Weed Management in Pastures and Rangeland—2017 by Brent A. Sellers, Jason A. Ferrell

“… Weeds in pastures and rangeland cost ranchers in excess of $180 million annually in Florida by reducing forage yield, lowering forage quality, and causing animal injury through toxicity or specialized plant organs (thorns and spines). …”
Get full text

Pesticide Application Best Management Practices for the Citrus Grove Worker by Brian Boman, Darren Cole, Steve Futch, Ward Gunter, Jack Hebb, P. Chris Wilson

“…It provides information for citrus grove workers about pests, pest control methods, pesticide toxicity, how to transport pesticides, first aid and decontamination, preventing exposure, worker protection standard, storage and disposal, pre-operation checkpoints, mixing and loading, container management, calibration, and application best management practices. …”
Get full text

2018–2019 Florida Citrus Production Guide: Best Management Practices for Soil-Applied Agricultural Chemicals by Joseph W. Noling, Lawrence R. Parsons

“…These BMPs must consider the soil properties of the application site and the mobility and toxicity of agrichemicals in soil, particularly with regard to rainfall and irrigation practices. …”
Get full text

In Vitro and In Silico Anthelmintic Activity of Extracts of Lannea kerstingii and Ficus thonningii on Heligmosomoides polygyrus by Ndjinkeu Ntcheuzing Serena, Masoud Besati, Noumedem Anangmo Christelle Nadia, Mahdi Yaghoobi, Yamssi Cédric, Claire Ciancia, Ngouyamsa Nsapkain Aboubakar Sidiki, Vincent Khan Payne, Mpoame Mbida, Haibo Hu

“…However, more research is required, especially on the acute toxicity and in vivo anthelmintic efficacy to validate this scientific investigation.…”
Get full text

Simultaneous exposure to microplastics and heavy metal lead induces oxidative stress, histopathological damage, and immune dysfunction in marine mussel Mytilus coruscus by Chuanyue Chen, Xueer Wang, Yingrong Jin, Yinchang Yao, Suchang Li, Zhi Liao, Xiaolin Zhang, Xiaojun Yan

“…MPs can interact with other environmental pollutants, such as heavy metals, and change their toxicity. In this study, we focused on the effects of MPs and lead (Pb), as a toxic heavy metal, on marine mussel Mytilus coruscus under separate and co-exposure situations at environmentally relevant concentrations: MPs (1 mg/L) and Pb (50 μg/L). …”
Get full text

Bacterial pathogens dynamic during multi-species infections by Barny, Marie-Anne, Thieffry, Sylvia, Gomes de Faria, Christelle, Thebault, Elisa, Pédron, Jacques

“…Antagonistic interactions were strain specific and not species specific. Toxicity interference was also observed within some communities, allowing the maintenance of strains otherwise sensitive to toxic compounds. …”
Get full text

PROTON RADIATION THERAPY: CLINICAL APPLICATION OPPORTUNITIES AND RESEARCH PROSPECTS by M. V. Zabelin, V. A. Klimanov, J. J. Galyautdinova, A. S. Samoilov, A. O. Lebedev, E. V. Shelyhina

“…There are data on extreme toxicity of a combination of a chemotherapy and photon radiation. …”
Get full text

Foliar spraying melatonin reduces the threat of chromium-contaminated water to wheat production by improving photosynthesis, limiting Cr translocation and reducing oxidative stress by Chuanjiao Sun, Libing Xu, Qiang Gao, Shuzhen Sun, Xiaoxue Liu, Zigang Zhang, Zhongwei Tian, Tingbo Dai, Jianyun Sun

“…This study aimed to investigate the effects of foliar spraying MT on alleviating Cr toxicity and accumulation in wheat irrigated with K2Cr2O7 solution at concentrations of 5, 10, and 20 mg/kg Cr in the soil. …”
Get full text

Personalized Therapy in a Patient With EGFR-Mutated NSCLC Developing Sequential CCDC6-RET Fusion and BRAF V600E Mutation as Bypass Resistance Mechanisms by Arianna Marinello, MD, Claudia Parisi, MD, Damien Vasseur, PhD, David Combarel, PharmD, Juliette Bihoreau, NP, Pernelle Lavaud, MD, Rémy Ezzedine, MD, Lodovica Zullo, MD, Luc Friboulet, PhD, Gerard Zalcman, MD, PhD, Antoine Italiano, MD, PhD, Benjamin Besse, MD, PhD, Mihaela Aldea, MD, PhD

“…Nevertheless, treatment was discontinued for toxicity, highlighting the challenges of using multiple drug combinations to address complex resistance.…”
Get full text

Safety and Tolerance of Donor-Derived Mesenchymal Stem Cells in Pediatric Living-Donor Liver Transplantation: The MYSTEP1 Study by Steffen Hartleif, Michael Schumm, Michaela Döring, Markus Mezger, Peter Lang, Marc H. Dahlke, Joachim Riethmüller, Alfred Königsrainer, Rupert Handgretinger, Silvio Nadalin, Ekkehard Sturm

“…Calcineurin inhibitors (CNI) have significantly improved patient and graft survival in pediatric liver transplantation (pLT). However, CNI toxicity leads to significant morbidity. Moreover, CNIs cannot prevent long-term allograft injury. …”
Get full text

