The Role of the Enterohepatic Circulation of Bile Salts and Nuclear Hormone Receptors in the Regulation of Cholesterol Homeostasis: Bile Salts as Ligands for Nuclear Hormone Recept... by Richard N Redinger

“…FXR also targets sodium taurocholate cotransport peptide and bile salt export pump (protein) genes to limit bile salt uptake and enhance export, respectively, which prevents bile salt toxicity. Other nuclear hormone receptors such as pregnan X receptor, which share the obligate partner, retinoid X receptor, and vitamin D receptor also function as bile acid sensors to signal detoxification by hydroxylation of toxic bile acids. …”
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Micro-PET/CT Monitoring of Herpes Thymidine Kinase Suicide Gene Therapy in a Prostate Cancer Xenograft: The Advantage of a Cell-specific Transcriptional Targeting Approach by Mai Johnson, Makoto Sato, Jeremy Burton, Sanjiv S. Gambhir, Michael Carey, Lily Wu

“…Liver serology, tissue histology, and frail condition of animals confirmed liver toxicity suffered by the constitutive active cohorts, whereas the prostate-targeted group was unaffected. …”
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Antioxidant peptides encrypted in flaxseed proteome: An in silico assessment by Dawei Ji, Chibuike C. Udenigwe, Dominic Agyei

“…Compared with other enzymes studied, the plant proteases (papain, ficin, and bromelain) were found to be superior to releasing APs from the flaxseed proteins. Analysis of toxicity by ToxinPred showed that none of the peptides released was toxic. …”
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Assessing the Ecological Risk of Polycyclic Aromatic Hydrocarbons in Sediments at Langkawi Island, Malaysia by Essam Nasher, Lee Yook Heng, Zuriati Zakaria, Salmijah Surif

“…The contamination and toxicity levels of polycyclic aromatic hydrocarbon (PAH) in the sediments of Langkawi were evaluated using sediment quality guidelines (SQGs) and toxic equivalent factors. …”
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In Vitro Cytotoxicity of Fluorinated Quaternary Ammonium Salts in Colorectal Cancer Cells and In Silico Pharmacology by Adriana Milena Olarte Aponte, Victoria Ospina, Sergio A. Pulido, Luz Amalia Ríos-Vásquez, Luz Adriana Betancur Jaramillo, Carlos Mario Muñetón Peña, Rogelio Ocampo-Cardona, Sara M. Robledo

“…Results showed that FQASs 9–14 exhibited significant cytotoxic activity against both premetastatic and metastatic CRC cell lines, with FQASs 9, 13, and 14 displaying selective toxicity toward CRC cells over normal murine colorectal cells. …”
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A review of bismuth‐based nanoparticles and their applications in radiosensitising and dose enhancement for cancer radiation therapy by Daryoush Shahbazi‐Gahrouei, Yazdan Choghazardi, Arezoo Kazemzadeh, Paria Naseri, Saghar Shahbazi‐Gahrouei

“…Recently, bismuth‐based nanoparticles (BiNPs) have become particularly popular in radiation therapy due to their high atomic numbers (Z), high X‐ray attenuation coefficient, low toxicity, and low cost. Moreover, it is easy to synthesise in a variety of sizes and shapes. …”
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Study on the antifungal potential of Piper betle methanol extract against Colletotrichum gloeosporioides cutinase by Nhung Nguyen Thi Ai, Hai Nguyen Thi Thanh, Quang Thanh Bui, Vinh Phu Nguyen, Tu Quy Phan

“….; dipole moment 2.61 Debye; no toxicity; content 49.90 %) and 6 (DS -10.9 kcal.mol-1; ground-state energy -652.15 a.u.; dipole moment 2.82 Debye; no toxicity; content 13.23 %), given by both their natural contents and predicted properties. …”
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Telomerase inhibiting phytochemicals derived from Blumea eriantha for cancer treatment: A comprehensive computational analysis by Rahil Ummar Faruk Abbu, Shaik Mohammad Abdul Fayaz, Divyashree M S, Raghu Chandrashekhar H, Prasanna Kumar Reddy Gayam, Archana Mahadev Rao

“…A comprehensive pharmacokinetic analysis using SwissADME and pkCSM (Pharmacokinetics and Toxicity by Computational Structure-based Models) supported these results by determining the drug-like qualities of these phytochemicals. …”
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Assessment of synergistic efficacy of carbaryl in combination with Cinnamomum cassia and Origanum vulgare essential oils against Dermanyssus gallinae by Zhonghao Wang, Kai Xu, Shuo Yin, Jing Liu, Jianhua Qin, Dehe Wang, Lijun Xu, Chuanwen Wang

