Neoadjuvant programmed death ligand-1 with chemotherapy versus chemotherapy alone for limited-stage small-cell lung cancer: a retrospective study by Zhi Yang, Yan-qing Wang, Xiujun Chang

“…There were no perioperative deaths.ConclusionsNeoadjuvant immunotherapy shows lower toxicity and fewer perioperative complications. ICI combined chemotherapy can achieve more pathological relief and clinical benefits in the neoadjuvant treatment of LS-SCLC without increased irAE and perioperative complications. …”
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High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery. by Nathalie Aulner, Anne Danckaert, Eline Rouault-Hardoin, Julie Desrivot, Olivier Helynck, Pierre-Henri Commere, Hélène Munier-Lehmann, Gerald F Späth, Spencer L Shorte, Geneviève Milon, Eric Prina

“…Based on their intramacrophagic leishmanicidal activity and their toxicity against host cells, compounds were classified as irrelevant or relevant for entering the next step in the drug discovery pipeline.…”
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Investigating the research landscape of chlorinated paraffins over the past ten decades by Chinemerem Ruth Ohoro, Chijioke Olisah, Victor Wepener

“…Despite having similar toxicity to short-chain chlorinated paraffin (SCCP), long-chain chlorinated paraffin (LCCP) has received less attention. …”
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The triphenylmethane dye brilliant blue G is only moderately effective at inhibiting amyloid formation by human amylin or at disaggregating amylin amyloid fibrils, but interferes w... by Rehana Akter, Alexander Zhyvoloup, Bingqian Zheng, Surita R Bhatia, Daniel P Raleigh

“…BBG also remodels preformed h-amylin amyloid fibrils if added in excess, however BBG has no significant effect on h-amylin induced toxicity towards cultured β-cells or cultured CHO-T cells except at high concentrations. …”
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Cytotoxic and Antioxidant Effects of Antimalarial Herbal Mixtures by Isaac Dadzie, Shaibu Adams Avorgbedo, Regina Appiah-Opong, Obed Cudjoe

“…The herbal mixtures may be potential sources of toxic agents to host cells. Therefore, further toxicity studies must be performed to safeguard health of the public. …”
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Insecticides Used in the Urban Environment: Mode of Action by S.M. Valles, P.G. Koehler

“…The article details how different chemicals, such as pyrethroids, carbamates, and organophosphates, disrupt insect physiology, leading to toxicity and death. It also highlights the specific mechanisms through which these insecticides operate, providing a comprehensive understanding of their biological impacts. …”
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Common Pokeweed by Brent Sellers, Jason Ferrell, Curtis Rainbolt

“… SS-AGR-123, a 2-page illustrated fact sheet by Brent Sellers, Jason Ferrell, and Curtis Rainbolt, provides key information on the biology, toxicity, cultural uses, and control of common pokeweed (Phytolacca americana) -- also called poke berry, pigeon berry, inkberry coakum, pocan bush, scoke, poke salad, and American nightshade. …”
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Myoclonic Jerks in an Ex-Preterm Undergoing Hernia Surgery Under Combined Spinal Caudal Block: Is It Time to Revisit the Test Dose? by Lakshmi Kumar, Neethu Padmanabhan, Dimple Elina Thomas, Pramod R. Pillai

“…We present the management of a possible local anesthetic systemic toxicity in an ex-preterm infant scheduled for an elective left inguinal herniotomy.…”
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Renal Aspects of Peptic Ulcer Pharmacology by Daniel Muruve, Ellen Burgess

“…The older agents, antacids and sucralfate, allow absorption of cations (calcium, magnesium and aluminum) which may result in toxicity. Newer medications (H2 blockers and omeprazole) appear to have fewer side effects and be better tolerated with appropriate dosage adjustments.…”
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Bismuth as Smart Material and Its Application in the Ninth Principle of Sustainable Chemistry by Ayodele Temidayo Odularu

“…The study also entails a green element called bismuth. Bismuth’s low toxicity and low cost have made researchers focus on its wide applications in catalysis. …”
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Two Cases of Paraquat Poisoning from Kota, Rajasthan, INDIA by Surendra Khosya, Sunil Gothwal

