Hypericum Perforatum-Derived Exosomes-Like Nanovesicles: A Novel Natural Photosensitizer for Effective Tumor Photodynamic Therapy by Ma X, Chen N, Zeng P, He Y, Zhang T, Lu Y, Li Z, Xu J, You J, Zheng Y, Wang L, Luo M, Wu J

“…In vivo, HPDEN-mediated PDT significantly suppressed tumor growth and induced extensive tumor necrosis, with no observable toxicity to major organs.Conclusion: HPDENs represent a novel plant-derived photosensitizer with dual ROS generation pathways and significant therapeutic efficacy, providing a promising platform for enhancing photodynamic therapy.Keywords: Hypericum perforatum-derived exosomes-like nanovesicles, photosensitizer, photodynamic therapy, reactive oxygen species, apoptosis…”
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Differential Effects of Chronic Pulsatile versus Chronic Constant Maternal Hyperglycemia on Fetal Pancreatic β-Cells by Mackenzie S. Frost, Aqib H. Zehri, Sean W. Limesand, William W. Hay, Paul J. Rozance

“…These results indicate that late gestation constant maternal hyperglycemia leads to significant β-cell toxicity (increased apoptosis and decreased GSIS). …”
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Natural Enrichment of Trace Elements in Surface Horizons of Calcareous Soils (La Mancha, Spain) by Sandra Bravo Martín-Consuegra, Jose A. Amorós Ortíz-Villajos, Caridad Pérez-de-los-Reyes, Francisco J. García Navarro, Rolando Ruedas Luna, Raimundo Jiménez Ballesta

“…Soil quality does not indicate toxicity although surficial enrichment suggests a weak threat from consuming crops.…”
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Layer-by-Layer Biopolymer-Coated Deformable Liposomes–In Situ Gel: A Hybrid Strategy for Enhanced Ocular Delivery of Itraconazole: In Vitro and In Vivo Appraisal by Mohamed M. Badran, Areej Alsubaie, Mounir M. Salem Bekhit, Abdullah H. Alomrani, Aliyah Almomen

“…Its oral administration is associated with systemic toxicity, and its efficacy in ocular formulations is limited. …”
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Targeted delivery of curcumin and CM11 peptide against hepatocellular carcinoma cells based on binding affinity of PreS1-coated chitosan nanoparticles to SB3 protein by Danial Rahmani, Ramezan Ali Taheri, Mehrdad Moosazadeh Moghaddam

“…The MTT assay showed that PreS1-Cur-CM11-CS NPs act in a targeted and specific manner with the highest toxicity on the HepG2 cells compared to the control by a decrease in viability of about 26% after 48 h based on cell apoptosis. …”
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An Open‐Label Phase II Trial of Pembrolizumab, an Immune Checkpoint Inhibitor Alone or in Combination With Oral Azacitidine as Second‐Line Therapy for Advanced Head and Neck Squamo... by Vinod K. Ramani, Srimonta Gayen, Radheshyam Naik

“…To evaluate the clinical effectiveness endpoints and toxicity of oral azacytidine when combined with pembrolizumab. ii. …”
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Breaking the shield of solid tumors: a combined approach for enhanced efficacy of CAR-T cells by Marat Khaliulin, Aygul Valiullina, Alexey Petukhov, Youyong Yuan, Sheila Spada, Emil Bulatov

“…Furthermore, concerns exist regarding tumor antigen loss and therapy-associated toxicity. Currently, scientists are working to enhance the structure of the CAR and improve the survival and efficiency of CAR-T cells in recognizing tumor antigens in solid tumors. …”
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Identification and pharmacokinetics of saponins in Rhizoma Anemarrhenae after oral administration to rats by HPLC-Q-TOF/MS and HPLC-MS/MS by Wang Hai-Qiao, Lan Fen, Zhang Yi-Han, Xia Jin-Er, Gong Xiao-Mei, Liu Min

“…It is essential to classify the properties of saponins which are associated with their toxicity and efficacy. In this study, 25 compounds were identified by HPLC-Q-TOF/MS in the extract of Rhizoma Anemarrhenae and 8 saponins were detected in rat plasma by HPLC-MS/MS after oral administration of this extract. …”
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99mTc-labeled benzenesulfonamide derivative-entrapped gold citrate nanoparticles as an auspicious tumour targeting by Adli A. Selim, Tamer M. Sakr, Basma M. Essa, Galal H. Sayed, Kurls E. Anwer

“…Gold nanoparticles (AuNPs) offer precise cancer treatment through targeted delivery, boasting high drug-loading capacity and low toxicity. This study aimed to develop and evaluate 99mTc-labeled benzenesulfonamide derivative-entrapped gold citrate nanoparticles as a tumor-targeting agent. …”
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Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance by Paulina Ruiz, Paula Maldonado, Yessia Hidalgo, Alejandra Gleisner, Daniela Sauma, Cinthia Silva, Juan Jose Saez, Sarah Nuñez, Mario Rosemblatt, Maria Rosa Bono

