Emerging Implications for Extracellular Matrix-Based Technologies in Vascularized Composite Allotransplantation by Ricardo Londono, Vijay S. Gorantla, Stephen F. Badylak

“…Despite recent progress in vascularized composite allotransplantation (VCA), limitations including complex, high dose immunosuppression regimens, lifelong risk of toxicity from immunosuppressants, acute and most critically chronic graft rejection, and suboptimal nerve regeneration remain particularly challenging obstacles restricting clinical progress. …”
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Renewable Energy Driven by Le Chatelier's Principle, Enzyme Function, and Non-Additive Contributions to Ion Fluctuations: A Hypothesis in Biomechanical and Nanotechnology Energy Th... by Sergio Manzetti

“…The search for green energy sources has populated the research arena with significant emphasis on green electronics, green fuels, and green batteries that reduce waste, emissions, and environmental toxicity. Simultaneously, nanotechnology has developed substantially in the recent years and the emerging area of nanoenergetics has shown impressive discoveries that can aid in the search for alternative and green energies. …”
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Dynamics of a plant-herbivore model with toxin-induced functional response by Ya Li, Z. Feng

“…The effect of plant toxicity on herbivore's intakerate is incorporated explicitly in the model by assuming anincreased handling time. …”
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Pulmonary Nodules After Leflunomide Therapy in Rheumatoid Arthritis: A Case Report by Mahdiye Abiyarghamsari, Arman Ahmadzadeh

“…This case highlights the need for vigilance regarding potential pulmonary toxicity in RA patients receiving leflunomide and underscores the importance of prompt recognition and management of drug‐induced complications.…”
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CC-96673 (BMS-986358), an affinity-tuned anti-CD47 and CD20 bispecific antibody with fully functional fc, selectively targets and depletes non-Hodgkin’s lymphoma by Dan Zhu, Haralambos Hadjivassiliou, Catherine Jennings, David Mikolon, Massimo Ammirante, Sharmistha Acharya, Jon Lloyd, Mahan Abbasian, Rama Krishna Narla, Joseph R. Piccotti, Katie Stamp, Ho Cho, Kandasamy Hariharan

“…To date, the advancement of CD47-targeted modalities is hindered by the ubiquitous expression of the target, often leading to rapid drug elimination and hematologic toxicity including anemia. To overcome those challenges a bispecific approach was taken. …”
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Multicentre, 26-week, open-label phase 2 trial of the JAK inhibitor filgotinib in Behçet’s disease, idiopathic inflammatory myopathies and IgG4-related disease: DRIMID study protoc... by Sander W Tas, Joost Raaphorst, Paco M J Welsing, Jacob M van Laar, Rogier M Thurlings, Robbert J Goekoop, César Magro Checa, Jan A M van Laar, Bettina C Geertsema-Hoeve, Nicolle H Rekers, Erik Present

“…Additionally, glucocorticoids carry long-term toxicity risks. Thus, there is an urgent need to develop more targeted and effective anti-inflammatory treatments. …”
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Comparison of Efficacy and Safety of First-Line Treatment Options for Unresectable Stage III Non-Small Cell Lung Cancer: A Retrospective Analysis by Luqing Zhao, Zhiting Zhao, Xiaoqi Yan, Fei Wu, Ning Sun, Renhong Guo, Shaorong Yu, Xiao Hu, Jifeng Feng

“…In the radiotherapy group, the chemoradiotherapy (CRT) plus immunotherapy subgroup had longer mPFS than the CRT subgroup, with increased toxicity at any grade (24.60 vs. 17.90 months, p = 0.025, and 83.17% vs. 65.52%, p = 0.011). …”
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Biological Safety Studies and Simultaneous Determination of Linagliptin and Synthetic Impurities by LC-PDA by Raquel Balestri Heleno Ferreira, Jonathaline Apollo Duarte, Flávio Dias Ferreira, Luis Flávio Souza de Oliveira, Michel Mansur Machado, Marcelo Donadel Malesuik, Fávero Reisdorfer Paula, Martin Steppe, Elfrides Eva Shermann Schapoval, Clésio Soldateli Paim

“…The selectivity was evidenced because the degradation products formed in stress conditions did not interfere in the determination of LGT and impurities. Toxicity prediction studies suggested toxicity potential of the impurities, which was confirmed using biological safety studies in vitro.…”
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Virulence changes in Vibrio parahaemolyticus during the freezing of Penaeus chinensis by Zenghui Gao, Heer Ding, Ke Li, Qiang Zhang, Xubo Zhao, Liu Bin, Tianli Yue

“…Moreover, tdh and trh also exhibited trends similar to that of the hemolysis toxicity test. tdh was almost to a two-fold expression level during ice-glazing phase, while trh only express at a low level, less than half of the expression level before inoculation. …”
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Safety and Efficacy of Incorporating Actellic^® 300 CS into Soil Wall Plaster for Control of Malaria Vectors in Rural Northeastern Uganda by Tonny Jimmy Owalla, Emmanuel Okurut, Kenneth Ssaka, Gonsaga Apungia, Barbara Cemeri, Andrew Akileng, Basil Ojakol, Mark J. I. Paine, Hanafy M. Ismail, Thomas G. Egwang

