Use of Minimal Residual Disease Status to Reduce Uncertainty in Estimating Long-term Survival Outcomes for Newly Diagnosed Multiple Myeloma Patients by Naomi van Hest, Peter Morten, Keith Stubbs, Nicola Trevor

“…**Background:** Demonstrating the cost-effectiveness of new treatments for multiple myeloma (MM) often relies on the extrapolation of overall survival (OS) trial data. This method can introduce uncertainty in long-term survival estimates if OS data are immature, as is often the case in newly diagnosed MM (NDMM). …”
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Effectof Unit Hydrographs and Rainfall Hyetographs on Critical Rainfall Estimates of Flash Flood by Fanzhe Kong, Wei Huang, Zhilin Wang, Xiaomeng Song

“…Different combinations of the three hyetographs and UHs including TVUHs and time-invariant unit hydrographs (TIVUHs) were utilized as input to the calibrated Xin’anjiang Model to compute the relationships between TR and Pa (TR-Pa curves) by using trial and error methodology. The computed TR-Pa curves reveal that, for given Pa and UH, the TR corresponding to linearly increasing hyetograph is the minimum one. …”
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Clinical outcomes of asynchronous telerehabilitation through a mobile app are equivalent to synchronous telerehabilitation in patients with fibromyalgia: a randomized control study by Eren Timurtaş, İrem Hüzmeli, İlkşan Demirbüken, Mine Gülden Polat

“…Future research should explore diverse telerehabilitation protocols and their impact on overall care burdens. Trial registration NCT06299527 (01/03/2024).…”
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Blood from septic patients with necrotising soft tissue infection treated with hyperbaric oxygen reveal different gene expression patterns compared to standard treatment by Julie Vinkel, Alfonso Buil, Ole Hyldegaard

“…Conclusion The global gene expression pattern in blood changed in response to HBO2 treatment in a direction associated with clinical biochemistry improvement, and the study provides potential novel biomarkers and pathways for monitoring HBO2 treatment effects and predicting an HBO2 responsive NSTI-sepsis profile. Trial registration Biological material was collected during the INFECT study, registered at ClinicalTrials.gov (NCT01790698) 04/02/2013.…”
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Measuring the duration of kangaroo mother care for neonates: a scoping review by Moffat Nyirenda, Cally J Tann, Melissa M Medvedev, Joy Lawn, Eva Loucaides, Victor Spector Tumukunde

“…We conducted a scoping review of KMC duration measurement methods and assessed their validation.Design Scoping review in accordance with Joanna Briggs Institute guidance for conducting scoping review.Data sources MEDLINE, Embase, Cochrane Library, PsycINFO, African Index Medicus, Latin American and Caribbean Health Sciences Literature, ClinicalTrials.gov, International Clinical Trials Registry Platform, International Standard Randomised Controlled Trial Number Registry, Medrxiv and OpenGrey were searched through November 2022.Eligibility criteria for selecting studies Publications with primary data on KMC duration were included. …”
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Improving clinical care of patients in Nipah outbreaks: moving beyond ‘compassionate use’ by Md Zakiul Hassan, Amanda Rojek, Piero Olliaro, Peter Horby

“…To improve NiVD care, we propose four key strategies: 1) Enhance early case detection, 2) optimize supportive care to improve outcomes and create a standard for future trials, 3) adopt a syndromic approach centered on encephalitis, and 4) explore innovative trial designs tailored to low case numbers as an alternative to ‘compassionate use’. …”
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Cognitive Deficit-Related Interhemispheric Asynchrony within the Medial Hub of the Default Mode Network Aids in Classifying the Hyperthyroid Patients by Mengmeng Zhi, Zhenghua Hou, Yuqun Zhang, Yingying Yue, Ling Li, Yonggui Yuan

“…The altered interhemispheric coordination in the hub of the default mode network may implicated in the modulation of episodic memory in HPs patients and the distinct feature of the interhemispheric asynchrony may be treated as a potential target for the early recognition and intervention for the HPs with cognitive impairments. Clinical Trial Registration. This is a study of the neurological basis for dysfunction of mood and cognition in hyperthyroid patients: a resting-state fMRI study (registration number: ChiCTR-OOC-16008607).…”
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Application of Stem Cell Therapy for ACL Graft Regeneration by Canlong Wang, Yejun Hu, Shichen Zhang, Dengfeng Ruan, Zizhan Huang, Peiwen He, Honglu Cai, Boon Chin Heng, Xiao Chen, Weiliang Shen

“…In the clinic, 4 relevant completed trials have been reported, but only one trial with BMSCs showed improved outcomes, while 5 relevant trials are still in progress. …”
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Prevalence of hepatitis B virus and associated factors among blood donors in Hossana blood bank catchment area, Southern Ethiopia by Mesfin Menza Jaldo, Mhireteab WoldeYohannes Joffe, Eyasu Samuel Zemedkun

