Safety Profile and Effects of Pulsed Methylprednisolone on Vital Signs in Thyroid Eye Disease by Kai-Ling Yong, Chiaw Ling Chng, Hla Myint Htoon, Lee Hooi Lim, Lay Leng Seah

“…No significant cardiovascular or hepatic toxicity was found. Conclusion. IVMP is relatively safe and efficacious. …”
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Lithium as an Alternative Option in Graves Thyrotoxicosis by Ishita Prakash, Eric Sixtus Nylen, Sabyasachi Sen

“…There were no signs of lithium toxicity within this time period. Conclusion. Lithium has a unique physiologic profile and can be used to treat thyrotoxicosis when thionamides cannot be used while awaiting elective radioablation. …”
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Interesting Cytokine Profile Caused by Clinical Strains of Pseudomonas aeruginosa MDR Carrying the exoU Gene by Nallely S. Badillo-Larios, Edgar Alejandro Turrubiartes-Martínez, Esther Layseca-Espinosa, Roberto González-Amaro, Luis Fernando Pérez-González, Perla Niño-Moreno

“…In addition, PBMC exposed to strains of four different categories according to their resistance and toxicity showed a differential pattern of cytokine expression, a decrease in IL-10, IL-6, and IL-8, and an over-secretion of IL-1b. …”
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Novel cisplatin-magnetoliposome complex shows enhanced antitumor activity via Hyperthermia by M. Carmen Jiménez-López, Ana Carolina Moreno-Maldonado, Natividad Martín-Morales, Francisco O’Valle, M. Ricardo Ibarra, Gerardo F. Goya, Ignacio J. Molina

“…The ML has no significant toxicity both in vitro and in vivo and, most importantly, enhances cell death by apoptosis after magnetic hyperthermia. …”
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Enhanced electrochemical performance of activated carbon derived from Acacia catechu bark by KOH activation for supercapacitor application by Mishra Pawan Kumar, Aryal Sabin, Bhakta Oli Hari, Shrestha Timila, Sapkota Thakur, Shrestha Ram Lal Swagat, Prasad Bhattarai Deval

“…Conversely, activated carbon sourced from biomass has emerged as a promising substitute due to its abundant presence in nature, high carbon content, and ease of processing with minimal toxicity. This study outlines the production of activated carbon from the matured bark of Acacia catechu through a sequence of processes, including pre-carbonization, carbonization, and activation at varying temperatures utilizing potassium hydroxide (KOH) as an activating agent. …”
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Major Outer Membrane Protein from Legionella pneumophila Inhibits Phagocytosis but Enhances Chemotaxis of RAW 264.7 Macrophages by Regulating the FOXO1/Coronin-1 Axis by Zehui Yang, Yingying Chen, Qiang Zhang, Xiaodong Chen, Ze Deng

“…The chemotactic activity, toxicity, and phagocytosis of RAW 264.7 cocultured with different concentrations of MOMP were determined by Transwell, CCK-8, and neutral red uptake assays, respectively. …”
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Optimization of Conditions for Production of Soluble <i>E. coli</i> Poly(A)-Polymerase for Biotechnological Applications by Igor P. Oscorbin, Maria S. Kunova, Maxim L. Filipenko

“…However, <i>E. coli</i> PAP 1’s toxicity and instability in low-salt buffers complicate its expression and purification. …”
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Spectroscopic, DFT, anti-bacterial, and in-silico investigations of novel semicarbazone and thiosemicarbazone synthesised from asymmetrical chalcones by Nikita Sharma, Har Lal Singh

“…Later, computational tools were utilised for evaluating pharmacological attributes such as bioavailability score, Lipinski rule, absorption, distribution, metabolism, excretion and toxicity. Also, density functional theory (DFT) was used to compute quantum computations such as HOMO, LUMO, and chemical descriptors. …”
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Sirolimus Enhances Cyclosporine A-Induced Cytotoxicity in Human Renal Glomerular Mesangial Cells by Séin O'Connell, Craig Slattery, Michael P. Ryan, Tara McMorrow

“…CsA treatment increased profibrotic TGF-β1 secretion in human mesangial cells whereas SRL did not, indicating a role for TGF-β in CsA toxicity. However we observed a synergistic nephrotoxic effect when CsA and SRL were co-administered. …”
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Advancing Neuroscience and Therapy: Insights into Genetic and Non-Genetic Neuromodulation Approaches by Weijia Zhi, Ying Li, Lifeng Wang, Xiangjun Hu

“…The transformative potential of these neuromodulation techniques in neuroscience research and clinical practice is underscored, emphasizing the need for integration and innovation in technologies, the optimization of delivery methods, the improvement of mediums, and the evaluation of toxicity to fully harness their therapeutic potential.…”
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Giant triple negative pregnancy-associated breast cancer (PABC) in a young woman: From diagnosis to therapy step by step: A case report by Micol Bottalico, Cristiana Boldrini

