The Management of Classical Hodgkin's Lymphoma: Past, Present, and Future by S. E. Richardson, C. McNamara

“…In addition, the young age of many Hodgkin's patients forces difficult decisions in balancing the benefit of early disease control against the survival disadvantage of late toxicity. In this article we aim to summarise past trials, define the current standard of care and appraise future developments in the management of CHL.…”
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Is It Safe to Restart Antivascular Endothelial Growth Factor Therapy in Patients with Renal Cell Carcinoma after Cardiac Ischemia? by Bo Zhao, Laura S. Wood, Karen James, Brian I. Rini

“…Studies have shown that sunitinib and axitinib can be associated with cardiac toxicity. Whether these agents should be restarted in patients who experience cardiac ischemia remains uncertain. …”
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Prediction of ADMET profile and anti-inflammatory potential of chamuangone by Sompot Jantarawong, Puripat Wathanaphanit, Pharkphoom Panichayupakaranant, Yutthana Pengjam

“…Yet, its absorption, distribution, metabolism, excretion, and toxicity (ADMET) profile as well as anti-inflammatory effects in macrophages remain unexplored. …”
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Chromium-Cobalt Intoxication with Intense Systemic Complications following Total Hip Revision after Per-Operative Ceramic Fracture by Paul Lecoanet, Mathias Blangis, Matthieu Garcia, Yohan Legallois, Thierry Fabre

“…We report the case of a 69-year-old woman, who presented intense systemic symptoms of chromium-cobalt intoxication after revision of per-operative fractured ceramic components with metal-on-polyethylene. Systemic toxicity occurred a year after surgery and expressed brutally with mostly central neurological symptoms. …”
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Comparative Study on Biosorption of Zn(II), Cu(II) and Cr(VI) from Textile Dye Effluent Using Sawdust and Neem Leaves Powder by K. Gopalakrishnan, V. Manivannan, T. Jeyadoss

“…The presence of the decreased heavy metal toxicity in the treated textile dye effluent was evaluated through the percentage of seed germination of Vigna mungo L. …”
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Dioxazolones as electrophilic amide sources in copper-catalyzed and -mediated transformations by Seungmin Lee, Minsuk Kim, Hyewon Han, Jongwoo Son

“…However, these catalytic systems often present several challenges associated with cost, toxicity, stability, and recyclability. Among the 3d transition metals, copper catalysts have been gaining increasing attention owing to their abundance, cost-effectiveness, and sustainability. …”
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The theory of oxidative stress as a direct cause of cell aging by Milagros Lisset León Regal, Raúl Cedeño Morales, Rodolfo Javier Rivero Morey, Jeisy Rivero Morey, Diana Laura García Pérez, Leissay Bordón González

“…It is concluded that oxygen which is necessary for cell viability and other exogenous substances show toxicity since they lead to the formation of free radicals whose action is the main cause of aging. …”
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Antibacterial Activity of Selected Essential Oil Components and Their Derivatives: A Review by Vuyolwethu Khwaza, Blessing A. Aderibigbe

“…Furthermore, this review highlights recent advancements in developing derivatives of these EO components, which have shown improved antibacterial activity with reduced toxicity. By summarizing recent studies, this review reveals the potential of these natural compounds and their derivatives as promising candidates for pharmaceuticals, food preservation, and as alternatives to synthetic antibiotics in combating bacterial resistance.…”
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Bacterial Infections, DNA Virus Infections, and RNA Virus Infections Manifest Differently in Neutrophil Receptor Expression by Esa-Matti Lilius, Jari Nuutila

“…Treating viral illnesses or noninfective causes of inflammation with antibiotics is ineffective and contributes to the development of antibiotic resistance, toxicity, and allergic reactions, leading to increasing medical costs. …”
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Primary Cutaneous Diffuse Large B-Cell Lymphoma of the Upper Limb: Double Hit/Double Expressor with CNS Involvement: From Hospice to Remission by Brenda S. Castillo, Maria L. Rodriguez, Ju-Hsien John Chao, Behyar Zoghi

