Antifungal Activity and Major Bioactive Compounds of Water Extract of Pangium edule Seed against Aspergillus flavus by Kharisma I. Listyorini, Harsi D. Kusumaningrum, Hanifah N. Lioe

“…The water extracts showed a moderate toxicity with LC50 of 100-500 μg/mL, determined by the brine-shrimp toxicity test. …”
Get full text

IONPs-induced neurotoxicity via cascade of neuro-oxidative stress, parthanatos-mediated cell death, neuro-inflammation and neurodegenerative changes: Ameliorating effect of rosemar... by Arwa A. Elsheikh, Noha Ali Abd-Almotaleb, Mona Mostafa Ahmed, Eman El-Sayed Khayal

“…Iron oxide nanoparticles (IONPs) are widely used in various fields, particularly in medicine, where they can be directly injected for diagnostic and therapeutic purposes, although they may induce certain types of toxicity. Therefore, the present work aimed to estimate the potential protective role of the oral extract of rosemary (RO)against the toxic effects of injected IONPs on the brain tissues of adult male rats, and to explore the potential underlying mechanisms involved in reversing such toxicity. …”
Get full text

Bio-computational modeling, POM analysis and molecular dynamic simulation for novel synthetic quinolone and benzo[d][1,3]oxazine candidates as antimicrobial inhibitors by Doaa A. Elsayed, Mohamed E. Abdu, Mohammed A. Marzouk, Elsayed M. Mahmoud, Walaa H. El-Shwiniy, Andrew M. Spring, Wesam S. Shehab

“…This indicates that these compounds may possess some level of selectivity and reduced toxicity towards normal cells, suggesting potential for further exploration as antibacterial agents with a safer profile for normal cells.…”
Get full text

Risk assessment of complex organoarsenic species in food by EFSA Panel on Contaminants in the Food Chain (CONTAM), Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Gisela Degen, Antonio Hernández‐Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean‐Charles Leblanc, Kyriaki Machera, Evangelia Ntzani, Guido Rychen, Salomon Sand, Katharina Vejdovszky, Barbara Viviani, Lars Barregård, Diane Benford, Eugenia Dogliotti, Kevin Francesconi, Jose Ángel Gómez Ruiz, Hans Steinkellner, Tanja Schwerdtle

“…For AsB, no reference point (RP) could be derived because of insufficient toxicity data. AsB did not show adverse effects in the two available repeat dose toxicity tests in rodents. …”
Get full text

Novel tetracycline hybrids: synthesis, characterization, docking studies and in-vitro evaluation of antibacterial activity by Mansi Shah, Bhanubhai Suhagia, Sunita Goswami, Sneha Sagar, Arpit Patwari

“…Molecular dynamic simulation studies and in silico pharmacokinetic and toxicity prediction studies were done to determine in silico pharmacokinetics and toxicity of compounds. …”
Get full text

Complications and Influential Perioperative Factors Associated with SpaceOAR Hydrogel Placement by Kerith R. Wang, Rishabh K. Simhal, Cassra B. Clark, Mark J. Mann, James R. Mark, Costas D. Lallas, Robert Den, Edouard J. Trabulsi

“…Overall, the hydrogel placement was well tolerated with low incidence of mild and transient procedure-related toxicity.…”
Get full text

Enhancement of in vitro antitumour activity of epirubicin in HER2+ breast cancer cells using immunoliposome formulation by Farnaz Khaleseh, Abbas Hemmati Azandaryani, Fatemeh Fathian Kolahkaj, Mozafar Khazaei, Katayoun Derakhshandeh

“…The preparation process of liposomes was a modified ethanol injection method followed by Herceptin conjugation. The in vitro cell toxicity and cellular uptake of optimum formulation against HER2+ and HER2− cancer cell lines were evaluated. …”
Get full text

Safety evaluation of the food enzyme α‐amylase from the non‐genetically modified Aspergillus sp. strain FUA by EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Monika Sramkova, Henk Van Loveren, Laurence Vernis, Cristina Fernàndez‐Fraguas, Magdalena Andryszkiewicz, Natalia Kovalkovicova, Eleonora Marini, Yi Liu

“…Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. …”
Get full text

Enhancing oral cancer treatment via photodynamic therapy: Gold nanoparticle-based delivery system for 5-aminolevulinic acid (5-ALA) by Romesa Soomro, Mohamed Abdelmonem, Bachren Azra Saputra, Che Azurahanim Che Abdullah

“…Traditional treatments, including surgery, radiation, and chemotherapy, often lead to severe side effects such as physical disfigurement, functional loss, and systemic toxicity. These limitations have spurred the search for alternative therapies, with photodynamic therapy (PDT) gaining recognition for its reduced invasiveness, improved targeting, and better cosmetic outcomes. …”
Get full text

Antifilarial Activity of the Methanolic Extract of Indigofera tinctoria (Fabaceae) on Bovine Parasites (Onchocerca ochengi) by Enock Enock Rakwa, Benoît Bargui Koubala, Bertrand Ndou Mando, Mathieu Djongra, Francis Nveikoueing, Dieudonné Ndjonka

