High Ki67 expression, HER2 overexpression, and low progesterone receptor levels in high-grade DCIS: significant associations with clinical practice implications by Hossein Schandiz, Hossein Schandiz, Lorant Farkas, Lorant Farkas, Daehoon Park, Yan Liu, Yan Liu, Solveig N. Andersen, Torill Sauer, Jürgen Geisler, Jürgen Geisler

“…This elucidation underscores the translational significance of Ki67 as a prognostic and predictive biomarker in DCIS, with implications for personalized treatment paradigms and patient outcomes.BackgroundThe Ki67 proliferation index is widely used in various tumors, including invasive breast carcinoma (IBC). …”
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After neonatal care, what next? A qualitative study of mothers’ post-discharge experiences after premature birth in Kenya by Justinah Maluni, Dorothy Oluoch, Sassy Molyneux, Mwanamvua Boga, Caroline Jones, Florence Murila, Mike English, Sue Ziebland, Lisa Hinton

“…After transcription, the interviews were translated, where applicable, and thematic analysis was undertaken. …”
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Sex and outcomes of patients with microsatellite instability-high and BRAF V600E mutated metastatic colorectal cancer receiving immune checkpoint inhibitors by Michael Hoffmeister, Hermann Brenner, Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Julien Taieb, David Tougeron, Robyn L Ward, Marco Vitellaro, Thierry André, Pierre Laurent-Puig, Jitendra Jonnagaddala, Francesca Bergamo, Raghav Sundar, Claire Gallois, Michael J Overman, Jakob Nikolas Kather, Lisa Salvatore, Romain Cohen, Rossana Intini, Priya Jayachandran, Miriam Koopman, Javier Ros, Marwan Fakih, Vincenzo Nasca, Giacomo Mazzoli, Jeanine M L Roodhart, Filippo Ghelardi, Elena Elez, Durgesh Wankhede, Marta Ligero, Joseph Zhao, Koen Zwart, Jeroen Derksen, Nicholas Hawkins, Javier Carmona

“…Finally, we explored two public microarray and RNA-seq datasets from patients with non-metastatic or metastatic MSI-H CRC to gain translational insights on the association between sex, BRAF status and immune contextures/ICI efficacy.Results Although no differences were observed between females and males either overall or in the BRAF wild-type cohort, male sex was associated with inferior progression-free survival (PFS) and overall survival (OS) in the BRAF mutated cohort (in multivariable models, HR for PFS: 1.79, 95% CI: 1.13 to 2.83, p=0.014, and for OS: 2.33, 95% CI: 1.36 to 3.98, p=0.002). …”
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Subcytotoxic transepidermal delivery using low intensity cold atmospheric plasma by Ga Ram Ahn, Hyung-Joon Park, Yu Jin Kim, Min Gyo Song, Hye Sung Han, Woo Geon Lee, Hyuck Ki Hong, Kwang Ho Yoo, Joon Seok, Kyu Back Lee, Beom Joon Kim

“…Under our study conditions, LICAP treatment seems to be a novel approach to facilitate TED with low safety concerns in vitro. Further translational studies are needed for clinical evaluation.…”
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The impact of architectural modifications on relative resistance to fluid flow in ventricular catheters by Rajesh Kumar Madhavan, Ahmad Faryami, Nathan Tappen, Pranav Gopalakrishnan, Shaheer H. Ajaz, Carolyn A. Harris

“…Relative resistance impacts fluid outflow efficiency, which may translate to clinical outcomes for hydrocephalus patients. …”
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Is There a Noninvasive Source of MSCs Isolated with GMP Methods with Better Osteogenic Potential? by Carla C. G. Pinheiro, Alessander Leyendecker Junior, Daniela Y. S. Tanikawa, José Ricardo Muniz Ferreira, Reza Jarrahy, Daniela F. Bueno

