TREM2 and sTREM2 in Alzheimer’s disease: from mechanisms to therapies by Lianshuai Zhang, Xianyuan Xiang, Yahui Li, Guojun Bu, Xiao-Fen Chen

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Endoplasmic Reticulum Stress‐Induced triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Downregulation Exacerbates Platelet Activation and Myocardial Infarction in Patients W... by Xiaowen Wu, Guanxing Pan, Lin Chang, Qian Liu, Yangyang Liu, Wei Zhang, Yifan Guo, Ge Zhang, Haoxuan Zhong, Zhiyong Qi, Jianjun Zhang, Ruyi Xue, She Chen, Hu Hu, Jianzeng Dong, Si Zhang, Zhongren Ding

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Preclinical development of an immunoassay for the detection of TREM2: a new biomarker for Alzheimer’s disease by Jie Hu, Huimei Zeng, Jiaqi Lu, Tianpeng Li, Xue Liu, Yang Liu, Weihuan Wen, Weijun Shen, Hongying Chen, Zhicheng Chen

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CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline by Marc Suárez‐Calvet, Anja Capell, Miguel Ángel Araque Caballero, Estrella Morenas‐Rodríguez, Katrin Fellerer, Nicolai Franzmeier, Gernot Kleinberger, Erden Eren, Yuetiva Deming, Laura Piccio, Celeste M Karch, Carlos Cruchaga, Katrina Paumier, Randall J Bateman, Anne M Fagan, John C Morris, Johannes Levin, Adrian Danek, Mathias Jucker, Colin L Masters, Martin N Rossor, John M Ringman, Leslie M Shaw, John Q Trojanowski, Michael Weiner, Michael Ewers, Christian Haass, the Dominantly Inherited Alzheimer Network, the Alzheimer's Disease Neuroimaging Initiative

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Myeloid TGF-β signaling shapes liver macrophage heterogeneity and metabolic liver disease pathogenesis by Ziyi Meng, Xiaoxue Qiu, Zhimin Chen, Yu-tung Lee, Linkang Zhou, You Lu, Tongyu Liu, Siming Li, Benjamin Levi, Katherine A. Gallagher, Jiandie D. Lin

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TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance by Xianyuan Xiang, Georg Werner, Bernd Bohrmann, Arthur Liesz, Fargol Mazaheri, Anja Capell, Regina Feederle, Irene Knuesel, Gernot Kleinberger, Christian Haass

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sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers by Marc Suárez‐Calvet, Gernot Kleinberger, Miguel Ángel Araque Caballero, Matthias Brendel, Axel Rominger, Daniel Alcolea, Juan Fortea, Alberto Lleó, Rafael Blesa, Juan Domingo Gispert, Raquel Sánchez‐Valle, Anna Antonell, Lorena Rami, José L Molinuevo, Frederic Brosseron, Andreas Traschütz, Michael T Heneka, Hanne Struyfs, Sebastiaan Engelborghs, Kristel Sleegers, Christine Van Broeckhoven, Henrik Zetterberg, Bengt Nellgård, Kaj Blennow, Alexander Crispin, Michael Ewers, Christian Haass

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TREM2 signaling pathway in sepsis-induced acute lung injury: physiology, pathology, and therapeutic applications by Hong-Lei Shen, Jing He, Fei Lin

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Trem2 regulates microglial migratory responses via type I interferon signaling during photoreceptor degeneration by Jincan He, Wenchuan Zhou, Jing Li

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Novel fully human high-affinity anti-TREM2 antibody shows efficacy in clinically relevant Alzheimer´s mouse model by Markus Kraller, Julia Faßbender, Ammar Jabali, Joseph Kroeger, Barbara Fink, Bastian Popper, Martin Ungerer, Miriam A. Christlmeier

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Upregulation of TREM2 expression in M2 macrophages promotes Brucella abortus chronic infection by Jingyu Wang, Zhirong Yan, Weiyu Zhang, Xiaofeng Liu, Jun Wang, Qisheng Peng

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Beta-hydroxybutyrate (BHB) elicits concentration-dependent anti-inflammatory effects on microglial cells which are reversible by blocking its monocarboxylate (MCT) importer by Chase Garcia, Ariana Banerjee, Claire Montgomery, Lauren Adcock, Izumi Maezawa, Jon Ramsey, Ana Cristina G. Grodzki, Kyoungmi Kim, Gino Cortopassi

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TREM2+ macrophages: a key role in disease development by Xinxin Wang, Yunhan Wang, Lei Yang, Lei Yang, Yi Zhang, Yi Zhang, Yi Zhang, Yi Zhang, Yi Zhang, Li Yang, Li Yang, Li Yang

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The double-edged role and therapeutic potential of TREM2 in atherosclerosis by Botao Zhu, Yuxuan Liu, Daoquan Peng

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Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation by Michael Ewers, Gloria Biechele, Marc Suárez‐Calvet, Christian Sacher, Tanja Blume, Estrella Morenas‐Rodriguez, Yuetiva Deming, Laura Piccio, Carlos Cruchaga, Gernot Kleinberger, Leslie Shaw, John Q Trojanowski, Jochen Herms, Martin Dichgans, the Alzheimer's Disease Neuroimaging Initiative (ADNI), Matthias Brendel, Christian Haass, Nicolai Franzmeier

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Foamy macrophages in atherosclerosis: unraveling the balance between pro- and anti-inflammatory roles in disease progression by Adil Ijaz, Bhavya Yarlagadda, Marco Orecchioni, Marco Orecchioni

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Molecular mechanism of METTL14-mediated m6A modification regulating microglial function post ischemic stroke by Xiaomin Zhang, Pengyang Du, Bo Bai, Xia Lian, Guofang Xue

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Metformin attenuates central sensitization by regulating neuroinflammation through the TREM2-SYK signaling pathway in a mouse model of chronic migraine by Zhenzhen Fan, Dandan Su, Zi Chao Li, Songtang Sun, Zhaoming Ge

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An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function by Kai Schlepckow, Gernot Kleinberger, Akio Fukumori, Regina Feederle, Stefan F Lichtenthaler, Harald Steiner, Christian Haass

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Identification of pyroptosis related genes and subtypes in atherosclerosis using multiomic and single cell analysis by Kaisheng Jiang, Yang He, Bingjie Hu, Li Quan, Longyun Peng, Juntao Tian, Nan Zhou, Erwen Huang, Qianhao Zhao

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