What is the Significance of a Part Per Million? by Frederick M. Fishel, Mark Mossler

“… The health effects of toxic substances are related to their doses—the amount of exposure to the toxic substance. …”
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Synthesis and Pharmacological Evaluation of 2-(4-Halosubstituted phenyl)-4,5-diphenyl-1H-imidazoles by G. Nagalakshmi

“…The structural assignment of this compound has been made on the basis of elemental analysis, UV, IR, 1H NMR and Mass spectral data. Toxicity of the compound has been determined. The synthesized compound was evaluated for antiinflammatory activity against carrageenan induced paw oedema and anticonvulsant activity against maximal electro-shock-induced convulsions in rats.…”
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Nonceliac Diaphragm Disease of the Duodenum by Hugh J Freeman

“…Further studies are needed to evaluate potential toxicity or protective effects of different ethnic diets and their relationship with the development of different intestinal diseases.…”
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Common Pokeweed by Brent Sellers, Jason Ferrell, Curtis Rainbolt

“… SS-AGR-123, a 2-page illustrated fact sheet by Brent Sellers, Jason Ferrell, and Curtis Rainbolt, provides key information on the biology, toxicity, cultural uses, and control of common pokeweed (Phytolacca americana) -- also called poke berry, pigeon berry, inkberry coakum, pocan bush, scoke, poke salad, and American nightshade. …”
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L-selenomethionine inhibits small intestinal ferroptosis caused by ammonia exposure through regulating ROS-mediated iron metabolism by Xinxin Zhang, Lepeng Gu, Ying Chen, Tianqi Wang, Houjuan Xing

“…However, the potential toxicity mechanism of ammonia exposure to the intestine remains unclear. …”
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Protective Effects of Sanyar Prebiotic on Immunity and Tissue Changes of Common Carp (Cyprinus carpio) Exposed to CuSO4 Stress by Ramezan Rajani, Mohammad Farhangi, Hojjatallah Jafaryan, Hossein Adineh, Maryam Alizadeh

“…At the end of the experimental period, the fish were exposed to acute toxicity of Cu (0.1 m/l) for 96 hours. Gill, kidney, and liver tissue samples were collected and evaluated after 96 hours. …”
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Integrating MAPK pathway inhibition into standard-of-care therapy for pediatric low-grade glioma by Erin E. Crotty, Aimee A. Sato, Aimee A. Sato, Mohamed S. Abdelbaki

“…We have adopted mitigation strategies for their associated toxicities; skin toxicity, in particular, is now managed by prevention strategies and early dermatologic intervention. …”
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Efficient Self-Assembly of mPEG End-Capped Porous Silica as a Redox-Sensitive Nanocarrier for Controlled Doxorubicin Delivery by Anh Khoa Nguyen, Thi Hiep Nguyen, Bui Quoc Bao, Long Giang Bach, Dai Hai Nguyen

“…Notably, the PNS-SS-ADA@CD-mPEG was a biocompatible nanocarrier, and the toxicity of DOX was dramatically reduced after loading drugs into the porous core. …”
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Efficacy of Anti-Cancer Immune Responses Elicited Using Tumor-Targeted IL-2 Cytokine and Its Derivatives in Combined Preclinical Therapies by Sahar Balkhi, Giorgia Bilato, Andrea De Lerma Barbaro, Paola Orecchia, Alessandro Poggi, Lorenzo Mortara

“…Preclinical and clinical studies highlight reduced toxicity and enhanced anti-tumor efficacy, overcoming TME-driven immune suppression. …”
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The effect of AKT inhibition in α-synuclein-dependent neurodegeneration by Bedri Ranxhi, Zoya R. Bangash, Zachary M. Chbihi, Sokol V. Todi, Sokol V. Todi, Peter A. LeWitt, Peter A. LeWitt, Peter A. LeWitt, Wei-Ling Tsou

“…However, in PD, α-Syn cumulatively misfolds into toxic aggregates that disrupt cellular processes and contribute to neuronal damage and neurodegeneration. …”
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Outcomes of Six-Dose High-Dose Cytarabine as a Salvage Regimen for Patients with Relapsed/Refractory Acute Myeloid Leukemia by Brandi Anders, Lauren Veltri, Abraham S. Kanate, Alexandra Shillingburg, Nilay Shah, Michael Craig, Aaron Cumpston

“…Thirty-five percent of patients were able to subsequently proceed to allo-HCT. Treatment-related toxicities included neutropenic fever (38%), infection (35%), neurotoxicity (8%), and skin toxicity (8%). …”
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A phase I/II study evaluating the feasibility and safety of delivering adjuvant hypofractionated radiotherapy in resected oral cavity cancers (HYPO-ART study) by Mranalini Verma, Divya Kukreja, Deep Chakrabarti, Aman Verma, MD, Naseem Akhtar, Kirti Srivastava, Sanjay Singhal