“…Based on these observations, and the distinct translational advantage of incorporating stem cells from noninvasive tissue sources into tissue engineering protocols, greater study of these specific cell lines in the setting of alveolar cleft repair is indicated.…”
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“I believe it when there is an expert next to me:” a qualitative analysis on the perceptions and experiences of pregnant women to self-monitor blood pressure in Lombok, Indonesia... by Tigest Tamrat, Yuni Dwi Setiyawati, Maria Barreix, Nya’Jeumpa Madani, Antoine Geissbühler, Anuraj H. Shankar, Ozge Tuncalp

“…Interviews were double transcribed in Bahasa Indonesia and translated to English for thematic analysis using inductive and deductive approaches. …”
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Prevalence of tooth decay in deciduous and permanent teeth in a schoolchildren population: an epidemiological investigation by Silvia Fanelli, Letizia Lugli, Francesca Chiara De Razza, Francesca Gazzani, Saveria Loberto, Elisabetta Cretella Lombardo, Francesco Fabi, Arianna Malara

“…A proper oral hygiene, especially if established at an early age, can translate into benefits in the permanent teeth that can last a lifetime if cared for properly. …”
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Harmful newborn cord care practices and associated factors among mothers who gave birth in the last six months in Chencha town, Southern Ethiopia: a mixed-methods study by Misgana Seifu, Sultan Hassen, Mekdim Kassa, Yosef Haile, Zeleke Girma, Temesgen Mohammed Toma, Agune Ashole, Mintesinot Melka Gujo, Wondimagegn Taye Dema, Aleme Mekuriya, Endashaw Shibru

“…The audio-recorded qualitative data were transcribed in Amharic language and then translated into English and entered into Open Code software version 3.6.2 for analysis using the thematic content analysis method.ResultsHarmful newborn cord care practice was prevalent among 55.8% (95% CI: 50.1, 61.4) of the mothers. …”
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Transposon-sequencing across multiple Mycobacterium abscessus isolates reveals significant functional genomic diversity among strains by Chidiebere Akusobi, Sanjeevani Choudhery, Bouchra S. Benghomari, Ian D. Wolf, Shreya Singhvi, Thomas R. Ioerger, Eric J. Rubin

“…This study reveals that Mab’s genetic diversity translates into significant functional differences among clinical isolates. …”
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Meta-analyses of mouse and human prostate single-cell transcriptomes reveal widespread epithelial plasticity in tissue regression, regeneration, and cancer by Luis Aparicio, Laura Crowley, John R. Christin, Caroline J. Laplaca, Hanina Hibshoosh, Raul Rabadan, Michael M. Shen

“…Conclusions Taken together, our analyses of cellular heterogeneity and plasticity provide important translational insights into the origin and treatment response of prostate cancer. …”
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Prevalence of peptic ulcer disease and its associated factors in Jeddah Saudi Arabia by Muazzam Sheriff Maqbul, Reem Saleh Alzaki, Reema Sami Meeralam, Norah Abdulmajeed Alqutami, Bayan Mohammed Alturki, Lina Sultan Alhazmi, Reem Mamdouh Alaseeri, Lama Saad Alghamdi, Reem Khalid bin Brik, Shaima Tariq Mansoor Beig, Muath Saeed Alamri, Wjood Abdullah A. Alshehri, Turki Ayed Almutairi, Maha Abdullah Alqurashi, Ahmed Jamal Nasef

“…Methodology: This cross-sectional study investigated the prevalence of peptic ulcer disease (PUD) and its associated factors in Jeddah, Saudi Arabia, using a validated questionnaire covered demographic details, knowledge, psychosocial aspects, symptoms, healthcare-seeking behavior, and medical history. It was translated into Arabic, culturally adapted, and validated through expert review and pilot testing. …”
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Sex differences in epigenetic ageing for older people living with HIVResearch in context by Carrie D. Johnston, Alina P.S. Pang, Eugenia L. Siegler, Charlene Thomas, Chelsie O. Burchett, Mia Crowley, Rochelle O'Brien, Lishomwa C. Ndhlovu, Marshall J. Glesby, Michael J. Corley

