Ionic Liquid‐Filled Polyamide Microcapsules Obtained by Interfacial Polymerization by Robin Scholl, Dominic Freudenmann

“…The IL‐filled microcapsules are obtained using a surfactant‐free synthesis process and inexpensive, low‐toxicity monomers and solvents and feature an exceptionally high core‐to‐shell weight ratio enabling a broad range of possible applications.…”
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Current state and prospects of using dendritic cell vaccination for cancer immunotherapy by I.Yu. Filin, K.V. Kitaeva, A.A. Rizvanov, V.V. Solovyeva

“…Recent advances in cancer immunotherapy have steadily increased the effectiveness of standard antitumor therapy methods. Due to their low toxicity and simple production process, personalized therapeutic vaccines based on dendritic cells are of particular clinical interest. …”
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Sublethal Effects of Diesel on Total Protein Levels and Cholesterol in <i>Tympanotonus Fuscatus</i> by OS Edori, IB Nwoke, ES Edori

“…This study showed that exposure of periwinkles (Tympanotonus fuscatus) to diesel toxicity could cause deleterious effects or changes in the organism biochemistry.…”
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The Redox System in C. elegans, a Phylogenetic Approach by Andrew D. Johnston, Paul R. Ebert

“…Oxidative stress is a toxic state caused by an imbalance between the production and elimination of reactive oxygen species (ROS). …”
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Teaching an old dog new tricks: re-engineering IL-2 for immuno-oncology applications by Mario Sznol, Naiyer Rizvi

“…Interleukin-2 has become a prominent focus of preclinical and clinical investigation, because of its known clinical activity, the important role of this cytokine in immune biology, and the ability to engineer variant proteins with potentially improved antitumor immunomodulatory activity and reduced toxicity. Bempegaldesleukin, the first of the modified IL-2 agents to reach phase 3 evaluation in combination with an anti-PD-1, did not improve outcome for patients with metastatic melanoma and renal carcinoma. …”
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Update on glasdegib in acute myeloid leukemia – broadening horizons of Hedgehog pathway inhibitors by Fersing Cyril, Mathias Fanny

“…Glasdegib, an oral Hedgehog pathway inhibitor, showed satisfactory response rates associated with moderate toxicity and less early mortality than standard induction regimens in this population. …”
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Atypical Manifestation of DRESS Syndrome by Christopher Hakim, Constantine Melitas, Eric Nguyen, Kha Ngo

“…The differential for liver transaminases over 1000 units/liter typically includes liver ischemia, acute viral hepatitis, acetaminophen toxicity, and autoimmune hepatitis. Prompt evaluation is imperative as these etiologies can lead to fulminant liver failure. …”
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Arsenic, Antimony, Chromium, and Thallium Speciation in Water and Sediment Samples with the LC-ICP-MS Technique by Magdalena Jabłońska-Czapla

“…Chemical speciation is a very important subject in the environmental protection, toxicology, and chemical analytics due to the fact that toxicity, availability, and reactivity of trace elements depend on the chemical forms in which these elements occur. …”
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Intralipid Therapy for Inadvertent Peripheral Nervous System Blockade Resulting from Local Anesthetic Overdose by Ihab Kamel, Gaurav Trehan, Rodger Barnette

“…Inadvertent intravascular injection of local anesthetics and/or the use of excessive doses have been the most frequent causes of local anesthetic systemic toxicity (LAST). Furthermore, excessive doses of local anesthetics injected locally into the tissues may lead to inadvertent peripheral nerve infiltration and blockade. …”
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Towards Point-of-Care Diagnostic and Staging Tools for Human African Trypanosomiaisis by Enock Matovu, Anne Juliet Kazibwe, Claire Mack Mugasa, Joseph Mathu Ndungu, Zablon Kithingi Njiru

“…Control of this disease almost exclusively relies on chemotherapy that should be driven by accurate diagnosis, given the unacceptable toxicity of the few available drugs. Unfortunately, the available diagnostics are characterised by low sensitivities due to the inherent low parasitaemia in natural infections. …”
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A Comprehensive Review on the Chemical Composition and Pharmacological Activities of Acacia catechu (L.f.) Willd. by Bikash Adhikari, Babita Aryal, Bibek Raj Bhattarai

