Implementation of in utero laparotomy-assisted fetoscopic spina bifida repair in two centers in Latin America: rationale for this approach in this regionAJOG Global Reports at a Gl... by Jezid Miranda, PhD, Miguel A. Parra-Saavedra, PhD, William O. Contreras-Lopez, PhD, Cristóbal Abello, MD, Guido Parra, MD, Juan Hernandez, MD, Amanda Barrero, MD, Isabela Leones, MD, Adriana Nieto-Sanjuanero, MD, Gerardo Sepúlveda-Gonzalez, MD, Magdalena Sanz-Cortes, PhD

“…These cases were compared to 78 cases from the MOMs trial and 314 from other Latin American centers using traditional open-hysterotomy methods. …”
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A serosurvey study of hand, foot and mouth disease in healthy children aged 6 to 71 months old in West Bandung and Bandung Region, Indonesia by Rodman Tarigan Girsang, Kusnandi Rusmil, Eddy Fadlyana, Budi Setiabudiawan, Riyadi Adrizain, Rizky Perdana Mulyadi, Arief Budiman, Rona Kania Utami, Behesti Zahra Mardiah, Muhammad Gilang Dwi Putra, Frizka Primadewi Fulendry, Dinda Tiaraningrum Nashsyah, Hadyana Sukandar

“…Further research is needed to investigate HFMD cases because of the lack of attention given to this disease and the need to consider whether immunisation is necessary to prevent HFMD. Trial registration This study is registered at clinicaltrials.gov, National Clinical Trial (NCT) No. …”
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Comparative evaluation of allograft particulate bone and cortical bone blocks combined with xenograft bone for labial bone defects in the aesthetic zone: a prospective cohort study by Li-Rong Huang, Yong-Jin Zhong, Xiao-Qing Zhang, Ze-Ru Feng, Yan-Cheng Lai, Hong-Kun Wu, An-Chun Mo

“…Further research with longer follow-up is required to confirm long-term stability. Trial registration The study was retrospectively registered in the Chinese Clinical Trial Registry ( http://www.chictr.org.cn/ ) with the registration number ChiCTR2300070538 on April 14, 2023.…”
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Effect of periodontal therapy on endothelial function and serum biomarkers in patients with periodontitis and established cardiovascular disease: a pilot study by Ana Molina, Nagore Ambrosio, María Molina, Eduardo Montero, Leire Virto, David Herrera, Elena Figuero, Mariano Sanz

“…AimTo investigate the effect of periodontal therapy on endothelial function of subjects with periodontitis in stages III or IV and established cardiovascular disease.Materials and methodsA triple-blinded, parallel groups, randomized clinical trial of 6 months duration, on patients with history of coronary heart disease and periodontitis in stages III or IV was performed. …”
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Efficacy of yeast beta-glucan 1,3/1,6 supplementation on respiratory infection, fatigue, immune markers and gut health among moderate stress adults in Klang Valley of Malaysia: pro... by Suzana Shahar, Kalavathy Ramasamy, Norhayati Ibrahim, Nur Nadia Mohamad Habibullah, Munirah Ismail, Mohd Zul Amin Kamaruddin, Shirley Gee Hoon Tang, Mohd Faisal Abdul Hamid

“…The findings will be disseminated to participants, healthcare professionals and researchers via conference presentations and peer-reviewed publications.Trial registration number ISRCTN48336189…”
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Positive end-expiratory pressure and risk of postoperative pulmonary complications in patients living at high altitudes and undergoing surgery at low altitudes: a single-centre, re... by Zhuoning Li, Kaixi Shang, Zongjing Xia, Xiaoli Ye, Chongcong Gong

“…Prospective longitudinal studies are needed to further investigate perioperative lung protection ventilation strategies for patients from high altitudes.Trial registration number Chinese Clinical Trial Registry (ChiCTR2100044260).…”
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The Efficacy of Moxibustion on the Serum Levels of CXCL1 and β-EP in Patients with Rheumatoid Arthritis by Siyu Tao, Xue Wang, Chenxi Liao, Yan Xiong, Jie Tang, Nannan Jiang, Yuan Li, Xinyue Hu, Rouxian Shuai, Yueyue Wang, Ping Wu

“…Moxibustion can improve the joint swelling and pain symptoms in patients with RA, which may be related to the fact that moxibustion can reduce the release of inflammatory factors in patients with RA and downregulate the level of CXCL1 and increase the level of β-EP at the same time. This trial is registered with ChiCTR-IOR-17012282.…”
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Effects of Stocking Density on Fatty Acid and Amino Acid Composition in Muscle, Serum Cortisol, Stress and Immune Response in Large Yellow Croaker (<i>Larimichthys crocea</i>) by Youbin Yu, Liang Wang, Wenyun Huang, Duo Yu, Qiaoxuan Sun, Mingcao Cui

“…At the end of this trial, the final densities were 10.38 ± 0.50, 14.41 ± 1.06, and 18.71 ± 0.99 kg/m³ in the LD, MD, and HD groups, respectively. …”
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Feasibility, acceptability and preliminary effects of a social network-based, peer-led HIV self-testing intervention among men in two Ugandan fishing communities, 2022 by Joseph KB Matovu, Aisha Twahiri Namwama, Linda Kemigisha, Geoffrey Taasi, Jennipher Nakabugo, Julius Wandabwa, Laura M. Bogart, Nuraan Fakier, Rhoda K. Wanyenze, Peter Olupot-Olupot, Joshua Musinguzi, David Serwadda

