Toxicological Characterization of Six Plants of the Beninese Pharmacopoeia Used in the Treatment of Salmonellosis by Boris Legba, Victorien Dougnon, Esther Deguenon, Jerrold Agbankpe, Maximin Senou, Alidah Aniambossou, Carène Gbaguidi, Kevin Sintondji, Lamine Baba-Moussa, Jacques Dougnon

“…Unfortunately, very little data exists on the toxicity of these species. This study aims to evaluate chemical characteristic of six Benin pharmacopoeial plants used in the traditional treatment of salmonellosis in Benin. …”
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GROWTH AND YIELD RESPONSES OF SOYBEAN (Glycine max L.) TO ZINC OXIDE (ZnO) NANOPARTICLES FOLIAR APPLICATION by Fayomi Omotola Michael, Olasan Joseph Olalekan, Aguoru Celestine Uzoma, Terhemba Mamnenge Sarah

“…Conversely, higher concentrations (100 ppm) exhibited inhibitory effects on plant height and leaf morphology, suggesting potential toxicity at elevated ZnO NP levels. Statistical analyses, including one-way ANOVA and Pearson’s correlation, confirmed significant treatment effects (P ≤ 0.05) on growth and yield parameters, highlighting the critical role of dose optimization. …”
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A Comparative Review: Biological Safety and Sustainability of Metal Nanomaterials Without and with Machine Learning Assistance by Na Xiao, Yonghui Li, Peiyan Sun, Peihua Zhu, Hongyan Wang, Yin Wu, Mingyu Bai, Ansheng Li, Wuyi Ming

“…However, nanomaterials have been identified as potentially toxic, with the toxicity of metal nanoparticles posing significant risks to both human health and the environment. …”
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Effect of copper ions on the associations of <i>Azospirillum</i> bacteria with wheat seedlings (<i>Triticum aestivum</i> L.) by A. Yu. Muratova, E. V. Lyubun, S. N. Golubev, O. V. Turkovskaya

“…All strains more or less compensated for copper toxicity to seedling development and increased metal accumulation in roots and shoots. …”
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Effects of nonspecific resistance in barley genotypes obtained by cell selection by O. N. Shupletsova, S. Yu. Ogorodnikova, Ya. I. Nazarova

“…The use of somaclones (regenerant forms) of barley with resistance to increased acidity, ionic toxicity of aluminum, heavy metals and drought is promising in the northeast of the Non-Black-Soil Zone of Russia. …”
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Identification of Two Flavonoids as New and Safe Inhibitors of Kynurenine Aminotransferase II via Computational and In Vitro Study by Redouane Rebai, Luc Jasmin, Abdennacer Boudah

“…The MTT assay for cell toxicity indicated that the two compounds do not affect HepG2 cell viability at the necessary concentration for KAT-II inhibition. …”
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<i>Cuphea hookeriana</i>: Phytochemical Profile and the Cosmeceutical and Dermatological Properties of Its Active Fraction from the Whole Plant by Xing Wu, Meng-Fei Wanyan, Bao-Bao Shi, Rong Huang, Hui-Xiang Yang, Xian Wang, Ji-Kai Liu

“…It inhibited the two target enzymes (tyrosinase and MMP-1) engaged in skin whitening and aging with comparable IC₅₀ values to the reference drugs. Acute toxicity experiments showed that mice gavage orally with the fine active fraction had no significant animal toxicity at a dose of 2000 mg/kg, and the maximum tolerated dose (MTD) in mice was greater than 2000 mg/kg. …”
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RETRACTED ARTICLE: A novel, bioactive and antibacterial scaffold based on functionalized graphene oxide with lignin, silk fibroin and ZnO nanoparticles by Reza Eivazzadeh-Keihan, Ensiye Zare-Bakheir, Hooman Aghamirza Moghim Aliabadi, Mostafa Ghafori Gorab, Hossein Ghafuri, Ali Maleki, Hamid Madanchi, Mohammad Mahdavi

“…As a result, the synthesized structure has a hemolysis percentage below 12% and its toxicity effect on Hu02 cells is below 9%.…”
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Vitamin E and N-Acetylcysteine as Antioxidant Adjuvant Therapy in Children with Acute Lymphoblastic Leukemia by Youssef Al-Tonbary, Mohammad Al-Haggar, Rasha EL-Ashry, Sahar EL-Dakroory, Hanan Azzam, Ashraf Fouda

“…Although cancer therapies have experienced great success nowadays, yet the associated toxic response and free radicals formation have resulted in significant number of treatment-induced deaths rather than disease-induced fatalities. …”
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Encapsulation of paclitaxel into date palm lipid droplets for enhanced brain cancer therapy by Amal YOUSFAN, Nour MOURSEL, Abdulsamie HANANO