“…After achieving complete remission, the patient underwent an autologous stem cell transplant with minimal transplant-related toxicity.…”
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Sublethal Effects of Diesel on Total Protein Levels and Cholesterol in <i>Tympanotonus Fuscatus</i> by OS Edori, IB Nwoke, ES Edori

“…This study showed that exposure of periwinkles (Tympanotonus fuscatus) to diesel toxicity could cause deleterious effects or changes in the organism biochemistry.…”
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Nanoexposure, Unusual Diseases, and New Health and Safety Concerns by Yuguo Song, Shichuan Tang

“…Accumulating studies in animals have shown that nanoparticles could cause unusual rapid lung injury and extrapulmonary toxicity. Whether exposure of workers to nanoparticles may result in some unexpected damage as seen in animals is still a big concern. …”
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Autoantibodies and Liver Disease: Uses and Abuses by Marilyn V Zeman, Gideon M Hirschfield

“…In the continued absence of pathognomonic serum markers, diagnosis requires evaluation of laboratory investigations and, frequently, a liver biopsy – all of which need to be interpreted in the correct clinical context, with an emphasis on exclusion of viral infections, drug toxicity and metabolic disease. However, clear diagnosis is important for appropriate and timely therapy. …”
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Therapeutic drug monitoring of atypical antipsychotic drugs by Grundmann Milan, Kacirova Ivana, Urinovska Romana

“…It can help in monitoring adherence, dose adjustment, minimizing the risk of toxicity and in cost-effectiveness in the treatment of psychiatric disorders. …”
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VDB Entropy Measures and Irregularity-Based Indices for the Rectangular Kekulene System by Weidong Zhao, K. Julietraja, P. Venugopal, Xiujun Zhang

“…Irregularity indices are numerical parameters that quantify the irregularity of a molecular graph and are used to predict some of the chemical properties, including boiling points, resistance, enthalpy of vaporization, entropy, melting points, and toxicity. This study aims to determine analytical expressions for the VDB entropy and irregularity-based indices in the rectangular Kekulene system.…”
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Sublethal Effects of Diesel on Total Protein Levels and Cholesterol in <i>Tympanotonus Fuscatus</i> by OS Edori, IB Nwoke, ES Edori

“…This study showed that exposure of periwinkles (Tympanotonus fuscatus) to diesel toxicity could cause deleterious effects or changes in the organism biochemistry.…”
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The Redox System in C. elegans, a Phylogenetic Approach by Andrew D. Johnston, Paul R. Ebert

“…Oxidative stress is a toxic state caused by an imbalance between the production and elimination of reactive oxygen species (ROS). …”
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Teaching an old dog new tricks: re-engineering IL-2 for immuno-oncology applications by Mario Sznol, Naiyer Rizvi

“…Interleukin-2 has become a prominent focus of preclinical and clinical investigation, because of its known clinical activity, the important role of this cytokine in immune biology, and the ability to engineer variant proteins with potentially improved antitumor immunomodulatory activity and reduced toxicity. Bempegaldesleukin, the first of the modified IL-2 agents to reach phase 3 evaluation in combination with an anti-PD-1, did not improve outcome for patients with metastatic melanoma and renal carcinoma. …”
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Update on glasdegib in acute myeloid leukemia – broadening horizons of Hedgehog pathway inhibitors by Fersing Cyril, Mathias Fanny

“…Glasdegib, an oral Hedgehog pathway inhibitor, showed satisfactory response rates associated with moderate toxicity and less early mortality than standard induction regimens in this population. …”
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Atypical Manifestation of DRESS Syndrome by Christopher Hakim, Constantine Melitas, Eric Nguyen, Kha Ngo

“…The differential for liver transaminases over 1000 units/liter typically includes liver ischemia, acute viral hepatitis, acetaminophen toxicity, and autoimmune hepatitis. Prompt evaluation is imperative as these etiologies can lead to fulminant liver failure. …”
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