Differences and Correlations of Anxiety, Sleep Quality, and Pressure-Pain Threshold between Patients with Chronic Low Back Pain and Asymptomatic People by Changming Xu, Zhiwei Fu, Juan Wang, Bao Wu, Xue-Qiang Wang

“…CLBP treatment could be considered from multiple perspectives and disciplines.This trial is registered with Chinese Clinical Trial Registry (Trial registration: ChiCTR-TRC-13003701).…”
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PROMETHEUS: Long-Term Exacerbation and Mortality Benefits of Implementing Single-Inhaler Triple Therapy in the US COPD Population by Gerard Criner, Fernando Martinez, Hitesh Gandhi, Norbert Feigler, Bruce Pyenson, Matthew Emery, Umang Gupta, Muthiah Vaduganathan

“…**Methods:** Exacerbation and all-cause mortality reductions reported in the Efficacy and Safety of Triple Therapy in Obstructive Lung Disease trial (ETHOS; NCT02465567) were used to project clinical outcomes in US patients meeting ETHOS trial eligibility criteria (ETHOS-Eligible) and patients meeting a practical definition of SITT eligibility (Expanded ETHOS-Eligible). …”
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Medication following bariatric surgery for type 2 diabetes mellitus (BY-PLUS) study: rationale and design of a randomised controlled study by Alexander Dimitri Miras, Carel le Roux, Alexis Sudlow, Ricardo Vitor Cohen, Hassan Kahal, Dimitri J Pournaras, Jill Townley, Helen Heneghan

“…Long-term studies suggest that although glycaemic control remains good, only 20%–40% of patients will maintain remission according to the American Diabetes Association criteria.Purpose This trial aims to examine the safety and efficacy of combining Roux-en-Y gastric bypass or sleeve gastrectomy with goal-directed medical therapy to improve long-term glycaemic control of T2DM.Methods and analysis This prospective, open-label multicentre randomised controlled trial (RCT) will recruit 150 patients with obesity and T2DM from tertiary care obesity centres. …”
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A qualitative study exploring depressed participants’ experiences of receiving Augmented Depression Therapy (ADepT) by Rebecca Watson, Kim A Wright, Nigel Reed, Barney Dunn, Emily Widnall, Kalliopi Demetriou, Laura Warbrick, Katie Marchant, Nicole Geschwind, Isabella Magner-Parsons, Rachel Barter

“…Perceived mechanisms of change were reorienting to the positive, engaging with valued goals, taking a proactive life stance, gaining confidence and motivation for change, breaking down tasks into small steps, cultivating self-care and self-compassion, enhancing help seeking and interpersonal effectiveness, changing the relationship to depression, and rediscovering the self beyond depression.Conclusions Findings suggest that the wellbeing focus of ADepT is acceptable and leads to positive impacts, supports the logic model underpinning the intervention, and warrants continuation to a definitive trial.Trial registration number ISRCTN85278228.…”
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Process evaluation of a cross-sectoral, coordinated follow-up care of stroke patients: a qualitative study by Theresa Schrage, Claudia Glissmann, Götz Thomalla, David Leander Rimmele, Holger Schmidt, Michael Rosenkranz, Stefan Boskamp, Martin Härter, Levente Kriston

“…However, high adoption and appropriateness in regard to patient-centeredness, psychosocial implications, and an overall benefit for the patients supported continuation of the remaining intervention components. Trial registration The trial is registered at ClinicalTrials.gov (NCT04159324), registration date 12/11/19.…”
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Use of DIABAX feed additive and a biogenic stimulant in calves during their rehabilitation after gastrointestinal infections by N. V. Shanshin

“…Three groups of calves at the age of less than 30 days old, two test groups and one control group, were formed for analogous pairs-based trial. Calves of control group were subcutaneously injected with saline solution at a dose of 8 mL on day 1, 5, 10 of the trial; calves of test group 1 (О-1) were fed with DIABAX feed additive with milk at a dose of 3.0 mL once a day; calves of test group 2 (О-2) were intramuscularly injected with the biogenic stimulant at a dose of 0.5 mL/10 kg of body weight on day 1, 5, 10 of the trial and also received DIABAX at a dose of 3.0 mL once a day during 15 days. …”
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Evaluation of undergraduate dental students’ awareness, knowledge, and attitudes towards teledentistry: does a course enhance this? by Gökçen Akçiçek, Ezgi Katı, Hatice Yağmur Zengin

“…Conclusions Enhancing dental students’ knowledge and awareness of teledentistry could beneficially influence their utilization of teledentistry in their future careers. Clinical trial number This study is not a clinical trial involving medicinal products or therapeutic interventions, so the clinical trial number is not applicable.…”
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Neonatal outcomes and resuscitation practices following the addition of heart rate-guidance to basic resuscitation. by Jackie K Patterson, Daniel Ishoso, Adrien Lokangaka, Pooja Iyer, Casey Lowman, Joar Eilevstjønn, Ingunn Haug, Beena D Kamath-Rayne, Eric Mafuta, Helge Myklebust, Tracy Nolen, Antoinette Tshefu, Carl Bose, Sara Berkelhamer

“…<h4>Methods</h4>We conducted a pre-post clinical trial comparing heart rate-guided basic resuscitation to Helping Babies Breathe in three facilities, enrolling in-born neonates ≥28 weeks gestation. …”
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Mixed vulnerabilities: the biological risk of high parity is aggravated by emergency referral in Benin, Malawi, Tanzania and Uganda by Manuela Straneo, Lenka Beňová, Thomas van den Akker, Muzdalifat S. Abeid, Elizabeth Ayebare, Jean-Paul Dossou, Greta Handing, Bianca Kandeya, Andrea B. Pembe, Claudia Hanson

