Observational study protocol: the faecal microbiome in the acute stage of new-onset paediatric type 1 diabetes in an Irish cohort by Eugene Dempsey, Catherine Stanton, Paul Ross, Colin Patrick Hawkes, Aonghus Lavelle, Carol-Anne O’Shea, Elaine Catherine Kennedy, Fiona Catherine Ross

“…Study results will be available to patients with T1D and their families, carers, support networks and microbiome societies and other researchers.Trial registration number The clinicaltrials.gov registration number for this trial is NCT06157736.…”
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LCZ696 Therapy Reduces Ventricular Tachyarrhythmia Inducibility in a Myocardial Infarction-Induced Heart Failure Rat Model by Po-Cheng Chang, Shien-Fong Lin, Yen Chu, Hung-Ta Wo, Hui-Ling Lee, Yu-Chang Huang, Ming-Shien Wen, Chung-Chuan Chou

“…LCZ696 (valsartan/sacubitril) therapy significantly reduced mortality in patients with heart failure (HF). Although a clinical trial (PARADISE-MI Trial) has been ongoing to examine the effects of LCZ696 in myocardial infarction (MI) patients, the effects of LCZ696 on remodeling of cardiac electrophysiology in animal models remain largely unclear. …”
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Medical thoracoscopy combined with intrapleural injection of urokinase for treatment of pleural infection-a multicenter, prospective, randomized controlled study: study protocol by Kaige Wang, Linhui Yang, Panwen Tian, Fen Tan, Dan Liu, Weimin Li

“…Methods This study is a prospective, multicenter, randomized controlled clinical trial involving patients with pleural infections. …”
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<i>Vibrio cholerae</i> Gut Colonization of Zebrafish Larvae Induces a Dampened Sensorimotor Response by Isabella Cubillejo, Kevin R. Theis, Jonathan Panzer, Xixia Luo, Shreya Banerjee, Ryan Thummel, Jeffrey H. Withey

“…<b>Results</b>: While there was no significant difference in the light/dark trial, we report a significant decrease in distance moved for C6706-colonized larvae during the single-tap trial. …”
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Health-related quality of life in patients with liver cirrhosis following adjunctive nurse-based care versus standard medical care: a pragmatic, multicentre, randomised controlled... by Anncarin Svanberg, Maria Hjorth, Daniel Sjöberg, Elenor Kaminsky, Fredrik Rorsman, Riccardo Lo Martire

“…However, RN involvement contributed to early identification of decompensation and reduced mortality.Trial registration number NCT02957253.…”
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Total glucosides of paeony for rheumatoid arthritis: a protocol for a systematic review by Jing Luo, Guo-Yan Yang, Di-Er Jin, Ying-Ze Zhang, Jian-Ming Wang, Wei-Ping Kong, Qing-Wen Tao

“…Many relevant randomised controlled trials (RCTs) of TGP for RA are available, but they have not been systematically reviewed. …”
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YAP1 as a Novel Negative Biomarker of Immune Checkpoint Inhibitors for EGFR-Mutant Non-Small-Cell Lung Cancer by Ling-Chen Li, Xie-Wan Chen, Ling Fang, Chun-Li Jian, Yong-Xin Yu, Xing-Yun Liao, Jian-Guo Sun

“…YAP1 is a novel negative biomarker of ICIs treatment in EGFR-mutant NSCLC population. Clinical Trials. This trial is registered with NCT03513666.…”
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Effect of different doses of ciprofol on hemodynamics induced by general anesthesia in elderly diabetic patients undergoing spinal surgery: a double-blind, randomized, controlled s... by Xiaorui Jiang, Linzhong Zhang, Jiawei Ji, Yan Jing, Meiping Li

“…This regimen was found to be more favorable compared to the 0.2 mg/kg and 0.4 mg/kg ciprofol dosing groups, demonstrating an optimal balance of safety and efficacy during anesthesia induction in this high-risk population. This trial was registered in the Chinese Clinical Trial Registry on February 26, 2024 (Registration Number: ChiCTR2400081164).…”
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Evaluation of the effect of 48 weeks of BIC/F/TAF and DRV/c/F/TAF on platelet function in the context of rapid ART start by Akif A. Khawaja, Gary Whitlock, Sarah Fidler, Alfredo Soler-Carracedo, Merle Henderson, Graham P. Taylor, Marta Boffito, Michael Emerson

“…Further data are required to explore whether there are biologically significant off-target effects, including effects on platelets and other components of the cardiovascular system between these two test-and-treat regimens. Clinical Trial Number NCT04653194.…”
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Crime in Kharkiv and Its Counteraction in 1880 by V. A. Hrechenko, O. M. Honcharuk

“…Each historical and social phenomenon has been considered in its diversity and contradiction, in the aggregate of both positive and negative manifestations. The Kharkiv trial of 1885 demonstrated the shortcomings of the Judicial Reform of 1864, the activities of lawyers and the jury. …”
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Effectiveness of deliberate practices versus conventional lecture in trauma training for medical students by Suksan Kanoksin, Bhapapak Na Songkhla, Amarit Tansawet, Issaree Laopeamthong, Pakkapol Sukhvibul, Suphakarn Techapongsatorn

