Cutting-edge Bioinformatics strategies for synthesizing Cyclotriazadisulfonamide (CADA) analogs in next-Generation HIV therapies by Jay Gabriel B. Larga, Wrynan T. Munabirul, Abu Tayab Moin, Md Maisum Sarwar Jyoti, Mst Sanjida Nasrin, Minhaz Abdullah Al Mueid, Abdul Ahad, Anwar Parvez, Mst Sabrina Yeasmin, Rupali M. Barhate, Rajesh B. Patil, Margel C. Bonifacio

“…Additionally, 33 of the 113 analogs were deemed bioavailable using a bioavailability criteria specific for macrocycles. Toxicity predictions using PASS Online and StopTox identified analogs JGL023, JGL024, JGL032, and JGL047 as potential drug candidates. …”
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Evaluating the potential of Kalanchoe pinnata, Piper amalago amalago, and other botanicals as economical insecticidal synergists against Anopheles gambiae by Sheena Francis, William Irvine, Lucy Mackenzie-Impoinvil, Lucrecia Vizcaino, Rodolphe Poupardin, Audrey Lenhart, Mark J. I. Paine, Rupika Delgoda

“…The combination of both insecticides and synergists increases the toxicity of the mixture. Given the demonstrated resistance to the classical insecticides in numerous Anopheles spp., the use of synergists is becoming increasingly pertinent. …”
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Life cycle assessment of paper products based on recycled and virgin fiber by J. Simamora, E.I. Wiloso, M. Yani

“…The results of the impact assessment of global warming potential fossil, acidification, particulates, fossil abiotic depletion, and human toxicity-cancer for duplex board were 1,848.26 kilogram carbon dioxide equivalent, 8.12 kilogram-sulfur-dioxide-equivalent, 2.12 kilogram particulate matter 2.5-equivalent, 14,668.06 megajoule, and 0.0000017 comparative toxic unit, while for folding boxboard 2,651.25 kilogram carbon- dioxide-equivalent, 13.95 kilogram sulfur-dioxide-equivalent, 3.27 kilogram particulate matter 2.5-equivalent, 22,395.81 mega-joule, and 0.0000021 comparative toxic unit, respectively. …”
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A Case Report of Subacute Combined Spinal Cord Degeneration Caused by Nitrous Oxide (‘Laughing Gas’) Abuse by J. Guk, J. Valančienė, A. Klimašauskienė

“…Early recognition and treatment of N2O toxicity are crucial. We present the case of an 18-year-old male who was diagnosed with subacute combined spinal cord degeneration related to N2O abuse. …”
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The Fate of Allogeneic Pancreatic Islets following Intraportal Transplantation: Challenges and Solutions by Xinyu Li, Qiang Meng, Lei Zhang

“…However, there are many obstacles contributing to the early mass loss of the islets and progressive islet loss in the late stages of clinical islet transplantation, including hypoxia injury, instant blood-mediated inflammatory reactions, inflammatory cytokines, immune rejection, metabolic exhaustion, and immunosuppression-related toxicity that is detrimental to the islet allograft. …”
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Innovative approaches to asthma treatment: harnessing nanoparticle technology by Vanshika Goswami, Kushneet Kaur Sodhi, Chandra Kant Singh

“…It has been shown in studies that these drug delivery systems can greatly enhance targeting and bioavailability and decrease the toxicity of medication. Nanoparticle drug delivery systems offer improved therapeutic efficacy compared to conventional administration techniques. …”
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Postplanting Nutritional Augmentation of Jeffrey Pine Seedlings on an Infertile Sierran Site by Roger F. Walker

“…Foliar analysis revealed that improved N nutrition was probably critical in the favorable growth responses to fertilization, that of P was a likely contributor, and amelioration of potential Mn toxicity may have assumed an accessory role.…”
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Ischemic Retinal Vasculitis Associated with Cataract Surgery and Intracameral Vancomycin by Lucas T. Lenci, Eric K. Chin, Christi Carter, Stephen R. Russell, David R. P. Almeida

“…Unlike prior reports, this report demonstrates a case of mild visual reduction and minimal inflammation with subtle but complete unilateral peripheral retinal ischemia associated with cataract surgery and intracameral vancomycin, suggesting a spectrum of toxicity that may be underrecognized.…”
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Hyaluronic Acid-Based Drug Delivery Systems for Cancer Therapy by Ekaterina Pashkina, Maria Bykova, Maria Berishvili, Yaroslav Lazarev, Vladimir Kozlov

“…Due to its unique properties, such as high biocompatibility, low toxicity, and modifiability, HA is becoming a basis for the creation of targeted drug delivery systems, especially in the field of oncology. …”
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Scorpion Venom and the Inflammatory Response by Vera L. Petricevich

