Clopidogrel-Induced Neutropenia after Coronary Stenting: Is Cilostazol a Good Alternative? by Massimo Montalto, Italo Porto, Antonella Gallo, Claudia Camaioni, Roberta Della Bona, Antonio Grieco, Filippo Crea, Raffaele Landolfi

“…We report a case of clopidogrel-induced bone marrow toxicity manifesting with severe neutropenia in a patient treated with multiple coronary stents and provide suggestions for an alternative treatment.…”
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Anticancer Activity of Kefir on Glioblastoma Cancer Cell as a New Treatment by Arghavan Fatahi, Neda Soleimani, Parviz Afrough

“…Results showed that the toxicity effect in all groups was dose-dependent, and by increasing the concentration, cell survival decreased noticeably. …”
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Methylene blue at recommended concentrations alters metabolism in early zebrafish development by Niepukolie Nipu, Lai Wei, Lauren Hamilton, Hyojin Lee, Jith Thomas, Jan A. Mennigen

“…The Organisation for Economic Co-operation and Development zebrafish embryo toxicity test guideline omits MB recommendations, leading to inconsistent MB use in zebrafish research. …”
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Possibilities of palliative chemotherapy in patients with locally advanced and metastatic pancreatic cancer by L. I. Moskvicheva, L. V. Bolotina

“…The choice of chemotherapy regimen depends primarily on the General somatic status of the patient and is determined by the potential toxicity of a particular combination of cytostatics. …”
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Fish Scale-Derived Scaffolds for Culturing Human Corneal Endothelial Cells by Mohit Parekh, Bert Van den Bogerd, Nadia Zakaria, Diego Ponzin, Stefano Ferrari

“…Hoechst, ethidium homodimer, and calcein AM (HEC) staining was performed to determine viability and toxicity (n=6). The cell surface area was calculated based on calcein AM staining. …”
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iPSC-derived exosomes as amphotericin B carriers: a promising approach to combat cryptococcal meningitis by Jingyu Zhao, Jingyu Zhao, Wei Fang, Yangjie Gao, Jiquan Chen, Guizhen Wang, Julin Gu

“…The minimum inhibitory concentration (MIC) of iPSC-Exo/AmB and conventional AmB against Cryptococcus was determined.ResultsThe iPSC-Exo/AmB complex exhibited reduced cytotoxicity in vitro and decreased AmB-induced renal and hepatic toxicity in vivo. Its MIC against Cryptococcus was over eight times lower than conventional AmB, significantly reducing fungal burden in the mouse brain and lowering serum inflammatory factors.ConclusionThe iPSC-Exo/AmB complex is a promising therapeutic strategy that enhances AmB efficacy while reducing toxicity, offering new hope for treating CM and other refractory fungal infections of the central nervous system.…”
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Comparison of new secondgeneration H1 receptor blockers with some molecules; a study involving DFT, molecular docking, ADMET, biological target and activity by Velid Unsal, Erkan Oner, Reşit Yıldız, Başak Doğru Mert

“…Vitamin C and Quercetin were found to be safer in terms of cardiac toxicity and mutagenic risks, while Desloratadine and Levocetirizine carried high risks of neurotoxicity and hematotoxicity, while CAPE was noted for its high enzyme inhibitory activities and low toxicity profiles, while the hERG blockade, DILI, and cytotoxicity values of other compounds pointed to various safety concerns. …”
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The Safety and Efficacy of the Repeated PRRT with [90Y]Y/[177Lu]Lu-DOTATATE in Patients with NET by Anna Zemczak, Paweł Gut, Dariusz Pawlak, Maciej Kołodziej, Leszek Królicki, Beata Kos-Kudła, Marek Ruchała, Grzegorz Kamiński, Jolanta Kunikowska

“…Myelodysplastic syndrome occurred in one patient (3.8%), and grade 4 renal toxicity was also detected in one patient (3.8%). No other cases of grade 3 or 4 bone marrow and renal toxicity were observed. …”
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Ru(II) Complexes Bearing O, O-Chelated Ligands Induced Apoptosis in A549 Cells through the Mitochondrial Apoptotic Pathway by Jincan Chen, Jie Wang, Yuanyuan Deng, Tao Wang, Tifang Miao, Chengpeng Li, Xianhong Cai, Ying Liu, Justin Henri, Lanmei Chen

“…Notably, complex Ru-1 showed low toxicity to developing zebrafish embryos. The obtained results suggest that these new synthetic complexes have the potential to be developed as low-toxicity agents for lung cancer treatment.…”
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Biological Evaluation of Garcinia kola Heckel by Abdulrahman Mahmoud Dogara, Saber W. Hamad, Harmand A. Hama, Sarwan W. Bradosty, Soran Kayfi, Sawsan S. Al-Rawi, Abubakar Abdullahi Lema

