Nanotherapeutics for Meningitis: Enhancing Drug Delivery Across the Blood-Brain Barrier by Hitaishi Sharma, Kannan Badri Narayanan, Shampa Ghosh, Krishna Kumar Singh, Prarthana Rehan, Aparajita Dasgupta Amist, Rakesh Bhaskar, Jitendra Kumar Sinha

“…Despite their potential, more studies are needed to ensure the safety and efficacy of NP-based drug delivery systems focusing on critical aspects such as toxicity, immunogenicity, and pharmacokinetics. Therefore, this review addresses current treatment strategies and innovative nanoparticle approaches, and it discusses future directions for efficient and targeted meningitis therapies.…”
Get full text

Suppression of IRE1α Attenuated the Fatty Degeneration in Parenteral Nutrition-Related Liver Disease (PNALD) Cell Model by Ningxun Cui, Mingling Cui, Jie Li, Xueping Zhu, Xiaoli Zhu

“…The results of Oil Red O staining indicated that the PNALD was successfully established in BRL cells and the CCK-8 data indicated which 0.6% that SO was further applied to the experiment owing to its better induction of PNALD and less toxicity to the cells. Besides, the value of biochemical parameters (TBIL, DBIL, ALT, and AST) was also elevated in the SO group compared with the NG group. …”
Get full text

Nanoparticles assisted drug delivery for effective management of Glioblastoma by Mansi Damani, Nagesh Nilawar, Munira Momin, Raghumani Singh Ningthoujham, Tabassum Khan

“…Due to their size, surface modifications, and capability to encapsulate drugs, nanocarriers like polymeric, metallic, and lipid nanoparticles have shown potential in enhancing the penetration of anticancer agents across the BBB and BBTB, thus increasing treatment efficacy and minimizing general toxicity. Moreover, lipid-based nanoparticles, such as solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs), offer advantages in drug encapsulation, stability, and controlled release metal nanoparticles, including gold and silver nanoparticles, provide unique properties for imaging and photothermal therapy, potentially augmenting the efficacy of conventional treatments. …”
Get full text

Machine learning insights into early mortality risks for small cell lung cancer patients post-chemotherapy by Min Liang, Min Liang, Fuyuan Luo

“…However, the treatment is associated with significant risks, including heightened toxicity and early mortality. This study aimed to quantify the 90-day mortality rate post-chemotherapy in SCLC patients, identify associated features, and develop a predictive machine learning model.MethodsThis study utilized data from the Surveillance, Epidemiology, and End Results (SEER) database (2000–2018) to identify prognostic features influencing early mortality in SCLC patients. …”
Get full text

Curcumin as a potential inhibitor of TGFβ3 computational insights for breast cancer therapy by Ali G. Alkhathami, Mohammad Y. Alshahrani, Saad Ali Alshehri, Nazim Nasir, Shadma Wahab

“…The curcumin has low Molecular Weight 368.130 (MW) and follows Lipinski Rule, Pfizer Rule, GSK Rule, Golden Triangle, BMS Rule, zero PAINS alert and Acute Toxicity Rule with zero alert. Any drug-like contender must follow these qualities. …”
Get full text

Immunoinformatics Approach to Design a Chimeric CD70-Peptide Vaccine against Renal Cell Carcinoma by Haideh Namdari, Farhad Rezaei, Fatemeh Heidarnejad, Mohammad Yaghoubzad-Maleki, Maryam Karamigolbaghi

“…Computational assessments were performed on these chimeric vaccines for antigenicity, allergenicity, peptide toxicity, population coverage, and physicochemical properties. …”
Get full text

Ambient fine particulate matter provokes multiple modalities of cell death via perturbation of subcellular structures by Yán Wāng

“…The mechanisms of PM2.5 toxicity, encompassing oxidative stress, inflammatory responses, and metabolic imbalances, are described in detail. …”
Get full text

Integrated strategies for effective remediation of chromium-contaminated soils: Advancements, challenges, and sustainability implications by Yingying Xing, Yu Zheng, Xiukang Wang

“…Soil chromium contamination represents a significant global environmental challenge, posing serious risks to human health and ecosystems. The toxicity of hexavalent chromium, in particular, underscores the need for effective remediation strategies to mitigate its harmful effects. …”
Get full text

A review of Psoralea corylifolia L.: a valuable plant with profound biological significance by Anni Yang, Lingping Kong, Zhibo You, Xinyu Li, Jian Guan, Fengjin Li, Lingyun Zhong, Hai Jiang

“…In the future, it will be necessary to focus on the active metabolites of PCL, analyze its targets and signaling pathway network to address potential toxicity and side effects in clinical applications, and further expand the potential application of PCL in medicine.…”
Get full text

Mitigation PFHxA-induced neurotoxicity in Carassius auratus brain cells by selenium-enriched Bacillus subtilis via the BDNF/PI3K/AKT/GSK-3β pathway by Yu-ting Lu, Zheng-yao Guo, Lei Guo, Yu-hua He, Li-ming Liu, Xue Jiao, Yue-hong Li