“…The primary end-point was the incidence of acute radiation-induced toxicities. Secondary endpoints were locoregional control and overall survival. …”
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Risks to human and animal health from the presence of bromide in food and feed by EFSA Scientific Committee, Susanne Hougaard Bennekou, Ana Allende, Angela Bearth, Josep Casacuberta, Laurence Castle, Tamara Coja, Amélie Crépet, Thorhallur Halldorsson, Laurentius (Ron) Hoogenboom, Helle Knutsen, Konstantinos Koutsoumanis, Claude Lambré, Søren Nielsen, Dominique Turck, Antonio Vicent Civera, Roberto Villa, Holger Zorn, Vasileios Bampidis, Jacqueline Castenmiller, Marie‐Christine Chagnon, Bruce Cottrill, Keyvin Darney, Jürgen Gropp, Secundino Lopez Puente, Martin Rose, Marco Vinceti, Maria Bastaki, Petra Gergelová, Luna Greco, Matteo Lorenzo Innocenti, Judit Janossy, Anna Lanzoni, Andrea Terron, Diane Benford

“…Abstract The European Commission mandated EFSA to assess the toxicity of bromide, the existing maximum residue levels (MRLs), and possible transfer from feed into food of animal origin. …”
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High-level biosynthesis and purification of the antimicrobial peptide Kiadin based on non-chromatographic purification and acid cleavage methods by Liangjun Zheng, Fengyi Yang, Chen Wang, Muhammad Zafir, Zishuo Gao, Pilong Liu, Fatma A. El-Gohary, Xin Zhao, Huping Xue

“…Despite their potential, the physiological toxicity of AMPs to host cells significantly hampers their biosynthetic production. …”
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Degradation of Benzotriazole from aqueous solutions: A synergistic effect of nano- Fe2O3@Alg-TiO2 on UV/Fe2O3@Alg-TiO2 process by Seyedeh Elahe Badiei Khairabadi, Hasan Rahmani, Mohammad Bagher Miranzadeh, Rouhullah Dehghani, Fatemeh Atoof

“…The results showed that the toxicity decreased in 200 minutes that if sufficient time is provided to complete the reaction toxicity can be reduced. …”
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Expert consensus guidelines on management and best practices for tumor-infiltrating lymphocyte cell therapy by Sarah Nikiforow, John Haanen, Omid Hamid, Igor Puzanov, Rodabe Amaria, Amod Sarnaik, Marcus O Butler, Michael R Bishop, Allison Betof Warner, Adam J Schoenfeld, Krishna Komanduri

“…This review includes clinical and toxicity management guidelines pertaining to the TIL cell therapy regimen prepared by the TIL Working Group, composed of internationally recognized hematologists and oncologists with expertize in TIL cell therapy, and relates to patient care and operational aspects. …”
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Role of polyethylene glycol to alleviate lead stress in Raphanus sativus by Muhammad Sajid, Shakil Ahmed, Rehana Sardar, Aamir Ali, Nasim Ahmad Yasin

“…The continuous contamination of heavy metals (HMs) in our ecosystem due to industrialization, urbanization and other anthropogenic activities has become a serious environmental constraint to successful crop production. Lead (Pb) toxicity causes ionic, oxidative and osmotic injuries which induce various morphological, physiological, metabolic and molecular abnormalities in plants. …”
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Dimethoate Induced Behavioural Changes in Juveniles of Cyprinus carpio var. communis under Temperate Conditions of Kashmir, India by Imtiyaz Qayoom, Feroz A. Shah, Malik Mukhtar, Masood H. Balkhi, Farooz A. Bhat, Bilal A. Bhat

“…The present study was designed to investigate acute toxicity of dimethoate on juvenile Cyprinus carpio var. communis. …”
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Malyngamide F Possesses Anti-Inflammatory and Antinociceptive Activity in Rat Models of Inflammation by Zhuocheng Li, Lei Zhang, Zhichao Zhao

“…Methods. The possible toxicity of Maltoamide F was evaluated by an acute toxicity test. …”
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Safety and Efficacy of Nusinersen Focusing on Renal and Hematological Parameters in Spinal Muscular Atrophy by Hüseyin Bahadır Şenol, Gizem Yıldız, Ayşe İpek Polat, Adem Aydın, Ayşe Semra Hız, Alper Soylu, Uluç Yiş

“…Conclusion Nusinersen treatment did not cause significant renal toxicity or affect platelet counts. Urine creatinine levels may serve as a potential biomarker for assessing treatment response in SMA Type 1.…”
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