Evaluation of the Acute Hepatoprotective Potential of Hydroethanolic Extract of Duranta erecta L. Parts by Shadrack Donkor, Christopher Larbie, Gustav Komlaga, Benjamin Obukowho Emikpe

“…The findings suggest that hydroethanolic Duranta erecta ripe fruits extract possesses hepatoprotective and antioxidative activities against CCl4- and acetaminophen-induced toxicity and could be developed as a potent agent for drug-induced liver diseases.…”
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Polyelectrolyte Complexation versus Ionotropic Gelation for Chitosan-Based Hydrogels with Carboxymethylcellulose, Carboxymethyl Starch, and Alginic Acid by Elizabeth Henao, Ezequiel Delgado, Héctor Contreras, Germán Quintana

“…Those materials are commercially available, have low toxicity, and are widely used in the area. These compounds interact through physical crosslinks, which are affected by physical changes of the medium. …”
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Transcriptome response in a marine copepod under multigenerational exposure to ocean warming and Ni at an environmentally realistic concentration by Yunlei Zhang, Shiru Lin, Yaolu Niu, Xiaoping Zhou, Qingxian Lin

“…Overall, this study indicates that both ocean warming and Ni pollution adversely affect the marine copepod T. japonicus from multigenerational transcriptome analysis, especially warming increased Ni toxicity to marine copepods, and our results also provide references to the mechanism concerning the effects of Ni and warming on marine copepods.…”
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Preparation and Optimization of 10-Hydroxycamptothecin Nanocolloidal Particles Using Antisolvent Method Combined with High Pressure Homogenization by Bolin Lian, Yong Li, Xiuhua Zhao, Yuangang Zu, Ying Wang, Yin Zhang, Yuanyuan Li

“…The aim of this study was to prepare 10-hydroxycamptothecin nanocolloidal particles (HCPTNPs) to increase the solubility of drugs, reduce the toxicity, improve the stability of the drug, and so forth. …”
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Evaluation of Toxicological Risks and Effects of Microplastics on Nile Tilapia (Oreochromisniloticus) under in Vitro Laboratory Conditions by Macarius Pancras Mtega, Matobola Joel Mihale, Kessy Fidel Kilulya

“…The objective of research was to determine the toxicity of microplastics to Nile tilapia (Oreochromis niloticus). …”
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Clove oil as a neuromodulator in environmental cadmium cognitive impairment on the prefrontal cortex of Wistar rats by Obinna O. Uchewa, Chinedu B. Egwuagu, Ogugua A. EGWU, Augustine O. Ibegbu

“…Conclusion: Clove oil alleviates cadmium toxicity by increasing antioxidant activity and improving cognition in rats.…”
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Comparative Study of <i>Phytolacca</i> Species Through Morphological, Chloroplast Genome, and Phylogenetic Analysis by Sumin Jeong, Yeseul Kim, Heewon Ji, Jun-Ho Song, Inkyu Park

“…However, because of their potent toxicity, it is essential to distinguish these species. …”
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Metabolomic profiling reveals systemic metabolic disruptions induced by combined exposure to particulate matter and ozone by Yue Ge, Maliha S. Nash, Aimen K. Farraj

“…In conclusion, this study provides new insights into the systemic metabolic effects of air pollutant exposure, identifies novel metabolic targets of pollutant-induced toxicity, highlights the complex interactions resulting from combined exposure to multiple pollutants, and underscores the importance of assessing the combined effects of multiple pollutants in air pollution risk assessments.…”
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Local control and recurrence patterns after stereotactic irradiation delivered in more than 4 fractions for hepatocellular carcinomas and liver metastases: a retrospective study by Alizée Renan, Marie Bruand, Maria Jolnerovski, Aboubacar Diallo, Nicolas Demogeot

“…Conclusion Despite dose reductions to spare OAR, SBRT showed satisfactory LC with low toxicity. Out-of-field recurrence remains the most common pattern identified and likely related to underlying disease. …”
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High antimony resistance strain Enterobacter sp. Z1 mediates biomineralization of antimony trioxide by Zijie Zhou, Hongbo Yu, Gejiao Wang, Mingshun Li, Kaixiang Shi

“…The increasing antimony (Sb) contamination prevalence poses a concern owing to its toxicity and potential carcinogenic properties. However, mechanisms underlying the microbial conversion of soluble Sb into insoluble Sb minerals remain unclear. …”
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Innovative approach to Pb (II) removal using zinc-based MOFs-derived carbon: In-depth analysis of adsorption mechanisms, isotherms, thermodynamics, and kinetics by Samira Ahmadzadeh, Alireza Hemmati

