A Computational Study on Selected Alkaloids as SARS-CoV-2 Inhibitors: PASS Prediction, Molecular Docking, ADMET Analysis, DFT, and Molecular Dynamics Simulations by Md. Golam Mortuza, Md Abul Hasan Roni, Ajoy Kumer, Suvro Biswas, Md. Abu Saleh, Shirmin Islam, Samia Sadaf, Fahmida Akther

“…Furthermore, assessments of molecular electrostatic potential surface (MEPS), density functional theory (DFT), and absorption, distribution, metabolism, excretion, and toxicity (ADMET) were performed, and a few of them appeared to have potential as candidates for oral administration. …”
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The Molecular Effects of SGLT2i Empagliflozin on the Autophagy Pathway in Diabetes Mellitus Type 2 and Its Complications by Ranin Saad, Hagar Tadmor, Offir Ertracht, Nakhoul Nakhoul, Farid Nakhoul, Farber Evgeny, Shaul Atar

“…Type 2 diabetes mellitus (T2DM), especially hyperglycemia, is associated with increased glucose cell toxicity and oxidative stress that can lead to irreversible damage in the kidney such as diabetic nephropathy (DN). …”
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Isolation, identification and optimization of fermentation conditions against Sclerotinia sclerotiorum strains in high salt Doenjang by Xian Zhang, Hongmei Li, Xiaoyu Kang, Seongil Lim, Fanzhu Li

“…In this study, in order to develop a bio-inhibitory agent with antibacterial effect and no toxicity and no residue, three strains with high inhibition rate against Sclerotinia sclerotiorum were screened from 69 samples of Doenjang collected in different regions. …”
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Influence of soil type on bacterial growth and tolerance to experimentally added human antibiotics by Laura Rodríguez-González, Montserrat Díaz-Raviña, Beatriz Sevilla-Morán, Elena García-Campos, Juan José Villaverde, Manuel Arias-Estévez, David Fernández-Calviño, Vanesa Santás-Miguel

“…The lack of studies on CXM and AZI in soils hinders our understanding of their potential toxic effects on soil bacterial communities and ecosystem services. …”
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<i>Tribulus terrestris</i> Fruit Extract: Bioactive Compounds, ADMET Analysis, and Molecular Docking with Penicillin-Binding Protein 2a Transpeptidase of Methicillin-Resistant <i>S... by Khalid J. Alzahrani

“…Among seventeen compounds, eight have favorable pharmacokinetics and medicinal chemistry; however, on the basis of in silico high water solubility, high GI absorption, blood–brain barrier non-permeability, lack of toxicity, and potential drug-likeness, 1-ethylsulfanylmethyl-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecane and phthalimide, N-(1-hydroxy-2-propyl), were processed for molecular docking. 1-ethylsulfanylmethyl-2,8,9-trioxa-5-aza-1-sila-bicyclo[3.3.3]undecane formed three hydrogen bonds with Ser-452, Thr-584, and Asn-454 residues of the PBP2a transpeptidase. …”
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Salt stress and its eco-friendly management using biostimulants in grain legumes: a review by Narayan Singh, Vasudha Maurya, Kriti Gupta, Indu Sharma, Ashutosh Sharma, Rahul Kumar

“…Biostimulants successfully alleviate salt stress-induced toxicities in legumes, when introduced either alone or in combination with other macro- or microorganisms in the soil. …”
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Nanoemulsion and Encapsulation Strategy of Hydrophobic Oregano Essential Oil Increased Human Prostate Cancer Cell Death via Apoptosis by Attenuating Lipid Metabolism by Haribalan Perumalsamy, Rajeshkumar Shanmugam, Jun-Ran Kim, Gokulanathan Anandapadmanaban, Md. Amdadul Huq, Kamal Dua, Dinesh Kumar Chellappan, Tae Hyun Yoon, Sri Renukadevi Balusamy

“…At first, we have synthesized OENE and characterized using various spectroscopic analyses. The toxicity and inhibitory concentration (IC50) of OENE toward prostate cancer by MTT analysis were performed. …”
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Assessing carbon emissions of facility agriculture involving photovoltaic greenhouses – insights from table grapes cultivation by Yichun Li, Shuyue Li, Yaru Luo, Xuecai Wang, Hengcheng Zhang, Yuquan W. Zhang, Shiren Song

“…Moreover, improved greenhouse utilizing photovoltaic power (1.26 × 103kgCO2-eq/mu-year) exhibits higher carbon emissions, however with lower levels of environmental toxicity due to utilizing grapevines for organic fertilizers. …”
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Evaluating the Impact of Commonly Used Pesticides on Honeybees (Apis mellifera) in North Gonder of Amhara Region, Ethiopia by Zewdie Abay, Amssalu Bezabeh, Alemayehu Gela, Asaminew Tassew

“…On the other hand, agro-2, 4-D and its mixture with glycel 41% EC are moderately toxic, and mancozeb 80% WP and glycel 41% EC were slightly toxic to honeybees as compared to the positive control (dimethoate 40% EC). …”
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A Comprehensive Review of Niobium Nanoparticles: Synthesis, Characterization, Applications in Health Sciences, and Future Challenges by Muhammad Usman Khalid, Austeja Rudokaite, Alessandro Marcio Hakme da Silva, Monika Kirsnyte-Snioke, Arunas Stirke, Wanessa C. M. A. Melo

