Traditional Uses, Bioactive Compounds, and Pharmacological Investigations of Calendula arvensis L.: A Comprehensive Review by Aya Khouchlaa, Aicha El Baaboua, Hamza El Moudden, Fatima Lakhdar, Saad Bakrim, Naoual El Menyiy, Omar Belmehdi, Hicham Harhar, Nasreddine El Omari, Abdelaali Balahbib, Moon Nyeo Park, Gokhan Zengin, Bonglee Kim, Abdelhakim Bouyahya

“…Nevertheless, pharmacokinetic validation and toxicological examinations are required to detect any possible toxicity for future clinical trials.…”
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Effects of polymethylmethacrylate nanoplastics on the swimming behaviour and gut microbiome of the freshwater amphipod Gammarus pulex by Sareh Yaripour, Mandar Bandekar, Jiri Vihavainen, Kuldeep More, Aslak Eronen, Manuela Faria Durão, Mikhail Daneliya, Tuure Houni, Tia Halonen, Jari T.T. Leskinen, Jaakko Haverinen, Hannu Huuskonen, Ulrika Candolin, Jukka Kekäläinen, Raine Kortet

“…Nanoplastic particles (NPs: <1000 nm) have been drawing attention for their potential toxicological implications on organisms. Aquatic animals are increasingly exposed to NPs but their effects on many aquatic invertebrates remain inadequately known. …”
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Increased miRNA-375 causes oxidative damage but promotes apoptosis resistance and cell migration in the clam Ruditapes philippinarum by Ming Cong, Zhaoshun Li, Wenwen Tian, Yixian Yu, Yu Che, Jiasen Lv

“…Overall, this study revealed for the first time the regulatory effects of miRNA-375 in the clams and gave valuable clues to understand the toxicological mechanisms of ammonia nitrogen on the marine bivalve.…”
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Sideroxylon inerme L. (Sapotaceae): A narrative of its uses as ethnoveterinary medicine and other medicinal applications by Alfred Maroyi

“…It is therefore recommended that further studies emphasizing toxicological assessments, in vivo, and clinical evaluations aimed at corroborating the EVM and ethnomedicinal applications of S. inerme should be conducted. …”
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Electrostatic properties of human germlines and biodistribution of small biologics by Leticia Maria De Souza Cordeiro, Kelley Christine Atkinson, Argin Aivazian, Patrick Frank Joyce, Fang Jia, Alessandro Mascioni

“…Off-target biodistribution of biologics bears important toxicological consequences. Antibody fragments intended for use as vectors of cytotoxic payloads (e.g. antibody-drug conjugates, radiotherapy) can accumulate at clearance organs like kidneys and liver, where they can cause dose-limiting toxicities. …”
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Toxicity of antimony in housefly after whole-life-cycle exposure: Changes in growth, development, redox homeostasis, mitochondrial function, and fecundity by Yuming Zhang, Jinghua Lv, Xiaoli Sun, Yiwen Zhang, Menghua Shao, Bingbing Shi, Yajie Zhang, Jihai Gu, Chenchen Zhao, Fengsong Liu

“…These comprehensive toxicological data provide insight into the prediction of toxicity and the assessment of the ecological risk of Sb.…”
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A Review of Perfluoroalkyl Acids (PFAAs) in terms of Sources, Applications, Human Exposure, Dietary Intake, Toxicity, Legal Regulation, and Methods of Determination by Katarzyna Sznajder-Katarzyńska, Magdalena Surma, Iwona Cieślik

“…A variety of possible toxicological effects to human health are also discussed. …”
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Impact of polyvinyl chloride nano-plastics on the biochemical status of Oreochromis niloticus under a predicted global warming scenario by Ahmed Mohamed Soliman, Ayman S. Mohamed, Amr A. Abdel-Khalek, Shereen R. Badran

“…So, this study aims to clarify the potential impact of temperature increases on the toxicological properties of polyvinyl chloride nano-plastics (PVC-NPs) in Nile tilapia (Oreochromis niloticus) by measuring biochemical and oxidative biomarkers. …”
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Environmental Applications of Mass Spectrometry for Emerging Contaminants by Anil Kumar Meher, Akli Zarouri

“…Emerging contaminants (ECs), encompassing pharmaceuticals, personal care products, pesticides, and industrial chemicals, represent a growing threat to ecosystems and human health due to their persistence, bioaccumulation potential, and often-unknown toxicological profiles. Addressing these challenges necessitates advanced analytical tools capable of detecting and quantifying trace levels of ECs in complex environmental matrices. …”
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Dimethomorph induces heart and vascular developmental defects by disrupting thyroid hormone in zebrafish embryos by You Wei, Yunlong Meng, Kun Jia, Weijian Lu, Yushan Huang, Huiqiang Lu

“…However, there is limited understanding of the toxicological properties of DMT on these organisms. In this study, we utilized zebrafish as an animal model to assess the toxicity of DMT induced by exposure 5.5–72 hours post-fertilization (hpf). …”
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Psychiatric assessment in image-based sexual abuse case: a case report on imputability in personality disorder with narcissistic traits by Lorenzo Lodde, Claudia Zandara, Andrea Martella, Mirko Manchia, Mirko Manchia, Pasquale Paribello, Irene Mascia, Martina Pinna

