History of the Organisation for Economic Co-operation and Development (OECD) test guidelines for non-animal test methods in Japan by Hajime Kojima

“…Drawing from this experience, I hope Japan will advance new approach methodologies for detecting systemic toxicity, which are in global demand.…”
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Transgenic Killer Commensal Bacteria as Mucosal Protectants by Luciano Polonelli

“…Unfortunately, current strategies for mucosal protection against candidiasis are severely limited by the lack of effective vaccines and the relative paucity and toxicity of commercially available antifungal drugs. …”
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Biosynthesis of Metal Nanoparticles: A Review by Narendra Kulkarni, Uday Muddapur

“…The limitation to the use of these nanoparticles is the paucity of an effective method of synthesis that will produce homogeneous size and shape nanoparticles as well as particles with limited or no toxicity to the human health and the environment. The biological method of nanoparticle synthesis is a relatively simple, cheap, and environmentally friendly method than the conventional chemical method of synthesis and thus gains an upper hand. …”
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Lead poisoning in ancient Rome by Francois P. Retief, Louise Cilliers

“…Although Roman writers commented on the toxicity of lead, classic chronic lead poisoning was first described only in the 7th century AD. …”
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Successful Use of Posaconazole to Treat Invasive Cutaneous Fungal Infection in a Liver Transplant Patient on Sirolimus by Randah Dahlan, Ameen Patel, Shariq Haider

“…The high morbidity and mortality associated with these infections necessitates urgent therapy with antifungal drugs; however, the interaction between these drugs and immunosuppressive therapies can be a major limitation because of drug toxicity. A case of soft tissue infection of the toe caused by Fusarium chlamydosporum and Candida guilliermondii in a liver transplant patient on sirolimus, who was successfully treated with the new antifungal agent posaconazole, is described. …”
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Fungal- and Algal-Derived Synthesis of Various Nanoparticles and Their Applications by Anugrah Michael, Aniket Singh, Arpita Roy, Md. Rabiul Islam

“…Most traditional methods to generate nanoparticles have certain limitations, like the toxicity of precursor materials, the need for high-temperature management, and the high cost of synthesis, which ultimately hinders their utility in sectors. …”
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Recent advancements to enhance the therapeutic efficacy of antiepileptic drugs by Li Fuquan, Singh Akhilesh Vikram

“…The application of novel drug delivery techniques could enhance the efficacy and reduce the toxicity of AEDs. These novel techniques aim to deliver an optimal concentration of the drug more specifically to the seizure focus or foci in the CNS without numerous side-effects. …”
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SOME ASPECTS ABOUT MATERIAL RECYCLING by Florin CIOFU

“…Some of these involve environmental and social issues such as pollution, disposal, recycling, toxicity and energy. This paper, in one way or another, addresses these issues related to material properties and manufacturing, as well as a relatively brief presentation of environmental and social considerations that are important in engineering practice.…”
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Bilateral Multifocal Central Serous-Like Chorioretinopathy due to MEK Inhibition for Metastatic Cutaneous Melanoma by Scott D. Schoenberger, Stephen J. Kim

“…The presumed mechanism involves toxicity to the retinal pigment epithelium, with breakdown of the blood-retinal barrier. …”
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Plant Tissue Analysis and Interpretation for Vegetable Crops in Florida by G. J. Hochmuth, E. Hanlon

“…The final section of the guide presents the deficiency, sufficiency, and toxicity ranges for plant nutrient concentrations. …”
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TLC densitometric method for screening of lycopsamine in comfrey root (Symphytum officinale L.) extracts using retrorsine as a reference compound by Janeš Damjan, Kreft Samo

“…Due to severe toxicity of pyrrolizidine alkaloids, their quantification in medicinal products is very important. …”
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Utilization of the Safe Surgical Dislocation Approach of the Hip to Retrieve a Bullet from the Femoral Head by Ruth Delaney, Maurice Albright, Gleeson Rebello

“…Retained intra-articular missiles from low-velocity handguns can lead to mechanical arthritis, synovitis, and lead toxicity. Various surgical approaches have been described to extract such foreign bodies from the hip joint. …”
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Hashish Body Packing: A Case Report by Manuel Jesus Soriano-Perez, Jose Luis Serrano-Carrillo, Inmaculada Marin-Montin, Alfonso Cruz-Caballero

“…Body packers may present to the emergency department because of drug toxicity, intestinal obstruction, or more commonly, requested by law-enforcement officers for medical confirmation or exclusion of suspected body packing.…”
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Pharmacological class effects of anticancer drugs: opportunities for decreasing healthcare spending by Gregory R Pond, Ian F Tannock, Daniel A Goldstein, Leonard B Saltz

“…The existence of such class effects enables healthcare payers to negotiate for substantially lower drug prices, thereby reducing financial toxicity, both at an individual and societal levels. …”
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Potential of Zinc Oxide Nanostructures in Biosensor Application by Ibrahim M. Maafa

“…Furthermore, ZnO’s biocompatibility and non-toxicity make it ideal for in vivo applications, reducing the chances of adverse biological responses. …”
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“Lost in translation?” Animal research in the era of precision medicine by Hamideh Frühwein, Norbert W. Paul

“…Abstract Preclinical animal research has long been a cornerstone in evaluating the efficacy, toxicity, and safety of potential drug treatments before they proceed to human clinical trials. …”
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Dendritic Cell-Based Approaches for Therapeutic Immune Regulation in Solid-Organ Transplantation by Giuseppe Vassalli

“…To avoid immune rejection, allograft recipients require drug-based immunosuppression, which has significant toxicity. An emerging approach is adoptive transfer of immunoregulatory cells. …”
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PSMA Theranostics: Current Status and Future Directions by Kambiz Rahbar MD, Ali Afshar-Oromieh MD, Hossein Jadvar MD, PhD, Hojjat Ahmadzadehfar MD, MSc

“…There is increasing evidence of encouraging response rates and a low toxicity profile of radioligand therapy (RLT) of metastatic castration-resistant prostate cancer using 177 Lu-labeled PSMA ligands. …”
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Ataxia and Seizures despite Phenytoin: A Case Report Highlighting the Importance of TDM and Genetic Influences by Rachel Manoj, Arpita Meher, Jefry Winner G.

“…Despite the standard dosage, the patient experienced toxicity symptoms and a seizure, prompting admission for assessment. …”
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Geriatric Chest Imaging: When and How to Image the Elderly Lung, Age-Related Changes, and Common Pathologies by J. Gossner, R. Nau

“…Pathologies with a special relevance for the elderly patient are discussed in detail: pneumonia, aspiration pneumonia, congestive heart failure, chronic obstructive pulmonary disease, the problem of overlapping heart failure and chronic obstructive pulmonary disease, pulmonary drug toxicity, incidental pulmonary embolism pulmonary nodules, and thoracic trauma.…”
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