Fabrication of a Porous Metal-Organic Framework with Polar Channels for 5-Fu Delivery and Inhibiting Human Osteosarcoma Cells by Li-Chun Zhao, Mei Tang, Qian-Hua Zhang, Zhi-Yi Hu, Hong-Wei Gao, Xia-Yun Liao, Gang Wang, Jing Leng

“…Furthermore, as indicated by the MTT assay, this drug/MOF composite shows low toxicity toward the human normal cells and demonstrates obvious anticancer activity against the human osteosarcoma cell line MG63.…”
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Risk Evaluation of Pyrolyzed Biochar from Multiple Wastes by Shem M. Ndirangu, Yanyan Liu, Kai Xu, Shaoxian Song

“…Determination of toxicity levels is a first step in the risk management of toxic biochar. …”
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Chitosan nanoparticles loaded with Lactobacillus rhamnosus bioactive metabolites: Preparation, characterization, and antifungal activity by Aya Abdel-Nasser, Hayam M. Fathy, Ahmed N. Badr, Olfat S. Barakat, Amal S. Hathout

“…Aspergillus flavus is a severe danger to worldwide maize (Zea mays) cultivation, due to its extreme toxicity of aflatoxins produced by the fungi, and its ability to cause economic losses while also posing a health concern to humans and animals. …”
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Design of pH-Responsive Nanomaterials Based on the Tumor Microenvironment by Liu Y, Si L, Jiang Y, Jiang S, Zhang X, Li S, Chen J, Hu J

“…These materials trigger drug release upon reaching the tumor microenvironment, enhancing therapeutic targeting and reducing toxicity to healthy cells. pH-responsive nanomaterials include organic nanomaterials, inorganic nanomaterials, and composite nanomaterials. …”
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Preliminary Results of Hyperthermic Intraperitoneal Intraoperative Chemotherapy as an Adjuvant in Resectable Pancreatic Cancer by Antonios-Apostolos K. Tentes, Dimitrios Kyziridis, Stylianos Kakolyris, Nicolaos Pallas, Georgios Zorbas, Odysseas Korakianitis, Christos Mavroudis, Nicolaos Courcoutsakis, Panos Prasopoulos

“…No patient was recorded with gemcitabine-induced toxicity. Conclusions. This clinical study of 21 patients is the first to combine an R0 pancreas cancer resection with HIPEC. …”
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Immunotherapy-associated autoimmune hemolytic anemia by Uqba Khan, Tarik Hadid, Farman Ali, Muhammad Siddique Khurram, Awais Zaka

“…When combined, CTLA-4 and PD-1 checkpoint inhibitors work synergistically, but with increased probability of toxicity. The following case represents an unusual adverse effect of combined treatment with ipilimumab and nivolumab used for treatment of metastatic melanoma.Case presentation A 43-year-old woman with metastatic melanoma presented with severe generalized weakness and fatigue. …”
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Autologous Blood Transfusion after Local Infiltration Analgesia with Ropivacaine in Total Knee and Hip Arthroplasty by Torben Breindahl, Ole Simonsen, Peter Hindersson, Bjarne Brødsgaard Dencker, Mogens Brouw Jørgensen, Sten Rasmussen

“…All concentrations observed were below the threshold for toxicity and no side effects were observed. Conclusion. …”
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Platycodon grandiflorum-derived extracellular vesicles suppress triple-negative breast cancer growth by reversing the immunosuppressive tumor microenvironment and modulating the gu... by Min Yang, Jia Guo, Jinxian Li, Shuyue Wang, Yuan Sun, Ying Liu, Yinghua Peng

“…In contrast, plant-derived extracellular vesicles (PEVs) exhibit promising potential in cancer therapy due to their negligible systemic toxicity, high bioavailability and cost- effectiveness. …”
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The Role of Quercetin, a Flavonoid in the Management of Pathogenesis Through Regulation of Oxidative Stress, Inflammation, and Biological Activities by Hajed Obaid A. Alharbi, Mohammad Alshebremi, Ali Yousif Babiker, Arshad Husain Rahmani

“…Furthermore, more research based on nanoformulations should be performed to minimize/overcome the hindrance associated with bioavailability, rapid degradation, and toxicity.…”
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Hepatoprotective Effects of Crude Stem Bark Extracts and Solvent Fractions of Cordia africana against Acetaminophen-Induced Liver Injury in Rats by Gudeta Duga Geresu, Shemsu Umer, Mahlet Arayaselassie, Genet Ashebir, Eyasu Makonnen

