Awardee Summary of 2023 Taiwan Oncology Society Clinical Research Award Recipient: Persistent Endeavors on Research of Digestive Cancers for Three Decades by Kun-Huei Yeh

“…HDFL exhibits satisfactory single-agent activity, minimal myelosuppression, and mild toxicity. A variety of HDFL-based doublet combinations (such as cisplatin-HDFL, oxaliplatin-HDFL, and paclitaxel-HDFL) have become cornerstone regimens for three decades for the treatment of gastric cancers, with high efficacy and manageable toxicity at our hospital. …”
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Winter rye cultivars moderately resistant to ergot by L. M. Shchekleina, T. K. Sheshegova

“…A biochemical analysis of the sclerotia of the fungus was carried out, the composition and content of ergot alkaloids (EA) in the sclerotia of C. purpurea from the Kirov population were studied, and the relationship between the biometry of sclerotia and the EA content, toxicity and pathogenicity of C. purpurea was analyzed. …”
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Quercetin Zinc and Iron Metal Complexes Protect against Sodium Arsenite Intoxication in the Hepato-Renal System of Wistar Rats via the Oxidative Stress Pathway by Oluwatoyin O. Ojo, Deborah I. Fatokun, Ikechukwu P. Ejidike, Rachel U. Awolope, Saheed O. Sanni

“…Treatment of arsenic-toxicity with quercetin and its complexes decreased the activities of ALT, AST, CREA, TP, CAT, and GST and concentration of LPO and GSH. …”
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Exploring the anticancer potential of Hewittia malabarica through phytochemical analysis and molecular docking study by Shiji Thozhukkad Moosaripparambil, Kannan Vadakkadath Meethal

“…These extracts were comparatively non-toxic to the normal human keratinocyte cell line, HaCaT, indicating its selective toxicity to cancerous cells. …”
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In Vivo Antiplasmodial Activity and Toxicological Analyses of the Ethanolic Leaf and Twig Extract of Faurea speciosa Welw. (Proteaceae) by Felix Ayisi, Caleb Nketia Mensah, Lawrence Sheringham Borquaye

“…The phosphomolybdenum and DPPH radical scavenging assays were used in the evaluation of antioxidant potential. Acute toxicity of the extract was evaluated using the Organization for Economic Cooperation and Development (OECD) guidelines. …”
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Sculpting multi-epitope vaccine against Monkeypox viral strains using immunoinformatics by Zaira Rehman, Ammad Fahim, Maryam Irtash

“…All the epitopes were further screened for antigenicity, allergenicity, and toxicity properties using VaxiJen, Allertop, and Toxinpred server. …”
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Abatement by Alhagi maurorum of lead-induced nephrotoxicity in rats: emphasis on Nrf2/HO-1 by Mardi M. Algandaby

“…Abstract Background Lead (Pb) is a heavy metal with extreme toxicity and numerous industrial uses. It produces nephrotoxicity with notable changes in renal architecture and function. …”
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Effect of extract and fractions of stem bark of Morinda lucida Benth (Rubicaceae) on castor-oil induced diarrhea in mice by Ibeabuchi Jude Ali, Obiora Celestine Ugwu, Cyril Chekwube Adonu, Romanus Chijioke Omeh, Felix Kenolisa Asogwa, Ndidiamaka Hannah Okorie, Raymond Maduabuchi Okonkwo, Onyeka Obidiegwu, Patrick Chibueze Onyegbulam, Festus Basden Chiedu Okoye

“…The method of Lorke’s was employed in the acute toxicity study. The evaluation of anti-diarrhea activity was carried out by the castor-Oil-induced gastro-intestinal motility model. …”
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Alcohol induces α2‐6sialo mucin O‐glycans that kill U937 macrophages mediated by sialic acid‐binding immunoglobulin‐like lectin 7 (Siglec 7) by Pi‐Wan Cheng, Vishwanath‐Reddy Hothpet, Ganapati Bhat, Kristina Bailey, Lei Li, Derrick R. Samuelson

“…These results provide a mechanistic insight into the cause of the toxic effects of alcohol and might contribute to the development of therapies to alleviate its toxicity.…”
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End-of-Life Options for (Bio)degradable Polymers in the Circular Economy by Wanda Sikorska, Marta Musioł, Barbara Zawidlak-Węgrzyńska, Joanna Rydz

“…If we add to their biodegradability the absence of toxicity, we have a biotechnological product of great industrial interest. …”
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Phytotoxicity and Benzoxazinone Concentration in Field Grown Cereal Rye (Secale cereale L.) by C. La Hovary, D. A. Danehower, G. Ma, C. Reberg-Horton, J. D. Williamson, S. R. Baerson, J. D. Burton

