siRNA therapeutics for effective management of rheumatoid arthritis by Vishakha R. Chakole, Tathagata Dutta, Priyankar Sen

“…All these disadvantages engender the need for new therapy. siRNA delivery carriers like liposomes, polymeric nanoparticles, and siRNA polymer bio-conjugates are proving to be particularly effective with less toxicity compared to the traditional treatments. A promising addition to these carriers is wrapsome (WS), which can be used as a favorable carrier for delivery of siRNA to its specific sites, such as inflamed joints or the inflamed synovium. …”
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A comprehensive in silico analysis of structural and functional impacts of natural nonsynonymous SNPs in the ALDH2_HUMAN gene by Mehr Ali Mahmood Janlou

“…Acetaldehyde exhibits a toxic effect, highlighting the necessity of ALDH2’s proper functioning to protect against diseases associated with aldehyde toxicity. …”
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Effect of 3-hydrazinylquinoxaline-2-thiol hydrogel on skin wound healing process in diabetic rats by Jehan Barakat Alamre, Huda Alkreathy, Ahmed S. Ali, Abdelbagi Alfadil, Sahar S. Alghamdi

“…In silico study indicated a favorable drug-like properties and toxicity profile. The present work showed that 3-hydrazinylquinoxaline-2-thiol holds great potential for the treatment of diabetic wounds.…”
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Protective Effects of Garlic and Cinnamon Oils on Hepatocellular Carcinoma in Albino Rats by Salah M. Aly, Hamdy A. Fetaih, Abeer A. I. Hassanin, Mosleh M. Abomughaid, Aliaa A. Ismail

“…The present findings proposed that these natural oils have the ability to improve liver function, significantly reduced the liver toxicity and HCC development. However, further sophisticated studies are recommended before their use as conventional therapeutics for HCC treatment.…”
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Sensitive and Simultaneous Determination of Hydroquinone and Catechol in Water Using an Anodized Glassy Carbon Electrode with Polymerized 2-(Phenylazo) Chromotropic Acid by Miao Zhang, Chuang-ye Ge, Ya-feng Jin, Liang-bin Hu, Hai-zhen Mo, Xiao-bo Li, Hao Zhang

“…Hydroquinone (HQ) and catechol (CT) are considered as environmental pollutants with high toxicity. We have developed a simple electrochemical sensor using an anodized glassy carbon electrode modified with a stable 2-(phenylazo) chromotropic acid- (CH-) conducting polymer (PCH/AGCE). …”
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Evaluation of the optical, structural, morphological and electronic properties of Rb3Bi2I9 Perovskites films prepared by Sequential Evaporation by G. Gordillo, O.G. Torres, C.A. Celis, M. Reinoso, J I Clavijo

“…Toxicity and poor stability remain major barriers to large-scale production of hybrid organic-inorganic lead halide perovskite solar cells. …”
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Lipid Horizons: Recent Advances and Future Prospects in LBDDS for Oral Administration of Antihypertensive Agents by null Preeti, Sharda Sambhakar, Rohit Malik, Saurabh Bhatia, Ahmed Al Harrasi, Renu Saharan, Geeta Aggarwal, Suresh Kumar, Renu Sehrawat, Chanchal Rani

“…The future of hypertension management using LBDDS is promising, with ongoing reviews focusing on precision medicine approaches, improved biocompatibility, and reduced toxicity. As we delve deeper into understanding the intricate mechanisms underlying hypertension, LBDDS offers a pathway to develop next-generation antihypertensive therapies that are safer, more effective, and tailored to individual patient needs.…”
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Polystyrene nanoplastics promote the blood-brain barrier dysfunction through autophagy pathway and excessive erythrophagocytosis by Eun-Hye Kim, Seung Mi Baek, Han Jin Park, Yiying Bian, Han Young Chung, Ok-Nam Bae

“…Our study will help to understand the cardiovascular toxicity of nano-sized plastics.…”
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Combustion Behaviour of ADN-Based Green Solid Propellant with Metal Additives: A Comprehensive Review and Discussion by Rushikesh Kore, Ashish Vashishtha

“…Ammonium dinitramide (ADN) has gained considerable attention as a potential oxidizer for green solid propellants due to its high oxygen content, significant energy density, non-toxicity, and non-polluting combustion products, leading to lower environmental impact. …”
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Cystatin C-Based Equations Detect Hidden Kidney Disease and Poor Prognosis in Newly Diagnosed Patients with Multiple Myeloma by Francisco-Javier Cepeda-Piorno, Esther González-García, Alba Méndez-Gallego, Juan Torres-Varona, Vanesa García-Moreira, Christian Sordo-Bahamonde, Cristina AlberdiGarcía-del-Castillo, Elene Astobieta-Madariaga, Maria-Victoria Mateos-Manteca, Segundo González-Rodríguez

