External beam radiation therapy versus radical prostatectomy for high-risk prostate cancer: protocol of the RECOVER study by Caroline M. van der Starre, Chris H. Bangma, Maarten J. Bijlsma, Alfons C.M. van den Bergh, Lambertus A.L.M. Kiemeney, Wietske Kievit, Kees Vos, Diederik M. Somford, Sally M. Wildeman, Katja K.H. Aben, Igle J. de Jong, Floris J. Pos, Berdine L. Heesterman

“…Discussion An observational prospective design was chosen since a randomized controlled trial comparing surgery and radiotherapy was not deemed feasible. …”
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The effect of prone positioning on maternal haemodynamics and fetal wellbeing in the third trimester-A primary cohort study with a scoping review. by Laura Ormesher, Jessica Catchpole, Linda Peacock, Heather Pitt, Anastasia Fabian-Hunt, Dexter Hayes, Claudia Popp, Jason M Carson, Raoul van Loon, Lynne Warrander, Karli Büchling, Alexander E P Heazell

“…Further work is needed to optimise the safety of prone positioning in pregnancy.<h4>Trial registration</h4>This trial was registered at clinicaltrials.gov (NCT04586283).…”
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Minimally important change on the Columbia Impairment Scale and Strengths and Difficulties Questionnaire in youths seeking mental healthcare by Peter Szatmari, Claire de Oliveira, Myla E Moretti, Kristin Cleverley, Lisa D Hawke, Amy H Cheung, Meaghen Quinlan-Davidson, Clement Ma, Karolin R Krause, Alina Lee, Di Shan, Katherine Tombeau Cost, Jo L Henderson

“…The minimally important change (MIC) indicator designates change as meaningful to patients, yet is rarely reported in youth mental health trials.Objective This study aimed to establish MIC thresholds for two patient-reported outcome measures (PROMs), the Columbia Impairment Scale (CIS) and the Strengths and Difficulties Questionnaire (SDQ), using different estimation methods.Methods A sample of 247 youths (14–17 years) completed the CIS and SDQ at baseline and at 6 months in a youth mental health and substance use trial. …”
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Pengembangan Media Pembelajaran Berbasis Website pada Mata Pelajaran Dasar Desain Grafis Menggunakan Model Pengembangan Four-D (Studi pada SMK Negeri 1 Rembang) by Azka Azkiyah, Satrio Hadi Wijoyo, faizatul amalia

“…In order to test the effectiveness and efficiency of learning media, the researcher involved 34 students in general trial. General trial consist of effectivity and efficiency test. …”
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Risk factors for the delayed discharge from anesthesia intensive care unit: a single-center retrospective study by Yue Qian, Jing Hao, Wei Zhu, Yan Yang, Zhuan-yun Zhang, Lu-yang Zhou, Xiao-ping Gu, Zheng-liang Ma, Yu-e Sun

“…The nomogram model exhibits excellent performance. Trial registration The single-center retrospective study was approved by the Ethics Committee of Nanjing Drum Tower Hospital (No. 2021-563-01, Data: 22 November 2021) and registered on the Chinese Clinical Trial Registry (No. …”
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Long-term safety and sustained efficacy of bimekizumab in patients with ankylosing spondylitis (radiographic axial spondyloarthritis): 5-year results from BE AGILE (phase 2b) and i... by Sofia Ramiro, Désirée van der Heijde, Atul Deodhar, Xenofon Baraliakos, Denis Poddubnyy, Lianne S Gensler, Helena Marzo-Ortega, Natasha de Peyrecave, Victoria Navarro-Compán, Tetsuya Tomita, Carmen Fleurinck, Ute Massow, Thomas Vaux

“…Objective Assess long-term safety, tolerability and efficacy of bimekizumab in ankylosing spondylitis (radiographic axial spondyloarthritis (r-axSpA)).Methods Patients with active r-axSpA completing the dose-ranging 48-week randomised controlled trial could enrol in the open-label extension, where patients received bimekizumab 160 mg every 4 weeks. …”
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Management of connective tissue disease-associated interstitial lung disease by Keerthi Talari

“…Evidence to guide treatment is insufficient with very few randomized trials reported till date. This review discusses the current evidence guiding management of CTD-ILD with a specific focus on corticosteroids, cyclophosphamide, mycophenolate, azathioprine, calcineurin inhibitors, and pirfenidone. …”
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Contributions to the elucidation of a controversial episode. The Ciulei Case. (2) by Liviu CORCIU

