Targeting of the G9a, DNMT1 and UHRF1 epigenetic complex as an effective strategy against pancreatic ductal adenocarcinoma by Daniel Oyon, Amaya Lopez-Pascual, Borja Castello-Uribe, Iker Uriarte, Giulia Orsi, Sofia Llorente, Jasmin Elurbide, Elena Adan-Villaescusa, Emiliana Valbuena-Goiricelaya, Ainara Irigaray-Miramon, Maria Ujue Latasa, Luz A. Martinez-Perez, Luca Reggiani Bonetti, Felipe Prosper, Mariano Ponz-Sarvise, Silvestre Vicent, Antonio Pineda-Lucena, David Ruiz-Clavijo, Bruno Sangro, Urko Aguirre Larracoechea, Tian V. Tian, Andrea Casadei-Gardini, Irene Amat, Maria Arechederra, Carmen Berasain, Jesus M. Urman, Matias A. Avila, Maite G. Fernandez-Barrena

Get full text

Glycosylation of ceramide synthase 6 is required for its activity by Alexandra J. Straus, Grace Mavodza, Can E. Senkal

Get full text

Prospective observational study to evaluate the feasibility of the mobile app for mild cognitive impairment detection and screening by Reo Hamaguchi, Seiji Hongo, Naoto Doi, Hisamitsu Ide, Ryozo Saito, Junji Kishimoto, Nobuhiro Handa, Shigeo Horie

Get full text

PGC1α −1 Nucleosome Position and Splice Variant Expression and Cardiovascular Disease Risk in Overweight and Obese Individuals by Tara M. Henagan, Laura K. Stewart, Laura A. Forney, Lauren M. Sparks, Neil Johannsen, Timothy S. Church

Get full text

The Effect of Shear Force on Skin Viability in Patients with Type 2 Diabetes by Luuk A. de Wert, Margot Geerts, Sander van der Brug, Laura Adriaansen, Martijn Poeze, Nicolaas Schaper, Nicole D. Bouvy

Get full text

Editorial: Vascular- and immuno-metabolism as drivers of cardiovascular disease: insights obtained from omics approaches by Emiel P. C. van der Vorst, Emiel P. C. van der Vorst, Emiel P. C. van der Vorst, Emiel P. C. van der Vorst, Jeffrey Kroon, Jeffrey Kroon, Jeffrey Kroon, Jeffrey Kroon, Raquel Guillamat-Prats, Raquel Guillamat-Prats, Raquel Guillamat-Prats, Yvonne Döring, Yvonne Döring, Yvonne Döring, Yvonne Döring

Get full text

State of the art progress of Evolvulus alsinoides in pharmacological activity and plant tissue culture: A potent Chinese medicinal plant by Collince Omondi Awere, Valentine Chikaodili Anadebe, Rakkammal Kasinathan, Pandiyan Muthuramalingam, Ramesh Manikandan

“…Nevertheless, thorough clinical trials and translational research are required to bridge the gap between conventional knowledge and current medical uses. …”
Get full text

Systemic Inflammatory Cytokines Predict the Infectious Complications but Not Prolonged Postoperative Ileus after Colorectal Surgery by G. S. A. Boersema, Z. Wu, A. G. Menon, G. J. Kleinrensink, J. Jeekel, J. F. Lange

Get full text

Intra-Bone Marrow Administration of Mesenchymal Stem/Stromal Cells Is a Promising Approach for Treating Osteoporosis by Hideki Agata, Yoshinori Sumita, Tatsuro Hidaka, Mayumi Iwatake, Hideaki Kagami, Izumi Asahina

Get full text

Comparative proteomic analysis of astrocytoma tissues from patients with and without seizures by Thanakorn Khaosuwan, Kittinun Leetanaporn, Pongsakorn Choochuen, Raphatphorn Navakanitworakul, Anukoon Kaewborisutsakul, Thara Tunthanatip, Surasak Sangkhathat, Wararat Chiangjong, Kanitpong Phabphal

Get full text

Potential Pathways Involved in Elaidic Acid Induced Atherosclerosis in Human Umbilical Vein Endothelial Cells by Huahong Yu, Xiangmei Li, Zhongshang Liang, Bin Qiu, Siguang Li, Ting Luo, Jing Li, Hongyan Li, Zeyuan Deng

Get full text

Innovative Drug Modalities for the Treatment of Advanced Prostate Cancer by Maurizio Capuozzo, Mariachiara Santorsola, Monica Ianniello, Francesco Ferrara, Andrea Zovi, Nadia Petrillo, Rosa Castiello, Maria Rosaria Fantuz, Alessandro Ottaiano, Giovanni Savarese

