Outcome Measurements Utilised in Regional Anesthesia Randomized Controlled Trials by E. Pushpanathan, T. Setty, B. Carvalho, P. Sultan

“…There are few published meta-analyses exploring pain outcome measures utilised in regional anesthesia randomized controlled trials (RCTs), which may be due to heterogeneity in outcomes assessed. …”
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Effect of a Short, Animated Storytelling Video on Transphobia Among US Parents: Randomized Controlled Trial by Doron Amsalem, Merlin Greuel, Shuyan Liu, Andrés Martin, Maya Adam

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Effect of Anodal Transcranial Direct Current Stimulation on Autism: A Randomized Double-Blind Crossover Trial by Anuwat Amatachaya, Narong Auvichayapat, Niramol Patjanasoontorn, Chanyut Suphakunpinyo, Niran Ngernyam, Benchaporn Aree-uea, Keattichai Keeratitanont, Paradee Auvichayapat

“…Twenty patients with autism received 5 consecutive days of both sham and active tDCS stimulation (1 mA) in a randomized double-blind crossover trial over the left dorsolateral prefrontal cortex (F3) for 20 minutes in different orders. …”
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Phase I trial of hydroxychloroquine to enhance palbociclib and letrozole efficacy in ER+/HER2− breast cancer by Akshara Singareeka Raghavendra, Nicole M. Kettner, Danielle Kwiatkowski, Senthil Damodaran, Yan Wang, David Ramirez, Dan S. Gombos, Kelly K. Hunt, Yu Shen, Khandan Keyomarsi, Debu Tripathy

“…We conducted a phase I trial (NCT03774472 registered in ClinicalTrials.gov on 8/20/2018) of HCQ (400, 600, 800 mg/day) with palbociclib (75 mg/day continuous) and letrozole, using a 3 + 3 design. …”
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A novel (targeted) kinesio taping application on chronic low back pain: Randomized clinical trial. by María Lourdes Peñalver-Barrios, Juan Francisco Lisón, Javier Ballester-Salvador, Julia Schmitt, Aida Ezzedinne-Angulo, María Dolores Arguisuelas, Julio Doménech

“…The aim of the present clinical trial is to evaluate the efficacy of kinesio taping on patients with chronic low back pain, when the exploration identifies skin/fascia mobilization as a factor that could modify the treatment effect. …”
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mHealth-Based Diabetes Prevention Program for Chinese Mothers With Abdominal Obesity: Randomized Controlled Trial by Qinyuan Huang, Qinyi Zhong, Yanjing Zeng, Yimeng Li, James Wiley, Man Ping Wang, Jyu-Lin Chen, Jia Guo

“…MethodsA randomized controlled trial was conducted at health management centers in 2 tertiary hospitals in Changsha, China. …”
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Rationale and design of the HOVON 170 DLBCL-ANTICIPATE trial: preventing anthracycline-induced cardiac dysfunction with dexrazoxane by Marijke Linschoten, Jesse Geels, Erik van Werkhoven, Heleen Visser-Wisselaar, Martine E. D. Chamuleau, Arco J. Teske, Lourens Robbers, Simone Oerlemans, Heleen Crommelin, Marleen Breems-de Ridder, Astrid Schut, Folkert W. Asselbergs, Anna van Rhenen, on behalf of the HOVON 170 DLBCL – ANTICIPATE consortium

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Effect of Esketamine on Cognitive Recovery After Propofol Sedation for Outpatient Colonoscopy: A Randomized Clinical Trial by Liu D, Gao X, Zhuo Y, Cheng W, Yang Y, Wu X, Yang H, Yao Y

“…This study investigated the effects of esketamine on multiple dimensions of recovery, particularly cognition, in patients undergoing colonoscopy with propofol-based sedation.Patients and Methods: We conducted this randomized, double-blinded, placebo-controlled trial from January 6, 2023, to May 20, 2024, at two hospitals in China. …”
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Retention in the Bukhali trial in Soweto, South Africa: a qualitative analysis using self-determination theory by Shane A Norris, Stephen Lye, Catherine E Draper, Nosibusiso Tshetu, Nokuthula Nkosi

“…Introduction There is limited research on applying theory to retention in complex intervention trials. To address this gap, this study aimed to qualitatively examine retention in the Bukhali randomised controlled trial, from the perspective of trial participants and staff, through the lens of self-determination theory (SDT). …”
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A Randomized Clinical Trial of Nutrition Education for Improvement of Diet Quality and Inflammation in Iranian Obese Women by Majid Mohammadshahi, Fatemeh Haidari, Majid Karandish, Sara Ebrahimi, Mohammad-Hosein Haghighizadeh

“…Sixty obese women voluntarily participated in this randomized clinical trial and were randomly assigned to intervention or control group (n=30). …”
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Jochen Burgtorf, Paul Crawford, Helen J. Nicholson (eds.), The Debate on the Trial of the Templars (1307-1314) by Cláudio Neto

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Participant experiences in HIV cure-directed trial with an extended analytical treatment interruption in Philadelphia, United States by Andrea Bilger, Eion Plenn, Frances K. Barg, Katharine A. Rendle, William B. Carter, Andrea Lamour-Harrington, Nora Jones, Beth Peterson, John A. Sauceda, Pablo Tebas, Karam Mounzer, David Metzger, Luis J. Montaner, Karine Dubé

“…Background A feature of HIV cure trials is the need to interrupt treatment to test the efficacy of experimental interventions—a process known as analytical treatment interruptions (ATIs). …”
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The Clinical Outcomes of Ventricular Septal Rupture Secondary to Acute Myocardial Infarction: A Retrospective, Observational Trial by Xin-Ying Zhang, Li-Zhao Bian, Nai-Liang Tian

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Developing generic clinical trial animated explainer videos in the UK: results of a survey and case study by Clare Calvert, Vicki S. Barber, Duncan Appelbe, Kirsty Sprange, Claire Nollett, Fiona Lugg-Widger, Samantha Tanner, Duncan B. Richards

“…Trials…”
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Chinese Herbal Medicine for Weight Management: A Systematic Review and Meta-Analyses of Randomised Controlled Trials by Ann Rann Wong, Angela Wei Hong Yang, Kangxiao Li, Harsharn Gill, Mingdi Li, George Binh Lenon

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Experimental paradigm to test the effects of providing social support: study protocol of the PROSPECT trial (Study 2) by Vivien Hajak, Simone Grimm, Ewa Gruszczyńska, Aleksandra Kroemeke, Natalia Józefacka, Lisa Marie Warner

“…Insights into the conditions under which the provision of social support is detrimental or beneficial to the provider can inform the development of preventive and interventional approaches across a range of life domains, motivational and developmental research across the lifespan (e.g. prevention of care-giver burnout), and applied clinical contexts (e.g. therapeutic interventions). Trial registration Pre-registration (2023-11-10): https://doi.org/10.17605/OSF.IO/8SPZW , retrospective registration with more details (2024-10-23): https://www.drks.de/DRKS00034287…”
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