Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial by Helen Macpherson, Robin M Daly, Patricia M Livingston, Declan G Murphy, Patrick J Owen, Timo Rantalainen, Niamh L Mundell, Jeremy L Millar, Steve F Fraser, Jack Dalla Via, Stephen J Foulkes

“…Exercise training adherence below recommended guidelines does not support cognitive health in men treated with ADT for prostate cancer.Trial registration number Australian and New Zealand Clinical Trial Registry (ACTRN12614000317695, registered 25/03/2014) and acknowledged under the Therapeutic Goods Administration Clinical Trial Notification Scheme (CT-2015-CTN-03372-1 v1).…”
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Determinants of 5-year survival in patients with advanced NSCLC with PD-L1≥50% treated with first-line pembrolizumab outside of clinical trials: results from the Pembro-real 5Y global registry by Mieke Van Hemelrijck, Salvatore Grisanti, Avinash Aujayeb, Martin Forster, Giannis Mountzios, Andrea Napolitano, Bruno Vincenzi, Joachim G J V Aerts, Marina Garassino, Valter Torri, Solange Peters, Alex Friedlaender, Alfredo Addeo, Giuseppe Lo Russo, Roberto Ferrara, Diego Signorelli, Alessandro Russo, So Yeon Kim, Jarushka Naidoo, Scott Gettinger, Heather Wakelee, Martin Sebastian, Mark Awad, Abdul Rafeh Naqash, Alessio Cortellini, Raffaele Giusti, Michele De Tursi, Federica Zoratto, Marco Russano, Rita Chiari, Biagio Ricciuti, Andrea De Giglio, Alain Gelibter, Giuseppe Tonini, Amin H Nassar, Alessandra Curioni-Fontecedro, Eleni Karapanagiotou, Emilio Bria, Jack Bell, Paolo Bironzo, Joao V Alessi, Alessandro Morabito, David J Pinato, Francesco Passiglia, Carlo Genova, Francesca Mazzoni, Alessandro Inno, Francesco Grossi, Luca Cantini, Lorenza Landi, Luigi Della Gravara, Margarita Majem, Uma Mukherjee, Federica Biello, Alessandro Leonetti, Annalisa Guida, Marianna Macerelli, Gabriele Minuti, Giulio Metro, Thomas Newsom-Davis, Eleni Josephides, Andrea Camerini, Elisa Roca, David O’Reilly, Mingjia Li, Laura Mezquita, Teresa Gorría, Claudia A M Fulgenzi, Lauren Young, Joel W Neal, Javier Baena, Francesco Pantano, Jacobo Rogado, Mary Jo Fidler, Teresa Beninato, Federica Pecci, Alessandro Di Federico, Kazuki Takada, Leonardo Brunetti, Talal El Zarif, Laura Moliner, Alberto Servetto, Sukumar Kalvapudi, Sai Yendamuri, Edoardo Garbo, Giuseppina Rita Di Fazio, Monica Loza, Ritujith Jayakrishnan, Michele Montrone, Nichola O Awosika, Bartlomiej Tomasik, Maximilian Rost, Isabelle Monnet, Francesco Agustoni, Artur Katz, Dwight Hall Owen, Michele Ghidini, Armida D’Incecco, Gianpaolo Spinelli, Monica Verrico, Manuel Dupont, Rafael Di Marco Barros, Diego Luigi Cortinovis, Chiara Bennati, Frank Aboubakar Nana, Anne-Marie Dingemans, Taher Abu Hejleh

“…Individual patient-level data (IPD) from the experimental arm of the KEYNOTE-024 trial were extracted (KN024 IPD cohort) to compare the long-term outcomes between the two cohorts. …”
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Implementation of Virtual and Face-to-Face Childbirth Preparation Training for the Spouses of the Primiparous Women to Reduce the Fear of Childbirth, Improve the Pregnancy Experience, and Enhance Mother- and Father-Infant Attachment: Protocol for a Quasiexperimental Clinical Trial by Zari Doaltabadi, Leila Amiri-Farahani, Seyedeh Batool Hasanpoor-Azghady

“…This trial is registered with TCTR20200515011.…”
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Erratum: Design and methodology of a randomized crossover trial to test the effect of low and high dAGE diets on metabolic risk factors and inflammatory markers among overweight and centrally obese Asian Indian adults