“…Water contamination by lead is a critical environmental problem due to its toxicity and persistence in industrial effluents. The removal of lead ions from aqueous solutions has become a significant concern for environmental and public health. …”
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Rutin Alleviates Zearalenone-Induced Endoplasmic Reticulum Stress and Mitochondrial Pathway Apoptosis in Porcine Endometrial Stromal Cells by Promoting the Expression of Nrf2 by Chuangjiang Chen, Chenlong Wang, Hui Jiang, Mengya Wang, Sajid Ur Rahman, Changjiang Chen, Hongyan Ding, Chang Zhao, Wanyue Huang, Xichun Wang

“…Zearalenone (ZEA) is a mycotoxin commonly found in moldy cereals and has a range of toxic effects that have seriously affected animal husbandry. …”
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PROTACs: Mechanism and Bioavailability enhancement strategies by nanotechnology, RNA viral infections (vaccine strategy) and Prodrug development by Sanaul Mustafa, Md Sabir Hussain Siddiquee

“…They improve the solubility and stability of PROTACs, allow for targeted delivery to the tumour site and minimize toxicity to healthy cells. Moreover, arguably the most interesting virtue of PROTACs is its applicability for RNA viral infections (new vaccine design) based on the degradation of viral proteins. …”
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Protective effects of gallic acid against nickel-induced kidney injury: impact of antioxidants and transcription factor on the incidence of nephrotoxicity by Areej I. Alhazmi, Mohamed F. El-Refaei, Eman A. A. Abdallah

“…Gallic acid has a protective role against kidney dysfunction and renal damage in Ni-nanoparticle toxicity.…”
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Impairment of Hepatic and Renal Functions by 2,5-Hexanedione Is Accompanied by Oxidative Stress in Rats by Isaac A. Adedara, Amos O. Abolaji, Blessing E. Odion, Isioma J. Okwudi, Abiola A. Omoloja, Ebenezer O. Farombi

“…2,5-Hexanedione (2,5-HD) is the toxic metabolite of n-hexane which is widely used as solvent in numerous industries. …”
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Inflammatory disease progression shapes nanoparticle biomolecular corona-mediated immune activation profiles by Jacob R. Shaw, Nicholas Caprio, Nhu Truong, Mehari Weldemariam, Anh Tran, Nageswara Pilli, Swarnima Pandey, Jace W. Jones, Maureen A. Kane, Ryan M. Pearson

“…Our findings illuminate the personalized nature of corona formation under a dynamic inflammatory condition and its impact on NP-mediated immune activation profiles and inflammation, suggesting that disease progression-related alterations in plasma composition can manifest in the corona to cause unintended toxicity and altered therapeutic efficacy.…”
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Novel yeast Pichia kudriavzevii alleviates aflatoxins induced toxicopathology in broiler chickens through immunomodulation and antioxidant enhancement by Ashiq Ali, Aisha Khatoon, Muhammad Kashif Saleemi, Rao Zahid Abbas, Bilal Murtaza, Kaynaat Akbar, Qaisar Tanveer, Sami Ullah Khan Bahadur, Hissah Abdulrahman Alodaini, Mai Ahmad Alghamdi

“…The study highlights Pichia kudriavzevii as a promising agent for mitigating aflatoxin-induced toxicity in broiler chicks by improving antioxidant and immunomodulatory status, normalizing biomarkers, and reversing pathological alterations through multifaceted protective mechanisms.…”
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mTOR Inhibitor Everolimus Modulates Tumor Growth in Small-Cell Carcinoma of the Ovary, Hypercalcemic Type and Augments the Drug Sensitivity of Cancer Cells to Cisplatin by Kewei Zheng, Yi Gao, Jing Xu, Mingyi Kang, Ranran Chai, Guanqin Jin, Yu Kang

“…When combined with cisplatin, everolimus notably enhances the therapeutic efficacy without increasing the toxicity typically associated with platinum-based drugs. …”
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Comparison of clinico-pathological characteristics and survival of recurrent ovarian cancer patients on seven different chemo-protocols by Sattar Saima, Ahmad Mobasher, Saeed Hamid, Saleem Zikria, Danish Zeeshan, Akhlaq Muhammad

“…These data suggest that CP regimen exhibited improved clinical efficacy and decreased toxicity related non-compliance in recurrent ovarian cancer patients of Lahore.…”
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Modeling the endocrine control of vitellogenin production in female rainbow trout by Kaitlin Sundling, Gheorghe Craciun, Irvin Schultz, Sharon Hook, James Nagler, Tim Cavileer, Joseph Verducci, Yushi Liu, Jonghan Kim, William Hayton

“…We anticipate that these mathematical and computational models will play an important role in future regulatory toxicity assessments and in the prediction of ecological risk.…”
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