“…The Actellic^® 300 CS toxicity on acetylcholinesterase activity among applicators of HD4MC was evaluated using the Test-mate (Model 400) erythrocyte acetylcholinesterase (AChE) test V.2, whereas toxicity in household occupants was monitored clinically. …”
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Harnessing Non-Antibiotic Strategies to Counter Multidrug-Resistant Clinical Pathogens with Special Reference to Antimicrobial Peptides and Their Coatings by Shyam Kumar Mishra, Tanzina Akter, Umme Laila Urmi, George Enninful, Manjulatha Sara, Jiawei Shen, Dittu Suresh, Liangjun Zheng, Elias Shiferaw Mekonen, Binod Rayamajhee, Francesco M. Labricciosa, Massimo Sartelli, Mark Willcox

“…Additionally, this review presents updates on strategies aimed at improving the cost, stability and selective toxicity of AMPs through the development of peptidomimetics. …”
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Enhanced Control Efficacy of Different Insecticides Mixed with Mineral Oil Against Asian Citrus Psyllid, <i>Diaphorina citri</i> Kuwayama, Under Varying Climates by Wei Hu, Kejing Wang, Xiaoyue Zhong, Pei Jiang, Shunchang Zhang, Zhanjun Lu, Zhixiang Zhang, Long Yi, Ning Zhang

“…To extend the product life of synthetic pesticides, we evaluated the toxicity of chlorpyrifos (CPF), thiamethoxam (THX), or pyriproxyfen (PPF) mixed with mineral oil Lvying (LY) against ACP nymphs under different weather conditions. …”
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DNA-loaded targeted nanoparticles as a safe platform to produce exogenous proteins in tumor B cells by Maria Cristina Grimaldi, Sara Bozzer, Dick J. Sjöström, Dick J. Sjöström, Linnea I. Andersson, Tom Eirik Mollnes, Tom Eirik Mollnes, Per H. Nilsson, Per H. Nilsson, Luca De Maso, Federico Riccardi, Michele Dal Bo, Daniele Sblattero, Paolo Macor

“…In the human/zebrafish lymphoma xenograft model, no evidence of toxicity was observed, and targeted NPs demonstrated the capacity to enhance exogenous pDNA expression.ConclusionOur findings provide a rationale for the use of targeted NPs as a DNA delivery system for the local expression of therapeutic proteins.…”
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Anti-arthritic potential of crude sulfated polysaccharide from marine macroalgae Sargassum ilicifolium (Turner) C. Agardh: Regulation of cytokine cascade by Ramamoorthi Lavanya, Jeyabalan Srikanth, Sankar Seethalakshmi, Begum M. Yasmin, Duraipandian Chamundeeswari, Sekar Mahendran, Wong Ling Shing, Subramaniyan Vetriselvan

“…The isolated and freeze-dried polysaccharide was tested for acute oral toxicity based on OECD 423. This step was followed by investigations on clinical signs and gross pathological alterations seen. …”
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Chlorambucil-Induced Acute Interstitial Pneumonitis by Hammad Shafqat, Adam J. Olszewski

“…We performed a systematic review of literature and identified 13 other case reports of chlorambucil-induced pulmonary toxicity, particularly interstitial pneumonitis. No unifying risk factor could be discerned and the mechanism of injury remains unknown. …”
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Novel Degree-Based Topological Descriptors of Carbon Nanotubes by M. C. Shanmukha, A. Usha, M. K. Siddiqui, K. C. Shilpa, A. Asare-Tuah

“…Topological indices are extensively used in modelling of chemical compounds to analyse the studies on quantitative structure activity/property/toxicity relationships and combinatorial library virtual screening. …”
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The influence of the ultrasonic field on the efficiency of leachate treatment in the SBR reactor by Monika Gałwa-Widera

“…The study showed that sonication increases biodegradability and reduces their toxicity. The use of pre-sonication before biological treatment improved the degree of removal of the tested parameters by about 10 %. …”
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An Adolescent Female with Bipolar Disorder Presenting with Lithium-Induced Hyperthyroidism by Pratibha Rana, Patria Alba Aponte, Ghufran Babar

“…Since thyroid autoantibodies were negative, thyroid dysfunction was attributed to lithium toxicity. Indeed, her clinical and biochemical hyperthyroid state resolved after stopping lithium therapy. …”
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CD19-directed chimeric antigen receptor T-cell therapy: what can we learn from the haematologist? by Marie José Kersten, Maria Theresa Kuipers

“…This article reviews the key principles learnt in haematology, the results and the mechanisms behind its efficacy, toxicities, and the challenges that need to be addressed for its broader application in clinical practice.…”
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Pathogenesis of Nonsteroidal Anti-Inflammatory Drug Gastropathy: Clues to Preventative Therapy by Salim MA Bastaki, John L Wallace

“…There is a strong possibility that new NSAIDs entering the market will have greatly reduced toxicity in the gastrointestinal tract.…”
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