Decitabine Compared with Low-Dose Cytarabine for the Treatment of Older Patients with Newly Diagnosed Acute Myeloid Leukemia: A Pilot Study of Safety, Efficacy, and Cost-Effectiven... by Linu A. Jacob, S. Aparna, K. C. Lakshmaiah, D. Lokanatha, Govind Babu, Suresh Babu, Sandhya Appachu

“…Our study has shown that both of these agents have similar OS and toxicity. Low-dose cytarabine scores over decitabine in developing countries as it is more cost-effective.…”
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Development, in vitro and ex vivo characterization of lamotrigine-loaded bovine serum albumin nanoparticles using QbD approach by Maryana Salamah, Bence Sipos, Zsuzsanna Schelz, István Zupkó, Ágnes Kiricsi, Ágnes Szalenkó-Tőkés, László Rovó, Gábor Katona, György Tibor Balogh, Ildikó Csóka

“…The cytotoxicity study indicated that BSA-NP reduced LAM toxicity, and GLUC 9 mM and EDC 1 mg could be alternative cross-linking agents to avoid GLUT 2% v/v toxicity. …”
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Determinants of Virologic Failure among Adult HIV Patients on First-Line Antiretroviral Therapy at Waghimra Zone, Northern Ethiopia: A Case-Control Study by Abrham Emagnu, Zenahebezu Abay, Abera Balcha Bulti, Yaregal Animut

“…This study showed that poor adherence to treatment, longer duration on ART, experiencing drug toxicity, older age, and recent CD4 <200 cell/mm³ are factors that increase the risk of virologic failure.…”
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Effects of Melatonin and Epiphyseal Proteins on Fluoride-Induced Adverse Changes in Antioxidant Status of Heart, Liver, and Kidney of Rats by Vijay K. Bharti, R. S. Srivastava, H. Kumar, S. Bag, A. C. Majumdar, G. Singh, S. R. Pandi-Perumal, Gregory M. Brown

“…Several experimental and clinical reports indicated the oxidative stress-mediated adverse changes in vital organs of human and animal in fluoride (F) toxicity. Therefore, the present study was undertaken to evaluate the therapeutic effect of buffalo (Bubalus bubalis) epiphyseal (pineal) proteins (BEP) and melatonin (MEL) against F-induced oxidative stress in heart, liver, and kidney of experimental adult female rats. …”
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In Vitro Antibacterial and Antioxidant Activities, Pharmacokinetics, and In Silico Molecular Docking Study of Phytochemicals from the Roots of Ziziphus spina-christi by Hadush Gebrehiwot, Urgessa Ensermu, Aman Dekebo, Milkyas Endale, Tariku Nefo Duke

“…Furthermore, the organ toxicity predictions showed that all the compounds exhibit no hepatotoxicity and cytotoxicity effects and stigmasterol (5) affords drug-likeness protocols. …”
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Cryptolepine, the Main Alkaloid of the Antimalarial Cryptolepis sanguinolenta (Lindl.) Schlechter, Induces Malformations in Zebrafish Embryos by Kwesi Boadu Mensah, Charles Benneh, Arnold Donkor Forkuo, Charles Ansah

“…Here, we hypothesized that cryptolepine-induced embryo toxicity occurs at least partly through direct inhibition of embryogenesis rather than indirectly through the induction of maternal toxicity. …”
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High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis by Arvind Pradip, Daniella Steel, Susanna Jacobsson, Gustav Holmgren, Magnus Ingelman-Sundberg, Peter Sartipy, Petter Björquist, Inger Johansson, Josefina Edsbagge

“…Recent advances in differentiating human induced pluripotent stem cells (hiPSCs) into pure cultures of hepatocyte-like cells expressing functional drug metabolizing enzymes open up possibilities for novel, more relevant human cell based toxicity models. The present study aimed to investigate the use of hiPSC derived hepatocytes for conducting mechanistic toxicity testing by image based high content analysis (HCA). …”
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Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology by Arthur D. Stem, Cole R. Michel, Peter S. Harris, Keegan L. Rogers, Matthew Gibb, Carlos A. Roncal-Jimenez, Richard Reisdorph, Richard J. Johnson, James R. Roede, Kristofer S. Fritz, Jared M. Brown

“…To determine how the cellular redox environment may influence PCT cell function and toxicity, the redox proteome was examined using cysteine-targeted click chemistry proteomics. …”
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Evaluation of Diabetic Patients with Breast Cancer Treated with Metformin during Adjuvant Radiotherapy by Adam Ferro, Sharad Goyal, Sinae Kim, Hao Wu, Neil K. Taunk, Devora Schiff, Aneesh Pirlamarla, Bruce G. Haffty

“…The purpose of this study was to evaluate acute locoregional toxicity in patients with breast cancer receiving concurrent metformin plus radiation therapy. …”
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Comparative environmental impacts analysis of technologies for recovering critical metals from copper anode slime: Insights from LCA by Yu Li, Jenny Baker, Yaxi Fang, Haizhou Cao, Cameron Pleydell-Pearce, Trystan Watson, Sha Chen, Guangling Zhao