“…Interestingly, the complexities posed by prostate cancer not only present a formidable challenge but also serve as a model and an opportunity for translational research and innovative therapies in the field of oncology.…”
Get full text

Neoadjuvant apatinib addition to sintilimab and carboplatin-taxane based chemotherapy in patients with early triple-negative breast cancer: the phase 2 NeoSAC trial by Guoshuang Shen, Zhilin Liu, Miaozhou Wang, Yi Zhao, Xinlan Liu, Yujin Hou, Wenbiao Ma, Jingqi Han, Xiaofeng Zhou, Dengfeng Ren, Fuxing Zhao, Zitao Li, Shifen Huang, Yongzhi Chen, Yingjian He, Yan Liu, Zijun Zhu, Yongxin Li, Jinming Li, Mengting Da, Hongnan Mo, Feng Du, Liang Cui, Jing Bai, Zhen Liu, Fei Ma, Jiuda Zhao

Get full text

The role of dendritic cells in tertiary lymphoid structures: implications in cancer and autoimmune diseases by Mariana Reste, Kristi Ajazi, Ayca Sayi-Yazgan, Ayca Sayi-Yazgan, Radmila Jankovic, Biljana Bufan, Sven Brandau, Espen S. Bækkevold, Florent Petitprez, Malin Lindstedt, Gosse J. Adema, Catarina R. Almeida

Get full text

Advancements in Managing Anthracycline-Induced Cardiotoxicity: Insights from Interventional Clinical Trials by Zhao M, Zhang X, Zhou D, Song J

“…Mei Zhao,1 Xiaohong Zhang,1 Dongyang Zhou,2 Junxian Song3– 5 1Department of Pharmacy, Peking University People’s Hospital, Beijing, People’s Republic of China; 2Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK; 3Department of Cardiology, Peking University People’s Hospital, Beijing, People’s Republic of China; 4Beijing Key Laboratory of Early Prediction and Intervention of Acute Myocardial Infarction, Peking University People’s Hospital, Beijing, People’s Republic of China; 5Center for Cardiovascular Translational Research, Peking University People’s Hospital, Beijing, People’s Republic of ChinaCorrespondence: Junxian Song, Department of Cardiology, Peking University People’s Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing, 100044, People’s Republic of China, Email sjx221@163.comPurpose: Anthracycline-induced cardiotoxicity (AIC) is a significant complication in cancer treatment, impacting long-term health outcomes. …”
Get full text

Escin Chemosensitizes Human Pancreatic Cancer Cells and Inhibits the Nuclear Factor-kappaB Signaling Pathway by A. Rimmon, A. Vexler, L. Berkovich, G. Earon, I. Ron, S. Lev-Ari

“…Moreover, Escin sensitized pancreatic cancer cells to chemotherapy. Further translational research is required.…”
Get full text

Determination of Curdlan Oligosaccharides with High-Performance Anion Exchange Chromatography with Pulsed Amperometric Detection by Lidong Cao, Huifang Tian, Miaomiao Wu, Hongjun Zhang, Puguo Zhou, Qiliang Huang

Get full text

The Role of Nonmetastatic Lymph Nodes in the Survival of Colorectal Cancer: A Systematic Review by Alexander J. Pennings, MSc, Brecht A. van der Velden, BSc, Maximilian Kloft, MSc, Loes F. S. Kooreman, MSc, Jos M. P. Kleijnen, PhD, Stephanie O. Breukink, PhD, Geerard L. Beets, PhD, Heike I. Grabsch, PhD, Jarno Melenhorst, PhD

Get full text

Serial Assessment of Immune Status by Circulating CD8+ Effector T Cell Frequencies for Posttransplant Infectious Complications by Shinji Uemoto, Kazue Ozawa, Hiroto Egawa, Yasutsugu Takada, Hiroshi Sato, Satoshi Teramukai, Mureo Kasahara, Kohei Ogawa, Masako Ono, Kenji Takai, Masanori Fukushima, Kayo Inaba, Koichi Tanaka

Get full text

Chemical composition and potential antioxidant, anti-inflammatory, and analgesic efficacy of Cistus albidus L. by Zouhri Aziz, Bouddine Toufik, Menyiy Naoual El, El-Mernissi Yahya, Laaroussi Hassan, Chebaibi Mohamed, Amhamdi Hassan, Elharrak Abdelhay, Nafidi Hiba-Allah, Sitotaw Baye, Jardan Yousef A. Bin, Bourhia Mohammed, Hajji Lhoussain

Get full text