“…Trial registration ClinicalTrials.Gov: NCT05685498 (retrospectively registered on January 17, 2023).…”
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Construct validity and responsiveness of clinical upper limb measures and sensor-based arm use within the first year after stroke: a longitudinal cohort study by Johannes Pohl, Geert Verheyden, Jeremia Philipp Oskar Held, Andreas Ruediger Luft, Chris Easthope Awai, Janne Marieke Veerbeek

“…The MIC values can be used as a benchmark for clinical stroke rehabilitation. Trial registration This trial was registered on clinicaltrials.gov; registration number NCT03522519.…”
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Systematic preclinical evaluation of CD33-directed chimeric antigen receptor T cell immunotherapy for acute myeloid leukemia defines optimized construct design by Haiying Qin, Nirali N Shah, Terry J Fry, Lila Yang, John A Chukinas, Samiksha Tarun, Marie Pouzolles, Christopher D Chien, Lisa M Niswander, Anthony R Welch, Sarah K Tasian, Naomi A Taylor

“…Based on this rigorous preclinical evaluation, our validated clinical grade lintuzumab-CD28/CD3ζ CD33CART immunotherapy is now under evaluation in a first-in-child/first-in-human phase 1 clinical trial for children and adolescents/young adults with relapsed/refractory AML.Trial registration number clinicaltrials.gov; NCT03971799.…”
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Movement therapy in advanced heart failure assisted by a lightweight wearable robot: a feasibility pilot study by Isabell Anna Just, Denis Fries, Sina Loewe, Volkmar Falk, Nikola Cesarovic, Frank Edelmann, Anna Feuerstein, Florian L. Haufe, Michele Xiloyannis, Robert Riener, Felix Schoenrath

“…The results are highly encouraging to further pursue this innovative approach in rehabilitation programmes. This trial was registered at ClinicalTrials.gov: NCT04839133.…”
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Phase Ib study of pembrolizumab in combination with trastuzumab emtansine for metastatic HER2-positive breast cancer by Sara M Tolaney, Tianyu Li, Edward T Richardson, Judith Agudo, Elizabeth A Mittendorf, Beth Overmoyer, Eric P Winer, Adrienne G Waks, Tanya E Keenan, Nabihah Tayob, Gerburg M Wulf, Victoria Attaya, Leilani Anderson, Ian E Krop, Eliezer M Van Allen

“…Programmed cell death ligand-1 and tumor infiltrating lymphocytes did not correlate with response in this small cohort.Conclusions T-DM1 plus pembrolizumab was a safe and tolerable regimen. Ongoing trials will define if there is a role for checkpoint inhibition in the management of HER2-positive metastatic breast cancer.Trial registration number NCT03032107.…”
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Impact of school salad bars on fruit and vegetable selection, intake, and waste in Mid-Atlantic elementary schools by Melanie K. Bean, Suzanne E. Mazzeo, Lilian de Jonge, Laura Thornton, Hollie Raynor, Ashley Mendoza, Sarah Farthing, Bonnie Moore

“…Findings can inform policies designed to increase FV intake within the NSLP. Trial registration This investigation reports results of a systematic evaluation of school salad bars and does not meet criteria for a clinical trial, yet was retrospectively registered (10/28/22) in clinicaltrials.gov (NCT05605483) as an observational study.…”
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Fucosylated haptoglobin promotes inflammation via Mincle in sepsis: an observational study by Taylor Roh, Sungeun Ju, So Young Park, Yeonghwan Ahn, Jiyun Chung, Miyako Nakano, Gyoungah Ryu, Young Jae Kim, Geumseo Kim, Hyewon Choi, Sung-Gwon Lee, In Soo Kim, Song-I Lee, Chaeuk Chung, Takashi Shimizu, Eiji Miyoshi, Sung-Soo Jung, Chungoo Park, Sho Yamasaki, Seung-Yeol Park, Eun-Kyeong Jo

“…Together, our findings reveal a role of Fu-Hp, derived from sepsis patients, in driving inflammation, and suggest that targeting Fu-Hp could serve as a promising intervention for combating sepsis. Trial registration NCT05911711…”
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Phase Ib open-label, multicenter study of pixatimod, an activator of TLR9, in combination with nivolumab in subjects with microsatellite-stable metastatic colorectal cancer, metast... by Matthew Burge, David Goldstein, Andrew Haydon, Nick Pavlakis, Charlotte Lemech, Edward Hammond, Darryn Bampton, Keith Dredge, Michael P Brown, Andrew Clouston, Nigel J Waterhouse, Amanda C Stanley, Lucie Leveque-El Mouttie, Grace M Chojnowski

“…The efficacy signal and pharmacodynamic changes in MSS mCRC warrants further investigation.Trial registration number NCT05061017.…”
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Ten Machine Learning Models for Predicting Preoperative and Postoperative Coagulopathy in Patients With Trauma: Multicenter Cohort Study by Xiaojuan Xiong, Hong Fu, Bo Xu, Wang Wei, Mi Zhou, Peng Hu, Yunqin Ren, Qingxiang Mao

“…Among the ML models, the random forest model was the most effective predictor. Trial RegistrationChinese Clinical Trial Registry ChiCTR2300078097; https://www.chictr.org.cn/showproj.html?…”
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The utilization of seagrass and macroalgae substrate for settlement of sandfish Holothuria scabra larvae by Lisa Fajar Indriana, , Marjuky, Sitti Hilyana

“…At the beginning of experiment trial, one thousand larvae were distributed into plastic tank containing 10 L seawater for each tank. …”
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