Is the benefit of sequential 5-fluorouracil and daylight photodynamic therapy versus daylight photodynamic therapy alone sustained over time? – 12-month follow-up of a randomized controlled trial by Stine Regin Wiegell, Gabriella Fredman, Flemming Andersen, Peter Bjerring, Uwe Paasch, Merete Haedersdal

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Effectiveness–implementation hybrid-2 randomised trial of a collaborative Shared Care Model for Detecting Neurodevelopmental Impairments after Critical Illness in Young Children (DAISY): pilot study protocol by Paula Lister, Kristen Gibbons, Zephanie Tyack, Luregn J Schlapbach, Samudragupta Bora, Maria Isabel Castillo, James Best, Debbie Long, Helen G Liley, Belinda Dow, Kerri-Lyn Webb, Christian Stocker, Debra Thoms, Carolyn Wharton, Lori Matuschka

“…Dissemination of the outcomes of the study is expected via publication in a peer-reviewed journal, presentation at relevant conferences, and via social media, podcast presentations and open-access medical education resources.Registration details The trial was prospectively registered with the Australian New Zealand Clinical Trials Registry as ‘Pilot testing of a collaborative Shared Care Model for Detecting Neurodevelopmental Impairments after Critical Illness in Young Children’ (the DAISY Pilot Study).Trial registration number ACTRN12621000799853.…”
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Embryo selection through non-invasive preimplantation genetic testing with cell-free DNA in spent culture media: a protocol for a multicentre, double-blind, randomised controlled trial by Jie Qiao, Yan Wang, Rong Li, Ping Liu, Liang Hu, Lin Zeng, Guimin Hao, Jin Huang, Bing Yao, Junzhao Zhao, Juanzi Shi, Liyi Cai, Xiu-Xia Wang, Yanwen Xu, Yuanqing Yao, Yichun Guan, Weiping Qian, Sijia Lu

“…The results will be disseminated through international conferences and scientific journals.Trial registration number NCT04339166.…”
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Proseal laryngeal mask airway and endotracheal intubation in lower abdominal gynecological surgeries for perioperative gastric volume assessment and assessing postoperative recovery of gastrointestinal functions: A randomized controlled trial by Ranjay Mahaseth, Bhavna Gupta, Gaurav Jain, Anupama Bahadur, Deepak Singla, Debendra K. Tripathy

“…Methods: The study commenced after obtaining approval from Institutional Ethical Committee (IEC number-AIIMS/IEC/22/251 Date: 27/05/2022) and after registration in Clinical Trials Registry - India (CTRI) (CTRI/2022/07/044102 Registered on: 18/07/2022) and was conducted from August 2022 to August 2023. …”
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Intranasal Insulin Diminishes Postoperative Delirium and Elevated Osteocalcin and Brain Derived Neurotrophic Factor in Older Patients Undergoing Joint Replacement: A Randomized, Double-Blind, Placebo-Controlled Trial by Yang M, Zhou L, Long G, Liu X, Ouyang W, Xie C, He X

“…Intranasal insulin administration reduced the HOMA-IR on D3 (P=0.002).Conclusion: Intranasal insulin notably reduced the incidence and severity of POD in older patients undergoing joint replacement, which may be related to the elevation in osteocalcin and BDNF levels.Trial Registry Numbers: Chinese Clinical Trial Registry (ChiCTR2300068073).Keywords: intranasal insulin, osteocalcin, postoperative delirium, brain derived neurotrophic factor, older patient…”
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Effects of Food on the Pharmacokinetics and Safety of HA121-28 Tablet, a Novel Multi-Targeting Tyrosine Kinase Inhibitor, in Healthy Chinese Subjects: A Phase I Clinical Trial by Liu Y, Li X, Zhang M, Men Y, Wang Y, Zhu X, Zheng L

