The XIAP inhibitor AZD5582 improves the treatment effect of microwave ablation on hepatocellular carcinoma by Wenhui Wang, Fuyuan Wu, Zhe Wu, Mengfan Zhang, Qiang Lu

“…Finally, AZD5582 drug toxicity was detected to confirm its feasibility.ResultsXIAP protein expression is significantly increased in recurrent hepatocellular carcinoma tissues of patients who previously received microwave ablation therapy. …”
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Decitabine Compared with Low-Dose Cytarabine for the Treatment of Older Patients with Newly Diagnosed Acute Myeloid Leukemia: A Pilot Study of Safety, Efficacy, and Cost-Effectiven... by Linu A. Jacob, S. Aparna, K. C. Lakshmaiah, D. Lokanatha, Govind Babu, Suresh Babu, Sandhya Appachu

“…Our study has shown that both of these agents have similar OS and toxicity. Low-dose cytarabine scores over decitabine in developing countries as it is more cost-effective.…”
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Development, in vitro and ex vivo characterization of lamotrigine-loaded bovine serum albumin nanoparticles using QbD approach by Maryana Salamah, Bence Sipos, Zsuzsanna Schelz, István Zupkó, Ágnes Kiricsi, Ágnes Szalenkó-Tőkés, László Rovó, Gábor Katona, György Tibor Balogh, Ildikó Csóka

“…The cytotoxicity study indicated that BSA-NP reduced LAM toxicity, and GLUC 9 mM and EDC 1 mg could be alternative cross-linking agents to avoid GLUT 2% v/v toxicity. …”
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Determinants of Virologic Failure among Adult HIV Patients on First-Line Antiretroviral Therapy at Waghimra Zone, Northern Ethiopia: A Case-Control Study by Abrham Emagnu, Zenahebezu Abay, Abera Balcha Bulti, Yaregal Animut

“…This study showed that poor adherence to treatment, longer duration on ART, experiencing drug toxicity, older age, and recent CD4 <200 cell/mm³ are factors that increase the risk of virologic failure.…”
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Quantitative Detection of Zinc Oxide Nanoparticle in Environmental Water by Cloud Point Extraction Combined ICP-MS by Yuan Yang, Xin Liu, Lin Luo, Wenjing Wei, Qiang Wang, Jiachao Zhang

“…To understand their fate and toxicity in water systems, a reliable method for the quantitative analysis of ZnONPs in environmental waters is urgently needed to be established. …”
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Effects of Melatonin and Epiphyseal Proteins on Fluoride-Induced Adverse Changes in Antioxidant Status of Heart, Liver, and Kidney of Rats by Vijay K. Bharti, R. S. Srivastava, H. Kumar, S. Bag, A. C. Majumdar, G. Singh, S. R. Pandi-Perumal, Gregory M. Brown

“…Several experimental and clinical reports indicated the oxidative stress-mediated adverse changes in vital organs of human and animal in fluoride (F) toxicity. Therefore, the present study was undertaken to evaluate the therapeutic effect of buffalo (Bubalus bubalis) epiphyseal (pineal) proteins (BEP) and melatonin (MEL) against F-induced oxidative stress in heart, liver, and kidney of experimental adult female rats. …”
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In Vitro Antibacterial and Antioxidant Activities, Pharmacokinetics, and In Silico Molecular Docking Study of Phytochemicals from the Roots of Ziziphus spina-christi by Hadush Gebrehiwot, Urgessa Ensermu, Aman Dekebo, Milkyas Endale, Tariku Nefo Duke

“…Furthermore, the organ toxicity predictions showed that all the compounds exhibit no hepatotoxicity and cytotoxicity effects and stigmasterol (5) affords drug-likeness protocols. …”
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NLS-binding deficient Kapβ2 reduces neurotoxicity via selective interaction with C9orf72-ALS/FTD dipeptide repeats by Kevin M. Kim, Amandeep Girdhar, Maria E. Cicardi, Vaishnavi Kankate, Miyuki Hayashi, Ruoyu Yang, Jenny L. Carey, Charlotte M. Fare, James Shorter, Gino Cingolani, Davide Trotti, Lin Guo

“…R-DPRs can cause toxicity by disrupting the natural phase behavior of RNA-binding proteins (RBPs). …”
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Cryptolepine, the Main Alkaloid of the Antimalarial Cryptolepis sanguinolenta (Lindl.) Schlechter, Induces Malformations in Zebrafish Embryos by Kwesi Boadu Mensah, Charles Benneh, Arnold Donkor Forkuo, Charles Ansah

“…Here, we hypothesized that cryptolepine-induced embryo toxicity occurs at least partly through direct inhibition of embryogenesis rather than indirectly through the induction of maternal toxicity. …”
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Association of genetically proxied cancer-targeted drugs with cardiovascular diseases through Mendelian randomization analysis by Chuchun Fang, Xuewei Liu, Chen Yu, Songlin Li, Xueying Liu, Shifeng Qiu, Hongbin Liang, Caiwen Ou, Jiancheng Xiu