“…In this study, we formulated binary mixtures of the median lethal concentrations (LC50) of carbaryl and EOs of Cinnamomum cassia and Origanum vulgare at ratios from 1:9 to 9:1 and then evaluated their contact toxicity, fumigant toxicity, and ovicidal effects against D. gallinae. …”
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Anti-lipid-oxidation effects and edible safety evaluation of the oil extracted by a supercritical CO2 process from coix seed fermented by Monascus purpureus by Haiying Zeng, Anran Zhu, Shengling He, Mingjun Wu, Muhammad Mazhar, Anyan Wen, Na Liu, Likang Qin, Song Miao

“…Anti-lipid-oxidation and edible safety were evaluated using a cholesterol-fish oil model, acute oral toxicity assay, and genetic toxicity assay in vitro and in vivo, respectively. …”
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CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses by Alice Bergamini, Barbara Camisa, Attilio Bondanza, Fabio Ciceri, Chiara Bonini, Monica Casucci, Beatrice Greco, Camilla Bove, Silvia Arcangeli, Laura Falcone, Rita El Khoury, Anna De Lucia

“…However, treatment failures are common and the occurrence of severe toxicities, such as cytokine release syndrome (CRS), still limits the full exploitation of this approach. …”
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Stinging Nettles of Florida: Urtica by Wendy B. Zomlefer

“…Zomlefer, describes this annual herb with stinging hairs, its classification, description, similar species, toxicity, and economic uses. Includes references. Published by the UF Herbarium, October 2008. …”
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REVIEW by Claudia-Ştefania Bala

“…Iron, ferroptosis and association with tumoral evolution and potential therapeutic impact Decision making in Merkel cell carcinoma – surgical oncologist point of view Cardiac toxicity of checkpoint inhibitors (CPI) used in cancer immunotherapy Immune-mediated complications of monoclonal antibodies used in onco-hematology …”
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Stinging Nettles of Florida: Urtica by Wendy B. Zomlefer

“…Zomlefer, describes this annual herb with stinging hairs, its classification, description, similar species, toxicity, and economic uses. Includes references. Published by the UF Herbarium, October 2008. …”
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Biochemical Constituent of Ginkgo biloba (Seed) 80% Methanol Extract Inhibits Cholinesterase Enzymes in Javanese Medaka (Oryzias javanicus) Model by Ibrahim Hassan, Wan Norhamidah Wan Ibrahim, Ferdaus Mohamat Yusuf, Siti Aqlima Ahmad, Syahida Ahmad

“…High anticholinesterase activities and low toxicity effect of this plant show its benefit to be used as natural medicine or supplements.…”
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Safety evaluation of the food enzyme endo‐1,4‐β‐xylanase from the non‐genetically modified Trichoderma citrinoviride strain HBI‐TX01 by EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Monika Sramkova, Henk Van Loveren, Laurence Vernis, Yi Liu, Ana Criado, Kyriaki Apergi, Magdalena Andryszkiewicz, Daniele Cavanna, Eleonora Marini

“…Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. …”
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Safety evaluation of the food enzyme containing endo‐polygalacturonase and β‐glucosidase from the non‐genetically modified Aspergillus tubingensis strain ARO by EFSA Panel on Food Enzymes (FEZ Panel), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Monika Sramkova, Henk Van Loveren, Laurence Vernis, Valentina Tokić, Ana Criado, Eleonora Marini, Laura Sanmartin Cabo, Yi Liu

“…Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. …”
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Comparative Analysis of Cytotoxicity and Odontogenic Differentiation of Novel Bioceramic Material on Human Dental Pulp Stem Cells – An In Vitro Study by G. R. Ishwarya Dhevi, Ponnudurai Arangannal, J Jeevarathan

“…Results: All four groups tested using MTT assay showed no toxicity and possess odontogenic potential in all the experimental durations. …”
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An In Silico Approach for Evaluating a Fraction-Based, Risk Assessment Method for Total Petroleum Hydrocarbon Mixtures by Nina Ching Y. Wang, Glenn E. Rice, Linda K. Teuschler, Joan Colman, Raymond S. H. Yang

“…Both organizations defined TPH fractions based on their expected environmental fate and by analytical chemical methods. They derived toxicity values for selected compounds within each fraction and used these as surrogates to assess hazard or risk of exposure to the whole fractions. …”
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Safety evaluation of the food enzyme fructan β‐fructosidase from the genetically modified Trichoderma reesei strain AR‐577 by EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Monika Sramkova, Henk Van Loveren, Laurence Vernis, Andrew Chesson, Lieve Herman, Natália Kovalkovičová, Jaime Aguilera, Magdalena Andryszkiewicz, Daniele Cavanna, Yi Liu

“…Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. …”
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