“…Methods A randomized controlled trial was conducted with 48 first- to third-year medical students at the Faculty of Medicine Vajira Hospital at Navamindradhiraj University (Thailand). …”
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Preliminary Evidence for Feasibility, Use, and Acceptability of Individualized Texting for Adherence Building for Antiretroviral Adherence and Substance Use Assessment among HIV-In... by David J. Moore, Jessica L. Montoya, Kaitlin Blackstone, Alexandra Rooney, Ben Gouaux, Shereen Georges, Colin A. Depp, J. Hampton Atkinson, The TMARC Group

“…Future studies will refine and improve iTAB for optimal acceptability and efficacy. This trial is registered with ClinicalTrials.gov NCT01317277.…”
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Evaluation of the role of hydroxychloroquine as a lipid profile improving and glucose adjusting drug in Egyptian females with inactive rheumatoid arthritis by Aliaa O. El-Hady, Mai M. Kamel, Yasmin T. Mosaad, Maha A. Ali, Soad S. El Molla

“…Subjects and methods This trial study included fifty adult RA females in remission treated with 400 mg daily of HCQ orally for 6 months. …”
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A prospective model of the potential clinical and economic impact of cervical cancer screening supported by a mobile phone app. by Fredrick Chite Asirwa, Brian W Bresnahan, Faith Yego, Dana Duncan, James K Karichu, Louis P Garrison

“…The model is structured to simulate a three-visit pathway for HPV-based screening used in a clinical trial of the app and based on epidemiological data, clinical guideline-based workflow, and patient-based behavioral pathways. …”
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The Effect of Repetitive Transcranial Magnetic Stimulation on Motor Symptoms in Hereditary Spastic Paraplegia by J. Antczak, J. Pera, M. Dąbroś, W. Koźmiński, M. Czyżycki, K. Wężyk, M. Dwojak, M. Banach, A. Slowik

“…The aim of this randomized, controlled trial was to investigate the therapeutic potential of rTMS in various forms of HSP, including pure and complicated forms, as well as adrenomyeloneuropathy. …”
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The Influence of Differences in Solvents and Concentration on the Efficacy of Propofol at Induction of Anesthesia by Yukako Obata, Yushi U. Adachi, Katsumi Suzuki, Taiga Itagaki, Hiromi Kato, Maiko Satomoto, Yoshiki Nakajima

“…The required dose of propofol was different among the formulations; however, the serum concentration showed no significant difference. This trial is registered with UMIN Clinical Trial Registry: UMIN000019925.…”
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The clinical journey of belantamab mafodotin in relapsed or refractory multiple myeloma: lessons in drug development by Pralay Mukhopadhyay, Hesham A. Abdullah, Joanna B. Opalinska, Prani Paka, Eric Richards, Katja Weisel, Suzanne Trudel, Maria-Victoria Mateos, Meletios Athanasios Dimopoulos, Sagar Lonial

“…Despite the 41% response rate and durable responses observed with belantamab mafodotin in the Phase III confirmatory DREAMM-3 trial, the marketing license for belantamab mafodotin was later withdrawn from US and European markets when the trial did not meet its primary endpoint of superiority for progression-free survival compared with pomalidomide and dexamethasone. …”
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Subthalamic Nucleus Deep Brain Stimulation in Early Stage Parkinson’s Disease Is Not Associated with Increased Body Mass Index by Sarah H. Millan, Mallory L. Hacker, Maxim Turchan, Anna L. Molinari, Amanda D. Currie, David Charles

“…This finding will be tested in an upcoming FDA-approved phase III multicenter, randomized, double-blind, placebo-controlled, pivotal clinical trial evaluating DBS in early stage PD (ClinicalTrials.gov identifier NCT00282152).…”
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Matching-Adjusted Indirect Comparison of the Efficacy at Week 32 of Tralokinumab and Dupilumab in the Treatment of Moderate-to-Severe Atopic Dermatitis by Tiago Torres, Anne Sohrt Petersen, Ulla Ivens, Albert Bosch Vilaro, John Stinson, José Manuel Carrascosa

“…Methods An unanchored matching-adjusted indirect comparison was conducted using individual patient data (IPD) from the ECZTRA 3 tralokinumab trial and aggregate data from the LIBERTY AD CHRONOS dupilumab trial. …”
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Assessment of Postresuscitation Volume Status by Bioimpedance Analysis in Patients with Sepsis in the Intensive Care Unit: A Pilot Observational Study by Bram Rochwerg, Jason H. Cheung, Christine M. Ribic, Faraz Lalji, France J. Clarke, Susheel Gantareddy, Nischal Ranganath, Aziz Walele, Ellen McDonald, Maureen O. Meade, Deborah J. Cook, Trevor T. Wilkieson, Catherine M. Clase, Peter J. Margetts, Azim S. Gangji

“…It is feasible to use BIA to predict postresuscitation volume status and patient-important outcomes in septic ICU patients. Trial Registration. This trial is registered with clinicaltrials.gov NCT01379404 registered on June 7, 2011.…”
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