Association of immune-related adverse events with the outcomes of immune checkpoint inhibitors in patients with dMMR/MSI-H metastatic colorectal cancer by Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Francesca Corti, Elisabetta Fenocchio, Massimiliano Salati, Margherita Ambrosini, Michael J Overman, Lisa Salvatore, Rossana Intini, Priya Jayachandran, Javier Ros, Maria Elena Elez, Marwan Fakih, Aakash Tushar Shah, Rosalba Miceli, Monica Niger, Vincenzo Nasca, Giacomo Mazzoli, Francesco Barretta

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MOMENT registry: Patients with advanced non-small-cell lung cancer harboring MET exon 14 skipping treated with systemic therapy by Michael Thomas, Petros Christopoulos, Wade T Iams, Julien Mazieres, Alexis B Cortot, Nir Peled, Gabriele Minuti, Egbert F Smit, Francois Audhuy, Karin Berghoff, S Peter Eggleton, Frank Fries, Maike Hildenbrand, Peter Liu, Seyed Hamidreza Mahmoudpour, Christoph Menzel, Dina Oksen

“…Patients with previous participation in a clinical trial can be included if they receive at least one subsequent therapy line in a routine clinical setting. …”

Evaluating the World Health Organization’s Hearts Model for Hypertension and Diabetes Management: A Pilot Implementation Study in Guatemala by Irmgardt Alicia Wellmann, Luis Fernando Ayala, Taryn M. Valley, Vilma Irazola, Mark D. Huffman, Michele Heisler, Peter Rohloff, Rocío Donis, Eduardo Palacios, Manuel Ramírez-Zea, David Flood

“…The study’s objective is to report outcomes from a pilot implementation trial of integrated hypertension and diabetes management based on the HEARTS model in Guatemala. …”
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Prospective Single-Arm Study of Remifentanil-Propofol Anesthesia with Manual Right Hypochondrial Compression for Painless Gastroscopy in Obese Patients by Wang M, Tang J, Pan Z, Jiang H, Hu D, Zhu B, Liang Z, Zhao X, Li Y

“…The finding might provide some new schedules for anesthetic management in the absence of advanced airway support instruments.Clinical Trial Registration: ChiCTR2300077889.Plain Language Summary: With the advancement of comfortable-oriented medication, gastroscopy is mostly performed under sedation and anesthesia. …”
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Efficacy of Chinese Medicine on Postoperative Rehabilitation of Non-small Cell Lung Cancer (NSCLC), a Randomized Controlled Study by Yifeng Gu MD, Yichao Wang MD, Huiling Zhou MD, Ao Qi PhD, Guanjin Wu MM, Jiaqi Li MMed, Congmeng Zhang MMed, Yong Yang MD, Jialin Yao MD, Wenxiao Yang PhD, Lingzi Su MMed, Yi Liu MMed, Xueqi Tian MMed, Jiajun Song MMed, Yabin Gong MD, Xiong Qin MD, Lijing Jiao PhD, Ling Xu PhD

“…Methods: A randomized, parallel-group clinical trial assigned 50 patients to receive Chinese herbal medicine and Liuzijue exercise plus symptomatic treatment, and 49 to symptomatic treatment alone. …”
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PrEP15-19 Choices: an implementation study protocol of HIV prevention with oral and long-acting injectable cabotegravir PrEP in real-world settings among sexual and gender minority... by Inês Dourado, Eliana Miura Zucchi, Laio Magno, Alexandre D Grangeiro, Márcia Thereza Couto, Mateus Westin, Eduardo Oliveira, Maria Mercedes Escuder, Dirceu Greco, Thais Regis Aranha Rossi, Fabiane Soares, Lorenza Dezanet, Paula Massa, Priscilla Caires, Ricardo de Paula Vasconcelos, Unaí Tupinambas, Beo Leite, Joilson Nascimento Paim, Guilherme Barreto Campos, Lucas Miranda Marques, Nathalia Suzart, Suilan Pedreira, DulceAurélia deSouza Ferraz, Dyemison Pinheiro, Eliane Sala, Raphaella Goulart, Ana Paula Silva, Erica Dumont Pena, Gabriella Jomara daSilva, Marília Greco, Matheus dePaula Alves

“…The trial registration number: RBR-104736f4…”
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Perbandingan Insidensi Hipotensi Saat Induksi Intravena Propofol 2 Mg/Kg Bb Pada Posisi Supine dengan Perlakuan dan Tanpa Perlakuan Elevasi Tungkai by Beni Indra, Untung Widodo, Yunita Widyastuti

“…This is </em><em>Open Randomized Control Trial</em><em> include 184 elective surgery patients with American Society of Anaesthesiologist (ASA) physical status I and II. …”
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Effects of different rapeseed varieties on egg production performance, egg quality, hormone levels, follicle development, and thyroid function in hens by Liping Zhu, Jianping Wang, Xuemei Ding, Shiping Bai, Qiufeng Zeng, Yue Xuan, Keying Zhang

“…Each group had eight replicates and each replicate had 15 hens. The trial lasted for 12 wk with 4 wk withdrawal. From 1 to 8 wk of the trial, 11.5% rapeseed reduced average daily feed intake (ADFI) compared to the control group (P = 0.002), and egg-laying rate of XH3 rapeseed was lower than that of DY6 rapeseed (P = 0.006), and egg weight of MB1, DY5, and XH3 rapeseed were lower than that of the control group (P = 0.007). …”
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Diastolic Cardiac Function Improvement by Liraglutide Is Mainly Body Weight Reduction Dependent but Independently Contributes to B-Type Natriuretic Peptide Reduction in Patients wi... by Kunimasa Yagi, Teruhiko Imamura, Hayato Tada, Daisuke Chujo, Jianhui Liu, Yuuki Shima, Azusa Ohbatake, Yukiko Miyamoto, Satoko Okazaki, Naoko Ito, Kaoru Nakano, Masataka Shikata, Asako Enkaku, Akiko Takikawa, Hisae Honoki, Shiho Fujisaka, Hideki Origasa, Kazuyuki Tobe