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Corrigendum to ‘Raising awareness of alcohol as a modifiable risk factor for breast cancer: A randomized controlled trial comparing the efficacy of accessing an interactive website with a non-interactive website’ [The Breast (2025) 103868] by Claudia Sardu, Fabrizio Angius, Paolo Contu, Sofia Cosentino, Monica Deiana, Matteo Fraschini, Clelia Madeddu, Elena Massa, Alessandra Mereu, Luigi Minerba, Carola Politi, Silvia Puxeddu, Francesco Salis, Julia M.A. Sinclair, Roberta Agabio

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A Randomized, Endoscopist-Blinded, Prospective Trial to Compare the Efficacy and Patient Tolerability between Bowel Preparation Protocols Using Sodium Picosulfate Magnesium Citrate and Polyethylene-Glycol (1 L and 2 L) for Colonoscopy by Sang Hoon Kim, Ji Hyeong Kim, Bora Keum, Han Jo Jeon, Se Hyun Jang, Seong Ji Choi, Seung Han Kim, Jae Min Lee, Hyuk Soon Choi, Eun Sun Kim, Yoon Tae Jeen, Hong Sik Lee, Hoon Jai Chun, Chang Duck Kim

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Challenges and ongoing initiatives towards better integrated EU scientific advice by Iordanis Gravanis, Michael Berntgen, Spiros Vamvakas, Pierre Demolis, Paolo Foggi

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Combined use of respiratory multiplex PCR and procalcitonin to reduce antibiotic exposure in sickle-cell adult patients with acute chest syndrome (The ANTIBIO-STA study): a randomised, controlled, open-label trialResearch in context by Alexandre Sabaté-Elabbadi, Armand Mekontso-Dessap, François Lionnet, Aline Santin, Charlotte Verdet, Paul-Louis Woerther, Julien Lopinto, Matthieu Turpin, Alexandra Rousseau, Romane Lacoste-Badie, Keyvan Razazi, Guillaume Voiriot, Muriel Fartoukh

“…The primary outcome was the number of days of antibiotic exposure at D28 after randomisation. This trial was registered on ClinicalTrial.gov (NCT03919266) and is closed to recruitment. …”
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Assessment of a novel unidirectional mid-term absorbable barbed suture versus a competitor barbed suture for vaginal cuff closure after gynaecology surgery, study protocol of a randomized controlled trial - BARHYSTER by Petra Baumann, Lourdes Hinojosa Sánchez, Núria Grané Garcia, Larisa Sologiuc, Amadeus Hornemann

“…Discussion This study will assess the clinical performance of a novel unidirectional mid-term absorbable barbed suture material for the first time in gynaecology surgery and, to our knowledge, it will be the second largest RCT performed so far in total laparoscopic hysterectomy using unidirectional mid-term absorbable barbed suture materials. Trial registration The study was prospectively registered before the enrolment of the first patient. …”
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Effect of intermittent theta burst stimulation combined with acoustic startle priming motor training on upper limb motor function and neural plasticity in stroke individuals: study protocol for a randomised controlled proof-of-concept trial by Jing Zhang, Yu Chen, Mingzhu Wang, Nan Xia, Jinghong Li, Weiqiang Liang, Yangyang Yin, Linhan Zhai, Qiuxia Wang

“…Secondary outcomes include neurophysiological metrics and neuroimaging results from diffusion tensor imaging and resting-state functional MRI.Ethics and dissemination The trial is registered with the Chinese Clinical Trial Registry (Registration No. …”
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Impact of non-invasive oxygen reserve index versus standard SpO2 monitoring on peripheral oxygen saturation during endotracheal intubation in the intensive care unit: Protocol for the randomized controlled trial NESOI2. by Hugo Hille, Aurélie Le Thuaut, Pierre Asfar, Quentin Quelven, Emmanuelle Mercier, Anthony Le Meur, Jean-Pierre Quenot, Virginie Lemiale, Grégoire Muller, Martin Cour, Alexis Ferré, Asael Berge, Anaïs Curtiaud, Maxime Touron, Gaetan Plantefeve, Jean-Charles Chakarian, Jean-Damien Ricard, Gwenhael Colin, Arthur Orieux, Patrick Girardie, Mathieu Jozwiak, Manon Rouaud, Camille Juhel, Jean Reignier, Jean-Baptiste Lascarrou, CRICS-TRIGGERSEP Network

“…Trial registration: Registered on ClinicalTrials.gov (NCT05867875) on April 27, 2023.…”
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Efficacy of Plantago major Homoeopathic Mother Tincture as Mouth Wash in Comparison with Chlorhexidine Gluconate (0.2%) Mouthwash in Management of Oral Hygiene among Students: A Double-Blind, Parallel-group, Randomized Control Trial by Kunal Deshmukh, Sahana Hegde Shetiya, Parth Aphale, Anindita Dutta, Dharmendra B. Sharma, Garvit Singh