“…Paraquat (1,1′-dimethyl-4,4′-dipyridylium) is a broad spectrum liquid herbicide associated with both accidental and intentional ingestion, leading to severe and often fatal toxicity. Despite widespread availability, reports of herbicide poisoning from India are not common. …”
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Use of Copper in Marine Aquaculture and Aquarium Systems by Roy P. Yanong

“…Yanong, discusses the use of “bluestone” or “blue copperas” copper sulfate — basic copper chemistry, chelated copper, toxicity to target and non-target organisms, determining dose, reaching and maintaining desired concentrations, and removing copper from the system. …”
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Nutritional care in cancer patients in Italy: state of the art and perspectives by Valentina Da Prat, Valentina Caissutti, Lorenzo Perrone, Francesco Serra, Elisabetta Iannelli, Francesco De Lorenzo, Paolo Pedrazzoli, Riccardo Caccialanza

“…In particular, malnutrition is associated with prolonged hospitalization, higher rates of treatment-related toxicity, lower chemotherapy dose-intensity, reduced response to cancer treatment, impaired quality of life, and increased mortality.…”
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Dynamic Analysis of DNA Damage by Flow Cytometry and FISH by Demetrios P. Matthopoulos

“…Although it is the test that can be used to assess agents' toxicity, it cannot provide information on the molecular events that result in the induction of micronuclei. …”
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Use of Copper in Marine Aquaculture and Aquarium Systems by Roy P. Yanong

“…Yanong, discusses the use of “bluestone” or “blue copperas” copper sulfate — basic copper chemistry, chelated copper, toxicity to target and non-target organisms, determining dose, reaching and maintaining desired concentrations, and removing copper from the system. …”
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Anti-VEGF Cancer Therapy in Nephrology Practice by Hassan Izzedine

“…Then, in nephrology practice, should we continue to perform kidney biopsy, and what should be done with the anti-VEGF agents in case of renal toxicity?…”
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Pesticide Labeling: Precautionary Statements by Frederick M. Fishel

“… Precautionary statements found on pesticide labeling tell the user information about the toxicity, irritation, and sensitization hazards associated with the use of the pesticide. …”
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A Phase I/II Study of Ultra-Hypofractionated Carbon-ion Radiation therapy for Low- and Intermediate-Risk Localized Prostate Cancer by Noriyuki Okonogi, MD, PhD, Hiroshi Tsuji, MD, PhD, Kana Kobayashi, MD, PhD, Mio Nakajima, MD, PhD, Shuri Aoki, MD, PhD, Takanobu Utsumi, MD, PhD, Hiroyoshi Suzuki, MD, PhD, Koichiro Akakura, MD, PhD, Tomohiko Ichikawa, MD, PhD, Hitoshi Ishikawa, MD, PhD

“…Eligible patients were randomly assigned (1:1) to a 1- or 2-week schedule. Dose-limiting toxicities (DLTs) were defined as any genitourinary (GU) or gastrointestinal (GI) toxicity grade 3 or higher within 90 days of beginning CIRT. …”
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Fractionated robotic radiosurgery for unfavorable nonfunctioning pituitary macroadenoma: 5-year outcomes from a single institution protocol by Akrita Bhatnagar, Monica Pernia Marin, Jonathan W. Lischalk, Min Ji Koh, Siviero Agazzi, Simeng Suy, Brent T. Harris, Susmeeta T. Sharma, Edward Aulisi, Amjad Anaizi, Mohamed H. Khattab, Walter C. Jean, Walter C. Jean, Sean P. Collins, Brian T. Collins

“…The median optic chiasm maximum point dose was 21.8 Gy (range: 12.0–25.0 Gy). Acute toxicity was minimal with eight patients (40%) developing short-lived headaches and one patient (5%) developing a brief ipsilateral sixth nerve palsy. …”
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Immune-related adverse events with PD-1/PD-L1 inhibitors: insights from a real-world cohort of 2523 patients by Ting Yan, Minghui Long, Chaoyi Liu, Jiwen Zhang, Jiwen Zhang, Xingyu Wei, Xingyu Wei, Fei Li, Fei Li, Dehua Liao

“…IrAEs affected various organ systems, with endocrine toxicity (17.7%), hepatic toxicity (17.2%), and hematologic toxicity (11.4%) being the most common. 20.5% patients experienced multi-system irAEs. …”
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