Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology by Mafalda Jesus, Ana P. J. Martins, Eugenia Gallardo, Samuel Silvestre

“…Due to its pharmacological and industrial importance, several extraction and analytical procedures have been developed and applied over the years to isolate, detect, and quantify diosgenin, not only in its natural sources and pharmaceutical compositions, but also in animal matrices for pharmacodynamic, pharmacokinetic, and toxicological studies. Within these, HPLC technique coupled to different detectors is the most commonly analytical procedure described for this compound. …”
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Biostatistical Assessment of Mutagenicity Studies: A Stepwise Confidence Procedure by Michael J. Adjabui, Nathaniel K. Howard, Mathias Akamba

“…The paper addresses the issue of identifying the maximum safe dose in the context of noninferiority trials where several doses of toxicological compounds exist. Statistical methodology for identifying the maximum safe dose is available for three-arm noninferiority designs with only one experimental drug treatment. …”
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Effects of Bile Acids and Nisin on the Production of Enterotoxin by Clostridium perfringens in a Nutrient-Rich Medium by Miseon Park, Fatemeh Rafii

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A Comparative Review: Biological Safety and Sustainability of Metal Nanomaterials Without and with Machine Learning Assistance by Na Xiao, Yonghui Li, Peiyan Sun, Peihua Zhu, Hongyan Wang, Yin Wu, Mingyu Bai, Ansheng Li, Wuyi Ming

“…However, nanomaterials have been identified as potentially toxic, with the toxicity of metal nanoparticles posing significant risks to both human health and the environment. Therefore, the toxicological risk assessment of metal nanomaterials is essential to identify and mitigate potential adverse effects. …”
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Biological Activity of Metal Complexes of Sulfamethoxazole and Its Derivatives: A Literature Review by Laith Jumaah Al-Gburi, Taghreed H. Al-Noor, Eid Ahmed Abdalrazaq

“…Some organic drugs, including sulfamethoxazole, exhibit toxicological and pharmacological properties that can be administered in the form of metal complexes. …”
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Crossroad of Tradition and Innovation – The Application of Lactic Acid Fermentation to Increase the Nutritional and Health-Promoting Potential of Plant-Based Food Products – a Revi... by Anna Maria Ogrodowczyk, Natalia Drabińska

“…In this review, the existing knowledge about the effects of LA fermentation in different types of plant-based food matrices on their nutritive and health-promoting potential is presented and discussed based on the most recent studies. Furthermore, the toxicological and unfavorable effects are addressed. …”
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Recent Nanotechnological Trends in the Management of Microbial Keratitis by Shraddha Jaiswal, Prabhavati Shinde, Vidya Tale

“…In addition, safety and toxicological concerns about the increasingly widespread use of contact lenses are also discussed. …”
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Comprehensive analysis of ionomic profiling in Chlorella exposed to chlorpyrifos by Qing-Qing Yu, Yulong Zhang, Shiyuan Zhao, Min Pang, Pei Jiang, Pei Qu

“…However, little is known about the toxicological mechanism of CPF on marine microalgae, which is the main primary producer in the marine ecosystem.MethodsThis study explored the ion changes of microalgae Chlorella vulgaris under the stress of CPF through Inductively Coupled Plasma Mass Spectrometry (ICP-MS).ResultsSignificant disparities in ionomics among control and treatment group were observed through pattern recognition analysis (principal component analysis, PCA; orthogonal partial least squares discriminant analysis, OPLS-DA), indicating that CPF may impede their growth by disrupting the homeostasis of crucial elements within algal cells.DiscussionThis study elucidated the inhibitory impact of CPF on green algae growth and its potential mechanism of toxicity through ICP-MS, providing crucial insights for a comprehensive understanding of the influence of organophosphorus pesticides on aquatic ecosystems.…”
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Identification of 24 Unknown Substances (NIAS/IAS) from Food Contact Polycarbonate by LC-Orbitrap Tribrid HRMS-DDMS3: Safety Assessment by Vicent Yusà, Antonio López, Pablo Dualde, Olga Pardo, Igor Fochi, Pablo Miralles, Clara Coscollá