“…Though post-donation counseling is important for the control and prevention of hepatitis b virus infection, it has been neglected since the establishment of the blood bank we strongly recommend counseling regular donors. Clinical trial number Not applicable.…”
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Effects of Clostridium butyricum on Growth Performance, Intestinal Health, and Disease Resistance of Hybrid Grouper (Epinephelus fuscoguttatus♀ × E. lanceolatus♂) Fed with Cottonse... by Ling Pan, Weikang Li, Ruitao Xie, Hongyu Liu, Beiping Tan, Xiaohui Dong, Qihui Yang, Shuyan Chi, Shuang Zhang

“…An 8-week feeding trial was conducted to investigate the effects of C. butyricum on the growth performance, microbiota, immunity response, and disease resistance in hybrid grouper fed with cottonseed protein concentrate (CPC) replacement of fishmeal. …”
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Noninvasive high-frequency oscillation ventilation as post- extubation respiratory support in neonates: Systematic review and meta-analysis. by Rameshwar Prasad, Bijan Saha, Md Habibullah Sk, Jagdish Prasad Sahoo, Bhupendra Kumar Gupta, Subhash Chandra Shaw

“…Data sources were MEDLINE (via Pubmed), Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, WHO international clinical trials registry platform and Clinical Trial Registry, forward and backward citation search. …”
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Comparison of Transcutaneous Electrical Nerve Stimulation and Parasternal Block for Postoperative Pain Management after Cardiac Surgery by Nilgun Kavrut Ozturk, Elif Dogan Baki, Ali Sait Kavakli, Ayca Sultan Sahin, Raif Umut Ayoglu, Arzu Karaveli, Mustafa Emmiler, Kerem Inanoglu, Bilge Karsli

“…Parasternal block was more effective than TENS in the management of early postoperative pain and the reduction of opioid requirements in patients who underwent cardiac surgery through median sternotomy. This trial is registered with Clinicaltrials.gov number NCT02725229.…”
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Effect of Combined Live Probiotics Alleviating the Gastrointestinal Symptoms of Functional Bowel Disorders by Jin Shi, Feng Gao, Jie Zhang

“…Combined live probiotic supplementation after the bowel preparation can alter the gut microbiota, decontaminate SIBO, and alleviate the gastrointestinal symptoms of FBDs. This trial is registered with ChiCTR1900026472.…”
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Oral health status, behavior and impact profile among naval personnel in the Malaysian naval armed forces by Nik Madihah Nik Azis, Raja Noreihan Raja Abdullah, Mohamad Nur Adzmi Mohamad Ayub, Badiah Baharin

“…These findings highlight the need for tailored oral health interventions within the naval setting to enhance deployment readiness, improve oral health outcomes, and elevate the quality of life for naval personnel. Clinical trial number Not applicable.…”
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Implant Stability Changes for Nonsubmerged and Submerged Protocols for a Single Implant Mandibular Overdenture Using Ball Attachment by Ahmed Salah, Karim Foda, Mohamed Farouk Abdalla, Marwa Abdel Aal, Amr Naguib, Nouran Abdel Nabi

“…The scope of this clinical trial focused only on results of the ball attachment. …”
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The Effect of Nintedanib in Post-COVID-19 Lung Fibrosis: An Observational Study by Narongkorn Saiphoklang, Pimchanok Patanayindee, Pitchayapa Ruchiwit

“…Trial Registration. This study was registered in TCTR20220426001.…”
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Acupuncture for Chronic Prostatitis or Chronic Pelvic Pain Syndrome: An Updated Systematic Review and Meta-Analysis by Juanhong Pan, Song Jin, Quan Xie, Ying Wang, Zhipeng Wu, Jianfeng Sun, Tai Pin Guo, Di Zhang

“…Result. Ten RCTs (11 trials) of high-quality methodology involving 798 patients were included. …”
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Inhibiting C-Reactive Protein for the Treatment of Cardiovascular Disease: Promising Evidence from Rodent Models by Alexander J. Szalai, Mark A. McCrory, Dongqi Xing, Fadi G. Hage, Andrew Miller, Suzanne Oparil, Yiu-Fai Chen, Michelle Mazzone, Richard Early, Scott P. Henry, Thomas A. Zanardi, Mark J. Graham, Rosanne M. Crooke

“…CRP specific ASOs might pave the way towards a placebo-controlled trial that could clarify the role of CRP in cardiovascular disease.…”
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The addition of vitamin E could reduce femoral head penetration of the polyethylene liners by Fanxiao Liu, Ling Gao, Dawei Wang, Qingyu Zhang

“…However, no improvement on the clinical functions and complications were identified, and whether HXLPE/Vit E has the potential to prevent implant loosening or revision surgery could not be identified, which requires to be elaborated by high-quality randomized controlled trials.…”
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Investigating the Efficacy of an Individualized Alpha/Delta Neurofeedback Protocol in the Treatment of Chronic Tinnitus by Dominik Güntensperger, Christian Thüring, Tobias Kleinjung, Patrick Neff, Martin Meyer

“…In sum, this study confirms the alpha/delta neurofeedback as a suitable option for the treatment of chronic tinnitus and represents a first step towards the development of individual neurofeedback protocols. This clinical trial was registered online at ClinicalTrials.gov (NCT02383147) and kofam.ch (SNCTP000001313).…”
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