“…The objectives of this study were to assess the effect of high-fat and high-calorie food on the pharmacokinetic (PK) profile and safety of HA121-28 tablet in healthy subjects.Patients and Methods: A single-dose, randomized, open-label, two-period, crossover-designed phase I clinical trial was conducted. Subjects received 200 mg HA121-28 in the fasted state or with high-fat and high-calorie breakfast. …”
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Immunogenicity and safety of a live attenuated varicella vaccine in children aged 1 to 12 years: A double-blind, randomized, parallel-controlled phase III clinical trial in China by Shiyuan Wang, Yang Zhang, Guifan Li, Jinhui Shi, Xianyun Chang, Hao Zhang, Fengcai Zhu, Jingxin Li, Kai Chu, Jinfang Sun

“…In this phase III, single-center, randomized, double-blind, active-controlled trial,1,200 healthy participants randomly assigned in a 1:1 ratio to receive one dose of either the test vaccine or the active control vaccine. …”
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Interstitial Lung Disease Associated with mTOR Inhibitors in Solid Organ Transplant Recipients: Results from a Large Phase III Clinical Trial Program of Everolimus and Review of the Literature by Patricia Lopez, Sven Kohler, Seema Dimri

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Double-blind, randomised, placebo-controlled trial to evaluate the effectiveness of late gestation oral melatonin supplementation in reducing induction of labour rates in nulliparous women: the MyTIME study protocol by Miranda Davies-Tuck, Emily Callander, Mary Sharp, Scott W White, Dorota A Doherty, Jane Warland, Zoe Bradfield, Lesley Kuliukas, Monique Rose, Amber Pettitt, Kylie Ekin, JA Keelan

“…All data will be analysed by intention to treat.Ethics and dissemination The study is approved by the Western Australia Health Central Human Research Ethics Committee (RGS0000006283). Trial findings will be disseminated through conference presentations and peer-reviewed publications.Trial registration number The trial has been prospectively registered on the Australian New Zealand Clinical Trials Registry as ACTRN12623000502639 on 17/05/2023.…”
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Ultrasound-guided deep versus superficial continuous serratus anterior plane block for pain management in patients with multiple rib fractures: A prospective randomized double-blind clinical trial by Mohamed F. Mostafa, Mohamed Abdel-Moniem Bakr, Mohamed Ismail Seddik, Mohammed Mamdouh Mohammed Mahmoud, Gamal M.A. Ibrahim, Ahmed Talaat Ahmed

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Comparison of efficacy and safety between palonosetron and ondansetron to prevent postoperative nausea and vomiting in patients undergoing non-laparoscopic surgery: A systematic review and meta-analysis of randomised controlled trials by Babu Lal, Ragavi Alagarsamy, Jitendra Kumar, Anshul J. Rai, Vineeta Yadav, Rajnish Joshi, Md. Yunus

“…Results: Nineteen randomised controlled trials were included. Pooled risk ratio (RR) revealed that patients receiving palonosetron were significantly less likely to develop nausea [0–2 h, RR = 0.82 (95% confidence interval (CI): 0.50, 1.34), P = 0.317, I2 = 15.3%], [0–6 h, RR = 0.76 (95% CI: 0.44, 1.29), P = 0.137, I2 = 45.7%], [12–24 h, RR = 0.39 (95%CI: 0.16, 0.96), P = 0.088, I2 = 54.2%], [24–48 h, RR = 0.44 (95% CI: 0.20, 0.96), P = 0.598, I2 = 0%], [24–72 h, RR 0.22 (95% CI: 0.08, 0.57), P = 0.119, I2 = 53.0%] and vomiting [0–2 h, RR = 0.59 (95% CI: 0.29, 1.23), P = 0.868, I2 = 0%], [0–6 h, RR = 1.42 (95% CI: 0.74, 2.72), P = 0.790, I2 = 0%], [12–24 h, RR = 0.14 (95% CI: 0.04, 0.51), P = 0.749, I2 = 0.0%], [24–48 h, RR = 0.24 (95%CI: 0.09, 0.62), P = 0.561, I2 = 0%], [24–72 h, RR = 0.11 (95% CI: 0.02, 0.58), P = 0.859, I2 = 0%]. …”
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Effect of transcranial direct current stimulation on postoperative sleep disturbance in older patients undergoing lower limb major arthroplasty: a prospective, double-blind, pilot, randomised controlled trial by Chunyan Li, Jie Yang, He Liu, Wen Tan, Song Zhang, Hongxing Zhang, Yuan Han, Mingshu Tao, Rongguang Liu, Jiaxing Fang, Dexian Chen, Qi Wei, Xingyu Xiong, Wenxin Zhao, Junli Cao