“…Their accumulation in tissues can lead to risks such as chronic inflammation or toxicity, emphasizing the importance of designing nanoparticles with controlled clearance and biodegradability. …”
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Biochemical Constituents of Phaleria macrocarpa (Leaf) Methanolic Extract Inhibit ROS Production in SH-SY5Y Cells Model by Ibrahim Maina Hassan, Wan Norhamidah Wan Ibrahim, Ferdaus Binti Mohamat Yusuf, Siti Aqlima Ahmad, Syahida Ahmad

“…High antioxidant activities and low toxicity effect of this crude revealed its high benefit to be used as natural medicine/supplements.…”
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Bactericide, Immunomodulating, and Wound Healing Properties of Transgenic Kalanchoe pinnata Synergize with Antimicrobial Peptide Cecropin P1 In Vivo by A. A. Lebedeva, N. S. Zakharchenko, E. V. Trubnikova, O. A. Medvedeva, T. V. Kuznetsova, G. A. Masgutova, M. V. Zylkova, Y. I. Buryanov, A. S. Belous

“…K. pinnata extracts (both wild-type and transgenic) did not exhibit general toxicity and accelerated wound recovery. Due to immunomodulating activity, wild-type K. pinnata extract accelerated granulation of the wound bed and marginal epithelialization even better than K. pinnata + CecP1 extract. …”
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Sawdust as an ameliorant to decontaminate Arsenic in potato soils by Md. Hossain, Tuhin Roy, Maruf Mostofa

“…To produce Potato under Arsenic contaminated soil, an experiment was conducted to find out the effect of sawdust as an adsorbent to decontaminate Arsenic toxicity in soil. Method The research was conducted in pot experiment. …”
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Gold nanorod-based engineered nanogels for cascade-amplifying photothermo-enzymatic synergistic therapy by Ling Ding, Xiaoshan Wang, Qing Wu, Xia Wang, Qigang Wang

“…Among these, cooperative physical and biochemical activation strategies have attracted increasing attention because of their spatiotemporal controllability, low toxicity, and high therapeutic efficacy. Herein, we demonstrate a nanogel complex as a multilevel ROS-producing system by integrating chloroperoxidase (CPO) into gold nanorod (AuNR)-based nanogels (ANGs) for cascade-amplifying photothermal-enzymatic synergistic tumor therapy. …”
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Changes in wheat protein digestibility and allergenicity: Role of Pediococcus acidilactici XZ31 and yeast during dough fermentation by Wenhui Fu, Chen Chen, Chenglong Liu, Sha Tao, Wentong Xue

“…These results gives valuable insight into the effects of P. acidilactici XZ31 fermentation on the allergenicity and toxicity of wheat proteins, which contribute to promoting the application of multi-strain leavening agent in hypoallergenic and gluten-free wheat products.…”
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Targeted Photodynamic Therapy: A Novel Approach to Abolition of Human Cancer Stem Cells by Anine Crous, Elvin Chizenga, Natasha Hodgkinson, Heidi Abrahamse

“…Photodynamic therapy (PDT) is a clinically approved, minimally invasive, therapeutic procedure that can exert a selective cytotoxic activity toward cancerous cells while reducing toxicity to normal cells. It uses a photosensitizer (PS) that becomes excited when subjected to light at a specific wavelength, and the PS forms reactive oxygen species (ROS) killing malignant cells. …”
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Pharmacophore-based approach for the identification of prospective UDP-2,3-diacylglucosamine hydrolase (LpxH) inhibitor from natural product database against Salmonella Typhi by Divyapriya Karthikeyan, Sanjit Kumar, NS Jayaprakash

“…Both compounds underwent toxicity prediction and ADMET analysis, showing favorable drug-like properties, with compound 1615 emerging as the most promising inhibitor due to its optimal electronic energy and minimal chemical potential. …”
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Advancements in Liposomal Nanomedicines: Innovative Formulations, Therapeutic Applications, and Future Directions in Precision Medicine by Izadiyan Z, Misran M, Kalantari K, Webster TJ, Kia P, Basrowi NA, Rasouli E, Shameli K

“…The recent COVID-19 pandemic has accelerated research in liposomal-based vaccines and antiviral therapies, underscoring the need for improved delivery mechanisms to overcome challenges like rapid clearance and organ toxicity. Furthermore, we discuss the potential of “smart” liposomes, which can respond to specific disease microenvironments, enhancing treatment efficacy and precision. …”
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Chitooligosaccharides suppress airway inflammation, fibrosis, and mucus hypersecretion in a house dust mite-induced allergy model by Yun-Ho Kim, Chan-Ho Park, Ju Myung Kim, Yeo Cho Yoon

“…Chitooligosaccharides (COS) are known for their antioxidant and anti-inflammatory properties.MethodsHuman airway epithelial cells (BEAS-2B) were cultured in DMEM/F12 medium containing COS at concentrations of 25–100 µg/ml for 24 h. No intracellular toxicity was observed up to 1,000 µg/ml. Cell experiments were conducted at COS concentrations below 100 µg/ml, while animal experiments were performed at concentrations below 100 mg/kg body weight for 4 weeks. …”
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Lobar Hepatocellular Carcinoma with Ipsilateral Portal Vein Tumor Thrombosis Treated with Yttrium-90 Glass Microsphere Radioembolization: Preliminary Results by M. Pracht, J. Edeline, L. Lenoir, M. Latournerie, H. Mesbah, O. Audrain, Y. Rolland, B. Clément, J. L. Raoul, E. Garin, E. Boucher

“…Patients were evaluated every 3 to 6 months for response, survival, and toxicity. Mean follow-up was 13.0 months (2.2–50.6). …”
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