“…Funding: National Institute on Aging (K23AG072960), National Center for Advancing Translational Sciences (UL1TR000457), National Institute of Mental Health (R21 MH115821).…”
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What’s Going On With Me and How Can I Better Manage My Health? The Potential of GPT-4 to Transform Discharge Letters Into Patient-Centered Letters to Enhance Patient Safety: Prospe... by Felix Eisinger, Friederike Holderried, Moritz Mahling, Christian Stegemann–Philipps, Anne Herrmann–Werner, Eric Nazarenus, Alessandra Sonanini, Martina Guthoff, Carsten Eickhoff, Martin Holderried

“…The resulting patient letters were analyzed for medical accuracy, patient centricity, and the ability to identify and translate the learning objectives. Bloom’s taxonomy was applied to analyze and categorize the learning objectives. …”
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Invasive fungal diseases in patients with autoimmune diseases: a case series from the French RESSIF network by Vincent Poindron, Benjamin Terrier, François Maillot, Jean-Pierre Gangneux, Nassim Kamar, Valéry Salle, Lilia Hasseine, François Danion, Lilia Merabet, Guillaume Desoubeaux, Éric Bailly, Milène Sasso, Antoine Néel, Simon Galmiche, Benjamin Thoreau, Stéphane Bretagne, Alexandre Alanio, André Paugam, Valérie Letscher-Bru, Sophie Cassaing, Hélène Guegan, Loïc Favennec, Alida Minoza, Florent Morio, Julie Bonhomme, Odile Eloy, Laurence Millon, Anne-Pauline Bellanger, Philippe Poirier, Maxime Moniot, Taieb Chouaki, Antoine Huguenin, Frédéric Dalle, Bernard Bouteille, Muriel Nicolas, Nicole Desbois-Nogard, Marie-Elisabeth Bougnoux, Karine Boukris-Sitbon, Fanny Lanternier, Caroline Mahinc, Marc Pihet, Magalie Demar, Céline Damiani, Marie-Fleur Durieux, Elena Charpentier, Cécile Nourrisson, Benoit Suzon

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Gestational exposure to arsenic reduces female offspring fertility by impairing the repair of DNA double-strand breaks and synapsis formation in oocytes by Cong Ma, Kaiqin Hu, Xueke Zhang, Yaru Yu, Zuying Xu, Tian Ma, Hongzhen Ruan, Yingying Zhang, Jiajia Wang, Xinyu Yue, Chunmei Liang, Huifen Xiang, Rui Guo, Yunxia Cao, Zhiming Ding

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Changes in the Expression of Mitochondrial Morphology-Related Genes during the Differentiation of Murine Embryonic Stem Cells by Jeong Eon Lee, Bong Jong Seo, Min Ji Han, Yean Ju Hong, Kwonho Hong, Hyuk Song, Jeong Woong Lee, Jeong Tae Do

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Children with autoimmune hepatitis receiving standard-of-care therapy demonstrate long-term obesity and linear growth delay by Or Steg Saban, Shannon M. Vandriel, Syeda Aiman Fatima, Celine Bourdon, Amrita Mundh, Vicky L. Ng, Simon C. Ling, Robert H.J. Bandsma, Binita M. Kamath

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Effect of auricular acupoint pressing combined with acupoint application in the treatment of senile constipation (耳穴压豆联合穴位贴敷治疗老年性便秘效果观察) by KAN Haiying (坎海英), ZHOU Weihua (周维华)

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Latent class cluster analysis of knowledge on acute myocardial infarction in community residents: a cross-sectional study in Tianjin, China by Jing Wang, Xu Zhang, Yan Zhang, Jing Ma, Nan Zhang, Yuan Wang, Jing Gao, Jian-yong Xiao, Yin Liu, Ji-xiang Wang, Xiao-wei Li, Ming-dong Gao, Jing-xian Wang, Shi-bo Xu

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