Advanced In Vitro Models for Preclinical Drug Safety: Recent Progress and Prospects by Dileep G. Nair, Ralf Weiskirchen

“…The use of advanced in vitro systems that closely mimic human physiology, such as organ-on-a-chip models like gut–liver-on-a-chip, can be crucial in improving drug efficacy while minimizing toxicity. Additionally, the adaptation of these technologies has the potential to significantly reduce both the time and cost associated with obtaining safe drug approvals, all while adhering to the 3Rs principle (replacement, reduction, refinement). …”
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Melittin, a Potential Natural Toxin of Crude Bee Venom: Probable Future Arsenal in the Treatment of Diabetes Mellitus by Md. Sakib Hossen, Siew Hua Gan, Md. Ibrahim Khalil

“…It has several important biological effects and has a relatively low toxicity. Recent studies using animal models have confirmed that melittin has significant glucose and lipid lowering activities by acting on several mechanistic pathways. …”
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Bismuth Schiff base complex and its oxide nanoparticles as photocatalyst for the removal of dyes from water by Behrouz Shaabani, Shadi Soleimaninia

“…Abstract Bismuth oxide and bismuth complexes with organic ligands, particularly Schiff bases, have received much attention due to their non‐toxicity, antibacterial, and photocatalytic properties in removing water and environmental contaminants by oxidative degradation. …”
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Estimation of serum calcium levels in apheresis platelet donors by P. Arpitha, Ravindra Prasad Thokala

“…CONCLUSION: SDP collection is essentially a safe procedure with minimal adverse effects. Toxicity of citrate is not much pronounced. Recovery of calcium levels is within 30 min of completion of plateletpheresis.…”
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Alkaloids in Processed Rhizoma Corydalis and Crude Rhizoma Corydalis Analyzed by GC/MS by Zhifeng Guo, Ru Cai, Huidan Su, Yunlong Li

“…The alkaloids in the processed sample were less than those in the crude Rhizoma Corydalis significantly, while almost the corydaline has been changed in conformation after the sample had undergone processing, which provided support for the conclusion of reducing toxicity when the herbal medicine having been undergone a traditional drugs treatment process.…”
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A Case of Acute Motor Sensory Axonal Neuropathy: A Variant of Guillain-Barré Syndrome, with Possible Syndrome of Irreversible Lithium-Effectuated Neurotoxicity by David Y. Liu, Jessica R. Hollenbach, Jason A. Gregorin, Jonathan H. Wynbrandt

“…We present a unique case of a 38-year-old female patient with decade-long use of lithium for bipolar disorder that presented with acute lithium toxicity. Though she was ultimately diagnosed with AMSAN, the Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT) may have also contributed to her persistent neurological sequelae.…”
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A Case of Chronic Calcific Nonalcoholic Pancreatitis by Aaron Kangas-Dick, Umair Khan, Oluwafunbi Awoniyi, Shanza Waqar, Nu Nwe Tun, Karthikeyan Viswanathan, Cynthia Wong

“…The etiology of TCP remains uncertain, with the current consensus suggesting genetics as well as possible toxicity from consuming large amounts of cassava, a tuber. …”
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Studies on Dyeing Performance of Novel Acid Azo Dyes and Mordent Acid Azo Dyes Based on 2,4-Dihydroxybenzophenone by Bharat C. Dixit, Hitendra M. Patel, Dhirubhai J. Desai, Ritu B. Dixit

“…Results of bactericidal studies of chrome pretreated fibers revealed that the toxicity of mordented dyes against bacteria is fairly good. …”
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Functionalized Selenium Nanoparticles Enhance Anticancer Efficacy of Doxorubicin for Hepatocellular Carcinoma Therapy by Min Guo, Ying Tang, Liang Hua, Wanling Li, Guifang Gong, Yali Zhu, Bing Zhu, Yu Xia

“…To address this dilemma, tumor-targeted nanotechnology has been proposed to balance the toxicity and efficacy of chemotherapy. Tumor-targeted selenium nanoparticles (HA-SeNPs) were prepared to load an anticancer drug doxorubicin (DOX). …”
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FK228 Analogues Induce Fetal Hemoglobin in Human Erythroid Progenitors by Levi Makala, Salvatore Di Maro, Tzu-Fang Lou, Sharanya Sivanand, Jung-Mo Ahn, Betty S. Pace

“…To determine the physiological relevance of these compounds, studies in primary erythroid progenitors confirmed that JMA26 and JMA33 activated HbF synthesis at levels comparable to FK228 with low cellular toxicity. These data support our lead compounds as potential therapeutic agents for further development in the treatment of SCD.…”
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Determining application rates of FYM and pressmud to improve soil health properties in salt degraded soils. by M L Dotaniya, M D Meena, R L Choudhary, M K Meena, V D Meena, H V Singh, R S Jat, R K Doutaniya, Kuldeep Kumar, Harpreet Singh, P K Rai