“…GLP-1 analog treatment could be considered a therapeutic option against diabetic diastolic cardiac dysfunction regardless of body weight. This trial is registered with the University Hospital Medical Information Network in Japan, with clinical trial registration number: UMIN000005565.…”
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Comparative phytochemical and pharmacological analysis of two cultivars of Annona squamosa L. cultivated in Egypt by Safaa Yassin, Samah M. Elsohafy, Amr El-Hawiet, Maged S. Abdel-Kader, Doaa A. Ghareeb, Fikria A. Darwish, Masouda E. Amer

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Guinea grass (Megathyrsus maximus) agronomic performances in mixed cultivation using irrigation condition, North-Western Ethiopia. by Mihret Anteneh Wolele, Fentahun Meheret Zeleke, Yeshambel Mekuriaw Chekol, Bimrew Asmare Limenih, Zemenu Birhan Zegeye

“…These factors were arranged according to a 3*3 factorial setting, which was fitted to a randomized complete block design and replicated three times. This trial used three planting spaces (20, 30 and 40 cm) and harvesting ages (60, 90 and 120 days), grown in a mixed cropping system with Silver leaf desmodium using a furrow irrigation. …”
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The role of informal caregivers in suicide prevention for men– findings from a psychological autopsy study by Laura Hofmann, Anna-Lena Springer, Birgit Wagner

“…These results highlight the need for accessible resources and assistance to better support both caregivers and the individuals they care for. Trial registration German Clinical Trials Register, DRKS00030758, Registered on 11.11.2022.…”
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Effectiveness of Palivizumab in Preventing RSV Hospitalization in High Risk Children: A Real-World Perspective by Nusrat Homaira, William Rawlinson, Thomas L. Snelling, Adam Jaffe

“…This recommendation is based on evidence of efficacy when used under clinical trial conditions. However the real-world effectiveness of palivizumab outside of clinical trials among different patient populations is not well established. …”
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Motor Cortical Networks for Skilled Movements Have Dynamic Properties That Are Related to Accurate Reaching by David F. Putrino, Zhe Chen, Soumya Ghosh, Emery N. Brown

“…Whilst the same groups of neurons were often functionally connected regardless of trial success, functional connectivity between neurons was significantly different at fine time scales when the outcome of task performance changed. …”
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Efficacy and Tolerability of the Association of Sibutramine and Orlistat for Six Months in Overweight and Obese Patients by Alfredo Halpern, Renata B. Pepe, Ana Paola Monegaglia, Mônica Beyruti, Maria Edna de Melo, Marcio C. Mancini

“…To assess the efficacy and tolerability of the association sibutramine (10–20 mg/day) and orlistat (120 mg 2-3 times a day) in the treatment of obesity in a six-month open trial. Methods. 446 overweight and obese patients who sought treatment for obesity in a private clinic were assessed every 2 weeks during a period of 3 and 6 months. …”
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Post-Pandemic Independent Learning Assistance Model for Improving Students’ Academic and Socio-Personal Competence: Campus on Duty (COD) Program, In Indonesia by Novi Nityasanti, Alfi Laila, Sutisno Sahari, Veny Iswantiningtyas, Rosa Imani Khan

“…The model was developed in ten stages: 1) preliminary study, 2) planning stage, 3) development, 4) limited trial,5) initial product revision, 6) wide-scale test, 7) operational product revision, 8) operational product test, 9) final product revision, and 10) dissemination and implementation. …”
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Inhaled Corticosteroids and the Risk of Lung Cancer in Chronic Obstructive Pulmonary Disease Patients: A Systematic Review and Meta-Analysis by Amare Abera Tareke, Wondwosen Debebe, Addis Alem, Nebiyou Simegnew Bayileyegn, Taddese Alemu Zerfu, Andualem Mossie Ayana

“…Studies with cohort, case-control, and randomized clinical trial designs for any ICS use reporting the incidence/hazard ratio (HR) of lung cancer were included. …”
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Case report: Patients with positive HER-2 amplification locally advanced gastroesophageal junction cancer achieved pathologic complete response with the addition of pembrolizumab t... by Huanhuan Li, Chao Ren, Donghai Cui, Tao Wu, Zhiyong Nie

“…However, targeted therapy did not significantly improve survival outcomes compared to those with neoadjuvant therapy. The KEYNOTE-811 trial revealed an improved objective response rate (74% vs. 52%; P=.0001) and median duration of response (10.6 vs 9.5 months) with the addition of pembrolizumab (PD-1) to chemotherapy plus trastuzumab compared to that with the addition of placebo in patients with HER-2 overexpression-positive advanced adenocarcinoma. …”
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Influence of Lidocaine including Buprenorphine for Postoperative Analgesia after the Extraction of Mandibular Third Molars: A Randomized Controlled, Double-Blind, Split-Mouth Study by Nimrat K. Jawanda, Anand Shukla, Anupam Singh, Kalyana C. Pentapati, Srikanth Gadicherla

“…We conducted a randomized, double-blinded, split-mouth trial among 21 patients with impacted mandibular third molars bilaterally. …”
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