Allograft Reconstruction of the Extensor Mechanism after Resection of Soft Tissue Sarcoma by Daniel A. Müller, Giovanni Beltrami, Guido Scoccianti, Pierluigi Cuomo, Francesca Totti, Rodolfo Capanna

“…The replacement of the extensor mechanism by an allograft is a reasonable option, allowing wide margins and restoration of active extension in most patients. Trial Registration. The presented study is listed on the ISRCTN registry with trial number ISRCTN63060594.…”
Get full text

Utilization of Oncotype DX in an Inner City Population: Race or Place? by Amber A. Guth, Susan Fineberg, Kezhen Fei, Rebeca Franco, Nina A. Bickell

“…Of 225 ER+ women participating in a patient assistance trial, 23% underwent Oncotype DX testing: 31% of whites, 21% of blacks, and 14% of Hispanics (P=0.04) were tested. …”
Get full text

Lack of Clinically Meaningful Effect of Cariprazine on the Pharmacokinetics of a Combined Oral Contraceptive by Márta Erzsébet Rosa, Zoltán Juhász, Gabriella Pásztor Mészáros, Gabriella Magyar, Judit Harsányi, Balázs Szatmári, Zoltán Hujber, Máté Szabó, Margit Kapás

“…Conclusions According to these results, hormonal contraceptives can be considered effective during CAR treatment. Trial Registration Trial registration number (EudraCT) 2018-003722-80.…”
Get full text

A Cost-effectiveness Analysis of Brentuximab Vedotin in Relapsed or Refractory Systemic Anaplastic Large Cell Lymphoma by Margaret Hux, Denise Zou, Esprit Ma, Peter Sajosi, Andreas Engstrom, Ross Selby, Eugene Benson, Andrew Briggs, Vijayveer Bonthapally

“…Survival was extrapolated using parametric distributions, with brentuximab vedotin risk after the trial period assumed equal to conventional chemotherapy. …”
Get full text

Abnormal Glucose Tolerance Is Associated with a Reduced Myocardial Metabolic Flexibility in Patients with Dilated Cardiomyopathy by Domenico Tricò, Simona Baldi, Silvia Frascerra, Elena Venturi, Paolo Marraccini, Danilo Neglia, Andrea Natali

“…The presence of AGT in patients with DCM exacerbates both the shift from fat to carbohydrates in resting myocardial metabolism and the reduced myocardial metabolic flexibility in response to an increased workload. This trial is registered with ClinicalTrial.gov NCT02440217.…”
Get full text

A Matching-Adjusted Indirect Comparison of Sonidegib and Vismodegib in Advanced Basal Cell Carcinoma by Dawn Odom, Deirdre Mladsi, Molly Purser, James A. Kaye, Eirini Palaka, Alina Charter, Jo Annah Jensen, Dalila Sellami

“…Objectives. Based on single-arm trial data (BOLT), sonidegib was approved in the US and EU to treat locally advanced basal cell carcinomas (BCCs) ineligible for curative surgery or radiotherapy. …”
Get full text

Treatment With Avacopan in Patients With Respiratory Tract Manifestations of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis by Ulrich Specks, Robert F. Spiera, Lynn A. Fussner, Robert Lebovics, Sarah Bray, Rachel E. Gurlin, Darcy Trimpe, David R. W. Jayne, Peter A. Merkel, for the ADVOCATE Study Group

“…Objective The ADVOCATE trial demonstrated that treatment of active granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) with avacopan was noninferior in achieving remission at week 26 and superior for sustained remission at week 52 compared with a prednisone taper. …”
Get full text

Comparison of the Effects of Maternal Supportive Care and Acupressure (BL32 Acupoint) on Pregnant Women’s Pain Intensity and Delivery Outcome by Marzieh Akbarzadeh, Zahra Masoudi, Mohammad Javad Hadianfard, Maryam Kasraeian, Najaf Zare

“…Therefore, these methods can be introduced to the medical team as effective strategies for decreasing delivery pain. This trial is registered with the Iranian Registry of Clinical Trial Code IRCT2014011011706N5.…”
Get full text

The Effects of Calcium Fertilizer Sprays during Fruit Development Stage on Pineapple Fruit Quality under Humid Tropical Climate by Supriyono Loekito, null Afandi, Auliana Afandi, Naomasa Nishimura, Hiroyuki Koyama, Masateru Senge

“…All treatments with calcium sprays reduced the fructose and glucose contents in the first trial and β-carotene content in the second trial. …”
Get full text

Avatars and humans may not elicit the same accent-related biases in mock courtroom research by Lara A. Frumkin, Anna Stone, Mary Jane Spiller

“…IntroductionConducting research to better understand the role of extralegal factors in courtroom decision-making requires either labor intensive methods, such as simulating a trial, or approaches that are not ecologically valid, such as using short written case vignettes. …”
Get full text