“…The promising plant extract’s acute and subacute oral toxicity were evaluated on both mice and rats. The result revealed a highest antifilarial activity of the methanolic extract (LC50=12.28 μg/mL) compared to ivermectin (LC50=26.50 μg/mL) after 72 h of treatment. …”
Get full text

Optimizing Bioaugmentation for Pharmaceutical Stabilization of Sewage Sludge: A Study on Short-Term Composting Under Real Conditions by Gabriela Angeles-De Paz, Juan Cubero-Cardoso, Clementina Pozo, Concepción Calvo, Elisabet Aranda, Tatiana Robledo-Mahón

“…Their uncomplete removal and lack of monitoring during composting neglects their potentially toxic effects when used as a soil organic amendment. …”
Get full text

Computational design of potent dimeric phenylthiazole NS5A inhibitors for hepatitis C virus by Wissal Liman, Mehdi Oubahmane, Nouhaila Ait Lahcen, Ismail Hdoufane, Driss Cherqaoui, Rachid Daoud, Achraf El Allali

“…Finally, the absorption, distribution, metabolism, excretion, and toxicity analysis were performed to assess the pharmacokinetic and toxicity profiles of the inhibitor candidates. …”
Get full text

Anthracycline-induced arrhythmias in breast cancer therapy: A meta-analysis of single-arm trials. by Tao Ran, Jinyao Chen, Qiurui She, Yi Mu, Min Zhang, Min Mao, Zhong Zuo, Juan Li

“…However, these anthracycline-based drugs are associated with cardiac toxicity. This study represents the first clinical quantitative analysis aimed at accurately determining the incidences of arrhythmia and abnormal electrocardiogram (ECG) changes, thereby providing valuable data to bolster clinical drug usage and monitoring.…”
Get full text

Treatment With Avacopan in Patients With Respiratory Tract Manifestations of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis by Ulrich Specks, Robert F. Spiera, Lynn A. Fussner, Robert Lebovics, Sarah Bray, Rachel E. Gurlin, Darcy Trimpe, David R. W. Jayne, Peter A. Merkel, for the ADVOCATE Study Group

“…The relapse rate, glucocorticoid toxicity, and measures of HRQoL favored avacopan for both respiratory tract manifestation groups. …”
Get full text

Determination of Crizotinib in Mouse Tissues by LC-MS/MS and Its Application to a Tissue Distribution Study by Fang Zhao, Yuan Wei, Yiming Yan, Han Liu, Sitong Zhou, Bo Ren, Ruijuan Liu

“…Toxicity induced by crizotinib, a small-molecule tyrosine kinase inhibitor, is a significant clinical issue during treatment. …”
Get full text

Vancomycin population pharmacokinetic models: Uncovering pharmacodynamic divergence amid clinicobiological resemblance by Peggy Gandia, Sahira Chaiben, Nicolas Fabre, Didier Concordet

“…Thus, it is fundamental to evaluate the impact of these differences on both efficacy/toxicity.…”
Get full text

Nanoformulation of Polymyxin E Through Complex Coacervation: A Pharmacokinetic Analysis by Xiaobao Chen, Li Liu, Weidan Wang, Yuan Yuan, Wei Wang

“…The positive charge inherent in PME causing its toxicity was mitigated after complex coacervation.…”
Get full text

Proliferative and viability effects of two cyanophages on freshwater bloom-forming species Microcystis aeruginosa and Raphidiopsis raciborskii vary between strains by Nada Tokodi, Antonia Łobodzińska, Barbara Klimczak, Adam Antosiak, Sara Młynarska, Sigitas Šulčius, Sarit Avrani, Takashi Yoshida, Dariusz Dziga

“…The high variability in responses observed with a limited subset of cyanophage-cyanobacteria combinations not only highlights the intricate role of viral infections in microbial ecosystems but also underscores the significant challenges in predicting the composition, toxicity, and dynamics of cyanobacterial blooms.…”
Get full text

Pretreatment with serine protease inhibitors impairs Leishmania amazonensis survival on macrophages by Patrícia de Almeida Machado, Pollyanna Stephanie Gomes, Elaine Soares Coimbra, Herbert Leonel de Matos Guedes

“…The current chemotherapy available for the treatment of leishmaniasis presents several problems, such as adverse effects, toxicity, long treatment time, and parasite resistance. …”
Get full text

Stimuli-responsive supramolecular hydrogels for paclitaxel delivery: Progress and prospects by Mohammad Qutub, Amol Tatode, Jayshree Taksande, Tanvi Premchandani, Milind Umekar, Ujban Md Hussain, Dinesh Biyani, Dadaso Mane

“…This review highlights recent advancements and future prospects of thermosensitive hydrogels for PTX delivery, emphasizing their potential to revolutionize cancer treatment by reducing systemic toxicity and improving localized therapeutic outcomes.…”
Get full text