Functionalized Bioadsorbent Application on Methylene Blue Removal From Wastewater—A Review by Jean B. Batchamen Mougnol, Sudesh Rathilal

“…Various industries such as petroleum, pharmaceuticals, textiles and households have been responsible for releasing MB into the environment. Its toxicity and acute health implications for animals and humans have suggested several technological applications for its removal. …”
Get full text

In Vivo Antiplasmodial Activity of Terminalia mantaly Stem Bark Aqueous Extract in Mice Infected by Plasmodium berghei by Mariscal Brice Tchatat Tali, Cedric Derick Jiatsa Mbouna, Lauve Rachel Yamthe Tchokouaha, Patrick Valere Tsouh Fokou, Jaures Marius Tsakem Nangap, Rodrigue Keumoe, Alvine Ngoutane Mfopa, Issakou Bakarnga-via, Raceline Gounoue Kamkumo, Fabrice Fekam Boyom

“…The present study is aimed at evaluating the in vitro and in vivo antiplasmodial activity and the oral acute toxicity of the Terminalia mantaly extracts. Materials and Methods. …”
Get full text

Real-world outdoor air exposure effects in a model of the human airway epithelium – A comparison of healthy and asthmatic individuals using a mobile laboratory setting by Pavel Rossner, Helena Libalova, Tereza Cervena, Michal Sima, Zuzana Simova, Kristyna Vrbova, Antonin Ambroz, Zuzana Novakova, Fatima Elzeinova, Anezka Vimrova, Lubos Dittrich, Michal Vojtisek, Martin Pechout, Michal Vojtisek-Lom

“…In samples originating from healthy and asthmatic individuals, we assessed the parameters of toxicity, lipid peroxidation and immune response; we further performed comprehensive monitoring of air pollutants at sampling sites. …”
Get full text

Impact of the Number of Administered Systemic Treatment Lines on Local Response to Radiation Therapy for Multiple Myeloma by Andrea Emanuele Guerini, MD, Eneida Mataj, MD, Paolo Borghetti, MD, Luca Triggiani, Ludovica Pegurri, MD, Stefania Nici, Stefano Riga, Alessandra Tucci, MD, Angelo Belotti, MD, Marco Lorenzo Bonù, MD, Giorgio Facheris, MD, Stefano Maria Magrini, Luigi Spiazzi, Michela Buglione

“…Disease control after RT was optimal, and instances of severe toxicities during treatment were rare.…”
Get full text

Bis(7)-harmine derivatives as potential multi-target anti-Alzheimer agents by Hongtao Du, Hongtao Du, Hongtao Du, Fang Ma, Fang Ma, Yuanyuan Cao, Miaoyan Bai, Xinyi Gao, Ziyi Yang, Yang Xu, Yan Yan, Yan Yan

“…Importantly, the multitarget compounds 6d, 8c, and 8d exhibited remarkable efficacy in simultaneously mitigating Aβ-induced toxicity in SH−SY5Y cells while demonstrating minimal cytotoxicity. …”
Get full text

Antileishmanial Effect of 5,3′-Hydroxy-7,4′-dimethoxyflavanone of Picramnia gracilis Tul. (Picramniaceae) Fruit: In Vitro and In Vivo Studies by Sara M. Robledo, Wilson Cardona, Karen Ligardo, Jéssica Henao, Natalia Arbeláez, Andrés Montoya, Fernando Alzate, Juan M. Pérez, Victor Arango, Iván D. Vélez, Jairo Sáez

“…(V.) panamensis (EC50 17.0 + 2.8 mg/mL, 53.7 μM) and low toxicity on mammalian U-937 cells, with an index of selectivity >11.8. …”
Get full text

Efficacy of natural killer T and gammadelta T cells in mesothelin-targeted immunotherapy of pancreatic cancer by Yuankui Zhu, Yaxi Yang, Linghe Yue, Lei Wan, Xuqian Ma, Qing Yang, Xuan Tian, Yuguan Li, Ke Wang, Shaozhong Wei, Shaozhong Wei, Shaozhong Wei, Dianbao Zuo, Mingqian Feng, Mingqian Feng

“…Despite their promise, dose-limited toxicity (DLT) remains a challenge in clinical practice. …”
Get full text

Epithelial–Mesenchymal Transition Suppression by ML210 Enhances Gemcitabine Anti-Tumor Effects on PDAC Cells by Keisuke Takemura, Kyohei Ikeda, Hayato Miyake, Yoshio Sogame, Hiroaki Yasuda, Nobuhiro Okada, Kazumi Iwata, Junichi Sakagami, Kanji Yamaguchi, Yoshito Itoh, Atsushi Umemura

“…However, if a patient’s general condition deteriorates due to NAC toxicity, surgical outcomes may be compromised. Therefore, we aimed to identify drug(s) that can be used in combination with gemcitabine (GEM), a drug widely used for the treatment of PDAC, to inhibit distant metastatic recurrence, particularly after surgery. …”
Get full text

Cutting-edge Bioinformatics strategies for synthesizing Cyclotriazadisulfonamide (CADA) analogs in next-Generation HIV therapies by Jay Gabriel B. Larga, Wrynan T. Munabirul, Abu Tayab Moin, Md Maisum Sarwar Jyoti, Mst Sanjida Nasrin, Minhaz Abdullah Al Mueid, Abdul Ahad, Anwar Parvez, Mst Sabrina Yeasmin, Rupali M. Barhate, Rajesh B. Patil, Margel C. Bonifacio

