Feasibility and Safety of Continuous and Chronic Bilateral Deep Brain Stimulation of the Medial Forebrain Bundle in the Naïve Sprague-Dawley Rat by Luciano L. Furlanetti, Máté D. Döbrössy, Iñigo A. Aranda, Volker A. Coenen

“…Deep brain stimulation (DBS) of the superolateral branch of the medial forebrain bundle (MFB) has provided rapid and dramatic reduction of depressive symptoms in a clinical trial. Early intracranial self-stimulation experiments of the MFB suggested detrimental side effects on the animals’ health; therefore, the current study looked at the viability of chronic and continuous MFB-DBS in rodents, with particular attention given to welfare issues and identification of stimulated pathways. …”
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Rationale and design of a prospective study evaluating population pharmacokinetics and pharmacodynamics of rivaroxaban in Chinese patients with non-valvular atrial fibrillation by Ming-Ming Yan, Xiao-Qin Liu, Yu-Fei Zhang, Hong-Yan Ding, Ming-Kang Zhong, Chun-Lai Ma

“…The study findings will be submitted to peer-reviewed journals and shared with public health authorities.Trial registration number ChiCTR2100046685.…”
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A Qualitative Exploration of Stakeholders’ Preferences for Early-Stage Rectal Cancer Treatment by Merrill E. Rubens, Timothy P. Mayo, Radhika K. Smith, Sean C. Glasgow, Mary C. Politi

“…As treatment options for patients with rectal cancer evolve, patients with early-stage rectal cancer may have a treatment choice between surgery and a trial of nonoperative management. Patients must consider the treatments’ clinical tradeoffs alongside their personal goals and preferences. …”
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Technical, forensic and organisational aspects of work with Monero cryptocurrency by V. V. Nosov, O. V. Manzhai, V. O. Kovtun

“…The forensic, organisational and technical features of law enforcement agencies' work with the Monero cryptocurrency in the context of pre-trial investigation and operational search activities are analysed. …”
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Rapid and Sensitive Method for Extraction of Plicosepalus acacia with Determination of Its Main Polyphenolic Compounds Using Validated HPLC by Mashail N. AlZain, Rashed N. Herqash, Abdulaziz N. Almoqbil, Omer Mohammed Almarfadi, Mansour N. Ibrahim, Riaz Ullah, Omar M. Noman

“…Matrix solid phase dispersion (MSPD) trailed by HPLC is a quick and fruitful technique utilized for fortitude of flavonoids such as Catechin, Kaempferol, Quercetin, and Rutin existing in P. acacia. The trial parameters that influenced the extraction potential (comprising the mass ratio of sample to the dispersant, nature of dispersant, and the nature of elution solvent and its volume) were examined and optimized. …”
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Vermicompost and vermiwash as supplement to improve seedling, plant growth and yield in Linum usitassimum L. for organic agriculture by Cinny Makkar, Jaswinder Singh, Chander Parkash

“…LC-54 and LC-2063 were grown in a polyhouse for a 2 years trial. A total of 960 seedlings and 240 plants were studied for assessment of result in 24 treatments. …”
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Factors predicting secondary hypertension in young adults with hypertension: a retrospective study by Nicha Prasert, Worapaka Manosroi, Benya Hankamolsiri, Muslimah Wae-uma, Papot Choonklai

“…Individuals who do not have any of these predictors may have a lower likelihood of secondary hypertension; however, these markers should always be used in conjunction with a thorough clinical assessment and are not intended to serve as definitive criteria for diagnosis. Clinical trial number Not applicable.…”
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Enhancing Safety in U.S. Coal Mines Through a Rib Support Recommendation Tool by Alper Kirmaci, Dakshith Ruvin Wijesinghe, Dogukan Guner, Kutay E. Karadeniz, Cameron Mitchell, Taghi Sherizadeh

“…Current practices are often based on trial-and-error or outdated methods, yielding unreliable outcomes. …”
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Evaluation of maxillary sinus pathologies and the posterior superior alveolar artery canal using cone-beam computed tomography by Melike Gulec, Veysel Icen, Elif Esra Ozmen

“…This study identified the PSAA as predominantly located in the lateral wall of the maxillary sinus, an anatomical feature of critical importance during preoperative radiological evaluations to minimize vascular complications. Clinical trial number Not applicable.…”
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Effectiveness of nurse-led multi-component intervention program (NLMIP) on improving antiretroviral therapy adherence, CD4 count, psychological distress, and quality of life of peo... by Gulati Sonia, Pandurangan Hariprasath, Gupta P. Kumar