“…Antioxidant, antimicrobial, antidiabetic, antibacterial, medications, antiviral, traditional medicine, ethnopharmacology, toxicity, cytotoxic action, chemical composition, mineral elements, GCMS analysis, and any other related phrases were used as filters to find studies. …”
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Severe and Fatal Multilobar Nonclassic Radiation Pneumonitis following Stereotactic Body Radiation Therapy (SBRT) for Treatment of Inoperable Non-Small-Cell Lung Cancer: A Report o... by Anastasios Georgiou, Adam Farmer

“…Given the rarity of fulminant radiation pneumonitis, especially with the relatively small fields treated by SBRT, we suspect that amiodarone enhanced the pulmonary toxicity.…”
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Protective Effect of Thyme Extract on Albino Rats Exposed to Paraquat by Nazar M. Shareef Mahmood

“…Therefore, the current results indicate that, the herbicide PQ showed adverse effects through initiation of lipid peroxidation, while T.vulgaris extract produced a significant recovery in ameliorating some aspects of PQ toxicity. …”
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Susceptibility Evaluation of Fall Armyworm (Spodoptera frugiperda) Infesting Maize in Kenya against a Range of Insecticides by Savinda Njeri Gichere, Kakai Shem Khakame, Okoth Patrick

“…The current study illustrated the high toxicity of spinetoram, spinosad, lufenuron, and pyridaben to fall armyworm while indoxacarb, deltamethrin, lambda-cyhalothrin, imidacloprid, and abamectin exhibited relatively low toxicity to fall armyworm. …”
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Pharmacokinetic Study of Di-Phenyl-Di-(2,4-Difluobenzohydroxamato)Tin(IV): Novel Metal-Based Complex with Promising Antitumor Potential by Yunlan Li, Zhuyan Gao, Pu Guo, Qingshan Li

“…Di-phenyl-di-(2,4-difluobenzohydroxamato)tin(IV)(DPDFT), a new metal-based arylhydroxamate antitumor complex, showed high in vivo and in vitro antitumor activity with relative low toxicity, but no data was reported regarding its pharmacokinetics and dependent toxicity. …”
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Adjuvant Bidirectional Chemotherapy with Intraperitoneal Pemetrexed Combined with Intravenous Cisplatin for Diffuse Malignant Peritoneal Mesothelioma by Lana Bijelic, O. Anthony Stuart, Paul Sugarbaker

“…The primary endpoint of the study was treatment related toxicity. From July 2007 until July 2009 ten patients were enrolled. …”
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In Vivo and Ex Vivo Evaluation of 1,3-Thiazolidine-2,4-Dione Derivatives as Euglycemic Agents by Diana Alemán-González-Duhart, Samuel Álvarez-Almazán, Miguel Valdes, Feliciano Tamay-Cach, Jessica Elena Mendieta-Wejebe

“…Unfortunately, they produce adverse effects, including weight gain, hepatic toxicity, and heart failure. Our group previously reported the design, synthesis, in silico evaluation, and acute oral toxicity test of two TZD derivatives, compounds 40 (C40) and 81 (C81), characterized as category 5 and 4, respectively, under the Globally Harmonized System. …”
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Biochemical Factors Modulating Cellular Neurotoxicity of Methylmercury by Parvinder Kaur, Michael Aschner, Tore Syversen

“…Methylmercury (MeHg), an environmental toxicant primarily found in fish and seafood, poses a dilemma to both consumers and regulatory authorities, given the nutritional benefits of fish consumption versus the possible adverse neurological damage. …”
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Solvent solutions: comparing extraction methods for edible oils and proteins in a changing regulatory landscape. General introduction☆ by Carré Patrick, Berthold Sebastian, Piofczyk Thomas, Bothe Sarah, Hadjiali Sara

“…However, this solvent poses health and environmental risks due to its toxicity. Recently, EFSA recommended a reevaluation of hexane as a processing aid due to gaps in toxicity studies and population exposure data. …”
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Application of Hyphenated Techniques in Speciation Analysis of Arsenic, Antimony, and Thallium by Rajmund Michalski, Sebastian Szopa, Magdalena Jabłońska, Aleksandra Łyko

“…Arsenic, antimony, and thallium are important examples of such toxic elements. Their speciation is especially important in the environmental and biomedical fields because of their toxicity, bioavailability, and reactivity. …”
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Significance of Algal Polymer in Designing Amphotericin B Nanoparticles by Saurabh Bhatia, Vikash Kumar, Kiran Sharma, Kalpana Nagpal, Tanmoy Bera

“…Degradation and dissolution studies suggested the stability of NPs over wide pH range. Hemolytic toxicity data suggested the safety of prepared formulation. …”
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