Melatonin in Hypoxic-Ischemic Brain Injury in Term and Preterm Babies by Justyna Paprocka, Marek Kijonka, Beata Rzepka, Maria Sokół

“…Melatonin efficacy, low toxicity, and ability to readily cross through the blood-brain barrier make it a promising molecule. …”
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Polymer and nanocomposite fillers as advanced materials in biomedical applications by Angeline Julius, Suresh Malakondaiah, Raghu Babu Pothireddy

“…Furthermore, the clinical translation of these materials is limited by gaps in toxicity assessment, biodegradation evaluation, and comprehensive in vivo studies. …”
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Belatacept and regulatory T cells in transplantation: synergistic strategies for immune tolerance and graft survival by Gil-Ran Kim, Kyung-Ho Nam, Je-Min Choi

“…Belatacept, a modified version of cytotoxic T lymphocyte antigen-4 immunoglobulin with increased binding affinity for its ligand, has emerged as a viable alternative to traditional CNIs due to its lower toxicity profile. Despite these benefits, belatacept is associated with a higher rate of acute rejection, which presents a challenge for long-term graft survival. …”
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HPRNA: Predicting synergistic drug combinations for angina pectoris based on human pathway relationship network algorithm. by Mengyao Zhou, Mengfan Xu, Xiangling Zhang, Xiaochun Xing, Yang Li, Guanghui Wang, Guiying Yan

“…Over the years, synergistic drug combinations therapies have attracted widespread attention due to its advantages of overcoming drug resistance, increasing treatment efficacy and decreasing toxicity. Compared to lengthy medical drugs experimental screening, mathematical models and algorithms show great potential in synergistic drug combinations prediction. …”
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Engineering a bacterial toxin deaminase from the DYW-family into a novel cytosine base editor for plants and mammalian cells by Dingbo Zhang, Fiona Parth, Laura Matos da Silva, Teng-Cheong Ha, Axel Schambach, Jens Boch

“…A G103S mutation in SsdA enhances C-to-T editing efficiency while reducing its toxicity. Truncations result in an extraordinarily small enzyme. …”
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Sulfurous Gases As Biological Messengers and Toxins: Comparative Genetics of Their Metabolism in Model Organisms by Neal D. Mathew, David I. Schlipalius, Paul R. Ebert

“…As gases with potent biological activities, they are toxic as air pollutants, and the sulfurous compounds are used as fumigants. …”
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Anticancer effects of olive oil polyphenols and their combinations with anticancer drugs by Torić Jelena, Marković Ana Karković, Brala Cvijeta Jakobušić, Barbarić Monika

“…The biggest issue concerning the chemotherapeutics is their toxicity on normal cells and persisting side effects. …”
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The Role of Cytokines in Nephrotic Syndrome by Elham Ahmadian, Yalda Rahbar Saadat, Elaheh Dalir Abdolahinia, Milad Bastami, Mohammadali M. Shoja, Sepideh Zununi Vahed, Mohammadreza Ardalan

“…Thus, the introduction of distinctive cytokines as novel biomarkers of SRNS enables both preventions of drug-related toxicity and earlier switch to more effective therapies. …”
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Anti-Retroviral Strategies for AIDS and Related Diseases by Mark A Wainberg, Andre Dascal, Jack Mendelson

“…Although AZT therapy has been reasonably successful, it has not been free from toxicity. In addition, there have been several reports of isolation of AZT-resistant variants of HIV-1.…”
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Harnessing nanotechnology for enhanced epilepsy management by V. Manasa, J. Joysa Ruby, Himadri Priya Gogoi, S. Vignesh, P. H. Anjaneya, Akhil

“…Nanocarrier systems—such as nanoparticles, micelles, and liposomes—enhance drug specificity for brain delivery, improving the therapeutic efficacy and reducing off-target toxicity. New developments in nanocarrier systems for AEDs, including phenytoin, phenobarbital, carbamazepine, and valproate, demonstrate increased brain penetration, solubility, and controlled drug release, offering promising benefits in epilepsy management. …”
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Synthesis of Pure Micro- and Nanopyrite and Their Application for As (III) Removal from Aqueous Solution by Guobao Chen, Zhangfu Zhu, Yong Qin

“…Arsenic is one of the materials that has a worldwide concern because of its high toxicity and chronic effects on human health. The existence of arsenic as As (III) is about 56 times poisonous as As (V) and more difficult to process. …”
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Nanomaterials based biosensors applied for detection of aflatoxin B1 in cereals: a review by Loyce Namanya, Emma Panzi Mukhokosi, Ediriisa Mugampoza

“…It causes immune-suppressive effects, raising the risk of mutagenicity, carcinogenicity, teratogenicity, hepatotoxicity, and embryonic toxicity, as well as increasing illness and death. …”
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Carboxylic Acid Bioisosteres in Medicinal Chemistry: Synthesis and Properties by Kato Bredael, Silke Geurs, Dorien Clarisse, Karolien De Bosscher, Matthias D’hooghe

