Long-Term Stability of Hydromorphone in Human Plasma Frozen at −20°C for Three Years Quantified by LC-MS/MS by Andreas Wehrfritz, Stefanie Schmidt, Harald Ihmsen, Jürgen Schüttler, Christian Jeleazcov

“…To evaluate the stability of the analgesic opioid hydromorphone, 44 human frozen plasma samples of a former clinical trial were reanalyzed after at least three years. …”
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Mathematical modeling of continuous and intermittent androgen suppression for the treatment of advanced prostate cancer by Alacia M. Voth, John G. Alford, Edward W. Swim

“…We will compute and analyze parameter sensitivity analysis for CAS and IAS which may give insight to plan effective data collection in a future clinical trial. Moreover, a periodic model for IAS is used to develop an analytical formulation for relapse times which then provides information about the sensitivity of relapse to the parameters in our models.…”
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Biomarker-Based Targeting of the Androgen-Androgen Receptor Axis in Advanced Prostate Cancer by Manish Kohli, Rui Qin, Rafael Jimenez, Scott M. Dehm

“…Specific examples of rational clinical trial designs incorporating potential predictive biomarkers from these pathways will illustrate several aspects of pharmacogenetic and pharmacogenomic predictive biomarker development in advanced prostate cancer therapeutics.…”
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Different Types of Resistant Starch Elicit Different Glucose Reponses in Humans by Mark D. Haub, Kelcie L. Hubach, Enas K. Al-tamimi, Sammy Ornelas, Paul A. Seib

“…The incremental area under the curve (iAUC) for the glucose response was calculated for all trials. The two types of resistant starch significantly (𝑃<.05) decreased iAUC compared with DEX. …”
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Balancing Technology, Ethics, and Society: A Review of Artificial Intelligence in Embryo Selection by Roberto Aufieri, Francesco Mastrocola

“…These findings, along with the results of the only randomized controlled trial available, suggest that the introduction of AI-driven embryo selection in clinical practice is not currently scientifically and ethically justified. …”
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The Combined Use of Metformin and Methotrexate in Psoriasis Patients with Metabolic Syndrome by Huynh Thi Xuan Tam, Luong Nguyen Dac Thuy, Ngo Minh Vinh, Tran Ngoc Anh, Bui Thi Van

“…A prospective clinical trial was conducted using metformin and MTX to treat psoriasis patients with metabolic syndrome. …”
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Treatment of posterolateral tibial plateau fractures through the articular line approach by Jinxi Hu, Hexin Zhang

“…It offers the benefits of reduced trauma, shortened recovery times, and minimized risk of infection, making it a recommendable technique for such fractures. Trial registration Not applicable.…”
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Determinants and Outcomes of Emergency Caesarean Section following Failed Instrumental Delivery: 5-Year Observational Review at a Tertiary Referral Centre in London by Sian McDonnell, Edwin Chandraharan

“…A ‘failed instrumental delivery score’ (FIDS) may aid practitioners in predicting an increased likelihood of a failed operative vaginal birth and therefore to consider a trial of operative vaginal delivery in the theatre. …”
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Math-Phys-Chem Approaches to Life by Hitomi Kitaojima, Shigeru Kanemitsu

“…This paper is an outcome of hard trial of mathematizing scientific disciplines which would allow description of life in terms of traditional means of mathematica, physics. chemistry, biology etc. …”
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Effect of Ice Bag Application to Femoral Region on Pain in Patients Undergoing Percutaneous Coronary Intervention by Sevda Korkut Bayındır, Gülsüm Nihal Çürük, Abdurrahman Oguzhan

“…A randomized controlled trial with repeated measures and two-group design. …”
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A framework to guide future farming research with Indigenous communities by Daniel Hayden, Amber Hayden

“…These principles have been pivotal to the primary author’s doctoral research as they collaborate with Indige­nous communities in Wisconsin to trial organic farming practices that utilize their traditional values and knowledge. …”
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Predicted missing information biases ensemble perception of temporally ordered facial expressions by Jiahao Lu, Jun Wang

“…In Experiment 1a and 1b, we manipulated the amount of prior information from local regularity by varying the position of the missing expression in the temporal sequence (1a: Neutral to Disgust and/or Disgust to Neutral,1b: Neutral to Happy and/or Happy to Neutral) within a trial. Results showed that ensemble estimates were towards the mean of expressions including both the presented and the missing faces, only when sufficient predictability (e.g. a missing expression in the late position) informed by local regularity. …”
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Immunological responses in patients with tuberculosis and in vivo effects of acetyl-L-carnitine oral administration by Emilio Jirillo, Maria Altamura, Carlo Marcuccio, Cosimo Tortorella, Claudio De Simone, Salvatore Antonaci

“…In view of the presence of nonspecific and specific immune deficits in TBC patients, a clinical trial was carried out in a group of 20 individuals with active pulmonary TBC by oral administration of acetyl-L-carnitine (ALC). …”
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Hepatoprotection by L-Ornithine L-Aspartate in Non-Alcoholic Fatty Liver Disease by Roger F. Butterworth, Ali Canbay

“…L-ornithine L-aspartate (LOLA) has hepatoprotective properties in patients with fatty liver of diverse etiology and results of a multicenter randomized clinical trial reveal that 12 weeks treatment with oral LOLA (6–9 g/d) results in a dose-related reduction in activities of liver enzymes and triglycerides together with significant improvements of liver/spleen CT ratios. …”
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Gastroesophageal Reflux Disease and Tooth Erosion by Sarbin Ranjitkar, John A. Kaidonis, Roger J. Smales

“…Though increasing evidence of associations between GERD and tooth erosion has been shown in both animal and human studies, relatively few clinical studies have been carried out under controlled trial conditions. Suspicion of an endogenous source of acid being associated with observed tooth erosion requires medical referral and management of the patient as the primary method for its prevention and control.…”
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A Novel Neural Network-Based Approach Comparable to High-Precision Finite Difference Methods by Fanghua Pei, Fujun Cao, Yongbin Ge

“…These basis functions are then used to create trial solutions, which are optimized using the least-squares method to solve for coefficients in a system of linear equations. …”
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Cavity nesting ants use more, larger grains of sand for nest entrance modification in repeated emigrations by M. Marczak, A. Gruszka, M. Rolski, S. Mitrus

“…We found a positive correlation between the number of grains used during the first and the second trials by specific colonies. Additionally, during the second trial the colonies used more grains of sand, and proportionally more of the larger grains. …”
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Time is Confidence: Monetary Incentives Metacognitive Profile on Duration Judgment by Mitra Taghizadeh Sarabi, Eckart Zimmermann

“…To test this question, we collected trial-based confidence reports in a task where participants made categorical decisions about probe durations relative to the reference duration. …”
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The Shoot Growth of Several Selected Clones of Teak after Coppicing in the Nursery by Hamdan Adma Adinugraha, Tri Maria Hasnah, Waris Waris

“…Teak hedge garden was established to multiply several selected clones of teak from clonal test trial. It was usually established on a certain arable land. …”
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Stem Cells in the Treatment of Neuropathic Pain: Research Progress of Mechanism by Meichen Liu, Kai Li, Yunyun Wang, Guoqing Zhao, Jinlan Jiang

“…In this review, we briefly introduce the neuropathic pain, the current treatment strategy, and the development of stem cell therapy, and we collected the experimental and clinical trial articles of many kinds of stem cells in the treatment of neuropathic pain from the past ten years. …”
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