“…It is in this context that the trial of Second Lieutenant Constantin Ciulei should also be analyzed, which thus takes on new meanings and significance. …”
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Expertise and community juridification: Defense of subsoil and communal lands in Oaxaca, Mexico by Salvador Aquino-Centeno

“…Methodologically, participant observation and the mapping of the injunction trial through information compiled in the community's archive stand out. …”
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The Amelioration of Detrimental Biochemical Anomalies by Supplementing B, C, and E Vitamins in Subjects with Type 2 Diabetes Mellitus May Reduce the Rate of Development of Diabetic... by Subhasish Pramanik, Kaustav Banerjee, Lakshmi Kanta Mondal

“…In this prospective clinical trial, 185 patients with T2DM who received B vitamins, vitamin C, and vitamin E along with antidiabetic medication for five years demonstrated a slower rate of the development of DR and reduced abnormal biochemical mediators like reactive oxygen species (ROS), malondialdehyde (MDA), AGE, and vascular endothelial growth factor (VEGF) compared to 175 T2DM individuals who were treated with only antihyperglycemic drugs.…”
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Procreative autonomy, gender equality and right to life: the decision of the Inter-American Court of Human Rights in Artavia Murillo v. Costa Rica by Teresinha Teles Pires

“…Resumo The trial and the reasons adopted by Inter-American Court of Human Rights (IACtHR) in Artavia Murillo v. …”
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Current Trends in Implantable Left Ventricular Assist Devices by Jens Garbade, Hartmuth B. Bittner, Markus J. Barten, Friedrich-Wilhelm Mohr

“…Currently, results using nonpulsatile continuous flow pumps document the evolution in outcomes following destination therapy achieved subsequent to the landmark Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure Trial (REMATCH), as well as the outcome of pulsatile designed second-generation LVADs. …”
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Harmonization of the fastest and densest responses reflects humanlike reaction time in mice by Chan Hee Kim

“…Unlike humans, whose RT usually reflects a one-to-one stimulus–response relationship, the RT of animals can show two peaks representing the fastest and densest responses in the response distribution due to multiple responses per trial and can be further delayed depending on stimulus duration.MethodsStimulus duration was controlled to investigate whether these two peak latencies align to form a single RT. …”
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Growing Plums in Florida by E. P. Miller, Peter C. Andersen, Jeffrey G. Williamson, James J. Ferguson, J. Bitter

“…Because they have cropped reliably and produced high quality fruit, these cultivars are recommended for trial in Florida. The names of all University of Florida plum cultivars begin with the prefix 'Gulf.' …”
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Pengembangan Buku Panduan Konseling Kognitif Behavioral Teknik Cognitive Restructuring Untuk Meningkatkan Resiliensi Akademik Siswa SMA by Serafina Elasa Budiono, Kadek Suranata, Dewi Arum Widhayanti Metra Putri

“…This study involved 5 experts in the field of Counseling Guidance, who evaluated the counseling manual theoretically, and involved 33 students as respondents to the counseling guidance books effectiveness trial. Data analysis related to the validity and effectiveness of the guidebook was carried out using the calculation of the Content Validity Ratio, Content Validity Index, and t-test. …”
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Dopamine Appetite and Cognitive Impairment in Attention Deficit/Hyperactivity Disorder by Jonathan Williams, Eric Taylor

“…Extending the TD model to incorporate either a state regulation deficit, or working memory deficit and delay in starting trials, can provide a good account of both control and ADHD results, at all trial-lengths. …”
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Impact of the Project P.A.T.H.S. in the Junior Secondary School Years: Objective Outcome Evaluation Based on Eight Waves of Longitudinal Data by Daniel T. L. Shek, Cecilia M. S. Ma

“…To assess the effectiveness of the Tier 1 Program of the Project P.A.T.H.S., a randomized group trial with eight waves of data collected was carried out. …”
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Docetaxel-Induced Stevens-Johnson Syndrome in a Patient with Metastatic Prostate Adenocarcinoma by Osama Diab, Dan Mcentire, Thamer Kassim, Ali Nayfeh, Abdel Rahman Dajani, Mitchell Kerfeld, Jonathon Campbell, Adbullah Alsuwaidan, Mahmoud Abu Hazeem, Maryam Gbadamosi-Akindele

“…This medication is not classically associated with the development of SJS but in our case, along with a number of other case reports, and a single phase II clinical trial, an association was recognized. We encourage clinicians who employ the use of this medication to be aware of this relationship.…”
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A Novel Curcumin-Based Drug Powder Inhalation Medicine for Chronic Obstructive Pulmonary Disease by Qin Shen, Yongjie Jiang, Jing Chen, Xueling Wang, Jiao Zheng

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