Miramistin effect on BHK-21 and PSGK-30 cell line proliferation and FMD virus reproduction in these cells by M. I. Doronin, D. A. Lozovoy, V. V. Pronin, D. V. Mikhalishin, V. A. Starikov, A. V. Borisov, A. A. Shishkova

“…Use of cell structures as test systems for assessing the toxicity of pharmacological substances instead of conventional tests on experimental animals allows us to better clarify the possible mechanism of the effect of the investigated substance. …”
Get full text

Integrating machine learning and structure-based approaches for repurposing potent tyrosine protein kinase Src inhibitors to treat inflammatory disorders by Muhammad Waleed Iqbal, Muhammad Shahab, Zakir ullah, Guojun Zheng, Irfan Anjum, Gamal A. Shazly, Atrsaw Asrat Mengistie, Xinxiao Sun, Qipeng Yuan

“…Molecular Mechanics/Generalized Born Surface Area (MMGBSA) analysis validated their binding affinities by providing comparably lower binding free energies for orlistat (− 33.4743 ± 3.8908), acarbose (− 19.5455 ± 5.4702), and afatinib (− 36.4944 ± 5.4929) than the control, dasatinib (− 13.7785 ± 5.8058). Finally, toxicity analysis revealed orlistat and acarbose as the possible safer therapeutics by eliminating afatinib as it showed significant toxicity concerns. …”
Get full text

Assessment of phytochemical screening, antibacterial, analgesic, and antipyretic potentials of Litsea glutinosa (L.) leaves extracts in a mice model. by Zubair Khalid Labu, Samira Karim, Md Tarekur Rahman, Md Imran Hossain, Sarder Arifuzzaman, Md Shakil

“…In addition, the research includes preliminary phytochemical screening to identify key bioactive compounds and an acute toxicity test to assess the safety profile of the extract.…”
Get full text

The Frequency of <i>DPYD</i> c.557A>G in the Dominican Population and Its Association with African Ancestry by Mariela Guevara, Carla González de la Cruz, Fernanda Rodrigues-Soares, Ernesto Rodríguez, Caíque Manóchio, Eva Peñas-Lledó, Pedro Dorado, Adrián LLerena

“…The <i>DPYD</i> genotype is linked to variability in enzyme activity, 5-FU elimination, and toxicity. Approximately 10–40% of patients treated with fluoropyrimidines develop severe toxicity. …”
Get full text

Dye-based fluorescent organic nanoparticles made from polar and polarizable chromophores for bioimaging purposes: a bottom-up approach by Daniel, Jonathan, Dal Pra, Ophélie, Kurek, Eleonore, Grazon, Chloé, Blanchard-Desce, Mireille

“…Yet, they raise concern with respect to toxicity and degradability issues. In that context, we have developed innovative bottom-up approaches towards ultrabright dye-based fluorescent organic nanoparticles (dFONs). …”
Get full text

Clinical efficacy and safety of proton radiotherapy for ocular conjunctival malignancies: a systematic review and meta-analysis by Tingwei Zheng, Tingwei Zheng, Dandan Wang, Yuxin Miao, Yuxin Miao, Meng Dong, Qin Liu, Qin Liu, Qiuning Zhang, Huiling Bai, Huiling Bai, Hongtao Luo, Meixuan Li

“…The GRADE assessment yielded a low certainty of evidence.ConclusionsProton therapy offers a viable alternative treatment for patients with conjunctival malignancies, with acceptable treatment-related toxicity rates.…”
Get full text

Comparative the effect of bisphenol A and bisphenol S on the development and spectral sensitivity of cone photoreceptors in zebrafish larvae (Danio rerio) by Liguo Qiu, Peng Yu, Qiang Li, Cuiping Wen, Haiyang Wang, Dongying Zhao, Tianyu Zhang, Chenghui Wang, Lixia Liu, Dongxue Li, Shiyong Wen, Yinghui Sun

“…Bisphenol A (BPA) and its substitute bisphenol S (BPS) have been widely used worldwide, while the evaluation of their safety, especially the newly discovered visual toxicity mechanism caused by them in recent years, has not been clearly explored. …”
Get full text

Zearalenone exacerbates lipid metabolism disorders by promoting liver lipid droplet formation and disrupting gut microbiota by Xiao Han, Bingxin Huangfu, Tongxiao Xu, Kunlun Huang, Xiaoyun He

“…In the absence of significant toxicity and without affecting glucose tolerance, 50 and 100 μg/kg b. w. …”
Get full text

Intraperitoneal paclitaxel for patients with primary malignant peritoneal mesothelioma: a phase I/II dose escalation and safety study—INTERACT MESO by Job P van Kooten, Jacobus W A Burger, Cornelis Verhoef, Joachim G J V Aerts, Eva V E Madsen, Alexandra R M Brandt-Kerkhof, Stijn L W Koolen, Ron H J Mathijssen, Michelle V Dietz, Niels A D Guchelaar

“…Systemic uptake will be limited, likely resulting in less toxicity. The aim of the INTERACT MESO trial is to determine the maximum tolerable dose of intraperitoneal paclitaxel monotherapy in patients with MPM. …”
Get full text

Du macaque rhésus au macaque fascicularis : le refus de l’Inde de l’exportation de ses rhésus (1970-1990) by Laure Hoenen

“…The use of the rhesus monkey as an animal model in biomedical research during the 1950’s, principally for toxicity tests and polio vaccine production, fostered a dependence upon countries that exported these animals. …”
Get full text