Comparison of Goal Achievement during an Early, Intensive Nutrition Intervention Delivered to People with Upper Gastrointestinal Cancer by Telephone Compared with Mobile Applicatio... by Kate Furness, Catherine E. Huggins, Lauren Hanna, Daniel Croagh, Mitchell Sarkies, Terry P. Haines

“…This study is aimed at exploring whether the mode of nutrition intervention delivery affected participant goal achievement in a three-arm randomised controlled trial of early and intensive nutrition intervention delivered to upper gastrointestinal cancer patients. …”
Get full text

Influence of Artificial Sweetener on Human Blood Glucose Concentration by Ilse Skokan, P. Christian Endler, Beatrix Wulkersdorfer, Dieter Magometschnigg, Heinz Spranger

“…In the sense of a cross-over design, three test trials were performed at intervals of several weeks. …”
Get full text

Prospective Randomized Controlled Study of Hemostatic Efficacy with Kaolin-Impregnated Dressings in Diabetic Foot Ulcers Taking Anticoagulants Undergoing Debridement in an Outpatie... by Yeok Gu Hwang, Jin Woo Lee, Eun Ae Won, Seung Hwan Han

“…A prospective, randomized, clinical trial study was performed in twenty-six patients with diabetic foot ulcers who take an anticoagulant requiring minor debridement in an outpatient clinic. …”
Get full text

Contemporary nutrition-based interventions to reduce risk of infection among elderly long-term care residents: A scoping review. by Athanasios Psihogios, Claudia Madampage, Brent E Faught

“…<h4>Results</h4>The search identified 1018 studies, of which 11 (nine clinical trials and two observational cohort studies) satisfied screening criteria. …”
Get full text

Efficacy and Safety of Immunotherapy with Interferon-Gamma in the Management of Chronic Sulfur Mustard-Induced Cutaneous Complications: Comparison with Topical Betamethasone 1% by Yunes Panahi, Amirhossein Sahebkar, Seyyed Masoud Davoudi, Mojtaba Amiri, Fatemeh Beiraghdar

“…The present trial investigated the efficacy of immunotherapy with interferon-gamma (IFN-γ) in the treatment of sulfur mustard (SM)-induced chronic skin complications. …”
Get full text

The Impact of the COVID-19 Pandemic on the Mental Health of Older Primary Care Patients and Their Family Members by Tara Seibert, Matthew W. Schroeder, Anthony J. Perkins, Seho Park, Eleanor Batista-Malat, Katharine J. Head, Tamilyn Bakas, Malaz Boustani, Nicole R. Fowler

“…This study compared the rates of depression and anxiety in a sample of older primary care patients (aged ≥65 years old) and their family members recruited for a clinical trial before and during the COVID-19 pandemic. Participants were dyads enrolled in the Caregiver Outcomes of Alzheimer’s Disease Screening (COADS) trial, which included 1,809 dyads of older primary care patients and one of their family members. …”
Get full text

Digital measurement of ocular microtremor in Parkinson's disease: Protocol for a pilot study to assess reliability and clinical validation. by Lisa Graham, Rodrigo Vitorio, Richard Walker, Alan Godfrey, Rosie Morris, Samuel Stuart

“…Identifying OMT as a PD biomarker could better support clinical assessment, enabling improved provision of care to patients with advanced disease monitoring. Clinical trial registration: This trial is registered at clinicaltrials.gov (NCT06051877; September 2023).…”
Get full text

Implementing E-MOTIVE for detection and treatment of postpartum haemorrhage in South Africa by M Singata-Madliki, S Fawcus, N Moran, E Arends, E Muller, S Mandondo, G J Hofmeyr

“…Certain research-related elements of the trial setting cannot be replicated in routine practice. …”
Get full text

Long-term Double-J stenting is superior to short-term Single-J stenting in kidney transplantation. by Christiaan A J Oudmaijer, Kelly Muller, Erika van Straalen, Robert C Minnee, Diederik J A N Kimenai, Marlies E J Reinders, Jacqueline van de Wetering, Jan N M IJzermans, Turkan Terkivatan

“…<h4>Conclusion</h4>This trial showed that Double-J stenting consistently reduced urological complications from 14.5% to 4.5%, while being highly cost-effective. …”
Get full text

Efficacy of Lazolex® Gel in the Treatment of Herpes Simplex Mucocutaneous Infections and the Prevention of Recurrences: A Pilot Study by Tina A. Kituashvili, Vakhtang G. Kvirkvelia, George G. Galdava, Nino G. Archvadze

“…A single-center, single-arm, open-label, phase II clinical trial was conducted with 30 patients divided into two groups: 15 patients with herpes simplex virus type 1 (HSV-1) infections and 15 with herpes simplex virus type 2 (HSV-2). …”
Get full text