The Potential of MicroRNAs as Novel Biomarkers for Transplant Rejection by Matthias Hamdorf, Satoru Kawakita, Matthew Everly

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Advancements in noninvasive techniques for transplant rejection: from biomarker detection to molecular imaging by Yuan Song, Yihui Wang, Wenyuan Wang, Yuji Xie, Junmin Zhang, Jing Liu, Qiaofeng Jin, Wenqian Wu, He Li, Jing Wang, Li Zhang, Yali Yang, Tang Gao, Mingxing Xie

Subjects: “…Transplant rejection…”
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Pulmonary Alveolar Microlithiasis: A Unique Case of Familial PAM Complicated by Transplant Rejection by Austin Helmink, Samir Atiya, Ernesto Martinez Duarte

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Pre-transplant T-cell clonal analysis identifies CD8+ donor reactive clones that contribute to kidney transplant rejection by Jes M. Sanders, Barbara L. Banbury, Erika L. Schumacher, Jie He, Yuvaraj Sambandam, Paul A. Fields, Lorenzo Gallon, Lorenzo Gallon, James M. Mathew, James M. Mathew, James M. Mathew, Joseph R. Leventhal, Joseph R. Leventhal

Subjects: “…kidney transplant rejection…”
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Immunosuppression and the Immune Response to Transplantation by David Ludwin, Dianne Arlen, J David Russell

“…OBJECTIVES: To review the roles of allorecognition, transplant rejection, and immunosuppressive therapy in predisposing patients to viral infections. …”
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ACUTE PURULENT COMPLICATED PYELONEPHRITIS IN THE PRACTICE OF AN OBSTETRICIAN-GYNECOLOGIST (CLINICAL CASE) by Алена Васильевна Иванникова, Елена Валентиновна Гришкевич, Елена Николаевна Орлова, Елена Владимировна Рудаева, Светлана Ивановна Елгина, Кира Борисовна Мозес

“…Acute purulent pyelonephritis in pregnant women is characterized by severe kidney damage, often leading to intoxication, sepsis, obstructive pyelonephritis, emphysematous pyelonephritis, perinephric abscess, kidney transplant rejection and death. At the same time, the issues of prevention, diagnostics and differential diagnostics of the stages of the disease are far from being resolved. …”
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Saving Death: Apoptosis for Intervention in Transplantation and Autoimmunity by Alice Li, Okechukwu Ojogho, Alan Escher

“…Here, we review the relationship between apoptotic cells, DCs, and Tregs, and its impact on prevention of transplant rejection and treatment of autoimmune diseases.…”
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Everolimus for Compassionate Use in Multiple Basal Cell Carcinomas by Laura Eibenschutz, Delia Colombo, Caterina Catricalà

“…Everolimus is an inhibitor of the mammalian target of rapamycin (mTOR) and has been shown to have antineoplastic activity in addition to its use as an immunosuppressive agent for the prevention of organ transplant rejection. We report the use of everolimus for the compassionate treatment of four elderly, nontransplant patients presenting with multiple basal cell carcinomas (BCC). …”
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A Knotless Technique for Kidney Transplantation in the Mouse by Song Rong, Alfor G. Lewis, Uta Kunter, Hermann Haller, Faikah Gueler

“…Mouse models of kidney transplantation are important to study molecular mechanisms of organ transplant rejection as well as to develop new therapeutic strategies aimed at improving allograft survival. …”
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Mesenchymal Stem Cells as Immunomodulators in a Vascularized Composite Allotransplantation by Yur-Ren Kuo, Chien-Chang Chen, Shigeru Goto, Pao-Yuan Lin, Fu-Chan Wei, Chao-Long Chen

“…Mesenchymal stem cells (MSCs) show promise as an immunomodulatory therapeutic agent and are currently being tested in preclinical and clinical settings as therapies for autoimmune disorders or transplant rejection. The mechanisms by which MSCs modulate the immune response are still under thorough investigation, but these most likely involve expression of local factors influencing T-cell regulation, modulation of cytokine expression (e.g., IL-10, TGF-β, TNF-, INF-γ, etc.), and interactions with dendritic or antigen presenting cells. …”
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Regulatory T Cells in the Immunodiagnosis and Outcome of Kidney Allograft Rejection by O. Franzese, A. Mascali, A. Capria, V. Castagnola, L. Paganizza, N. Di Daniele

