Prolonged venous transit is associated with worse neurological recovery in successfully reperfused large vessel strokes by Janet Mei, Hamza Adel Salim, Dhairya A. Lakhani, Licia Luna, Aneri Balar, Mona Shahriari, Nathan Z. Hyson, Francis Deng, Adam A. Dmytriw, Adrien Guenego, Vaibhav Vagal, Victor C. Urrutia, Elisabeth B. Marsh, Hanzhang Lu, Risheng Xu, Rich Leigh, Dylan Wolman, Gaurang Shah, Benjamin Pulli, Kambiz Nael, Gregory W. Albers, Max Wintermark, Jeremy J. Heit, Tobias D. Faizy, Argye E. Hillis, Raf Llinas, Vivek Yedavalli

“…After adjusting for age, sex, hypertension, diabetes, atrial fibrillation, administration of intravenous thrombolysis (IVT), Alberta Stroke Program Early CT Scores (ASPECTS), mTICI 2c and/or 3, Tmax >6 s volume, and hemorrhagic transformation, PVT+ was significantly associated with lower NIHSS percent change (B = −0.163, 95%CI −0.326 to −0.001, p = 0.049) and was less likely to achieve higher than 70% NIHSS improvement (OR = 0.331, 95% CI 0.127–0.863, p = 0.024). …”
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Glucagon-Like Peptide-2 Analogue ZP1849 Augments Colonic Anastomotic Wound Healing by Marie Kjaer, Wayne Russell, Peter Schjerling, Elena Cottarelli, Kennet N. Christjansen, Ditte M. G. Olsen, Peter-Martin Krarup, Lene Jessen, Mark Berner-Hansen, Lars N. Jorgensen, Magnus S. Ågren

“…Breaking strength, myeloperoxidase (MPO), transforming growth factor- (TGF-) β1, and soluble collagen proteins were measured on days 3 and 5. …”
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Fabrication and Characterization of Chitosan-Polyethylene Glycol (Ch-Peg) Based Hydrogels and Evaluation of Their Potency in Rat Skin Wound Model by Md Mahmudul Hasan, Md Forhad Uddin, Nayera Zabin, Md Salman Shakil, Morshed Alam, Fahima Jahan Achal, Most. Hosney Ara Begum, Md Sakib Hossen, Md Ashraful Hasan, Md Mahbubul Morshed

“…After that, the structural characterization technique named Fourier-transform infrared spectroscopy (FTIR) was used to describe the composites (SEM). …”
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Classification and diagnosis of cervical lesions based on colposcopy images using deep fully convolutional networks: A man-machine comparison cohort study by Binhua Dong, Huifeng Xue, Ye Li, Ping Li, Jiancui Chen, Tao Zhang, Lihua Chen, Diling Pan, Peizhong Liu, Pengming Sun

“…Moreover, Dense-U-Net is more accurate in diagnosing the type III cervical transformation zone, which is difficult to diagnose by experts (P < 0.001). …”
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Uncertainty quantification in multi-parametric MRI-based meningioma radiotherapy target segmentation by Lana Wang, Zhenyu Yang, Zhenyu Yang, Dominic LaBella, Zachary Reitman, John Ginn, Jingtong Zhao, Justus Adamson, Kyle Lafata, Kyle Lafata, Kyle Lafata, Evan Calabrese, John Kirkpatrick, Chunhao Wang

“…As an equivalence of a nonlinear image transform, projections enhance locoregional details while maintaining the global field of view. …”
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Microplastic analysis in soils: A comparative assessment by Stoyana Peneva, Quynh Nhu Phan Le, Davi R. Munhoz, Olivia Wrigley, Flora Wille, Heidi Doose, Crispin Halsall, Paula Harkes, Michael Sander, Melanie Braun, Wulf Amelung

“…We compared analytical protocols for MiP quantification in soil, consisting of Digital, Fluorescence, Fourier-transform infrared (FTIR), and Raman Microscopy as well as quantitative Pyrolysis-Gas Chromatography-Mass Spectroscopy (Py-GC-MS) and 1-proton nuclear magnetic resonance (1H NMR) spectroscopy as detection techniques. …”
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Construction of "One Syndrome and One Product" Traditional Chinese Medicine nursing service in the specialized spine department (脊柱专科“一证一品”中医特色护理服务品牌建设思路)... by AN Ying (安影), HAO Juntao (郝俊涛), GAO Xinxia (高新霞), XU Huirong (许慧荣), JIANG Tingjie (姜婷杰), JIA Xin (贾昕)