“…Results showed that rye tissue harvested in March was the most toxic to indicator species, with toxicity decreasing thereafter. …”
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Magnetic precision: Unleashing the therapeutic potential of paclitaxel-loaded nanoparticles in breast cancer treatment by N. Shobhana, N Raghavendra Naveen, Prakash Goudanavar

“…With its high incidence and significant impact on morbidity and mortality, breast cancer necessitates novel treatment modalities to enhance therapeutic outcomes and mitigate systemic toxicity associated with conventional chemotherapeutic agents. …”
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Hydroxychloroquine and Fabry Disease: Three Case Reports Examining an Unexpected Pathologic Link and a Review of the Literature by Rouhin Sen, Kathleen Borghoff, Kirk W. Foster, Stanley J. Radio, Alan Erickson, Michelene Hearth-Holmes

“…All three patients were on hydroxychloroquine therapy for varying amounts of time with histologic evidence of hydroxychloroquine toxicity that is three is present in histological samples of the kidney, the heart, and the skeletal muscle. …”
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Nanoparticles in Soil Reclamation: A Review of Their Role in Reducing Soil Compaction by Hasan Alkhaza’leh, Michel Rahbeh, Imad Hamadneh, Habes AL-Mashakbeh, Zohuir Albalawna

“…However, questions about their long-term biodegradability, ecological toxicity, and health effects require further investigation. …”
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Development of Cutaneous Bioadhesive Ureasil-Polyether Hybrid Films by João Augusto Oshiro Junior, Flávia Chiva Carvalho, Christiane Pienna Soares, Marlus Chorilli, Leila Aparecida Chiavacci

“…The hybrids formed by more hydrophilic PEO chains are more bioadherent, since they can interact more efficiently with the water present in the stratum corneum increasing the bioadhesion. Due to their low toxicity and high bioadhesion, the ureasil-PEO films obtained by using HCl as catalyst agent are good candidates for application to the skin as bioadhesive films.…”
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Detection of Dose Response in Chronic Doxorubicin-Mediated Cell Death with Cardiac Technetium 99m Annexin V Single-Photon Emission Computed Tomography by Kathleen L. Gabrielson, Greta S.P. Mok, Srihdar Nimmagadda, Djahida Bedja, Scott Pin, Allison Tsao, Yuchuan Wang, Dhrtti Sooryakumar, S. Jianhua Yu, Martin G. Pomper, Benjamin M.W. Tsui

“…Biodistribution of 99m Tc-HYNIC-annexin V uptake, CUR from SPECT/CT fused cardiac images, and TUNEL of myocardium demonstrated a dose-dependent toxicity response, with the cumulative 15 mg/kg DOX treatment showing the greatest degree of cell death. …”
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Synthesis of Cr3+-doped Al2O3 in nanoscale for bio-labels in myocardial cells by Sida Chen, Jian Hou, Yang Huang, Jinyu Pan, Kaizheng Liu, Guangxian Chen, Zhongkai Wu, Haoyi Wu

“…The material shows relatively stable in water and it was employed to cultivate the H9C2 cells, and the NIR emission from the cells was observed, indicating the successful absorption of the material by the cells. Additionally, the toxicity of the material was examined, by reducing the concentration to 2 nM/mL, the toxicity of the material was significantly reduced to a promising level. …”
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Levels of PAHs in the Waters, Sediments, and Shrimps of Estero de Urias, an Estuary in Mexico, and Their Toxicological Effects by Foday M. Jaward, Henry A. Alegria, Jose G. Galindo Reyes, Armando Hoare

“…High concentrations were also measured during the rainy season and during the first quarter of the year. Toxicity tests were also carried out, exposing fish embryos and juvenile shrimps to some of these PAHs. …”
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Allium Cepa (Onion) Extract Enhances and Protects Testicular Function and Architecture against Paraquat Induced Oxidative Damage. by Uzozie Chikere, Ofoego, Ejike, Daniel Eze

“…This study investigated the therapeutic potentials of ethanolic extract of A. cepa bulbs against paraquat-induced testicular toxicity in animal model. Thirty Wistar rats were split into control and five test groups (n=5). …”
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Properties of new polycationic bacteriochlorin photosensitizers: cytotoxicity and interaction with biofilms by Irina Tiganova, Yulia Zhizhimova, Eteri Tolordava, Elena Makarova, Natalia Shevlyagina, Alexander Barmashov, Maria Baryshnikova, Vladimir Zhukhovitsky, Yulia Romanova

“…Now, we compared the toxicity of these PS to bacteria and human fibroblasts, under irradiation and in the dark. …”
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