“…Many studies have been performed in order to define the role of Tregs either in the immunodiagnosis of transplant rejection or as predictor of the clinical outcome. …”
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Acute graft-versus-host disease: a case report by JIANG Yuyang, TANG Lulu, CHEN Haiju, LV Chunying, XIONG Hongdi, WU Yi

“…No new lesions or liver transplant rejection occurred during 4-month follow-up.…”
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Successful Outcome of a Corticodependent Henoch-Schönlein Purpura Adult with Rituximab by Taylor Pindi Sala, Jean-Marie Michot, Renaud Snanoudj, Marion Dollat, Emmanuel Estève, Bernadette Marie, Yacine Taoufik, Jean-François Delfraissy, Thierry Lazure, Olivier Lambotte

“…Eight years after the transplantation, while taking combined immunosuppressive therapy with tacrolimus and azathioprine indicated for the prevention against transplant rejection, she developed a Henoch-Schönlein purpura. …”
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Mucosal Epithelial Jak Kinases in Health and Diseases by Narendra Kumar, Longxiang Kuang, Ryan Villa, Priyam Kumar, Jayshree Mishra

“…A selective Jak3 inhibitor CP-690550 (Xeljanz) approved by the FDA for certain chronic inflammatory conditions demonstrates immunosuppressive activity in rheumatoid arthritis, psoriasis, and organ transplant rejection. Here, we also focus on the consequences of Jak3-directed drugs on adverse effects in light of recent discoveries in mucosal epithelial functions of Jak3 with some information on other Jaks. …”
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Immune Toxicity with Checkpoint Inhibition for Metastatic Melanoma: Case Series and Clinical Management by Anna J. Lomax, Jennifer Lim, Robert Cheng, Arianne Sweeting, Patricia Lowe, Neil McGill, Nicholas Shackel, Elizabeth L. Chua, Catriona McNeil

“…Thyroiditis was characterised by a brief asymptomatic hyperthyroid phase followed by a symptomatic hypothyroid phase requiring thyroxine replacement. Transplant rejection doses of methylprednisolone were necessary to manage refractory hepatotoxicity. …”
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Neoadjuvant atezolizumab plus bevacizumab prior liver transplantation for hepatocellular carcinoma by Parissa Tabrizian, Rebecca Marino, Sherrie Bhoori, Marcus Zeitlhoefler, Neil Mehta, Vanessa Banz, Salvatore Gruttadauria, Massimo Iavarone, Chiara Mazzarelli, Nicolò Simonotti, Francis Yao, Vincenzo Mazzaferro, Josep M. Llovet

“…This immune-based combination was safe in terms of treatment-related adverse events, and absence of severe post-transplant rejection or graft loss. These preliminary results could pave the way for expanding transplant eligibility criteria in patients at more advanced HCC stages. …”
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Profiling the Resident and Infiltrating Monocyte/Macrophages during Rejection following Kidney Transplantation by Jie Wang, Peiling Luo, Jingjie Zhao, Junhua Tan, Feifan Huang, Ruiying Ma, Peng Huang, Meiying Huang, Yuming Huang, Qiuju Wei, Liuzhi Wei, Zechen Wang, Lingzhang Meng

“…Other than antibody and T cell-mediated immune rejection, macrophage-mediated innate immunity plays an important role in the onset phase of transplantation rejection. However, due to the complexity of the kidney environment as well as its diversity and low abundance, studies pertaining to monocyte/macrophages in kidney transplantation require further elucidation. …”
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Protective Effect of CXCR3+CD4+CD25+Foxp3+ Regulatory T Cells in Renal Ischemia-Reperfusion Injury by Cao Jun, Li Qingshu, Wei Ke, Li Ping, Dong Jun, Luo Jie, Min Su

“…Regulatory T cells (Tregs) suppress excessive immune responses and are potential therapeutic targets in autoimmune disease and organ transplantation rejection. However, their role in renal ischemia-reperfusion injury (IRI) is unclear. …”
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