“…Abstract Paclitaxel, a powerful anticancer drug, is limited by its poor water solubility and systemic toxicity, which hinder its effectiveness against aggressive brain tumors. …”
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N-3 Polyunsaturated Fatty Acids Stimulate Bile Acid Detoxification in Human Cell Models by Anna Cieślak, Jocelyn Trottier, Mélanie Verreault, Piotr Milkiewicz, Marie-Claude Vohl, Olivier Barbier

“…Cholestasis is characterized by the accumulation of toxic bile acids (BAs) in liver cells. The present study aimed to evaluate the effects of n-3 polyunsaturated fatty acids (n-3 PUFAs), such as docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids, on BA homeostasis and toxicity in human cell models. …”
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Engineering a tumor-selective prodrug T-cell engager bispecific antibody for safer immunotherapy by Amelia C. McCue, Stephen J. Demarest, Karen J. Froning, Michael J. Hickey, Stephen Antonysamy, Brian Kuhlman

“…On-target, off-tumor toxicity can arise when the target antigen is also present on healthy cells. …”
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Anti-Biofilm Effect of Ampicillin-Loaded Poly (Lactic-co-glycolic Acid) Nanoparticles Conjugated with Lysostaphin on Methicillin-Resistant Staphylococcus aureus by Elahe Norouzi, Seyed Mostafa Hosseini, Babak Asghari, Reza Mahjoub, Ehsan Nazarzadeh Zare, Mohammad-Ali Shahbazi, Fereshte Kalhori, Mohammad Reza Arabestani

“…The biofilm investigation’s findings, however, indicated that compared to the free drug, the hindering effect of the nanodrug carrier was greater after 72 hours. The toxicity test findings revealed that the synthesized nanodrug had no toxic effects on the cells. …”
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Strategies to Enhance Nanocrystal Formulations for Overcoming Physiological Barriers Across Diverse Routes of Administration by Yanamadala Y, Muthumula CMR, Khare S, Gokulan K

“…However, the challenges related to toxicity, scale-up, and clinical translation still need further attention. …”
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In Vitro Vitamin K3 Effect on Conjunctival Fibroblast Migration and Proliferation by I. Pinilla, L. B. Izaguirre, F. J. Gonzalvo, E. Piazuelo, M. A. Garcia-Gonzalez, A. I. Sanchez-Cano, F. Sopeña

“…Vitamin K3 2 mg/L or higher doses inhibit wound healing repair, exhibiting cellular toxicity at 4 and 6 mg/L.…”
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Silver nanoparticle induced immunogenic cell death can improve immunotherapy by Ara Sargsian, Xanthippi Koutsoumpou, Hermon Girmatsion, Can Egil, Kiana Buttiens, Carla Rios Luci, Stefaan J. Soenen, Bella B. Manshian

“…Here, we set out to screen a variety of metallic nanoparticles and explored their in vitro toxicity against a series of tumor and non-tumor cell lines. …”
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Complex System Analysis of Blumeria graminis f.sp. tritici Isolates Collected in Central Hebei Province, China by Qingping Zhou, Lingli Li, Long Wang

“…In this study, using wheat seedling culture in vitro, the physiological races of wheat powdery mildew in central Hebei province were identified, and the population toxicity frequency was analyzed. The results were as follows: (1) 36 strains were purified and 20 physiological races were identified. …”
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Traditional Uses, Bioactive Compounds, and Pharmacological Investigations of Calendula arvensis L.: A Comprehensive Review by Aya Khouchlaa, Aicha El Baaboua, Hamza El Moudden, Fatima Lakhdar, Saad Bakrim, Naoual El Menyiy, Omar Belmehdi, Hicham Harhar, Nasreddine El Omari, Abdelaali Balahbib, Moon Nyeo Park, Gokhan Zengin, Bonglee Kim, Abdelhakim Bouyahya

“…Nevertheless, pharmacokinetic validation and toxicological examinations are required to detect any possible toxicity for future clinical trials.…”
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Synthesis and Characterization of 5-Fluoroacil Loaded Calcium Carbonate Nanoparticles for Targeted Cancer Therapy by Kshidan Marim Abdullah Salem, Mohamed Ahmed Ibrahim, Kim Wei Chan, Md Zuki Abu Bakar, Noorjahan Banu Alitheen, Mohammed Alsubbi, Ahmad Faizal Abdull Razis, Norsharina Ismail

“…1736142025"> Chemotherapy is often limited by its systemic toxicity and lack of specificity, necessitating the development of targeted drug delivery systems that can enhance therapeutic efficacy while minimizing adverse effects. …”
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Organic UV-filters and freshwater organisms: data gaps impede a robust retrospective environmental risk assessment by Alexandra Kroll, Cornelia Kienle, Marion Junghans

“…Therefore, new assessment methods (NAMs) are recommended, including the use of fish cell lines for acute toxicity testing and alternatives for the assessment of chronic toxicity.…”
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