“…To avert these adverse events, emergency referral must be avoided by ensuring high parity women give birth in hospitals.  Trial registration Pan African Clinical Trial Registry ( www.pactr.org ): PACTR202006793783148. …”
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Mixed-methods evaluation of a behavioural intervention package to identify and amend incorrect penicillin allergy records in UK general practice by Sarah Tonkin-Crine, Robert West, Sinisa Savic, Jonathan Sandoe, Ly-Mee Yu, Sue Pavitt, Ushma Galal, Christopher C Butler, Marta Wanat, Bethany Shinkins, Mina Davoudianfar, Emily Bongard, Sue H Pavitt, Philip Howard, Catherine Porter, Mandy East, Marta Santillo, Louise Savic, Joanne Fielding, Jenny Boards, Catherine E Porter, Jonathan AT Sandoe

“…In the ALABAMA (Allergy Antibiotics and Microbial resistance) feasibility trial, primary care patients with penicillin allergy were randomised to penicillin allergy assessment pathway or usual care to assess the effect on health outcomes. …”
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Utilizing MV-FLOW™ and multidimensional ultrasound characteristics for prognosticating FET outcomes in RIF patients: Study Protocol for a cross-sectional study. by Ying Zhou, Li-Ying Liu, Hua-Ju Yang, Yuan-Yuan Lai, Di Gan, Jie Yang

“…The objective is to determine the predictive role of multimodal transvaginal ultrasound in embryo transfer outcomes and provide evidence for the clinical application of MV-FLOW™. Trial registration: Trial Registration: ChiCTR2400086401.…”
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Optimization of Microwave-Assisted Extraction Method for Increased Extraction Yield and Total Phenol Content from Moringa Leaves (Moringa oleifera Lam.) var. PKM 1 by Sandeep Gunalan, Arumugam Thangaiah, Janavi Gnanaguru Janaki, Anitha Thiyagarajan, Senthil Kuppusamy, Lakshmanan Arunachalam

“…The main aim of this experimental trial is to optimize three independent factors including power (500 W–700 W), temperature (30°C–50°C), and extraction time (20 min–40 min) consisting of two levels of dependent variables such as extraction yield (EY) and total phenol content (TPC) using Response Surface Methodology (RSM) constructed by Central Composite Design (CCD) with 20 trial runs. …”
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Fiber isolated from discarded fruits and vegetables reduces valproic acid-induced hepatotoxicity in rats by Maria Rosana Ramirez, Debora Manuale, Juan Carlos Yori

“…For this purpose, two different trials were conducted. In the preventive trial, VPA (250 mg/kg/day; oral) was administered concomitantly with DF (0.3 and 0.15 mg/kg/day) for 14 days. …”
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PENGEMBANGAN MODEL PEMBELAJARAN RECIPROCAL TEACHING PAIR SHARE (RTPS) UNTUK MENINGKATKAN HASIL BELAJAR MIKROBIOLOGI MAHASISWA IKIP BUDI UTOMO by Purwaning Budi Lestari, Diyah Ayu Widyaningrum

“…Design test for individual testing and small scale trial is descriptive, whereas for largescale field trials using quasi-experimental. …”
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Ethyl Lauroyl Arginate (LAE): Antimicrobial Activity of LAE-Coated Film for the Packaging of Raw Beef and Pork by Erica Tirloni, Cristian Bernardi, Simone Stella

“…In the first trial, LAE-coated packaging was applied to test its activity towards the natural meat microflora over a period of 24 days at 6-7°C. …”
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Development of Learning Media for the Elderly to Promote Child Health in the Community by Napalai Chaimaha, Supawadee Putthinoi, Suchitporn Lersilp

“…Efficiency of the learning media was evaluated after the trial, when the participants expressed their opinion, and the users perceived that the learning media was effective, motivating, easy to use, and simple in the terms used, as well as appropriate in the sequence of contents and pictures and font, size, and color of the text.…”
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PENGEMBANGAN MODUL ANATOMI REPTIL DI DAERAH ALIRAN SUNGAI MAOSPATI MAGETAN UNTUK MENINGKATKAN PEMAHAMAN KONSEP MATA KULIAH STRUKTUR HEWAN DI IKIP PGRI MADIUN by Daniel Sugiarto

“…Results of development in the form of draft module to be tested and improved understanding of the concept of students. The trial results are obtained material content of the course structure validator experts percentage of 86.66% was obtained animals can be categorized valid (good). …”
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Repurposing radiosensitising medicines for radiotherapy: an overview by Geoff S Higgins, Jie Man Low, Gonzalo Rodriguez-Berriguete

“…We provide an overview on these successfully repurposed drugs, and highlight some examples of unsuccessful repurposing efforts and drug candidates with an uncertain prospect of success. Upon reviewing the trials, we identified some common themes behind the unsuccessful efforts, including poor trial reporting, absence of biomarkers and patient selection, sub-optimal pharmacological properties, inappropriate trial design, lack or inadequate consideration of pre-clinical and clinical data, and limited funding support. …”
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A Computational Model for Biomechanical Effects of Arterial Compliance Mismatch by Fan He, Lu Hua, Li-jian Gao

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Development of prose appreciation teaching materials based on experiential learning by Dian Ramadan Lazuardi, Syukri Hamzah, Arono Arono

“…Furthermore, the small group trial showed that the Prose Appreciation teaching material was practical to use and the large group trial showed that the Prose Appreciation teaching material was very practical to use.…”
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