Feasibility Aspects of Exploring Exercise-Induced Neuroplasticity in Parkinson’s Disease: A Pilot Randomized Controlled Trial by Hanna Johansson, Malin Freidle, Urban Ekman, Ellika Schalling, Breiffni Leavy, Per Svenningsson, Maria Hagströmer, Erika Franzén

“…Reports of feasibility outcomes from existing pilot trials however are, of date, insufficient to enable replication by others in larger definitive trials. …”
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Single Dose Intravenous Paracetamol versus Placebo in Postorthognathic Surgery Pain: A Randomized Clinical Trial by Thunshuda Sumphaongern, Pornchai Jansisyanont

“…It provided significant benefits to patients, including reduced pain scores, decreased opioid consumption, reduced nausea and vomiting, and improved satisfaction. This trial is registered with TCTR20210908002.…”
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The effect of combined fig-Walnut syrup on functional constipation in pregnant women: a randomized controlled trial by Roghayyeh Valizadeh, Sakineh Mohammad-Alizadeh-Charandabi, Khadijeh Hajizadeh, Mostafa Araj-Khodaei, Mojgan Mirghafourvand

“…Further studies are needed to reach a conclusive determination. Trial registration Iranian Registry of Clinical Trials (IRCT): IRCT2012071801032N79. …”
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Decision Making in the PICU: An Examination of Factors Influencing Participation Decisions in Phase III Randomized Clinical Trials by Laura E. Slosky, Marilyn Stern, Natasha L. Burke, Laura A. Siminoff

“…The purpose of this study was to evaluate the role of clinician influence and other factors on decision making regarding participation in a randomized clinical trial (RCT). Method. Participants were 76 children under sedation in a PICU and their surrogate decision makers. …”
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Autologous Stem Cell Therapy in Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials by Baocheng Xie, Houlong Luo, Yusheng Zhang, Qinghui Wang, Chenhui Zhou, Daohua Xu

“…A systematic literature search was performed in the SinoMed, PubMed, Embase, ClinicalTrials.gov, and Cochrane Controlled Trials Register databases from building database to January 2018. …”
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Gingivitis Effectiveness of Emulgel Containing 2% Resveratrol in Orthodontic Patients: An 8-Week Randomized Clinical Trial by Amin Golshah, Shahla Mirzaeei, Nafiseh Nikkerdar, Fatemeh Ghorbani

“…The Emulgel containing 2% resveratrol is effective in improving gingival health in orthodontic patients and can lower gingival inflammation over 8 weeks. This trial is registered with the Iranian registry of clinical trials (https://irct.ir/) IRCT20130812014333N91.…”
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CEMP-1 Levels in Periodontal Wound Fluid during the Early Phase of Healing: Prospective Clinical Trial by Claudia Dellavia, Elena Canciani, Giulio Rasperini, Giorgio Pagni, Matteo Malvezzi, Gaia Pellegrini

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Submental liposuction for the management of lymphedema following head and neck cancer treatment: a randomized controlled trial by Uthman Alamoudi, Benjamin Taylor, Colin MacKay, Matthew H. Rigby, Robert Hart, Jonathan R. B. Trites, S. Mark Taylor

“…Study design was a non-blinded randomized controlled trial. Twenty patients were randomized into a treatment arm (underwent submental liposuction n = 10) and control arm (n = 10). …”
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Fifteen-second bouts of hyperoxia improve 5-minute time-trial performance in acute hypoxic conditions by Martin Faulhaber, Sina Schneider, Linda K. Rausch, Tobias Dünnwald, Verena Menz, Hannes Gatterer, Michael D. Kennedy, Wolfgang Schobersberger

“…Methods 17 healthy and recreationally trained individuals (7 females, 10 males, age 27 ± 4 years) participated in this randomized placebo-controlled cross-over trial. The procedures included a graded cycle ergometer test until exhaustion and three maximal 5-minute cycling time trials (TT). …”
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Efficacy of Tui Na in idiopathic constipation in children with cerebral palsy: a randomized controlled clinical trial by Huijuan Wang, Bichan Chen, Qian Long, Qiuping Yang, Jiawen Mao, Qinghua Ma, Xingqian Yi, Ying Wang, Yinghan Liu, Zhiliang Cao, Jianda Xu, Yong Ye, Wei Tang