“…Imaging techniques such as ultrasonography (and mammography as an adjunct) and nonenhanced MRI (due to potential toxicity of gadolinium to the fetus) can be used for staging maternal breast disease during pregnancy. …”
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Evaluation of aluminum tolerance diversity in <i>Avena sativa</i> L. from the VIR collection by I. G. Loskutov, E. V. Blinova, L. Yu. Novikova

“…Despite the crop’s high environmental plasticity, an important condition for obtaining sustainable oat yields is the development of new cultivars with resistance to adverse environmental factors, including metal toxicity and high soil acidity.The objective of this work was to search for oat cultivars resistant to soil stressors (excess of Н+ and Al3+) for use in breeding for edaphic resistance.Materials and methods. …”
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Targeting BCMA in multiple myeloma: designs, challenges, and future directions by Yi Hu, Yuetao Xie, Xiaodong Wang, Lufeng Yang, He Geng, Zugang Yi, Yao Zhang, Lin Ma, Fang Chen

“…It critically addresses emerging challenges such as antigen escape and toxicity profiles, which have surfaced alongside therapeutic advances. …”
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Safety of oil from Schizochytrium limacinum (strain ATCC‐20889) for use in infant and follow‐on formula as a novel food pursuant to Regulation (EU) 2015/2283 by EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Helle Katrine Knutsen, Monika Neuhäuser‐Berthold, Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Alexandros Siskos, Henk vanLoveren, Irene Nuin Garciarena, Emanuela Turla, Harry J. McArdle

“…., the QPS status of the source of the NF, the production process, the composition of the NF, the absence of marine biotoxins and viable cells in the NF, the Panel considers that there are no concerns with regard to the toxicity of the NF. The Panel concludes that the NF is safe under the proposed conditions of use.…”
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Muscle Relaxant and Sedative-Hypnotic Activities of Extract of Viola betonicifolia in Animal Models Supported by Its Isolated Compound, 4-Hydroxy Coumarin by Naveed Muhammad, Mohammad Saeed, Haroon Khan, Achyut Adhikari, Khalid Mohammed Khan

“…The whole plant of V. betonicifolia led to the isolation of 4-hydroxyl coumarin (4HC) which showed substantial safety profile in acute toxicity test. When challenged in Traction and Chimney tests, it showed significant (P<0.05) muscle relaxant effect in both muscle relaxant paradigms at 20 and 30 mg/kg during various assessment times. …”
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Severe Diltiazem Poisoning Treated with Hyperinsulinaemia-Euglycaemia and Lipid Emulsion by Nadine Monteiro, Joana Silvestre, João Gonçalves-Pereira, Camila Tapadinhas, Vitor Mendes, Pedro Póvoa

“…CCB poisoning is associated with significant cardiovascular toxicity and is potentially fatal. Currently, there is no specific antidote and the treatment of CCB poisoning is supportive; however, this supportive therapy is often insufficient. …”
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Staphylococcal SSL5 Binding to Human Leukemia Cells Inhibits Cell Adhesion to Endothelial Cells and Platelets by Annemiek M. E. Walenkamp, Jovanka Bestebroer, Ingrid G. J. Boer, Roeline Kruizinga, Henk M. Verheul, Jos A. G. van Strijp, Carla J. C. de Haas

“…Binding of SSL5 was rapid and without observed toxicity. Competition of SSL5 with the binding of three anti-PSGL-1 antibodies and P-selectin to HL-60 cells identified PSGL-1 as the ligand on HL-60 cells. …”
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A novel two-component system contributing the catabolism of c-di-GMP influences virulence in Aeromonas veronii by Chaolun Liu, Jia Shao, Xiang Ma, Yanqiong Tang, Juanjuan Li, Hong Li, Xue Chi, Zhu Liu

“…In a murine model, ΔarrS exhibited increased pathogenicity, leading to elevated TNF-α and IFN-γ levels in serum, and severer toxicity to spleen and kidney. These effects might be elucidated by the upregulated inflammation-associated proteins in ΔarrS. …”
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Nanoliposomal Coencapsulation of Dorema aucheri Extract and Curcumin; Enhanced Cytotoxicity, Apoptosis Induction, and Inhibition of EGFR Gene Expression in Oral Cancer Cells OCC-02 by Mahshid Azizi, Ghasem Ghalamfarsa, Fatemeh Khosravani, Hassan Bardania, Shahriar Azizi

“…Free curcumin, the extract, and the curcumin-extract combination showed dose-dependent toxicity against cancer cells; yet, the extract (IC50: 86 µg/ml) and curcumin-extract (IC50: 65 µg/ml) activities were much more than curcumin (IC50: 121 µg/ml). …”
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Hypolipidemic Effect of Chloroform Extract of Lagenaria siceraria: Potential Inhibitory Activity of Phytochemicals Targeting the HMG-CoA Reductase Revealed by Molecular Docking and... by Qudsia Kanwal, Mahmood Ahmed, Atiq Ur-Rehman, Aneela Anwar, Samiah Shahid, Atif Shahzad, Attaullah Shah Bukhari, Muhammad Ahmad, Numan Yousaf, Muhammad Muddassar

“…The experimental animals did not display any acute toxicity. Atorvastatin (10 mg/kg bw) was used as a standard drug. …”
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