“…Thus, this study aimed to investigate the hepatoprotective effects of an aqueous (CAAE), 80% methanol extracts of C. africana stem bark (CAME), and the solvent fractions of the methanol extract against acetaminophen (APAP)-induced liver injury in rats. Acute toxicity test and APAP-induced lethality test were done on mice of either sex, while APAP dose selection test was done on female rats. …”
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Isotherms and Kinetic Studies of Copper Removal from Textile Wastewater and Aqueous Solution Using Powdered Banana Peel Waste as an Adsorbent in Batch Adsorption Systems by Momina Seleman, Takele Sime, Abate Ayele, Assefa Sergawie, Thabo Nkambule, Jemal Fito

“…Heavy metals that are present in surface water and wastewater are becoming a severe environmental problem. Because of its toxicity, heavy metal removal has become the main priority for environmental concerns. …”
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Polystyrene microplastics disrupt adrenal steroid synthesis in male mice via mitochondrial dysfunction by Ying Xiong, Zhe Chen, Hanmin Xiang, Yi Liu, Yanlin Wang

“…The latter may represent a common mechanism underlying the multi-organ toxicity induced by PS-MPs in the body. Our findings would provide new insights for the development of more effective environmental protection measures and the reduction of plastic pollution.…”
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Therapeutic potential of phytocompounds of Bacopa monnieri (L.) Wettst (literature review) by O.O. Nikitina, D.S. Tsyba

“…Considering the amphiphilicity of bacosides and the non-toxicity of extracts, they can be involved in the development of various dosage forms with a wide range of therapeutic applications. …”
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Technical explorations for manufacturing of NiTi unibody vascular stents through metal injection molding: Materials performance, fatigue properties and biocompatibility by Dongyang Li, Junwei Wang, Changhai Du, Hao He, Zheyu He, Tun Wang, Chang Shu, Yimin Li, Jing Pan

“…The biocompatibility of MIM NiTi was evaluated based on toxicity, migration, and adhesion of the human umbilical vein endothelial cells. …”
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Sophocarpine inhibits the proliferation and induces apoptosis of glioblastoma cells through regulating the miR-21/PTEN/PI3K/AKT axis by Feng Si, Qian Wang, Fei Chen, Xiangdong Lu

“…CCK-8 was applied to analyze cell toxicity and proliferation. qRT-PCR and western blot were used to measure RNA and protein expressions, respectively. …”
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Drug Target Investigation of <i>N</i>-<i>p</i>-Coumaroyl-<i>N</i>’-Caffeoylputrescine, a Naturally-Occurring Alkaloid Derived from <i>Saxifraga tangutica</i> by Chuang Liu, Jun Dang, Minchen Wu

“…Furthermore, a prediction of the absorption, distribution, metabolism, excretion, and toxicity was also applied to evaluate the drug-like properties of PCC. …”
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Biological Evaluation of Platinum(II) Sulfonamido Complexes: Synthesis, Characterization, Cytotoxicity, and Biological Imaging by Charini Maladeniya, Taniya Darshani, Sameera R. Samarakoon, Frank R. Fronczek, W. M. C. Sameera, Inoka C. Perera, Theshini Perera

“…L1 displays intense fluorescence from the 1LC excited state, while C1 gives phosphorescence from the 3LC state. Mammalian cell toxicity of ligands and complexes was assessed with NCI–H292 nonsmall-cell lung cancer cells. …”
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GC–MS analysis and in silico approaches to Stichopus hermanii as anti-inflammatory through PKC-β inhibition by Kurnia Fatwati, Asmawati Amin, Lenni Indriani, Rusdina Bte Ladju, Fuad Husain Akbar, Nurlindah Hamrun

“…Through ADMET prediction tests, these compounds exhibited better pharmacokinetics activity and non- toxic.…”
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Radiation Therapy with Concurrent Chemotherapy for Locally Advanced Cervical Carcinoma: Outcome Analysis with Emphasis on the Impact of Treatment Duration on Outcome by Juan Diaz, Daohai Yu, Bizhan Micaily, J. Stuart Ferriss, Enrique Hernandez

“…To assess the effectiveness and toxicity of carboplatin concurrent with pelvic external beam radiation and low-dose rate brachytherapy and to assess the impact that adherence to the treatment plan has on outcomes. …”
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Additive Effects of Glutathione in Improving Antibiotic Efficacy in HIV–<i>M.tb</i> Co-Infection in the Central Nervous System: A Systematic Review by Leena Nabipur, Michael Mouawad, Vishwanath Venketaraman

“…N-acetylcysteine (NAC), a GSH precursor, was shown to significantly enhance the efficacy of first-line TB antibiotics and mitigate treatment-associated toxicity. Discussion: GSH shows promise as an adjunct therapy for HIV–<i>M.tb</i> co-infection, particularly for cases involving the CNS, where it may improve immune recovery and reduce inflammation. …”
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