“…The findings of this study suggested that organic amendments can improve soil fertility, mitigate salt ion toxicity, and enhance food production potential, particularly in arid and semi-arid soils.…”
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From detection to elimination: iron-based nanomaterials driving tumor imaging and advanced therapies by Dong Xie, Linglin Sun, Manxiang Wu, Qiang Li

“…Regarding treatment, INMs play a key role in advanced strategies such as immunotherapy, magnetic hyperthermia, and synergistic combination therapy, which effectively overcome tumor-induced drug resistance and reduce systemic toxicity. The integration of INMs with artificial intelligence (AI) and radiomics further expands its capabilities for precise tumor identification, and treatment optimization, and amplifies treatment monitoring. …”
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Targeting Apoptosis Pathways in Cancer with Alantolactone and Isoalantolactone by Azhar Rasul, Muhammad Khan, Muhammad Ali, Jiang Li, Xiaomeng Li

“…Inula japonica, Aucklandia lappa, Inula racemosa, and Radix inulae, have been found to have various pharmacological actions including anti-inflammatory, antimicrobial, and anticancer properties, with no significant toxicity. Recently, the anticancer activity of alantolactone and isoalantolactone has been extensively investigated. …”
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Analysis of Hepatic Artery Infusion (HAI) Chemotherapy Using Randomized Trials of Floxuridine (FUDR) for Colon Cancer Patients with Multiple Liver Metastases by Yuanming Li

“…The parameters like toxicity, overall survival rate, response rate, and progression-free response for the suggested therapy are also analyzed. …”
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Prediction of hemolytic peptides and their hemolytic concentration by Anand Singh Rathore, Nishant Kumar, Shubham Choudhury, Naman Kumar Mehta, Gajendra P. S. Raghava

“…Abstract Peptide-based drugs often fail in clinical trials due to their toxicity or hemolytic activity against red blood cells (RBCs). …”
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Phytosynthesis of Titanium Dioxide Nanoparticles Using King of Bitter Andrographis paniculata and Its Embryonic Toxicology Evaluation and Biomedical Potential by S. Rajeshkumar, J. Santhoshkumar, Leta Tesfaye Jule, Krishnaraj Ramaswamy

“…The phytosynthesis TiO2 shows the antioxidant and antidiabetic activities. Similarly, toxicity studies have demonstrated the hatching and viability LD 50 value of TiO2 250 μg/L. …”
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Exploring effector protein dynamics and natural fungicidal potential in rice blast pathogen Magnaporthe oryzae. by Jannatul Ferdousy, Tanjin Barketullah Robin, Mst Sanjida Nasrin, Istiak Ahmed, Tawsif Hossain, Md Mehedi Hasan, Mehrab Hassan Soaeb, Md Ahsanul Tamim, Nusrat Jahan Yeasmin, Ummay Habiba, Nadim Ahmed, Nurul Amin Rani, Md Shishir Bhuyian, Suvarna N Vakare, Abu Tayab Moin, Rajesh B Patil, Mohammad Shahadat Hossain

“…Additionally, the compounds were evaluated based on Lipinski's rule of five and toxicity predictions, indicating their suitability for agricultural use. …”
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Current Status of Plant-Based Bioactive Compounds as Therapeutics in Alzheimer’s Diseases by Dan Chen, Yun Sun

“…The pathogenesis of AD remains unclear and current Western medicines treatment are purely symptomatic, with a singular pathway, limited efficacy, and substantial toxicity and side effects. In recent years, as research into AD has deepened, there has been a gradual increase in the exploration and application of medicinal plants for the treatment of AD. …”
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Rising incidence of recreational ketamine use: Clinical cases and management in emergency settings by Sabrina Marongiu, Maarten van Eijk, Femke M.J. Gresnigt, Esther A. Croes, Eric J.F. Franssen

“…This trend has been accompanied by an increase in first aid incidents involving ketamine, often in combination with other substances such as alcohol or MDMA, leading to heightened toxicity. Acute intoxication with ketamine manifests through symptoms like agitation, hallucinations, nausea, tachycardia, and hypertension, while frequent use is associated with long-term complications, including ketamine-induced uropathy. …”
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Intravenous γ Globulin for Intractable Abdominal Pain due to IgA Vasculitis by George Naifa, George Totikidis, Sonia Alexiadou, Christina Kolona, Elpis Mantadakis

“…We present two children with IgA vasculitis and severe abdominal pain despite corticosteroid administration, who responded promptly to intravenous γ globulin (IVIg) with complete resolution of their symptoms and review of the relevant medical literature. Given the toxicity and/or need for long-term administration of other second-line immunosuppressive therapies in corticosteroid-resistant IgA vasculitis, such as rituximab, cyclosporine, cyclophosphamide, azathioprine, or colchicine, we propose that IVIg may be a useful and safe treatment option, although randomized controlled clinical trials are needed in order to clarify its role in the treatment of abdominal pain in IgA vasculitis.…”
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