“…Despite the potential of organ transplantation, the administration of immunosuppressive drugs required for allograft acceptance induces severe immunosuppression in transplanted patients, which leads to serious side effects such as infection with opportunistic pathogens and the occurrence of neoplasias, in addition to the known intrinsic toxicity of these drugs. To solve this setback in allotransplantation, researchers have focused on manipulating the immune response in order to create a state of tolerance rather than unspecific immunosuppression. …”
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Indomethacin-Induced Gastric Ulcer in Rats: Gastroprotectivity of <i>Muscari neglectum</i> in Water by Menekse Soydan, Gulnur Arabaci, Necati Utlu, Mesut Bünyami Halici, Esra Aktas Senocak, Metin Kiliçlioglu

“…<b>Methods:</b> 60 male Sprague Dawley rats were utilized for the purposes of evaluating the acute toxicity and gastric ulcer models, with a total of 36 rats employed for these experiments (n = 6). …”
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Lysophosphatidic Acid Induced Apoptosis, DNA Damage, and Oxidative Stress in Spinal Cord Neurons by Upregulating LPA4/LPA6 Receptors by Yifan Yang, Jing Xu, Qingxin Su, Yiran Wu, Qizheng Li, Zongren Ma, Tao Ding

“…Recently, LPA has been reported to be involved in spinal cord neuronal injury and toxicity, promoting the pathogenesis of LSS. However, the exact effects of LPA on spinal cord neurons remain unknown. …”
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Comparison of inhaled versus intravenous anesthesia for laryngoscopy and laryngeal electromyography in a rat model by M. Gazzaz, J. Saini, S. Pagliardini, B. Tsui, C. Jeffery, H. El-Hakim

“…Three mortalities were encountered, one of which was due to lidocaine toxicity and two were during anesthetic induction. …”
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Assessing Redox Properties of Natural Organic Matters with regard to Electron Exchange Capacity and Redox-Active Functional Groups by Zhiyuan Xu, Zhen Yang, Hongping Wang, Jie Jiang

“…Redox processes in groundwater play an important role in bioavailability, toxicity, and mobility of redox-active elements and contaminants. …”
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Nanoparticle-based drug delivery system for Oral Cancer: Mechanism, challenges, and therapeutic potential by Nurhasni Hasan, Maryam Aftab, Muneeb Ullah, Phuong Tram Nguyen, Rina Agustina, Yulia Yusrini Djabir, Theofilus A. Tockary, Satoshi Uchida

“…Recent advancements in nanotechnology provide innovative, targeted therapeutic strategies that enhance bioavailability and decrease toxicity. This review provides an overview of nanoparticle applications in oral cancer therapy, outlining mechanisms, advantages, limitations, and potential clinical impacts. …”
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Silver Nanoparticles: Biosynthesis Using an ATCC Reference Strain of Pseudomonas aeruginosa and Activity as Broad Spectrum Clinical Antibacterial Agents by Melisa A. Quinteros, Ivana M. Aiassa Martínez, Pablo R. Dalmasso, Paulina L. Páez

“…In addition, these Ag-NPs showed negligible cytotoxic effect in human neutrophils suggesting low toxicity to the host.…”
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Biological Response Modifiers in Combination with Antivirals against Experimentally-Induced Virus Infections by Robert W Sidwell, John H Huffman, Donald F Smee, John Gilbert, Roland K Robins, Meir Kende, John Huggins

“…In each experiment. multiple dosages of both BRM and ribavirin were selected to range from ineffective levels to, in certain cases with ribavirin, lethally toxic levels. Ribavirin was always administered orally twice daily for three days starting 24 h after virus inoculation. …”
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Influence of Heat Treatment on Biocorrosion and Hemocompatibility of Biodegradable Mg-35Zn-3Ca Alloy by Jeong-Hui Ji, Il-Song Park, Yu-Kyoung Kim, Sook-Jeong Lee, Tae-Sung Bae, Min-Ho Lee

“…The hemolysis value was ≤5% in all groups, indicating no toxicity during short-term blood reaction.…”
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Evaluation of Toxicological Risks and Effects of Microplastics on Nile Tilapia (Oreochromisniloticus) under in Vitro Laboratory Conditions by Macarius Pancras Mtega, Matobola Joel Mihale, Kessy Fidel Kilulya

“…The objective of research was to determine the toxicity of microplastics to Nile tilapia (Oreochromis niloticus). …”
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Decitabine Increases the Transcription of <i>RIG-I</i> Gene to Suppress the Replication of Feline Calicivirus and Canine Influenza Virus by Shaotang Ye, Zhen Wang, Aolei Chen, Ying Chen, Gaoming Lou, Qingmei Xie, Gang Lu, Shoujun Li

“…A preliminary screening from a natural product library was conducted, with subsequent assessments to ascertain their toxicity levels and antiviral capabilities. The results showed that decitabine and alprostadil were effective in reducing FCV replication. …”
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