“…Implementation of "One Syndrome and One Product" nursing plan was associate with a continued increase of patient satisfaction, establishment of a humanistic care service model, transformation of nurses’ service concepts, and the formation of caring culture in the department. …”
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Composite Sorbents Based on Chitosan Polymer Matrix and Derivatives of 4-Amino-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide for Uranium Removal from Liquid Mineralized Media by Anna I. Matskevich, Konstantin V. Maslov, Veronika A. Prokudina, Daria D. Churakova, Oleg Yu. Slabko, Dmitry K. Patrushev, Nikita S. Markin, Eduard A. Tokar’

“…As the mass content of chitosan increases, the material gradually dissolves and transforms into a gel, resulting in the formation of liquid radioactive waste with a complex chemical composition. …”
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TCF1-positive and TCF1-negative TRM CD8 T cell subsets and cDC1s orchestrate melanoma protection and immunotherapy response by Saraí G De León-Rodríguez, Cristina Aguilar-Flores, Julián A Gajón, Ángel Juárez-Flores, Alejandra Mantilla, Raquel Gerson-Cwilich, José Fabián Martínez-Herrera, Diana Alejandra Villegas-Osorno, Claudia T Gutiérrez-Quiroz, Sergio Buenaventura-Cisneros, Mario Alberto Sánchez-Prieto, Edmundo Castelán-Maldonado, Samuel Rivera Rivera, Ezequiel M Fuentes-Pananá, Laura C Bonifaz

“…Background Melanoma, the most lethal form of skin cancer, has undergone a transformative treatment shift with the advent of checkpoint blockade immunotherapy (CBI). …”
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Is first-line treatment with polatuzumab vedotin–rituximab–cyclophosphamide, doxorubicin and prednisone (pola-R-CHP) for previously untreated diffuse large B-cell lymphoma cost-eff... by Lin Yang, Ting Chen, Qiuling Zhao, Liangliang Dong, Wanfu Zhong, Wenbin Liu, Xiuliang Qiu, Ruyi Huang, Shengqiang Huang, Ruixiang Xie

“…The clinical outcomes were obtained from the POLARIX(NCT03274492), SCHOLAR-1, ZUMA-7(NCT03391466) and TRANSFORM(NCT03575351) trials. Costs were derived from the Chinese official websites and published literature, and utility values were obtained from the published literature. …”
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Impacts of Recent Climate Trends and Human Activity on the Land Cover Change of the Abbay River Basin in Ethiopia by Asaminew Abiyu Cherinet, Denghua Yan, Hao Wang, Xinshan Song, Tianlin Qin, Mulualem T. Kassa, Abel Girma, Batsuren Dorjsuren, Mohammed Gedefaw, Hejia Wang, Otgonbayar Yadamjav

“…In addition, Normalized Difference Vegetation Index (NDVI), Enhanced Vegetation Index (EVI), and Transformation Matrix were employed to analyze the spatial and temporal patterns of land cover and vegetation impacted by changes in climate. …”
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Cardiovascular risk burden, dementia risk and brain structural imaging markers: a study from UK Biobank by Ting Li, Jing Chen, Yan Zheng, Klodian Dhana, Geng Zong, Yuan Ma, Trudy Voortman, Wei Gan, Yaying Cao, Yonghua Hu, Changzheng Yuan, Jie Shen, Gaohong Zhu, Chengwu Feng

“…For brain volumes, higher FGCRS was associated with greater log-transformed white matter hyperintensities, smaller cortical volume and smaller grey matter volume.Conclusions Our findings suggest that the positive association of cardiovascular risk burden with dementia risk also applies to major dementia subtypes. …”
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Delivery of dendritic cells targeting 3M2e-HA2 nanoparticles with a CpG adjuvant via lysosomal escape of Salmonella enhances protection against H9N2 avian influenza virus by Futing Jia, Wenfeng Wang, Yawen Tian, Ainul Zahra, Yingkai He, Chongbo Ge, Tongyu Zhang, Mingyue Wang, Jingshuo Gong, Gerui Zhang, Guilian Yang, Wentao Yang, Chunwei Shi, Jianzhong Wang, Haibin Huang, Xin Cao, Yang Zeng, Nan Wang, Zhannan Wang, Chunfeng Wang, Yanlong Jiang

“…All the constructed plasmids were then transformed into the sifA gene-deficient Salmonella vector χYL56 for oral immunization.The results showed that sifA-deficient Salmonella could efficiently increase antigen-specific mucosal sIgA antibody titers, especially in alveolar lavage samples, whereas the presence of the phage-54 nanobody could dramatically increase intracellular IFN-γ mRNA levels, indicating its ability to enhance the Th1-type immune response. …”
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Enhancing immunotherapy through PD‐L1 upregulation: the promising combination of anti‐PD‐L1 plus mTOR inhibitors by Anna Hernández‐Prat, Alejo Rodriguez‐Vida, Laura Cardona, Mengjuan Qin, Oriol Arpí‐Llucià, Luis Soria‐Jiménez, Sílvia Menendez, Fabricio Gerel Quimis, Miguel Galindo, Edurne Arriola, Marta Salido, Nuria Juanpere‐Rodero, Federico Rojo, Aura Muntasell, Joan Albanell, Ana Rovira, Joaquim Bellmunt