“…Although the metabolites from the plant are reported with diverse pharmacological applications, there is little information in regards to toxicity and clinical trials on bioactive compounds of this plant. …”
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Photoactive Thin Silver Films by Atmospheric Pressure CVD by Heather M. Yates, Lucy A. Brook, David W. Sheel

“…This approach overcomes many of the previously encountered limitations to silver deposition by employing an atmospheric pressure process, low-cost and low-toxicity precursors. The resultant films are assessed for activity using stearic acid destruction as a model compound. …”
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Timing of Antiretroviral Therapy for HIV in the Setting of TB Treatment by Damani A. Piggott, Petros C. Karakousis

“…This paper will review data from recent studies regarding the optimal timing of HAART initiation relative to TB treatment, with the ultimate goal of improving coinfection-related morbidity and mortality while mitigating toxicity resulting from concurrent treatment of both infections.…”
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Hemin Augments Growth and Hemoglobinization of Erythroid Precursors from Patients with Diamond-Blackfan Anemia by Eitan Fibach, Memet Aker

“…In erythroid precursors derived from DBA patients, hemin significantly stimulated growth and hemoglobinization. Thus, heme toxicity is unlikely to play a role in the pathophysiology of most DBA cases. …”
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Carcinogenic and Genotoxicity of some PAHs in commonly consumed smoked fish (<i>Parachanna obscura</i> and <i>Ethmalosa fimbriata) </i> by N.O. Erhunmwunse, S.A. Ekaye

“…Risk assessment conducted using benzo(a)pyrene carcinogenic and mutagenic toxicity equivalent factor (TEQ & MEQ) showed slight to high risk (7.44 x10-5 -1.95 x10-3 ) and exceeded the USEPA guideline (1.0 x 10-5 ) for potential Cancer. …”
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Case Report of Probable DRESS Syndrome Associated with Ribociclib by Florian Carneiro, Marine Bove, Frédérique Beau-Salinas, Tevy San, Pierre Combe

“…Another CDK4/6 inhibitor, palbociclib, was introduced later without any cross-toxicity and with an excellent therapeutic response for more than 3 years.…”
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Effects of Exposure to Semiconductor Nanoparticles on Aquatic Organisms by Kenton Leigh, Jennifer Bouldin, Roger Buchanan

“…Because surface waters receive pollutants and contaminants from many sources including nanoparticles and act as reservoirs and conduits for many environmental contaminants, understanding the potential impacts of nanoparticles on the organisms within these environments is critical to evaluating their potential toxicity. While there is much to be learned about interactions between nanomaterials and aquatic systems, there have been a number of recent reports of interactions of quantum dots (QDs) with aquatic environments and aquatic organisms. …”
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A Basic Guide to Mushrooms Commonly Encountered in Potted Plants in Florida by Elena Karlsen-Ayala, Romina Gazis, Matthew Smith

“…Unknown fungi can also be concerning to retailers and homeowners because of potential toxicity to pets and children. The purpose of this publication is to provide homeowners and retail nursery growers with an overview of some of the most common mushroom-forming fungi found in potted plants and potting soils in Florida. …”
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The N17 domain of huntingtin as a multifaceted player in Huntington’s disease by Hyunju Cho

“…Diverse post-translational modifications (PTMs) in the N17 domain alter the aggregation state, thus modulating the cellular toxicity of mHttex1. Furthermore, the N17 domain serves as a nuclear export signal (NES) and mediates the cytoplasmic localization of mHttex1. …”
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miR-16-1 Promotes the Aberrant α-Synuclein Accumulation in Parkinson Disease via Targeting Heat Shock Protein 70 by Zhelin Zhang, Yan Cheng

“…However, how the Hsp70 in neurons fails to prevent or even reverse α-synuclein aggregation and toxicity in PD still remains to be determined. In the present study, we constructed an α-synuclein-overexpressed human neuroblastoma cell line, SH-SY5Y-Syn, in which the blockage of Hsp70 promoted α-synuclein aggregation. …”
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