“…The IMWG criteria may underestimate kidney disease, mostly in women, which could affect the dose received as well as its toxicity. Altogether, our data suggest that equations that include CysC are more accurate to detect hidden kidney disease, as well as patients with more and worse prognostic factors, in newly diagnosed MM.…”
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Experimental Research on Mechanical Property and Environmental Safety of an Industrial Residue Waste Subgrade Material by Yangpeng Zhang, Jianping Xiong, Qinglin Li, Jiuhui Cui

“…Furthermore, the chemical stability and toxicity of SOF leachates are environmentally friendly, which are in line with the benchmarks of Class II surface water and Class III ground water. …”
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MoS₂–Plasmonic Hybrid Platforms: Next-Generation Tools for Biological Applications by Nayra A. M. Moussa, Seungah Lee, Seong Ho Kang

“…Despite the promising advancements of MoS₂–plasmonic hybrids, translating these platforms into clinical practice requires overcoming considerable challenges, such as synthesis reproducibility, toxicity, stability in physiological conditions, targeted delivery, and scalable manufacturing. …”
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Increased miRNA-375 causes oxidative damage but promotes apoptosis resistance and cell migration in the clam Ruditapes philippinarum by Ming Cong, Zhaoshun Li, Wenwen Tian, Yixian Yu, Yu Che, Jiasen Lv

“…Results showed that increased expression of miRNA-375 interfered with the expression levels of both its target genes and ammonia toxicity-related genes, which would probably lead to oxidative stress, migration of damaged cells, apoptosis resistance, and increased possibility of tumor formation. …”
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Metabolic and Genetic Determinants of Lipid Metabolism Disruption in Non-Alcoholic Fatty Liver Disease by O. Yu. Kytikova, T. P. Novgorodtseva, Yu. K. Denisenko, D. A. Kovalevsky

“…The progression of NAFLD is associated with the powerful toxicity of lipids released in the liver parenchyma upon the loss of the cell biomembrane integrity.Conclusions. …”
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Biochemical Behaviours of Salmeterol/Fluticasone Propionate in Treating Asthma and Chronic Obstructive Pulmonary Diseases (COPD) by Hilla Mills, Ronald Acquah, Nova Tang, Luke Cheung, Susanne Klenk, Ronald Glassen, Magali Pirson, Alain Albert, Duong Trinh Hoang, Thang Nguyen Van

“…This work focuses on salmeterol/fluticasone propionate combination and aspects which has to do with administration, monitoring, metabolism, toxicity, and adverse effects.…”
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Speciation of heavy metals in coastal water of Qeshm Island in the Persian Gulf by A.R. Karbassi, S. Tajziehchi, H. Khoshgalb

“…Since all the studied elements were within the water stability range, they were stable, and there were no environmental risks of contamination and toxicity. The results of cluster analysis did not show any relation between Eh and pH. …”
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Chitosan and its derivatives as promising plant protection tools by A. B. Shcherban

“…However, traditional, chemical PPPs, despite their effectiveness, have significant drawbacks, namely, pollution of environment, ecological damage, toxicity to humans. Recently, biological PPPs based on natural compounds have attracted more attention, since they do not have these disadvantages, but at the same time they can be no less effective. …”
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A review of leishmaniasis: current knowledge and future directions of heterocyclic molecules by Tejaswini Masne, Dileep Kumar, Deepali Bansode

“…Furthermore, it discusses ongoing research efforts aimed at developing novel drug formulations, such as liposomal and nano-carrier-based delivery systems, to enhance drug efficacy and reduce toxicity. This article crucially focuses on future perspectives in heterocyclic drug therapies for leishmanial diseases. …”
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Vaccines for cancer interception in familial adenomatous polyposis by David E. Johnson, Mary L. Disis

“…Immunologic memory will allow the immune response to persist and the specificity of the immune response will limit toxicity to the targeted polyp. This review will examine the current state of vaccines directed against FAP lesions and highlight the challenges and opportunities of translating vaccines for cancer interception in FAP to the clinic.…”
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The Multiple Effects of Precursors on the Properties of Polymeric Carbon Nitride by Wendong Zhang, Qin Zhang, Fan Dong, Zaiwang Zhao

“…Considering the cost, toxicity, and yield of the precursors and the properties of g-C3N4, the best precursor for preparation of g-C3N4 was melamine. …”
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