“…To check for the safety of the migration from the food contact polycarbonate, a risk assessment was achieved using the threshold of the toxicological concern (TTC) approach. Except for the slip agent hexadecanamide, the compounds tentatively identified do not represent a risk.…”
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Effects of benzotriazoles UV-328, UV-329, and UV-P on the self-renewal and adipo-osteogenic differentiation of human mesenchymal stem cells by Yue Zhang, Hui Zhao, Qianxi Feng, Rui Guo, Li Zhong, Shengxian Liang

“…These findings raise concerns about the health impacts of BUVSs, particularly UV-P, and underscore the need for further investigation into their toxicological profiles.…”
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Analytical Strategies for the Determination of Arsenic in Rice by Bruno E. S. Costa, Luciana M. Coelho, Cleide S. T. Araújo, Helen C. Rezende, Nívia M. M. Coelho

“…Arsenic is an element of concern given its toxicological significance, even at low concentrations. …”
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Dietary exposure to essential oils of selected Pinus and Abies species leads to morphological changes in Drosophila melanogaster wings by Cvetković Vladimir J., Lazarević Maja, Mitić Zorica S., Zlatković Bojan, Stojković-Piperac Milica, Jevtović Snežana, Stojanović Gordana, Žikić Vladimir

“…We believe that this study lays the foundation for further evaluation of Abies and Pinus EOs in targeted toxicological studies against pest insects by focusing on the potential of EOs to disrupt pest activities that depend on wing morphology.…”
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Venoms and Extracellular Vesicles: A New Frontier in Venom Biology by Auwal A. Bala, Naoual Oukkache, Elda E. Sanchez, Montamas Suntravat, Jacob A. Galan

“…Extracellular vesicles (EVs) are nanoparticle-sized vesicles secreted by nearly all cell types under normal physiological conditions. In toxicological research, EVs have emerged as a crucial link between public health and multi-omics approaches, offering insights into cellular responses to disease-causing injury agents such as environmental and biological toxins, contaminants, and drugs. …”
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Phaleria macrocarpa (Scheff.) Boerl. in Ethnopharmacology: Pharmacognosy, Safety, and Drug Development Perspectives by Anandarajagopal Kalusalingam, Kamaliah Kamal, Abdullah Khan, Bama Menon, Ching Siang Tan, Venkateshan Narayanan, Sattanathan Kumar, Khang Wen Goh, Kah Seng Lee, Jactty Chew, Long Chiau Ming

“…This review aims to comprehensively summarize the phytochemical, pharmacological, and toxicological aspects of P. macrocarpa, along with modern approaches and safety concerns. …”
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Arsenic Transfer from As-Rich Sediments to River Water in the Presence of Biofilms by Diego Martiñá Prieto, Verónica Martín-Liñares, Verónica Piñeiro, María Teresa Barral

“…AsIII concentration was higher (up to 12% of total dissolved As) in the control systems than in the systems with biofilms, where this species was almost absent. This fact is of toxicological relevance due to the usually higher mobility and toxicity of the reduced AsIII species. …”
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Overview of (1→3)-β-D-glucan immunobiology by David L. Williams

“…In addition to the potent immune stimulatory effects of (1→3)-β-D-glucans, there are a number of toxicological effects associated with exposure to the water-insoluble, microparticulate form of the polymer. …”
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Spray Dried Extract of Phormidium valderianum as a Promising Source of Natural Antioxidant by Dipan Chatterjee, Paramita Bhattacharjee, Gour Gopal Satpati, Ruma Pal

“…Microencapsulation conditions that provided the best combination of phytochemical properties such as antioxidant activity, phenolic content, and reducing power with reasonable powder yield were an inlet temperature of 130°C and wall material composition as maltodextrin: gum arabic = 70 : 30. Toxicological study reported that the Anatoxin-a content of this encapsulated powder was below the limit of detection of HPLC. …”
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Autoriser pour interdire. La fabrique des savoirs sur les molécules et leurs risques dans le règlement européen REACH by Henri Boullier

“…In order to have such applications accepted, firms provide public authorities with new toxicological and exposure data for very specific uses, and socio-economic analyses that had never been produced before. …”
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Interplay between Hormones, the Immune System, and Metabolic Disorders by Francisco J. Rios, Naïma Moustaïd-Moussa, Joilson O. Martins

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The Role of Endocrine System in the Inflammatory Process by Christian Bowman-Colin, Luis A. Salazar, Joilson O. Martins

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