“…However, there was no significant difference in GI and PI between the CHX mouthwash (0.2%) and P. major mouthwash group at the end of the trial.…”
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Rationale and design of the multicenter, national, randomized, open labeled phase III trial: allogeneic stem cell transplantation as a potential curative treatment for patients with relapsed or progressed multiple myeloma (AlloRelapseMM Study) by Annemarie Glöckner, Stefan Schönland, Hermann Einsele, Nicolaus Kröger

“…Methods This clinical trial is a national, multicenter, randomized, open labeled phase III study conducted in 30 hospitals spread all over Germany. …”
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Effectiveness and cost-effectiveness of a web-based routine assessment with integrated recommendations for action for depression and anxiety (RehaCAT+): protocol for a cluster randomised controlled trial for patients with elevated depressive symptoms in rehabilitation facilities by Reinhold Kilian, Harald Baumeister, Yannik Terhorst, Johannes Knauer, Paula Philippi, Selina Kallinger, Sandro Eiler, Tamara Waldmann, Morten Moshagen, Martina Bader

“…Results will be published via peer-reviewed journals.Trial registration number DRKS00027447…”
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Does awake prone positioning prevent the use of mechanical respiratory support or death in COVID-19 patients on standard oxygen therapy hospitalised in general wards? A multicentre randomised controlled trial: the PROVID-19 protocol by Benjamin Planquette, Christophe Perrin, Thierry Boulain, Mai-Anh Nay, Louis Bernard, Laurent Plantier, Léa Colombain, Jérémy Clément, Aymeric Sève, Sylvie Druelle, Marine Morrier, Jean-Baptiste Lainé, Grégory Corvaisier, Nicolas Bizien, Xavier Pouget-Abadie, Adrien Bigot, Elsa Nyamankolly, Guillaume Fossat

“…The results will be submitted for publication in peer-reviewed journals.Trial registration number NCT04363463.…”
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Effect of Treatment Delay, Stroke Type, and Thrombolysis on the Effect of Glyceryl Trinitrate, a Nitric Oxide Donor, on Outcome after Acute Stroke: A Systematic Review and Meta-Analysis of Individual Patient from Randomised Trials by Philip M. Bath, Lisa Woodhouse, Kailash Krishnan, Craig Anderson, Eivind Berge, Gary A. Ford, Thompson G. Robinson, Jeffrey L. Saver, Nikola Sprigg, Joanna M. Wardlaw, Blood pressure in Acute Stroke Collaboration (BASC)

“…Nitric oxide (NO) donors are a candidate treatment for acute stroke and two trials have suggested that they might improve outcome if administered within 4–6 hours of stroke onset. …”
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Evaluation of efficacy of two bag-mask ventilation techniques by novice airway providers: Two-handed CE versus dominant-hand CE–non-dominant-hand thenar eminence techniques – A randomised controlled trial by Neetu Saroye, Gurpreeti Kaur, Udeyana Singh, Anju Grewal, Akshita Khanna, Rushal Nayyar

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Comparison of surgical wound infection and dehiscence following the use of two methods of nylon sutures and skin staples in staples in diabetic mellitus patients undergoing total knee arthroplasty surgery: a randomized clinical trial study by Haadiyeh Rahbari, Mohammadamin Ahmadi, Mina Amiri Doreh, Samira Mahmoudi, Parvin Ghaemmaghami, Armin Fereidouni

“…IRCT20230928059543N1, Trial Id:74754, approved on 12/01/2024, https://irct.behdasht.gov.ir/user/trial/74754/view ) and conducted according to Consolidated Standards of Reporting Trials (CONSORT) guidelines.…”
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A novel “lateral approach short axis in-plane” technique vs. conventional “short-axis out-of-plane approach” for ultrasound-guided internal jugular vein access: a prospective randomized non-inferiority trial by Michal Kalina, Patricia Vargová, Adéla Bubeníková, Roman Škulec, Vladimír Černý, David Astapenko

“…Objectives The primary objective of the trial was to prove that the first attempt success rate in the novel technique is non-inferior to the conventional technique. …”
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Left Ventricular End-Diastolic Pressure and B-Type Natriuretic Peptide Levels Guidance of Low-Dose Furosemide Treatment to Prevent Contrast-Induced Nephropathy in Patients with Percutaneous Coronary Intervention: A Randomized Controlled Trial by Guoqiang Gu, Demin Liu, Rui Lu, Wei Cui

“…This parallel randomized clinical trial was conducted at a tertiary hospital in China. …”
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