“…Despite its common use as a key functionality in drugs, its presence in a lead molecule is often associated with poor pharmacokinetic properties and toxicity. In this literature overview, we discuss how the shortcomings of a carboxylic acid can be circumvented by replacing this functionality with bioisosteres. …”
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AM3, an Oral BRM: Protective Agent against Iatrogenic Bone-Marrow and Liver Damage in Breast Cancer Patients under Conventional Adjuvant Radiochemotherapy by Vicente G Villarrubia, Paula Marquez, Jose Cobo, Guillermo J Sada

“…Besides these hematological effects, AM3 palliated subclinical hepatic toxicity due to combined radio-chemotherapy. Finally, studies on acute-phase reactants, such as C-reactive protein, IgA. and factors B, C'3, and C'5 of the complement system, suggest that a modulation of hepatic inflammatory responses by AM3 appears to be essential for clinical effects described.…”
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NK Cell and CD4+FoxP3+ Regulatory T Cell Based Therapies for Hematopoietic Stem Cell Engraftment by Antonio Pierini, Maite Alvarez, Robert S. Negrin

“…The intensive conditioning regimens used to allow for donor hematopoietic stem cell (HSC) engraftment are often associated with severe toxicity, delayed immune reconstitution, life-threatening infections, and thus higher relapse rates. …”
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Comparative Study On Effectiveness Of Citrus Limon Peelings And Cymbopogon Citratus Leaves Powder On Termites, Isoptera Rhinotimitidae. by Abeneitwe, Joshua

“…However, their use raised new issues, such as environmental degradation, toxicity to animals and humans, and adverse impacts on the quality of yields. …”
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Long-Term Effects of Ozone Treatment in Patients with Persistent Numbness and Tingling Secondary to Chemotherapy-Induced Peripheral Neuropathy. A Retrospective Study by Bernardino Clavo MD, PhD, Delvys Rodríguez-Abreu MD, PhD, Saray Galván-Ruiz MD, Mario Federico MD, PhD, Angeles Cánovas-Molina RN, Yolanda Ramallo-Fariña MSc, Carla Antonilli MD, Gretel Benítez MD, Himar Fabelo BEng MSc, PhD, Carla García-Lourve RN, MRes, Damián González-Beltrán CNS, MSc, Ignacio J. Jorge MD, PhD, Francisco Rodríguez-Esparragón BSc, PhD, Gustavo M. Callico MEng, PhD

“…Before and after ozone treatment, and at 3- and 6- months after the end of treatment, they were assessed (i) the grade of CIPN-toxicity, and (ii) the self-reported decrease in numbness and tingling. …”
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Hyperleukocytosis in a neuroblastoma patient after treatment with natural killer T cells expressing a GD2-specific chimeric antigen receptor and IL-15 by Xin Xu, Shantan Reddy, Saleh Bhar, Frederic D Bushman, Amy N Courtney, Gabriel A Barragán, Gengwen Tian, Erica J Di Pierro, Leonid S Metelitsa, Antonino Montalbano, Hangjin Yu, Claudia Martinez Amador, Nisha Ghatwai, Michael S Wood, Deborah Schady, Aoife M Roche, David de la Cerda, Donald Williams Parsons, Andras Heczey

“…The ability of immune cells to expand numerically after infusion distinguishes adoptive immunotherapies from traditional drugs, providing unique therapeutic advantages as well as the potential for unmanageable toxicities. Here, we describe a case of lethal hyperleukocytosis in a patient with neuroblastoma treated on phase 1 clinical trial (NCT03294954) with autologous natural killer T cells (NKTs) expressing a GD2-specific chimeric antigen receptor and cytokine interleukin 15 (GD2-CAR.15). …”
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Chemoimmunotherapy as induction treatment in concurrent chemoradiotherapy for patients with nasopharyngeal carcinoma stage IVa by Kun-Peng Wu, Qing-Qing Li, Xu-Qiang Luo, Xiao-Xi Wang, Yan-Zhen Lai, Dan Tian, Hong-cheng Yang, Xue-Ling Wei, Lan-Ying Wang, Qiu-Ming Li, Dao Zhu, Si-Jie Chen, Yang-Si Li

“…This study aimed to evaluate the efficacy, toxicity, and survival outcomes of induction chemoimmunotherapy in patients with locoregionally advanced NPC.Methods This study analyzed 50 patients with stage IVa NPC between January 2020 and December 2023 in our hospital. …”
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Deep learning-based synthetic CT for dosimetric monitoring of combined conventional radiotherapy and lattice boost in large lung tumors by Hongwei Zeng, Xiangyu E, Minghe Lv, Su Zeng, Yue Feng, Wenhao Shen, Wenhui Guan, Yang Zhang, Ruping Zhao, Jingping Yu

“…Abstract Purpose Conventional radiotherapy (CRT) has limited local control and poses a high risk of severe toxicity in large lung tumors. This study aimed to develop an integrated treatment plan that combines CRT with lattice boost radiotherapy (LRT) and monitors its dosimetric characteristics. …”
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