“…Six impact categories—climate change, freshwater ecotoxicity, marine ecotoxicity, terrestrial ecotoxicity, human toxicity (cancer), and human toxicity (non-cancer)—were assessed and compared across the four recycling technologies. …”
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Glutathione reductase plays a role in the metabolism of methylmercury degradation in Rhodotorula mucilaginosa by Yi Guo, Wenlong Deng, Qigui Mo, You Yu, Zhenwang Zhang, Mingjie Wei, Ruiling Tang, Surui Lu, Yanting Su

“…ABSTRACT Mercury pollution is a kind of heavy metal pollution with great harm and strong toxicity which exists worldwide. Some microorganisms can convert highly toxic methylmercury into inorganic mercury compounds with significantly reduced toxicity. …”
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Metabolic conversion of phenol to polyhydroxyalkanoate (PHA) for addressing dual environmental challenges: A review by Izzati Sabri, Mohd Zulkhairi Mohd Yusoff, Nor Azlan Nor Muhammad, Li Sim Ho, Norhayati Ramli

“…A sustainable approach to microbial polyhydroxyalkanoate (PHA) production involves utilizing waste as a substrate, which can include toxic pollutants like phenol as a carbon feedstock. …”
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Evaluation and Comparison of Iodine-Based and Biosynthesized Gold Nanoparticles as X-Ray Contrast Agent and Their Effects on Renal Functions in Male Wistar Rats by Paul Ayanlola, Gbadebo Isola, Waidi Saka, Margaret Akinloye, Abraham Aremu, Mustapha Lawal

“…Introduction: Gold nanoparticles (AuNPs) have gained significant attention as a promising contrast agent to overcome the challenges of iodine-based contrast agents (ICAs), such as poor contrast, and renal toxicity. However, studies have associated toxicity with AuNPs synthesized through chemical methods, thereby raising concerns regarding the safety of such AuNPs. …”
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Water-Soluble Vitamins: Hypo- and Hypervitaminosis in Pediatric Population by Roberto Paparella, Fabiola Panvino, Lucia Leonardi, Ida Pucarelli, Michela Menghi, Ginevra Micangeli, Francesca Tarani, Marcello Niceta, Debora Rasio, Rouzha Pancheva, Marco Fiore, Luigi Tarani

“…Conversely, although uncommon, excessive intake of certain water-soluble vitamins may cause mild toxicity, primarily gastrointestinal or neurological. …”
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Comprehensive analysis of histophysiology, transcriptomics and metabolomics in goslings exposed to gossypol acetate: unraveling hepatotoxic mechanisms by Jun Yu, Jun Yu, Haiming Yang, Jian Wang, Zixin Huang, Shi Chen, Hongchang Zhao, Jun Wang, Zhiyue Wang

“…Although the general toxicity of free gossypol is well-known, its specific effects on the liver—the primary site where it accumulates—are less thoroughly studied, particularly at the molecular level. …”
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Facile Synthesis, Characterization, and Cytotoxic Activity of Europium-Doped Nanohydroxyapatite by Paulina-Guadalupe Miranda-Meléndez, Gabriel-Alejandro Martínez-Castañón, Nereyda Niño-Martínez, Nuria Patiño-Marín, Miguel-Ángel Casillas-Santana, Brenda-Erendida Castillo-Silva, Facundo Ruiz

“…Also, impregnation and release of 5-fluorouracil were assessed in PBS. The toxicity effects of all samples were studied using viability assays on human fibroblasts cells (HGF-1) in vitro. …”
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Metronomic Cyclophosphamide and Methotrexate Chemotherapy Combined with 1E10 Anti-Idiotype Vaccine in Metastatic Breast Cancer by Jorge L. Soriano, Noyde Batista, Eduardo Santiesteban, Mayté Lima, Joaquín González, Robin García, Yohanka Zarza, María V. López, Myriam Rodríguez, Jorge L. Loys, Narciso Montejo, Frank Aguirre, Amparo Macías, Ana M. Vázquez

“…The median duration of the response (CR+PR+SD) was 18,43 months (12,20–24,10 months), being higher than 12 months in 76,9% of the patients. Overall toxicity was generally mild. Metronomic chemotherapy combined with 1E10-Alum vaccine immunotherapy might be a useful therapeutic option for the treatment of metastatic breast cancer due to its potential impact on survival and patient quality of live, low toxicity and advantages of the administration.…”
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Restricted Use Pesticides for Use in Florida by Frederick M. Fishel

“…All pesticides are classified according to their toxicity, use pattern, and environmental effects. The two main classifications are unclassified use and restricted use, though unclassified pesticides are commonly referred to as general use pesticides. …”
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Acute diquat poisoning induces paralytic ileus and hepatic portal venous gas: a case report by Hongji Yin, Dongxing Sun, Fengting Liu, Ruosai Xin

“…Diquat is a non-selective, broad-spectrum herbicide. Although its toxicity is significantly lower than paraquat, it still has a high mortality rate when ingested in large quantities. …”
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Therapeutic Drug Monitoring in the Treatment of Active Tuberculosis by Aylin Babalik, Sharyn Mannix, Denis Francis, Dick Menzies

“…Therapeutic drug monitoring ensures optimal dosing while aiming to reduce toxicity. However, due to the high costs and complexity of testing, therapeutic drug monitoring is not routinely used in the treatment of individuals with active tuberculosis, despite the efficacy demonstrated in several randomized trials. …”
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