“…Background Postoperative sleep disturbance (PSD) is a common and serious postoperative complication and is associated with poor postoperative outcomes.Aims This study aimed to investigate the effect of transcranial direct current stimulation (tDCS) on PSD in older patients undergoing lower limb major arthroplasty.Methods In this prospective, double-blind, pilot, randomised, sham-controlled trial, patients 65 years and over undergoing lower limb major arthroplasty were randomly assigned to receive active tDCS (a-tDCS) or sham tDCS (s-tDCS). …”
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Effects of perioperative treatment of resectable adenocarcinoma of esophagogastric junction by immunotherapy (Adebrelimab) combined with chemotherapy (XELOX): protocol for a single-center, open-labeled study (AEGIS trial, neoadjuvant immunochemotherapy) by Yingyi Li, Yuqin Cao, Xipeng Wang, Chengqiang Li, Liqin Zhao, Hecheng Li

“…The trial was prospectively registered on 22 May 2024, https://clinicaltrials.gov/study/NCT06482788 .…”
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Optimizing Soft Tissue Emergence Profile Around One-Piece Dental Implants by Abduljaleel Azad Samad

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Improving neuroendocrine tumor treatments with mathematical modeling: lessons from other endocrine cancers by John Metzcar, Rachael Guenter, Yafei Wang, Kimberly M Baker, Kate E Lines

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A Review of Human Studies Assessing the Efficacy of Cannabidiol for Anxiety Disorders by Kuba Borys Romańczuk, Katarzyna Kamińska-Omasta, Bartosz Omasta, Olga Krupa, Paulina Dorota Pietrukaniec, Zofia Martyna Wójcik, Kinga Furtak, Szymon Przemysław Stolarczyk, Magdalena Agata Czerska, Daria Rybak

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The role of sacubitril/valsartan in abnormal renal function patients combined with heart failure: a meta-analysis and systematic analysis by Xinyue Yang, Jingjing Jin, Meijuan Cheng, Jinsheng Xu, Yaling Bai

Subjects: “…randomized controlled trials…”
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A Double-Blind, Randomized, Controlled Trial of Topical Polysporin Triple Compound Versus Topical Mupirocin for the Eradication of Colonization with Methicillin-Resistant Staphylococcus aureus in a Complex Continuing Care Population by S O’Grady, Z Hirji, B Pejcic-Karapetrovic, S Fung, H Dedier, J Takata-Shewchuk, K Zhang, J Conly

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Prospective Multicenter Open-Label One-Arm Trial Investigating a Pumpkin Seed, Isoflavonoids, and Cranberry Mix in Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia: A Pilot Study by Elie Nemr, Elie El Helou, Georges Mjaess, Albert Semaan, Josselin Abi Chebel

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mHealth Intervention for Dementia Prevention through lifestyle Optimisation (MIND-PRO) in a primary care setting: protocol for a randomised controlled trial in people with low SES and/or migration background by Edo Richard, Esther Van den Berg, Ron Handels, Henrike Galenkamp, Eric P Moll van Charante, Marieke P Hoevenaar-blom, Anne Roos van der Endt, Martien J H Kas

“…Results are expected in 2026 and will be submitted for publication in a peer-reviewed journal, and presented at scientific conferences.Trial registration number ISRCTN92928122.…”
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