“…Our previous studies have shown that selenium-rich Bacillus subtilis can not only alleviate the cause of brain damage by perfluorohexanoic acid (PFHxA) in Carassius auratus via the intestinal axis of the brain, but its metabolites can also alleviate PFHxA toxicity. This study further explores the potential mechanism through in vitro experiments. …”
Get full text

A randomized controlled trial: Effects of compression therapy combined with exercise on chemotherapy-induced peripheral neuropathy in patients with breast cancer by Yu Xiaoqian, Hu Jiwei, Zhou Lizhi, Guo Baojia, Guo Luyan, Xu Huiqian, Li Hong, Fan Yijing

“…The National Institute of Cancer Drug Toxicity Rating Scale and the Chemotherapy-Induced Peripheral Neuropathy Assessment Tool were assessed and compared between groups. …”
Get full text

N-acetylated sugars in clownfish and damselfish skin mucus as messengers involved in chemical recognition by anemone host by Sara Heim, Tony Teav, Fabio Cortesi, Hector Gallart-Ayala, Julijana Ivanisevic, Nicolas Salamin

“…Abstract The clownfish - sea anemone system is a great example of symbiotic mutualism where host «toxicity» does not impact its symbiont partner, although the underlying protection mechanism remains unclear. …”
Get full text

Antibacterial Activity of Rationally Designed Antimicrobial Peptides by Marius B. Tincho, Thureyah Morris, Mervin Meyer, Ashley Pretorius

“…The reasons may either be the antibiotic resistance towards the available therapeutic molecules or the slow rate of producing adequate therapeutic regimens to tackle the rapid growth of new infectious diseases, as well as the toxicity of current treatment regimens. Due to these reasons, there is a need to seek and develop novel therapeutic regimens to reduce the rapid scale of bacterial infections. …”
Get full text

Pesticides in Honeybee Products—Determination of Pesticides in Bee Pollen, Propolis, and Royal Jelly from Polish Apiary by Agata Swiatly-Blaszkiewicz, Agnieszka Klupczynska-Gabryszak, Eliza Matuszewska-Mach, Joanna Matysiak, Everaldo Attard, Dariusz Kowalczyk, Aleksandra Adamkiewicz, Bogumiła Kupcewicz, Jan Matysiak

“…It should be noted that any dose of pesticides can cause a health hazard due to toxicity, since these substances may act synergistically. …”
Get full text

Formulation Design and Cell Cytotoxicity of Curcumin-Loaded Liposomal Solid Gels for Anti-Hepatitis C Virus by Helmy Yusuf, Erlyn K. D. D. Novitasari, Ni L. W. Purnami, Adhe W. Mahbub, Retno Sari, Dwi Setyawan

“…These data confirmed that the developed liposomal solid gels were not cytotoxic to Huh7it cell line, indicating that the anti-HCV activity would be through a specific pathway and not by its toxicity. Conclusion. The CUR-loaded liposomal solid gels exhibited the potential and offered an alternative dosage form to improve the therapeutic efficacy of curcumin as an anti-HCV.…”
Get full text

Effect of platelet activating factor antagonist treatment on gentamicin nephrotoxicity by A. Rodriguez-Barbero, E. Bosque, L. Rivas-Cabaero, M. Arévalo, J. M. López-Novoa

“…The present results suggest a role for PAF in the gentamicininduced nephro-toxicity.…”
Get full text

<i>Epigynum auritum</i>-Derived Near-Infrared Carbon Dots for Bioimaging and Antimicrobial Applications by Wenfeng Shi, Jiahui Li, Junmei Pu, Guiguang Cheng, Yaping Liu, Shanshan Xiao, Jianxin Cao

“…The NIR-CDs exhibited minimal toxicity, excellent biocompatibility, and high penetrability in both in vivo and in vitro environments, making them ideal luminescent probes for bioimaging applications. …”
Get full text

Comparative Pharmacokinetic Profiles of Puerarin in Rat Plasma by UHPLC-MS/MS after Oral Administration of Pueraria lobata Extract and Pure Puerarin by Guozhe Zhang, Jianwei Ji, Mingzhong Sun, Yuqiao Ji, Hongjian Ji

“…Compared with puerarin, the Pueraria lobata extract (PLE) has better water solubility, lower toxicity, and less side effects. In this study, the pharmacokinetics of orally administered puerarin (100 mg/kg) and PLE (763 mg/kg, equivalent to 100.0 mg/kg of puerarin) to rats was investigated by the UHPLC-MS/MS method. …”
Get full text

Interspecific differences in the response of autotrophic microorganisms to atrazine and S-metolachlor exposure by Laura Malbezin, Nicolas Mazzella, Sébastien Boutry, Isabelle Lavoie, Soizic Morin

“…Indeed, atrazine seemed to explain the toxicity of the mixture for photosynthetic parameters, while certain lipid classes showed intermediate responses between compounds. …”
Get full text

Chinchorro culture: An analysis from the learning perspective by Liliana Pedraja-Rejas, Emilio Rodríguez-Ponce, Camila Muñoz-Fritis, Miguel-Ángel Garrido-Tamayo, Javier Vélez, David Laroze

“…Regarding the topics addressed, three main areas of study were found: 1) pathologies and toxicity, 2) life, society and cultural interactions, and 3) funerary traditions and mummification. …”
Get full text