“…These findings underscore the delicate balance between cardiovascular toxicity risk and the benefits of cancer-targeted therapy.…”
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High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis by Arvind Pradip, Daniella Steel, Susanna Jacobsson, Gustav Holmgren, Magnus Ingelman-Sundberg, Peter Sartipy, Petter Björquist, Inger Johansson, Josefina Edsbagge

“…Recent advances in differentiating human induced pluripotent stem cells (hiPSCs) into pure cultures of hepatocyte-like cells expressing functional drug metabolizing enzymes open up possibilities for novel, more relevant human cell based toxicity models. The present study aimed to investigate the use of hiPSC derived hepatocytes for conducting mechanistic toxicity testing by image based high content analysis (HCA). …”
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Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology by Arthur D. Stem, Cole R. Michel, Peter S. Harris, Keegan L. Rogers, Matthew Gibb, Carlos A. Roncal-Jimenez, Richard Reisdorph, Richard J. Johnson, James R. Roede, Kristofer S. Fritz, Jared M. Brown

“…To determine how the cellular redox environment may influence PCT cell function and toxicity, the redox proteome was examined using cysteine-targeted click chemistry proteomics. …”
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Cocoa pod husk wastes derived biochar for overcoming potassium deficiency in organic agriculture by Murali Gopal, Elain Apshara S., Sathyaseelan Neenu, Alka Gupta

“…An ecotoxicity assay using earthworms indicated no acute toxicity, although earthworms took longer to acclimatize to the cocoa pod husk biochar compared to coconut residue biochar. …”
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Antibiofilm and Anticancer Activity of Multi-Walled Carbon Nanotubes Fabricated with Hot-Melt Extruded Astaxanthin-Mediated Synthesized Silver Nanoparticles by You HS, Jang YS, Sathiyaseelan A, Ryu SJ, Lee HY, Baek JS

“…MWCNT-AST showed higher anticancer activity against breast cancer cells (MDA-MB-231) than MWCNT-Ag, and lower toxicity in normal cells HaCaT and NIH3T3.Conclusion: MWCNT-AST exhibits higher antioxidant, antibiofilm, and anticancer activities than MWCNT-Ag, and exhibits lower toxicity to normal cells. …”
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Evaluation of Diabetic Patients with Breast Cancer Treated with Metformin during Adjuvant Radiotherapy by Adam Ferro, Sharad Goyal, Sinae Kim, Hao Wu, Neil K. Taunk, Devora Schiff, Aneesh Pirlamarla, Bruce G. Haffty

“…The purpose of this study was to evaluate acute locoregional toxicity in patients with breast cancer receiving concurrent metformin plus radiation therapy. …”
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Comparison of oxidative stress status in the kidney tissue of male rats treated with paraquat and nanoparaquat by Fatemeh Bahramibanan, Mohammad Vahabi Rad, Akram Ranjbar, Ashkan Karbasi, Anahita Abbasifard

“…Newly developed nanoparaquat formulations may modify its toxicity profile and tissue distribution patterns. …”
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Comparative environmental impacts analysis of technologies for recovering critical metals from copper anode slime: Insights from LCA by Yu Li, Jenny Baker, Yaxi Fang, Haizhou Cao, Cameron Pleydell-Pearce, Trystan Watson, Sha Chen, Guangling Zhao

“…Six impact categories—climate change, freshwater ecotoxicity, marine ecotoxicity, terrestrial ecotoxicity, human toxicity (cancer), and human toxicity (non-cancer)—were assessed and compared across the four recycling technologies. …”
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Glutathione reductase plays a role in the metabolism of methylmercury degradation in Rhodotorula mucilaginosa by Yi Guo, Wenlong Deng, Qigui Mo, You Yu, Zhenwang Zhang, Mingjie Wei, Ruiling Tang, Surui Lu, Yanting Su

“…ABSTRACT Mercury pollution is a kind of heavy metal pollution with great harm and strong toxicity which exists worldwide. Some microorganisms can convert highly toxic methylmercury into inorganic mercury compounds with significantly reduced toxicity. …”
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Metabolic conversion of phenol to polyhydroxyalkanoate (PHA) for addressing dual environmental challenges: A review by Izzati Sabri, Mohd Zulkhairi Mohd Yusoff, Nor Azlan Nor Muhammad, Li Sim Ho, Norhayati Ramli

“…A sustainable approach to microbial polyhydroxyalkanoate (PHA) production involves utilizing waste as a substrate, which can include toxic pollutants like phenol as a carbon feedstock. …”
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Evaluation and Comparison of Iodine-Based and Biosynthesized Gold Nanoparticles as X-Ray Contrast Agent and Their Effects on Renal Functions in Male Wistar Rats by Paul Ayanlola, Gbadebo Isola, Waidi Saka, Margaret Akinloye, Abraham Aremu, Mustapha Lawal

“…Introduction: Gold nanoparticles (AuNPs) have gained significant attention as a promising contrast agent to overcome the challenges of iodine-based contrast agents (ICAs), such as poor contrast, and renal toxicity. However, studies have associated toxicity with AuNPs synthesized through chemical methods, thereby raising concerns regarding the safety of such AuNPs. …”
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