“…Additionally, 33 of the 113 analogs were deemed bioavailable using a bioavailability criteria specific for macrocycles. Toxicity predictions using PASS Online and StopTox identified analogs JGL023, JGL024, JGL032, and JGL047 as potential drug candidates. …”
Get full text

Evaluating the potential of Kalanchoe pinnata, Piper amalago amalago, and other botanicals as economical insecticidal synergists against Anopheles gambiae by Sheena Francis, William Irvine, Lucy Mackenzie-Impoinvil, Lucrecia Vizcaino, Rodolphe Poupardin, Audrey Lenhart, Mark J. I. Paine, Rupika Delgoda

“…The combination of both insecticides and synergists increases the toxicity of the mixture. Given the demonstrated resistance to the classical insecticides in numerous Anopheles spp., the use of synergists is becoming increasingly pertinent. …”
Get full text

Energetic disorder dominates optical properties and recombination dynamics in tin-lead perovskite nanocrystals by Dandan Wang, Yusheng Li, Yongge Yang, Chao Ding, Yuyao Wei, Dong Liu, Hua Li, Huan Bi, Shikai Chen, Sujun Ji, Boyu Zhang, Yao Guo, Huiyun Wei, Hongshi Li, Shuzi Hayase, Qing Shen

“…Tin-lead alloyed perovskite nanocrystals (PNCs) offer a promising pathway toward low-toxicity and air-stable light-emitting devices. However, substantial energetic disorder has thus far hindered their lighting applications compared to pure lead-based PNCs. …”
Get full text

Life cycle assessment of paper products based on recycled and virgin fiber by J. Simamora, E.I. Wiloso, M. Yani

“…The results of the impact assessment of global warming potential fossil, acidification, particulates, fossil abiotic depletion, and human toxicity-cancer for duplex board were 1,848.26 kilogram carbon dioxide equivalent, 8.12 kilogram-sulfur-dioxide-equivalent, 2.12 kilogram particulate matter 2.5-equivalent, 14,668.06 megajoule, and 0.0000017 comparative toxic unit, while for folding boxboard 2,651.25 kilogram carbon- dioxide-equivalent, 13.95 kilogram sulfur-dioxide-equivalent, 3.27 kilogram particulate matter 2.5-equivalent, 22,395.81 mega-joule, and 0.0000021 comparative toxic unit, respectively. …”
Get full text

A Case Report of Subacute Combined Spinal Cord Degeneration Caused by Nitrous Oxide (‘Laughing Gas’) Abuse by J. Guk, J. Valančienė, A. Klimašauskienė

“…Early recognition and treatment of N2O toxicity are crucial. We present the case of an 18-year-old male who was diagnosed with subacute combined spinal cord degeneration related to N2O abuse. …”
Get full text

The Fate of Allogeneic Pancreatic Islets following Intraportal Transplantation: Challenges and Solutions by Xinyu Li, Qiang Meng, Lei Zhang

“…However, there are many obstacles contributing to the early mass loss of the islets and progressive islet loss in the late stages of clinical islet transplantation, including hypoxia injury, instant blood-mediated inflammatory reactions, inflammatory cytokines, immune rejection, metabolic exhaustion, and immunosuppression-related toxicity that is detrimental to the islet allograft. …”
Get full text

Innovative approaches to asthma treatment: harnessing nanoparticle technology by Vanshika Goswami, Kushneet Kaur Sodhi, Chandra Kant Singh

“…It has been shown in studies that these drug delivery systems can greatly enhance targeting and bioavailability and decrease the toxicity of medication. Nanoparticle drug delivery systems offer improved therapeutic efficacy compared to conventional administration techniques. …”
Get full text

Postplanting Nutritional Augmentation of Jeffrey Pine Seedlings on an Infertile Sierran Site by Roger F. Walker

“…Foliar analysis revealed that improved N nutrition was probably critical in the favorable growth responses to fertilization, that of P was a likely contributor, and amelioration of potential Mn toxicity may have assumed an accessory role.…”
Get full text

Ischemic Retinal Vasculitis Associated with Cataract Surgery and Intracameral Vancomycin by Lucas T. Lenci, Eric K. Chin, Christi Carter, Stephen R. Russell, David R. P. Almeida

“…Unlike prior reports, this report demonstrates a case of mild visual reduction and minimal inflammation with subtle but complete unilateral peripheral retinal ischemia associated with cataract surgery and intracameral vancomycin, suggesting a spectrum of toxicity that may be underrecognized.…”
Get full text

Hyaluronic Acid-Based Drug Delivery Systems for Cancer Therapy by Ekaterina Pashkina, Maria Bykova, Maria Berishvili, Yaroslav Lazarev, Vladimir Kozlov

“…Due to its unique properties, such as high biocompatibility, low toxicity, and modifiability, HA is becoming a basis for the creation of targeted drug delivery systems, especially in the field of oncology. …”
Get full text

Scorpion Venom and the Inflammatory Response by Vera L. Petricevich

“…Scorpion venoms consist of a complex of several toxins that exhibit a wide range of biological properties and actions, as well as chemical compositions, toxicity, and pharmacokinetic and pharmacodynamic characteristics. …”
Get full text

Sonication-Assisted Synthesis of β-Mercuric Sulfide Nanoparticles by Xin Xu, Elizabeth R. Carraway

“…Continued development of synthesis methods is needed to expand approaches that produce uniform particles, while avoiding reagents of high toxicity and ecological impact. A solvent‐based approach was developed using mercuric chloride and elemental sulphur as the mercury and chalcogenide sources. …”
Get full text