“…We report on a case of a 27-year-old young adult who is accused of image-based sexual abuse and other crimes, for whom the examining judge requested psychiatric assessment.MethodsWe conducted anamnestic collection (family, physiological and pathological, psychiatric, and toxicological), direct evaluation of the examinee, assessment of acquired health records, psychodiagnostic tests (i.e. graphic tests: Machover test, Koch test), Montreal Cognitive Assessment, Minnesota Multiphasic Personality Inventory 2, Pathological Narcissism Inventory, State-Trait Anger Expression Inventory 2, Toronto Alexithymia Scale, Thematic Apperception Test.ResultsThe clinical forensic assessment led to a diagnosis of Unspecified Personality Disorder (predominantly narcissistic traits) according to the DSM-5 criteria. …”
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Cellular and metabolic impacts of repeated sub-acute exposures to biomass-burning extracts in vitro by Michal Pardo, Chunlin Li, Amani Jabali, Yinon Rudich

“…The increasing exposure to biomass-burning emissions underscores the need to understand their toxicological impacts on human health. In this study, we developed a laboratory model to evaluate the effects of single and repeated sub-acute exposures to water-soluble wood tar (WT) extracts, a product of biomass burning, on human lung, liver, and immune cells. …”
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Synthesis, antimicrobial evaluation, ADMET prediction, molecular docking and dynamics studies of pyridine and thiophene moiety-containing chalcones by Fahmida Akhter, Sumita Saznin Marufa, S. M. Anyet Ullah Shohag, Hiroshi Nishino, Mohammad Sayed Alam, Md. Aminul Haque, Mohammad Mostafizur Rahman

“…All the newly synthesized derivatives satisfied the ADME properties, and no toxicological risks were found. All compounds were docked against three protein receptors with the range of binding affinity of −6.3 to −9.6 kcal mol−1. …”
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Defensive responses of most antioxidant genes in the freshwater dinoflagellate Palatinus apiculatus to cadmium stress and their implications by Quynh Thi Nhu Bui, Taehee Kim, Han-Sol Kim, Jang-Seu Ki

“…Some freshwater dinoflagellates are known to be sensitive to environmental conditions, like water quality and contaminants; however, their molecular toxicological responses are insufficiently discovered. …”
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The Effects of Disinfection Byproduct 2,6-Dichloro-1,4-benzoquinone on the Cyanobacterium <i>Microcystis aeruginosa</i>: From the Perspectives of Biochemistry and Non-Targeted Meta... by Tianqi Zhang, Zhaoyang Wang, Liang Wu, Chaonan Liu, Liang Meng, Fuxiang Tian, Meifang Hou, Haizhuan Lin, Jing Ye

“…In this study, the toxicological mechanisms of 2,6-DCBQ in <i>Microcystis aeruginosa</i> (<i>M. aeruginosa</i>) were investigated through physiological and nontargeted metabolomic assessments. …”
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An Investigation for Heavy Metals’ Contamination in Farmers’ Fingernails: Case Study in Libya by Aiman M. Bobaker, Intisar Alakili, Elrashied E. Elkhidir, Sukiman B. Sarmani, Zaher Mundher Yaseen

“…As a conclusion, the results of this study clearly indicated that Libyan farmers have been exposed to high levels of toxic heavy metals as a result of their agricultural activities compared with the general population living in the same geographical area as farmers, which, in turn, pose a high risk to their health. Thus, toxicological, epidemiological, and clinical studies for the Libyan farmers are strongly recommended.…”
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A Low-Cost Electrochemical Cell Sensor Based on MWCNT-COOH/α-Fe₂O₃ for Toxicity Detection of Drinking Water Disinfection Byproducts by Ying Liu, Zhipeng Zhang, Yuling Wu, Huan Yang, Jiao Qu, Xiaolin Zhu

“…However, this process generates various disinfection byproducts (DBPs), which toxicological research indicates can have detrimental effects on living organisms. …”
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Strategies of physiological, morpho-anatomical and biochemical adaptation in seedlings of native species exposed to mining waste by Belén Heredia, Pablo Diaz Recio, Brian Jonathan Young, Pablo Pacheco, Franco Barcelo Zungre, Silvina Hruby, Maria Andreína Acevedo, María Inés Mercado, Gonzalo Roqueiro

“…The seed germination of L. cuneifolia, B. retama, and P. tetracantha was fully inhibited in 100 % contaminated soil. Toxicological endpoints as NOEC, LOEC and IC50 ranged from 10 % to 25 % of soil contaminated with mining waste. …”
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Perfluorooctane sulfonate (PFOS) induced bone loss by inhibiting FoxO1-mediated defense against oxidative stress in osteoblast by Liming Xue, Jiale Xu, Ping Xiao, Yiping Jiang, Yuanjie Lin, Chao Feng, Yu’e Jin, Zhijun Zhou, Guoquan Wang, Dasheng Lu

“…Our research is aimed at examining the effects of PFOS on osteoblastic activity and investigating the toxicological mechanisms of PFOS-induced bone loss. Cell proliferation, ALP activity, bone nodule formation, ROS levels, and cell apoptosis were assessed after treating osteoblasts with different concentrations of PFOS. …”
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Predictive Assessment of the Antiviral Properties of Imperata cylindrica against SARS-CoV-2 by Frank Eric Tatsing Foka, Hazel Tumelo Mufhandu

“…The in silico pharmacokinetic and toxicological assays revealed that tabanone was the best and safest phytochemical for the development of an inhibitory agent against coronavirus main protease. …”
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