“…The research design is a randomized controlled trial (pre-test-post-test, control group design/repeated measure design). …”
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Using Social Marketing to Reduce Intention of Cesarean Section in Iranian Women by Mostafa Maleki, Ali Mousavizadeh, Saadat Parhizkar, Mohsen Shams

“…Methods. In this field trial, 39 of primigravida women were identified and selected as a target group. …”
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Acceptance and commitment therapy reduces perceived ostracism in suicidal patients by Emilie Olié, Manon Malestroit, Véronique Brand-Arpon, Philippe Courtet, Deborah Ducasse

“…Methods This randomized controlled trial included 32 patients with a history of suicide attempt in the past year who followed seven weekly sessions of ACT or progressive relaxation therapy (PRT). …”
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Association of hearing loss with cognitive function and mental health in Africa: A systematic review by Abdulazeez Ahmed, Fatimah Tsiga-Ahmed, Nafisatu Bello-Muhammad, Abdulrazaq Ajiya, Mustapha Gudaji, Denes Stefler

“…However, the number of relevant studies is small, and more research is needed to provide evidence for public health interventions across the continent. Trial registration PROSPERO—CRD42024520957.…”
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Physical and Mechanical Properties of Sheepskin Pickled by Recycled Curing Salt by Awoke Fenta Wodag, Girmaw Yeshanbel Kefale

“…The recipes were developed based on the weight of the pelt which was going to be pickled with 0.8% H2SO4, 0.5% formic acid, and 80% H2O for each trial and the recycled salt at different concentrations (8%, 8.5%, 6.5%, 7%, and 7.5%) for S1, S2, S3, S4, and S5, respectively. …”
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Inhibitory Effect of (2S)-Pinocembrin From Goniothalamus macrophyllus on the Prostaglandin E2 Production in Macrophage Cell Lines by Hilwan Yuda Teruna, Kamal Rullah, Rudi Hendra, Rahayu Utami, Deri Islami, Siti Munirah Mohd Faudzi, Mohd Fadhlizil Fasihi Mohd Aluwi, Kok Wai Lam

“…Pinocembrin (PCB), a flavonoid known for its anti-inflammatory properties, has been approved for various clinical trial applications. To evaluate deeper into the anti-inflammatory potential of the specific enantiomer of natural PCB, we conducted the first investigation into the efficacy of the pure enantiomer (2S)-PCB in modulating inflammatory mediators induced by lipopolysaccharide (LPS) in both murine RAW 264.7 and human U937 macrophage cell lines. …”
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Mitigating soil compaction and enhancing corn (Zea mays L.) growth through biological and non-biological amendments by Shahrzad Hejazi Mahabadi, Mahdi Shorafa, Babak Motesharezadeh, Hassan Etesami

“…Future research should focus on understanding the underlying mechanisms of these interactions and their long-term implications for soil health and agricultural sustainability. Clinical trial number Not applicable.…”
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Barriers faced by undergraduate dental students when conducting research: a qualitative study by Mohammed Mahmoud Sarhan, Lama Nasser Aljohani, Raghad Ibrahim Alsaleh, Roze Abdulaziz Mubaraki, Malak Abdulaziz Almozaen, Rimas Sabih Alharbi

“…Additional qualitative research in this area would help to reveal further details of the barriers to research, while additional quantitative studies are required to assess the frequency and trends of the newly revealed barriers. Clinical trial number Not applicable.…”
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Efficacy and tolerance of second-generation antipsychotics in anorexia nervosa: A systematic scoping review. by Solène Thorey, Corinne Blanchet, Sélim Benjamin Guessoum, Marie Rose Moro, Maude Ludot, Emilie Carretier

“…Olanzapine is the treatment most frequently prescribed and studied with 7 randomized double-blind controlled trials. Other atypical antipsychotics have been evaluated much less often, such as aripiprazole (no randomized trials), quetiapine (two randomized controlled trials), and risperidone (one randomized controlled trial). …”
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Sex differences in the association between repetitive negative thinking and neurofilament light by Yolanda Lau, Amit Bansal, Cassandre Palix, Harriet Demnitz-King, Miranka Wirth, Olga Klimecki, Gael Chetelat, Géraldine Poisnel, Natalie L. Marchant, The Medit-Ageing Research Group

“…Baseline data from 134 cognitively healthy older adults in the Age-Well clinical trial were utilised. Worry and brooding were assessed using questionnaires. …”
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Nondigital skin ulcers in systemic sclerosis: A neglected entity by Benzeeta Pinto, Ramya Janardana, Sowmya Kaimal, B Sheba Charles, K N Sangeeta, Jasmine Mathew, Kodishala Chanakya, John Michael Raj, Vineeta Shobha

“…There is an unmet need to incorporate non-DU in clinical trial outcomes and address them in patient management guidelines.…”
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