“…Scorpion venoms consist of a complex of several toxins that exhibit a wide range of biological properties and actions, as well as chemical compositions, toxicity, and pharmacokinetic and pharmacodynamic characteristics. …”
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Sonication-Assisted Synthesis of β-Mercuric Sulfide Nanoparticles by Xin Xu, Elizabeth R. Carraway

“…Continued development of synthesis methods is needed to expand approaches that produce uniform particles, while avoiding reagents of high toxicity and ecological impact. A solvent‐based approach was developed using mercuric chloride and elemental sulphur as the mercury and chalcogenide sources. …”
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Acute Renal Failure Secondary to Inadvertent Propylene Glycol Overdose with Single-Day High-Dose Vitamin D (Stosstherapy) by David H. Jelley, Deborah Zayneb Mohamad Ali, Michelle Condren

“…We present an as yet unreported complication of acute renal injury due to propylene glycol toxicity in a 7-month infant treated with vitamin D stosstherapy. …”
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Arsenic Contamination of Groundwater: A Review of Sources, Prevalence, Health Risks, and Strategies for Mitigation by Shiv Shankar, Uma Shanker, Shikha

“…The paper also critically reviews the As led human health risks, its uptake, metabolism, and toxicity mechanisms. The paper provides an overview of the state-of-the-art knowledge on the alternative As free drinking water and various technologies (oxidation, coagulation flocculation, adsorption, and microbial) for mitigation of the problem of As contamination of groundwater.…”
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Emergency Evacuation of Hazardous Chemical Accidents Based on Diffusion Simulation by Jiang-Hua Zhang, Hai-Yue Liu, Rui Zhu, Yang Liu

“…The recent rapid development of information technology, such as sensing technology, communications technology, and database, allows us to use simulation experiments for analyzing serious accidents caused by hazardous chemicals. Due to the toxicity and diffusion of hazardous chemicals, these accidents often lead to not only severe consequences and economic losses, but also traffic jams at the same time. …”
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Piperine: Chemical, biological and nanotechnological applications by Quijia Christian Rafael, Araujo Victor Hugo, Chorilli Marlus

“…The present article provides a comprehensive review of PIP research in the last years concerning its chemical properties, synthesis, absorption, metabolism, bioavailability and toxicity. The reviewed PIP literature has shown many pharmacological properties, such as antidiabetic, antidiarrheal, antioxidant, antibacterial, and anti-parasitic activity of PIP. …”
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Toxicological Review of Anticancer Plants Used in Traditional Medicine in Morocco by Soufiane Drioua, Abha Cherkani-Hassani, Otman El-Guourrami, Mouna Ameggouz, Ahmed Zahidi, Abdelhakim Bouyahaya, Sayyed Ibrahim Shah, Yaser Mohammed Al-Worafi, Long Chiau Ming, Hanane Benzaied, Anass Doukkali

“… In Morocco, traditional medicine utilizes many toxic plants for cancer treatment, despite a lack of scientific evidence supporting their effectiveness. …”
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Midregion PTHrP and Human Breast Cancer Cells by Claudio Luparello

“…The midregion PTHrP domain (38-94)-amide was found to restrain growth and invasion in vitro of some breast cancer cell lines, causing striking toxicity and accelerating death; the most responsive being MDA-MB231, whose tumorigenesis was also attenuated in vivo. …”
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TOXICOLOGIC CHARACTERISTICS OF THE PREVENTIVE IODINE-CONTAINING PREPARATION “VANGTSEYOD” by T. V. Kruchinkina, Yu. A. Gavrilov, G. A. Gavrilova

“…Studies of the preparation safety performed on white mice showed that “Vangtseyod” does not have acute toxicity. It’s inclusion into mice diet at 1.0 and 2.0 g/kg dose during two months did not induce any signs of chronic intoxication as 100% mice of experimental group survived in comparison with the control group (57%). …”
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Recurrence of Chronic Myeloid Leukemia during Pregnancy Subsequently Achieving Complete Medical Remission by Sasha Mikhael, Ashlee Pascoe, Joseph Prezzato

“…Much controversy exists regarding continuation versus discontinuation of its use in pregnancy with some studies suggesting safety of TKIs before and during pregnancy and others reporting toxicity and adverse outcomes. TKIs have become a well-established treatment option for CML, significantly improving prognosis, and yet have been reported to be fetotoxic. …”
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Oral Cavity Squamous Cell Carcinoma: Impact of Clear Margin Distance on Locoregional Control in Patients Undergoing Postoperative Radiotherapy by Erkan Topkan MD, Efsun Somay PhD, Ugur Selek MD

“…We congratulate Lang and colleagues for their study investigating the impact of resection margin (RM) size on locoregional control (LC) outcomes, overall survival (OS), progression-free survival (PFS), and treatment-related toxicity in 162 patients with oral cavity squamous cell carcinoma (OCSCC) who received postoperative radiotherapy (PORT).1 In this study, 77 (47.5%), 22 (13.6%), and 63 (38.9%) patients had involved (5 mm) RM, respectively. …”
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