“…Immune checkpoint inhibitors (ICIs) targeting the programmed cell death protein 1 (PD‐1)/programmed cell death 1 ligand 1 (PD‐L1) pathway have transformed urothelial cancer (UC) therapy. The correlation between PD‐L1 expression and ICI effectiveness is uncertain, leaving the role of PD‐L1 as a predictive marker for ICI efficacy unclear. …”
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Valorization of buffalo mozzarella cheese whey as human functional food and soil fertilizer by Raffaele Conte, Anna Valentino, Silvia Romano, Sorur Yazdanpanah, Anna Di Salle, Fahd Kandsi, Gianfranco Peluso

“… Purpose: This study examines the potential of transforming buffalo mozzarella cheese whey, a significant byproduct in Mediterranean and Middle Eastern dairy production, into valuable resources. …”
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The Complete Inpatient Record Using Comprehensive Electronic Data (CIRCE) project: A team‐based approach to clinically validated, research‐ready electronic health record data by Andrea L. C. Schneider, Jennifer C. Ginestra, Meeta Prasad Kerlin, Michael G. S. Shashaty, Todd A. Miano, Daniel S. Herman, Oscar J. L. Mitchell, Rachel Bennett, Alexander T. Moffett, John Chandler, Atul Kalanuria, Zahra Faraji, Nicholas S. Bishop, Benjamin Schmid, Angela T. Chen, Kathryn H. Bowles, Thomas Joseph, Rachel Kohn, Rachel R. Kelz, George L. Anesi, Monisha Kumar, Ari B. Friedman, Emily Vail, Nuala J. Meyer, Blanca E. Himes, Gary E. Weissman

“…The CIRCE Project includes three layers: (1) raw data comprised of direct SQL query output, (2) cleaned data with errors removed, and (3) transformed data with standardized implementations of commonly used case definitions and clinical scores. …”
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Increased methane production associated with community shifts towards Methanocella in paddy soils with the presence of nanoplastics by Zhibin He, Yarong Hou, Ying Li, Qicheng Bei, Xin Li, Yong-Guan Zhu, Werner Liesack, Matthias C. Rillig, Jingjing Peng

“…Here, we employed a combination of process measurements, short-chain and long-chain fatty acid (SCFAs and LCFAs) profiling, Fourier-transform ion cyclotron resonance mass spectrometry, quantitative PCR, metagenomics, and mRNA profiling to investigate the impact of LDPE nanoplastics (NPs) on dissolved organic carbon (DOC) and CH4 production in both black and red paddy soils under anoxic incubation over a 160-day period. …”
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Thermoresponsive Gels with Rosemary Essential Oil: A Novel Topical Carrier for Antimicrobial Therapy and Drug Delivery Applications by Ludovic Everard Bejenaru, Adina-Elena Segneanu, Cornelia Bejenaru, Ionela Amalia Bradu, Titus Vlase, Dumitru-Daniel Herea, Marius Ciprian Văruţ, Roxana Maria Bălăşoiu, Andrei Biţă, Antonia Radu, George Dan Mogoşanu, Maria Viorica Ciocîlteu

“…These microparticles were thoroughly characterized using Fourier-transform infrared (FTIR) spectroscopy to confirm functional group interactions, scanning electron microscopy (SEM) for surface morphology, X-ray diffraction (XRD) for crystalline properties, and thermal analysis for stability assessment. …”
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A Review on Blockchain Applications in Operational Technology for Food and Agriculture Critical Infrastructure by Chengliang Zheng, Xiangzhen Peng, Ziyue Wang, Tianyu Ma, Jiajia Lu, Leiyang Chen, Liang Dong, Long Wang, Xiaohui Cui, Zhidong Shen

“…Blockchain technology (BT) has emerged as a transformative solution for addressing these challenges by enhancing network security, traceability, and system resilience. …”
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First-in-human phase 1 dose-escalation results with livmoniplimab, an antibody targeting the GARP:TGF-ß1 complex, as monotherapy and in combination with the anti–PD-1 antibody budi... by Toshio Shimizu, Toshio Shimizu, John Powderly, Albiruni Abdul Razak, Patricia LoRusso, Kathy D. Miller, Steven Kao, Sarah Kongpachith, Catherine Tribouley, Michelle Graham, Brian Stoll, Maulik Patel, Mohammad Sahtout, Martha Blaney, Rachel Leibman, Talia Golan, Talia Golan, Anthony Tolcher

“…BackgroundTransforming growth factor (TGF)-ß1 is a pleiotropic cytokine that can promote tumor growth and suppress antitumor immune responses. …”
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