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Preovulatory uterine flushing with saline as a treatment for unexplained infertility: a randomised controlled trial protocol by Lynne Moore, Jessica Lefebvre, Sarah Maheux-Lacroix, Marie-Ève Bergeron, Emmanuel Bujold, Sylvie Dodin

“…We plan to communicate the results of the review by presenting research abstracts at conferences and by publishing the results in a peer-reviewed journal.Trial registration number NCT02539290; Pre-results.…”
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Antisecretory factor in severe traumatic brain injury (AFISTBI): protocol for an exploratory randomized placebo-controlled trial by Linus Réen, David Cederberg, Niklas Marklund, Edward Visse, Peter Siesjö

“…Trials…”
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A Randomized Controlled Clinical Trial of Lifestyle Intervention and Pioglitazone for Normalization of Glucose Status in Chinese with Prediabetes by Yingying Luo, Hongyuan Wang, Xianghai Zhou, Cuiqing Chang, Wei Chen, Xiaohui Guo, Jinkui Yang, Linong Ji, Sanjoy K. Paul

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The role of social, economic, and medical marginalization in cancer clinical trial participation inequities: A systematic review by Grace Ann Hanvey, Hannah Johnson, Gabriel Cartagena, Duane E. Dede, Janice L. Krieger, Kathryn M. Ross, Deidre B. Pereira

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Research on therapeutic clinical trials including immunotherapy in triple-negative breast cancer: a bibliometric analysis by Qi Xu, Xiaoyu Feng, Siyuan Qin, Yu Hong, Rui Cui, Jia Liang, Zhuya Xiao, Yuan Li

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Social vulnerability and genetic service utilization among unaffected BRIDGE trial patients with inherited cancer susceptibility by Jemar R. Bather, Melody S. Goodman, Adrian Harris, Guilherme Del Fiol, Rachel Hess, David W. Wetter, Daniel Chavez-Yenter, Lingzi Zhong, Lauren Kaiser-Jackson, Rachelle Chambers, Richard Bradshaw, Wendy Kohlmann, Sarah Colonna, Whitney Espinel, Rachel Monahan, Saundra S. Buys, Ophira Ginsburg, Kensaku Kawamoto, Kimberly A. Kaphingst, on behalf of the BRIDGE research team

“…Existing and future cohort studies can incorporate census data to derive analytic insights for clinical scientists. Trial registration BRIDGE was registered as NCT03985852 on June 6, 2019 at clinicaltrials.gov.…”
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Effect of propofol and ciprofol in patients undergoing bronchoscopy: protocol for a double-blind, randomised controlled trial by Fang Chen, Cheng Li, Dongliang Li, Jinxuan Tang, Jiayu Huang

“…Academic dissemination will include publication in peer-reviewed journals and presentations at national and international conferences.Trial registration number ChiCTR2200063048.…”
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Effect of Antioxidants on the Gut Microbiome Profile and Brain Functions: A Review of Randomized Controlled Trial Studies by Aleksandra Hyży, Hanna Rozenek, Ewa Gondek, Mariusz Jaworski

“…Objectives: This review aims to evaluate the effects of antioxidants on the gut microbiome and cognitive function, with a focus on findings from randomized controlled trials (RCTs). Methods: The studies involved human participants across a range of age groups, with interventions encompassing natural antioxidant sources, such as berries, as well as specific antioxidant vitamins. …”
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Melatonin supplementation for the treatment of infantile spasms: protocol for a randomised placebo-controlled triple-blind trial by Jing Wang, Tao Xu, Miao Liu, Jian Chen, Guang Yang, Weiwei Feng, Yulin Sun, Xiuyu Shi, Liping Zou

“…This study aims to analyse the therapeutic effect of melatonin supplementation for the treatment of IS.Methods and analysis This is a triple-blinded (trial participant, outcome assessor and the data analyst), prospective, randomised controlled trial to be conducted in the Department of Paediatrics, The First Medical Center of Chinese PLA General Hospital, Beijing, China from November 2020. …”
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An Iterative, Mixed Usability Approach Applied to the Telekit System from the Danish TeleCare North Trial by Pernille Heyckendorff Lilholt, Clara Schaarup, Ole Kristian Hejlesen

“…The iterative, mixed usability approach yields a strong result owing to the high number of problems identified in the tests because the double experts and the COPD participants focus on different aspects of Telekit’s usability. This trial is registered with Clinicaltrials.gov, NCT01984840, November 14, 2013.…”
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